The heat-induced -H2AX response does not play a role in hyperthermic cell killing

International Journal of Hyperthermia

Volumn 25, Issue 3, 2009, Pages 199-209

  Laszlo, Andrei ^a   Fleischer, Ilona ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

H2AX; Cell survival; DNA damage; Heat shock; Hyperthermia

Indexed keywords

CHAPERONE; GAMMA HISTONE H2AX; HISTONE H2AX; UNCLASSIFIED DRUG; ARSENIC TRIOXIDE; ARSENOUS ACID DERIVATIVE; AZETIDINE 2 CARBOXYLIC ACID; CANAVANINE; GAMMA H2AX PROTEIN, MOUSE; GAMMA-H2AX PROTEIN, MOUSE; GLYCEROL; H2AFX PROTEIN, HUMAN; HEAT SHOCK PROTEIN 27; HISTONE;

ANIMAL CELL; ARTICLE; CELL KILLING; CONTROLLED STUDY; HEAT SENSITIVITY; HEAT TOLERANCE; HYPERTHERMIC THERAPY; NONHUMAN; OXIDATIVE STRESS; PROTEIN SYNTHESIS; ANIMAL; CELL CULTURE; CELL LINE; CHO CELL; CRICETULUS; DRUG EFFECT; HAMSTER; HEAT; HUMAN; PHYSIOLOGY;

ANIMALS; ARSENITES; AZETIDINECARBOXYLIC ACID; CANAVANINE; CELL LINE; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; GLYCEROL; HISTONES; HOT TEMPERATURE; HSP27 HEAT-SHOCK PROTEINS; HUMANS; MOLECULAR CHAPERONES; OXIDATIVE STRESS;

EID: 67949100595     PISSN: 02656736     EISSN: 14645157     Source Type: Journal    
DOI: 10.1080/02656730802631775     Document Type: Article

References (49)

1. Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A. H2AX: The histone guardian of the genome. DNA Repair (Amst) 2004;3:959-967.
2. Takahashi A, Ohnishi T. Does gammaH2AX foci formation depend on the presence of DNA double strand breaks? Cancer Lett 2005;229:171-179.
3. Sedelnikova OA, Rogakou EP, Panyutin IG, Bonner WM. Quantitative detection of (125)IdU-induced DNA doublestrand breaks with gamma-H2AX antibody. Radiat Res 2002;158:486-492.
4. Takahashi A, Matsumoto H, Nagayama K, Kitano M, Hirose S, Tanaka H, Mori E, Yamakawa N, Yasumoto J, Yuki K, et al. Evidence for the involvement of double-strand breaks in heat-induced cell killing. Cancer Res 2004;64:8839-8845.
5. Kaneko H, Igarashi K, Kataoka K, Miura M. Heat shock induces phosphorylation of histone H2AX in mammalian cells. Biochem Biophys Res Commun 2005;328:1101-1106.
6. Hunt CR, Pandita RK, Laszlo A, Higashikubo R, Agarwal M, Kitamura T, Gupta A, Rief N, Horikoshi N, Baskaran R, et al. Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status. Cancer Res 2007;67:3010-3017.
7. Ohtsuka K, Laszlo A. The relationship between hsp70 localization and heat resistance. Exp Cell Res 1992;202: 507-518.
8. Riballo E, Kuhne M, Rief N, Doherty A, Smith G, Reico M, Reis C, Dahm K, Fricke A, Krempler A, et al. A pathway of double-strand break rejoining dependent upon ATM, artemis, and proteins locating to gamma-H2AX foci. Mol Cell 2004;16:715-724.
9. Ward I, Kim JE, Minn K, Chini CC, Mer G, Chen J. The tandem BRCT domain of 53BP1 is not required for its repair function. J Biol Chem 2006;281:38472-38477.
10. Laszlo A, Davidson T, Harvey A, Sim J, Malyapa R, Spitz D, Roti Roti J, et al. Alterations in heat-induced radiosensitization accompanied by nuclear structure alterations in Chinese hamster cells. Int J Hyperthermia 2006;22:43-60.
11. Laszlo A. Evidence for two states of thermotolerance in mammalian cells. Int J Hyperthermia 1988;4:513-526.
12. Borrelli MJ, Stafford DM, Karczewski LA, Rausch CM, Lee YJ, Corry PM. Thermotolerance expression in mitotic CHO cells without increased translation of heat shock proteins. J Cell Physiol 1996;169:420-428.
13. Laszlo A. The thermoresistant state: Protection from initial damage or better repair? Exp Cell Res 1992;202:519-531.
14. Stege GJ, Brunsting JF, Kampinga HH, Konings AW. Thermotolerance and nuclear protein aggregation: Protection against initial damage or better recovery? J Cell Physiol 1995;164:579-586.
15. Kampinga HH. Thermotolerance in mammalian cells. Protein denaturation and aggregation, and stress proteins. J Cell Sci 1993;104:11-17.
16. Kampinga HH, Brunsting JF, Stege GJ, Burgman PW, Konings AW. Thermal protein denaturation and protein aggregation in cells made thermotolerant by various chemicals: Role of heat shock proteins. Exp Cell Res 1995;219:536-546.
17. Chen MS, Featherstone T, Laszlo A. Amplification and altered expression of the hsc70/U14 snoRNA gene in a heat resistant Chinese hamster cell line. Cell Stress Chaperones 1996;1:47-61.
18. Landry J, Chretien P, Lambert H, Hickey E, Weber LA. Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells. J Cell Biol 1989;109:7-15.
19. Laszlo A, Li GC. Heat-resistant variants of Chinese hamster fibroblasts altered in expression of heat shock protein. Proc Natl Acad Sci USA 1985;82:8029-8033.
20. Laszlo A. The relationship of heat-shock proteins, thermotolerance, and protein synthesis. Exp Cell Res 1988;178:401-414.
21. Laszlo A, Davidson T, Hu A, Landry J, Bedford J. Putative determinants of the cellular response to hyperthermia. Int J Radiat Biol 1993;63:569-581.
22. Harvey WF, Bedford JS. Isolation and characterization of heat-sensitive, thermotolerant defective mutants of CHO cells. Radiat Res 1988;113:526-542.
23. Henle KJ, Warters RL. Heat protection by glycerol in vitro. Cancer Res 1982;42:2171-2176.
24. Pittet JF, Lee H, Pespeni M, O'Mahony A, Roux J, Welch WJ. Stress-induced inhibition of the NF-kappaB signaling pathway results from the insolubilization of the IkappaB kinase complex following its dissociation from heat shock protein 90. J Immunol 2005;174:384-394.
25. Welch WJ, Brown CR. Influence of molecular and chemical chaperones on protein folding. Cell Stress Chaperones 1996;1:109-115.
26. Kampinga HH, Turkel-Uygur N, Roti Roti JL, Konings AW. The relationship of increased nuclear protein content induced by hyperthermia to killing of HeLa S3 cells. Radiat Res 1989;117:511-522.
27. Li GC, Laszlo A. Amino acid analogs while inducing heat shock proteins sensitize CHO cells to thermal damage. J Cell Physiol 1985;122:91-97.
28. Laszlo A, Li GC. Effect of amino acid analogs on the development of thermotolerance and on thermotolerant cells. J Cell Physiol 1993;154:419-432.
29. Takahashi A, Ohnishi T. What is the critical hyperthermia target in cancer cells. Jpn J Hyperthermic Oncol 2006;22:229-237.
30. Spitz DR, Li GC, McCormick ML, Sun Y, Oberley LW. Stable H2O2-resistant variants of Chinese hamster fibroblasts demonstrate increases in catalase activity. Radiat Res 1988;114:114-124.
31. Spitz DR, Adams DT, Sherman CM, Roberts RJ. Mechanisms of cellular resistance to hydrogen peroxide, hyperoxia, and 4-hydroxy-2-nonenal toxicity: The significance of increased catalase activity in H2O2-resistant fibroblasts. Arch Biochem Biophys 1992;292:221-227.
32. Spitz DR, Kinter MT, Roberts RJ. Contribution of increased glutathione content to mechanisms of oxidative stress resistance in hydrogen peroxide resistant hamster fibroblasts. J Cell Physiol 1995;165:600-609.
33. Spitz DR, Li GC. Heat-induced cytotoxicity in H2O2- resistant Chinese hamster fibroblasts. J Cell Physiol 1990;142:255-260.
34. Bassing CH, Chua KF, Sekiguchi J, Suh H, Whitlow S, Fleming J, Monroe B, Ciccone D, Yan C, Vlaskova K, et al. Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Nat Acad Sci USA 2002;99:8173-8178.
35. Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen H, Sedelnikova O, Reina-San-Martin B, Coppola V, Meffre E, et al. Genomic instability in mice lacking histone H2AX. Science (New York) 2002;296:922-927.
36. Laszlo A. The effects of hyperthermia on mammalian cell structure and function. Cell Prolif 1992;25:59-87.
37. Bruskov VI, Malakhova LV, Masalimov ZK, Chernikov AV. Heat-induced formation of reactive oxygen species and 8-oxoguanine, a biomarker of damage to DNA. Nucleic Acids Res 2002;30:1354-1363.
38. Kampinga HH, Dikomey E. Hyperthermic radiosensitization: Mode of action and clinical relevance. Int J Radiat Biol 2001;77:399-408.
39. Kampinga HH, Dynlacht JR, Dikomey E. Mechanism of radiosensitization by hyperthermia ( 43-C) as derived from studies with DNA repair defective mutant cell lines. Int J Hyperthermia 2004;20:131-139.
40. Lepock JR. How do cells respond to their thermal environment? Int J Hyperthermia 2005;21:681-687.
41. Roti Roti JL, Kampinga HH, Malyapa RS, Wright WD, vanderWaal RP, Xu M. Nuclear matrix as a target for hyperthermic killing of cancer cells. Cell Stress Chaperones 1998;3:245-255.
42. Li G. Induction of thermotolerance and enhanced heat shock protein synthesis in Chinese hamster fibroblasts by sodium arsenite and ethanol. J Cell Phys 1983;115:116-122.
43. Bakkenist CJ, Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003;421:499-506.
44. Kusch T, Workman JL. Histone variants and complexes involved in their exchange. Sub Cell Biochem 2007;41:91-109.
45. Chowdhury D, Keogh MC, Ishii H, Peterson CL, Buratowski S, Lieberman J. Gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol Cell 2005;20:801-809.
46. Mirzayans R, Severin D, Murray D. Relationship between DNA double-strand break rejoining and cell survival after exposure to ionizing radiation in human fibroblast strains with differing ATM/p53 status: Implications for evaluation of clinical radiosensitivity. Int J Radiat Oncol Biol Phys 2006;66:1498-5105.
47. Soutoglou E, Misteli T. Activation of the cellular DNA damage response in the absence of DNA lesions. Science Express 2008;320:1507-1510.
48. Roti Roti JL. Cellular responses to hyperthermia (40-46): Cell killing and molecular events. Int J Hyperthermia 2008;24:3-15.
49. Lukas C, Melander F, Stucki M, Falck J, Bekker-Jensen S, Goldberg M, Lerenthal Y, Jackson S, Bartek J, Lukas J. Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J 2004;23: 2674-2683.