Thermal modulation of radiation-induced DNA damage responses

Current Cancer Research

Volumn 19, Issue , 2011, Pages 227-249

  Roti Roti, Joseph L ^a   Vanderwaal, Robert P ^b   Laszlo, Andrei ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

H2AX; 53BP1; DNA repair; Heat shock proteins; Hyperthermia; MRE11; Nucleophosmin; Radiation sensitivity

Indexed keywords

53BP1 PROTEIN; HISTONE H2AX; HISTONE H2AX GAMMA; MRE11 PROTEIN; NUCLEOPHOSMIN; PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; CELL CYCLE CHECKPOINT; CELL NUCLEUS; CELL STRESS; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN STRUCTURE; DNA DAMAGE; DNA REPAIR; DNA SUPERCOILING; HUMAN; HYPERTHERMIA; IONIZING RADIATION; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RADIATION INJURY; RADIOSENSITIVITY; RADIOSENSITIZATION; REVIEW; SIGNAL TRANSDUCTION;

EID: 84870679117     PISSN: 09400745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-8044-1_11     Document Type: Review

References (95)

1. Adams MM, Carpenter PB (2006). Tying the loose ends together in DNA double strand break repair with 53BP1. Cell Div 1:19
2. Bassing CH, Alt FW (2004). H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity. Cell Cycle 3:149-153
3. Batuello CN, Kelley MR, Dynlacht JR (2009). Role of Ape1 and base excision repair in the radioresponse and heat-radiosensitization of HeLa cells. Anticancer Res 29:1319-1325
4. Beckmann RP, Lovett M, Welch WJ (1992). Examining the function and regulation of hsp 70 in cells subjected to metabolic stress. J Cell Biol 117:1137-1150
5. Bukau B, Weissman J, Horwich A (2006). Molecular chaperones and protein quality control. Cell 125:443-451
6. Chen MS, Featherstone T, Laszlo A (1996). Amplification and altered expression of the hsc70/U14 snoRNA gene in a heat resistant Chinese hamster cell line. Cell Stress Chaperones 1:47-61
7. Clark EP, Dewey WC, Lett JT (1981). Recovery of CHO cells from hyperthermic potentiation to X-rays repair of DNA and chromatin. Radiat Res 85:302-313
8. Coffey DS, Getzenberg RH, DeWeese TL (2006). Hyperthermic biology and cancer therapies: a hypothesis for the "Lance Armstrong effect". JAMA 296:445-448
9. D'Amours D, Jackson SP (2002). The Mre11 complex: at the crossroads of DNA repair and checkpoint signalling. Nature Rev Mol Cell Biol 3:317-327
10. Dewey WC, Sapareto SA, Betten DA (1978). Hyperthermic radiosensitization of synchronous Chinese hamster cells: relationship between lethality and chromosomal aberrations. Radiat Res 76:48-59
11. Difilippantonio S, Gapud E, Wong N et al (2008). 53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature 456:529-533
12. Dimitrova N, Chen YC, Spector DL et al (2008). 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature 456:524-528
13. DiTullio RA Jr, Mochan TA, Venere M et al (2002). 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat Cell Biol 4:998-1002
14. Dynlacht JR, Xu M, Pandita RK et al (2004). Effects of heat shock on the Mre11/Rad50/Nbs1 complex in irradiated or unirradiated cells. Int J Hyperthermia 20:144-156
15. Fernandez-Capetillo O, Lee A, Nussenzweig M et al (2004). H2AX: the histone guardian of the genome. DNA Repair (Amst) 3:959-967
16. Fey EG, Wan KM, Penman S (1984). Epithelial cytoskeletal framework and nuclear matrix-intermediate filament scaffold: three-dimensional organization and protein composition. J Cell Biol 98:1973-1984
17. He DC, Nickerson JA, Penman S (1990). Core filaments of the nuclear matrix. J Cell Biol 110:569-580
18. Huen MS, Grant R, Manke I et al (2007). RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell 131:901-914
19. Huen MS, Chen J (2008). When loose ends finally meet. Nature Struct Mol Biol 15:1241-1242.
20. Hunt CR, Pandita RK, Laszlo A et al (2007). Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status. Cancer Res 67:3010-3017
21. Horsman MR, Overgaard J (2007). Hyperthermia: a potent enhancer of radiotherapy. Clin Oncol 19:418-426
22. Illiakis G, Wu W, Wang M (2008). DNA double strand break repair inhibition as a cause of radiosensitization:Re-evaluation considering backup pathways of NHEJ. Int J Hyperthermia 24:17-29
23. Jackson SP (2002). Sensing and repairing DNA double-strand breaks. Carcinogenesis 23:687-696
24. Kampinga HH, Wright WD, Konings AW et al (1988). The interaction of heat and radiation affecting the ability of nuclear DNA to undergo supercoiling changes. Radiat Res 116:114-123
25. Kampinga HH, Turkel-Uygur N, Roti Roti JL et al (1989). The relationship of increased nuclear protein content induced by hyperthermia to killing of HeLa S3 cells. Radiat Res 117:511-522
26. Kampinga HH (1993). Thermotolerance in mammalian cells. Protein denaturation and aggregation and stress proteins. J Cell Sci 104:11-17
27. Kampinga HH, Hiemstra YS, Konings AW et al (1997). Correlation between slowly repairable double-strand breaks and thermal radiosensitization in the human HeLa S3 cell line. Int J Radiat Biol 72:293-301
28. Kampinga HH, Dikomey E (2001). Hyperthermic radiosensitization: mode of action and clinical relevance. Int J Radiat Biol 77:399-408
29. Kampinga HH, Dynlacht JR, Dikomey E (2004). Mechanism of radiosensitization by hyperthermia (> or = 43°C) as derived from studies with DNA repair defective mutant cell lines. Int J Hyperthermia 20:131-139
30. Kampinga HH, Laszlo A (2005). DNA double strand breaks do not play a role in heat-induced cell killing. Cancer Res 65:10632-10633
31. Kaneko H, Igarashi K, Kataoka K et al (2005). Heat shock induces phosphorylation of histone H2AX in mammalian cells. Biochem Biophys Res Commun 328:1101-1106
32. Kolas NK, Chapman JR, Nakada S et al (2007). Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science 318:1637-1640
33. Laszlo A, Li GC (1985). Heat-resistant variants of Chinese hamster fibroblasts altered in expression of heat shock protein. Proc Natl Acad Sci USA 82: 8029-8033
34. Laszlo A (1992a). The effects of hyperthermia on mammalian cell structure and function. Cell Prolif 25:59-87
35. Laszlo A (1992b). The thermoresistant state: protection from initial damage or better repair? Exp Cell Res 202:519-531
36. Laszlo A, Davidson T, Hu A et al (1993). Putative determinants of the cellular response to hyperthermia. Int J Radiat Biol 63:569-581
37. Laszlo A, Davidson T, Harvey A et al (2006). Alterations in heat-induced radiosensitization accompanied by nuclear structure alterations in Chinese hamster cells. Int J Hyperthermia 22:43-60
38. Laszlo A, Fleischer I (2009a). Heat-induced perturbations of DNA damage signalling pathways are modulated by molecular chaperones. Cancer Res 69:2042-2049
39. Laszlo A, Fleischer I (2009b). The heat-induced g-H2AX response does not play a role in hyperthermic cell killing. Int J Hyperthermia 25:199-209
40. Laszlo A, Li GC (1993). Effect of amino acid analogs on the development of thermotolerance and on thermotolerant cells. J Cell Physiol 154:419-432
41. Lee JH, Paull TT (2004). Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science 304:93-96
42. Lee JH, Paull TT (2005). ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308:551-554
43. Lepock JR (2004). Role of nuclear protein denaturation and aggregation in thermal radiosensitization. Int J Hyperthermia 20:115-130
44. Lepock JR (2005). How do cells respond to their thermal environment? Int J Hyperthermia 21:681-687
45. Li GC, Laszlo A (1985). Amino acid analogs while inducing heat shock proteins sensitize CHO cells to thermal damage. J Cell Physiol 122:91-97
46. Locke JE, Bradbury CM, Wei SJ et al (2002). Indomethacin lowers the threshold thermal exposure for hyperthermic radiosensitization and heat-shock inhibition of ionizing radiation-induced activation of NF-kB. Int J Radiat Biol 78:493-502
47. Lou Z, Minter-Dykhouse K, Franco S et al (2006). MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell 21:187-200
48. Luo J, Solimini NL, Elledge SJ (2009). Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 136:823-837
49. Mailand N, Bekker-Jensen S, Faustrup H et al (2007). RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell 131:887-900
50. Manis JP, Morales JC, Xia Z et al (2004). 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol 5:481-487
51. Mills MD, Meyn RE (1981). Effects of hyperthermia on repair of radiation-induced DNA strand breaks. Radiat Res 87:314-328
52. Mills MD, Meyn RE (1983). Hyperthermic potentiation of unrejoined DNA strand breaks following irradiation. Radiat Res 87:314-328
53. Mirzayans R, Severin D, Murray D (2006). Relationship between DNA double-strand break rejoining and cell survival after exposure to ionizing radiation in human fibroblast strains with differing ATM/p53 status: implications for evaluation of clinical radiosensitivity. Int J Radiat Oncol Biol Phys 66:1498-1505
54. Mirzoeva OK, Petrini JH (2001). DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol Cell Biol 21:281-288
55. Mitchel RE, Chan A, Smith BP et al (1984). The effects of hyperthermia and ionizing radiation in normal and ataxia telangiectasia human fibroblast lines. Radiat Res 99:627-635
56. Mochan TA, Venere M, DiTullio RA Jr et al (2004). 53BP1, an activator of ATM in response to DNA damage. DNA Repair (Amst) 3:945-952
57. Newmyer SL, Schmid SL (2001). Dominant-interfering Hsc70 mutants disrupt multiple stages of the clathrin-coated vesicle cycle in vivo. J Cell Biol 152:607-620
58. Paull TT, Rogakou EP, Yamazaki V et al (2000). A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 10:886-895
59. Posey JE, Brandt VL, Roth DB (2004). Paradigm switching in the germinal center. Natl Immunol 5:476-477
60. Pryde F, Khalili S, Robertson K et al (2005). 53BP1 exchanges slowly at the sites of DNA damage and appears to require RNA for its association with chromatin. J Cell Sci 118:2043-2055
61. Rappold I, Iwabuchi K, Date T et al (2001). Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J Cell Biol 153:613-620
62. Riballo E, Kuhne M, Rief N et al (2004). A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to g-H2AX foci. Mol Cell 16:715-724
63. Robinson JE, Wizenberg MJ, McCready WA (1974). Radiation and hyperthermal response of normal tissue in situ. Radiology 113:195-198
64. Rogakou EP, Boon C, Redon C et al (1999). Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 146:905-916
65. Roti Roti JL, Wright WD (1987). Visualization of DNA loops in nucleoids from HeLa cells: assays for DNA damage and repair. Cytometry 8:461-467
66. Roti Roti JL, Kampinga HH, Malyapa RS et al (1998). Nuclear matrix as a target for hyperthermic killing of cancer cells. Cell Stress Chaperones 3:245-255
67. Roti Roti JL, Pandita R, Mueller J et al (2010). Severe, short duration (0-3 minutes) heat shocks (50-52°C) inhibit the repair of DNA damage. Int J Hyperthermia 26:67-78
68. Roussou I, Nguyen T, Pagoulatos GN et al (2000). Enhanced protein denaturation in indomethacintreated cells. Cell Stress Chaperones 5:8-13
69. Schultz LB, Chehab NH, Malikzay A et al (2000). p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J Cell Biol 151:1381-1390
70. Sedelnikova OA, Rogakou EP, Panyutin IG et al (2002). Quantitative detection of (125)IdUinduced DNA double-strand breaks with g-H2AX antibody. Radiat Res 158:486-492
71. Sekhar KR, Sonar VN, Muthusamy V et al (2007). Novel chemical enhancers of heat shock increase thermal radiosensitization through a mitotic catastrophe pathway. Cancer Res 67:695-701
72. Senisterra GA, Huntley SA, Escaravage M et al (1997). Destabilization of the Ca2+-ATPase of sarcoplasmic reticulum by thiol-specific, heat shock inducers results in thermal denaturation at 37°C. Biochemistry 36:11002-11011
73. Seno JD, Dynlacht JR (2004). Intracellular redistribution and modification of proteins of the Mre11/Rad50/Nbs1 DNA repair complex following irradiation and heat-shock. J Cell Physiol 199:157-170
74. Shiloh YE (2004). Bridges over broken ends-the cellular response to DNA breaks in health and disease. DNA Repair (Amst) 3:779-1251
75. Sonar VNT, Reddy Y, Sekhar KR et al (2007). Novel substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one and (Z)-(+/-)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol derivatives as potent thermal sensitizing agents. Bioorg Med Chem Lett 17:6821-6824
76. Stavnezer J, Guikema JE, Schrader CE (2008). Mechanism and regulation of class switch recombination. Annu Rev Immunol 26:261-292
77. Stege GJ, Kampinga HH, Konings SW (1995). Heat-induced intranuclear protein aggregation and thermal radiosensitization. Int J Radiat Biol 67:203-209
78. Stucki M, Jackson SP (2006). g-H2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair (Amst) 5:534-543
79. Takahashi A, Matsumoto H, Nagayama K et al (2004). Evidence for the involvement of doublestrand breaks in heat-induced cell killing. Cancer Res 64:8839-8845
80. Takahashi A, Ohnishi T (2005). Does gH2AX foci formation depend on the presence of DNA double strand breaks? Cancer Lett 229:171-179
81. van den Bosch M, Bree RT, Lowndes NF (2003). The MRN complex: coordinating and mediating the response to broken chromosomes. EMBO Reports 4:844-849
82. VanderWaal R, Thampy G, Wright WD et al (1996). Heat-induced modifications in the association of specific proteins with the nuclear matrix. Radiat Res 145:746-753
83. Vanderwaal RP, Roti Roti JL (2004). Heat induced 'masking' of redox sensitive component(s) of the DNA-nuclear matrix anchoring complex. Int J Hyperthermia 20:234-239
84. VanderWaal RP, Maggi LB, Weber JD et al (2009). Nucleophosmin redistribution following heat shock: a role in heat-induced radiosensitization. Cancer Res 69:6454-6462
85. Ward IM, Minn K, van Deursen J et al (2003). p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol Cell Biol 23:2556-2563
86. Ward I, Chen J (2004). Early events in the DNA damage response. Curr Top Dev Biol 63:1-35
87. Warters RL, Roti Roti JL (1978). Production and excision of 5¢6¢-dihydroxydihydrothymine type products in the DNA of preheated cells. Int J Radiat Biol Relat Stud Phys Chem Med 34:381-384
88. Wong RS, Dynlacht JR, Cedervall B et al (1995). Analysis by pulsed-field gel electrophoresis of DNA double-strand breaks induced by heat and/or X-irradiation in bulk and replicating DNA of CHO cells. Int J Radiat Biol 68:141-152
89. Wright WD, Higashikubo R, RotiRoti JL (1989). Flow cytometric studies of the nuclear matrix. Cytometry 10:303-311
90. Wright WD, Lagroye I, Zhang P et al (2001). Cytometric methods to analyze ionizing-radiation effects. In: Darzynkiewicz Z (ed) Methods Cell Biol, Academic Press, New York, p. 251-268
91. Wynstra JH, Wright WD, Roti Roti JL (1990). Repair of radiation-induced DNA damage in thermotolerant and nonthermotolerant HeLa cells. Radiat Res 124:85-89
92. Xu M, Myerson RJ, Hunt C et al (2004). Transfection of human tumour cells with Mre11 siRNA and the increase in radiation sensitivity and the reduction in heat-induced radiosensitization. Int J Hyperthermia 20:157-162
93. Xu M, Myerson RJ, Straube WL et al (2002). Radiosensitization of heat resistant human tumour cells by 1 hour at 41.1°C and its effect on DNA repair. Int J Hyperthermia 18:385-403
94. Xu M, Myerson RJ, Xia Y et al (2007). The effects of 41°C hyperthermia on the DNA repair protein, MRE11, correlate with radiosensitization in four human tumor cell lines. Int J Hyperthermia 23:343-351
95. Zhu WG, Seno JD, Beck BD et al (2001). Translocation of MRE11 from the nucleus to the cytoplasm as a mechanism of radiosensitization by heat. Radiat Res 156:95-102