Translocation of MRE11 from the nucleus to the cytoplasm as a mechanism of radiosensitization by heat

Radiation Research

Volumn 156, Issue 1, 2001, Pages 95-102

  Zhu, W G ^a   Seno, J D ^a   Beck, B D ^a   Dynlacht, J R ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; MRE11 PROTEIN; NUCLEAR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; DNA REPAIR; DNA STRAND BREAKAGE; HEATING; HUMAN; HUMAN CELL; HYPERTHERMIA; IMMUNOFLUORESCENCE; IONIZING RADIATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN TRANSPORT; RADIOSENSITIZATION; WESTERN BLOTTING;

MAMMALIA;

EID: 0034951854     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/0033-7587(2001)156[0095:TOMFTN]2.0.CO;2     Document Type: Article

References (46)

1. The current and potential role of hyperthermia in radiotherapy
2. Thermally enhanced radioresponse of cultured Chinese hamster cells: Inhibition of repair of sublethal damage and enhancement of lethal damage
3. Hyperthermic radio-sensitization of synchronous Chinese hamster cells: Relationship between lethality and chromosomal aberrations
4. Hyperthermic effects on DNA repair mechanisms
5. Effects of hyperthermia on DNA repair mechanisms
6. Effects of hyperthermia on the repair of X-ray induced DNA double strand breaks in mouse L cells
7. Effect of heat on induction and repair of DNA strand breaks in X-irradiated CHO cells
8. Association of HSP72 with the nuclear (TX-100 -insoluble) fraction upon heating tolerant and non-tolerant HeLa S3 cells
9. Content of nonhistone protein in nuclei after hyperthermic treatment
10. The effects of hyperthermia on the protein to DNA ratio of isolated HeLa chromatin
11. Effects of hyperthermia on non-histone proteins isolated with DNA
12. Heat-induced intranuclear protein aggregation and thermal radiosensitization
13. The nuclear matrix: A target for heat shock effects and a determinant for stress response
14. Heat shock (45°C) results in an increase in nuclear matrix protein mass in HeLa cells
15. Initial characterization of heat-induced excess proteins in HeLa cells
16. Analysis by pulsed field gel electrophoresis of DNA double-strand breaks induced by heat and/or X-irradiation in bulk and replicating DNA of CHO cells
17. Excision of X-ray-induced thymine damage in chromatin from heated cells
18. Alterations in the nuclear matrix protein mass correlate with heat-induced inhibition of DNA single-strand-break repair
19. Effect of hyperthermia on CHO DNA polymerases α and β
20. A comparison of the effect of hyperthermia on DNA polymerase in hamster and human glioma cells
21. Heat-induced alterations in DNA polymerase activity of HeLa cells and isolated nuclei
22. Inhibition of repair of X-ray induced DNA damage by heat. I. The role Of hyperthermia inhibition of DNA polymerase alpha activity
23. Strand break repair, DNA polymerase activity and heat radiosensitization in thermotolerant cells
24. Heat inactivation of Ku autoantigen: Possible role in hyperthermic radiosensitization
25. A possible mechanism for hyperthermic radiosensitization mediated through hyperthermic lability of Ku subunits in DNA-dependent protein kinase
26. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
27. Human Rad50 is physically associated with human Mre11: Identification of a conserved multiprotein complex implicated in recombinational DNA repair
28. The many interfaces of hMre11
29. Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
30. Complex formation and functional versatility of Mre11 of budding yeast in recombination
31. hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks
32. In situ visualization of DNA double-strand break repair in human fibroblasts
33. The hMre11/ hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
34. The mammalian Mre11-Rad50-Nbs1 protein complex: Integration of functions in the cellular DNA-damage response
35. The 3′ to 5′ exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks
36. Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
37. A comprehensive study on the isolation and characterization of the HeLa S3 nuclear matrix
38. Protein measurement with the Folin phenol regent
39. Repair of DNA strand breaks at hyperthermic temperature in Chinese hamster ovary cells
40. The occurrence of DNA strand breaks after hyperthermic treatment of mammalian cells with and without radiation
41. Apurine site induction in the DNA of cells heated at hyperthermic temperatures
42. Hyperthermia inhibits the repair of DNA double-strand breaks induced by ionizing radiation as determined by pulsed-field gel electrophoresis
43. Transient thermal tolerance: Cell killing and polymerase activities
44. X-ray-induced breakage and rejoining of human interphase chromosomes
45. Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: Joining of correct and incorrect ends
46. Excess protein in nuclei isolated from heat-shocked cells results from a reduced extractability of nuclear proteins