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Volumn 14, Issue 6, 2012, Pages 510-516

Mechanisms and consequences of inflammatory signaling in the myocardium

Author keywords

Chemokine; Cytokine; Heart failure; Inflammasome; Interleukin; Ischemia reperfusion; Myocardial inflammation; Nuclear factor kappaB; Protease; Protease activated receptors; Reactive oxygen species; Receptor activator of nuclear factor kappaB ligand; Tumor necrosis factor; Ventricular remodeling

Indexed keywords

ANTIINFLAMMATORY AGENT; CHEMOKINE RECEPTOR CX3CR1; ETANERCEPT; FLUINDOSTATIN; GLUCOCORTICOID; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLIXIMAB; METHYLPREDNISOLONE; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; PENTOXIFYLLINE; PHOSPHOLIPASE A2; PLACEBO; PROTEINASE ACTIVATED RECEPTOR; TOLL LIKE RECEPTOR 4;

EID: 84870545235     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-012-0309-0     Document Type: Article
Times cited : (40)

References (89)
  • 1
    • 47849125899 scopus 로고    scopus 로고
    • Heart failure-related hospitalization in theu.s., 1979 to 2004
    • Fang J, Mensah GA, Croft JB, et al. Heart failure-related hospitalization in theU.S., 1979 to 2004. JAmColl Cardiol. 2008;52:428-34.
    • (2008) JAmColl Cardiol , vol.52 , pp. 428-34
    • Fang, J.1    Mensah, G.A.2    Croft, J.B.3
  • 2
    • 43449083224 scopus 로고    scopus 로고
    • Prevention of heart failure: A scientific statement from the american heart association councils on epidemiology and prevention, clinical cardiology, cardiovascular nursing, and high blood pressure research; quality of care and outcomes research interdisciplinary working group; and functional genomics and translational biology interdisciplinary working group
    • Schocken DD, Benjamin EJ, Fonarow GC, et al. Prevention of heart failure: a scientific statement from the American Heart Association Councils on Epidemiology and Prevention, Clinical Cardiology, Cardiovascular Nursing, and High Blood Pressure Research; Quality of Care and Outcomes Research Interdisciplinary Working Group; and Functional Genomics and Translational Biology Interdisciplinary Working Group. Circulation. 2008;117:2544-65.
    • (2008) Circulation , vol.117 , pp. 2544-65
    • Schocken, D.D.1    Benjamin, E.J.2    Fonarow, G.C.3
  • 3
    • 57149134513 scopus 로고    scopus 로고
    • Long-term trends in the incidence of heart failure after myocardial infarction
    • Velagaleti RS, Pencina MJ, Murabito JM, et al. Long-term trends in the incidence of heart failure after myocardial infarction. Circulation. 2008;118:2057-62.
    • (2008) Circulation , vol.118 , pp. 2057-62
    • Velagaleti, R.S.1    Pencina, M.J.2    Murabito, J.M.3
  • 4
    • 82955233194 scopus 로고    scopus 로고
    • From risk factors to structural heart disease: The role of inflammation
    • Kalogeropoulos AP, Georgiopoulou VV, Butler J. From risk factors to structural heart disease: the role of inflammation. Heart Fail Clin. 2012;8:113-23.
    • (2012) Heart Fail Clin , vol.8 , pp. 113-23
    • Kalogeropoulos, A.P.1    Georgiopoulou, V.V.2    Butler, J.3
  • 5
    • 84855372880 scopus 로고    scopus 로고
    • Inflammation in myocardial diseases
    • This article addresses the specific pathways and mechanisms contributing to cardiac dysfunction in four classic settings marked by inflammation: ischemiareperfusion injury, sepsis, myocarditis, and transplant rejection.
    • Marchant D, Boyd J, Lin D, et al. Inflammation in myocardial diseases. Circ Res. 2012;110:126-44. This article addresses the specific pathways and mechanisms contributing to cardiac dysfunction in four classic settings marked by inflammation: ischemiareperfusion injury, sepsis, myocarditis, and transplant rejection.
    • (2012) Circ Res , vol.110 , pp. 126-44
    • Marchant, D.1    Boyd, J.2    Lin, D.3
  • 7
    • 79955601433 scopus 로고    scopus 로고
    • The emerging role of innate immunity in the heart and vascular system: For whom the cell tolls
    • This article reviews the biology of innate immune signaling in the heart, suggesting that the innate immune system is involved in the pathogenesis of atherosclerosis, acute coronary syndromes, stroke, viral myocarditis, sepsis, ischemia/reperfusion injury, and heart failure.
    • Mann DL. The emerging role of innate immunity in the heart and vascular system: for whom the cell tolls. Circ Res. 2011;108:1133-45. This article reviews the biology of innate immune signaling in the heart, suggesting that the innate immune system is involved in the pathogenesis of atherosclerosis, acute coronary syndromes, stroke, viral myocarditis, sepsis, ischemia/reperfusion injury, and heart failure.
    • (2011) Circ Res , vol.108 , pp. 1133-45
    • Mann, D.L.1
  • 8
    • 64549091508 scopus 로고    scopus 로고
    • Inflammation as a therapeutic target in heart failure? A scientific statement from the translational research committee of the heart failure association of the european society of cardiology
    • Heymans S, Hirsch E, Anker SD, et al. Inflammation as a therapeutic target in heart failure? A scientific statement from the translational research committee of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2009;11:119-29.
    • (2009) Eur J Heart Fail , vol.11 , pp. 119-29
    • Heymans, S.1    Hirsch, E.2    Anker, S.D.3
  • 9
    • 84861095145 scopus 로고    scopus 로고
    • Variable phenotype in murine transverse aortic constriction
    • Mohammed SF, Storlie JR, Oehler EA, et al. Variable phenotype in murine transverse aortic constriction. Cardiovasc Pathol. 2012;21:188-98.
    • (2012) Cardiovasc Pathol , vol.21 , pp. 188-198
    • Mohammed, S.F.1    Storlie, J.R.2    Oehler, E.A.3
  • 10
    • 84855371108 scopus 로고    scopus 로고
    • Inflammation endoplasmic reticulum stress autophagy and the monocyte chemoattractant protein-1 ccr2 pathway
    • This article reviews the role of ER stress and inflammation, with an emphasis on newly discovered roles for the chemokine monocyte chemoattractant protein-1 (MCP-1) and its downstream effector and novel zinc finger protein, MCP-1-induced protein.
    • Kolattukudy PE, Niu J. Inflammation, endoplasmic reticulum stress, autophagy, and the monocyte chemoattractant protein-1/CCR2 pathway. Circ Res. 2012;110:174-89. This article reviews the role of ER stress and inflammation, with an emphasis on newly discovered roles for the chemokine monocyte chemoattractant protein-1 (MCP-1) and its downstream effector and novel zinc finger protein, MCP-1-induced protein.
    • (2012) Circ Res , vol.110 , pp. 174-89
    • Kolattukudy, P.E.1    Niu, J.2
  • 11
    • 37749028373 scopus 로고    scopus 로고
    • Role of patternrecognition receptors in cardiovascular health and disease
    • Mitchell JA, Ryffel B, Quesniaux VF, et al. Role of patternrecognition receptors in cardiovascular health and disease. Biochem Soc Trans. 2007;35:1449-52.
    • (2007) Biochem Soc Trans. , vol.35 , pp. 1449-52
    • Mitchell, J.A.1    Ryffel, B.2    Quesniaux, V.F.3
  • 12
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell. 2010;140:805-20.
    • (2010) Cell , vol.140 , pp. 805-20
    • Takeuchi, O.1    Akira, S.2
  • 13
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder K, Tschopp J. The inflammasomes. Cell. 2010;140:821-32.
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 14
    • 84863838171 scopus 로고    scopus 로고
    • Toll-like receptors and myocardial inflammation
    • Feng Y, Chao W. Toll-like receptors and myocardial inflammation. Int J Inflam. 2011;2011:170352.
    • (2011) Int J Inflam , vol.2011 , pp. 170352
    • Feng, Y.1    Chao, W.2
  • 15
    • 58149500135 scopus 로고    scopus 로고
    • Toll-like receptor signaling: A critical modulator of cell survival and ischemic injury in the heart
    • Chao W. Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart. Am J Physiol Heart Circ Physiol. 2009;296:H1-12.
    • (2009) Am J Physiol Heart Circ Physiol , vol.296
    • Chao, W.1
  • 16
    • 79959602165 scopus 로고    scopus 로고
    • Protease-activated receptors and myocardial infarction
    • Antoniak S, Pawlinski R, Mackman N. Protease-activated receptors and myocardial infarction. IUBMB Life. 2011;63:383-9.
    • (2011) IUBMB Life , vol.63 , pp. 383-9
    • Antoniak, S.1    Pawlinski, R.2    Mackman, N.3
  • 17
    • 0034717192 scopus 로고    scopus 로고
    • Signaling properties and functions of two distinct cardiomyocyte protease-activated receptors
    • Sabri A, Muske G, Zhang H, et al. Signaling properties and functions of two distinct cardiomyocyte protease-activated receptors. Circ Res. 2000;86:1054-61.
    • (2000) Circ Res , vol.86 , pp. 1054-61
    • Sabri, A.1    Muske, G.2    Zhang, H.3
  • 18
    • 0027296403 scopus 로고
    • Myocardial a-thrombin receptor activation induces hypertrophy and increases atrial natriuretic factor gene expression
    • Glembotski CC, Irons CE, Krown KA, et al. Myocardial a-thrombin receptor activation induces hypertrophy and increases atrial natriuretic factor gene expression. J Biol Chem. 1993;268:20646-52.
    • (1993) J Biol Chem , vol.268 , pp. 20646-52
    • Glembotski, C.C.1    Irons, C.E.2    Krown, K.A.3
  • 19
    • 34250342563 scopus 로고    scopus 로고
    • Sch 79797, a selective par1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts
    • Strande JL, Hsu A, Su J, et al. SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts. Basic Res Cardiol. 2007;4:350-8.
    • (2007) Basic Res Cardiol , vol.4 , pp. 350-8
    • Strande, J.L.1    Hsu, A.2    Su, J.3
  • 20
    • 78149280410 scopus 로고    scopus 로고
    • Protease-activated receptor 2 deficiency reduces cardiac ischemia/reperfusion injury
    • Antoniak S, Rojas M, Spring D, et al. Protease-activated receptor 2 deficiency reduces cardiac ischemia/reperfusion injury. Arterioscler Thromb Vasc Biol. 2010;30:2136-42.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 2136-42
    • Antoniak, S.1    Rojas, M.2    Spring, D.3
  • 21
    • 0036087115 scopus 로고    scopus 로고
    • Protease-activated receptor-2 activation improves efficiency of experimental ischemic preconditioning
    • Napoli C, De Nigris F, Cicala C, et al. Protease-activated receptor-2 activation improves efficiency of experimental ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2002;282:H2004-10.
    • (2002) Am J Physiol Heart Circ Physiol , vol.282
    • Napoli, C.1    De Nigris, F.2    Cicala, C.3
  • 22
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-?b: A pivotal transcription factor in chronic inflammatory diseases
    • Barnes PJ, Karin M. Nuclear factor-?B: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med. 1997;336:1066-71.
    • (1997) N Engl J Med , vol.336 , pp. 1066-71
    • Barnes, P.J.1    Karin, M.2
  • 23
    • 0038587747 scopus 로고    scopus 로고
    • The two faces of ikk and nf-?b inhibition: Prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
    • Chen LW, Egan L, Li ZW, et al. The two faces of IKK and NF-?B inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med. 2003;9:575-81.
    • (2003) Nat Med , vol.9 , pp. 575-81
    • Chen, L.W.1    Egan, L.2    Li, Z.W.3
  • 24
    • 0033831027 scopus 로고    scopus 로고
    • A direct requirement of nuclear factor-?b for suppression of apoptosis in ventricular myocytes
    • Mustapha S, Kirshner A, De Moissac D, et al. A direct requirement of nuclear factor-?B for suppression of apoptosis in ventricular myocytes. Am J Physiol Heart Circ Physiol. 2000;279:H939-45.
    • (2000) Am J Physiol Heart Circ Physiol , vol.279
    • Mustapha, S.1    Kirshner, A.2    De Moissac, D.3
  • 25
    • 33644874937 scopus 로고    scopus 로고
    • Nuclear factor-?b-mediated cell survival involves transcriptional silencing of the mitochondrial death gene bnip3 in ventricular myocytes
    • Baetz D, Regula KM, Ens K, et al. Nuclear factor-?B-mediated cell survival involves transcriptional silencing of the mitochondrial death gene BNIP3 in ventricular myocytes. Circulation. 2005;112:3777-85.
    • (2005) Circulation , vol.112 , pp. 3777-85
    • Baetz, D.1    Regula, K.M.2    Ens, K.3
  • 26
    • 24944489952 scopus 로고    scopus 로고
    • Stimulus specificity of gene expression programs determined by temporal control of ikk activity
    • Werner SL, Barken D, Hoffmann A. Stimulus specificity of gene expression programs determined by temporal control of IKK activity. Science. 2005;309:1857-61.
    • (2005) Science , vol.309 , pp. 1857-61
    • Werner, S.L.1    Barken, D.2    Hoffmann, A.3
  • 27
    • 79955605472 scopus 로고    scopus 로고
    • Multiple facets of nf-?b in the heart: To be or not to nf-?b
    • This study provides evidence of the duality of beneficial and deleterious effects of NF-?B in the heart such as potentially harmful inflammation as well as promoting cardiomyocyte survival.
    • Gordon JW, Shaw JA, Kirshenbaum LA. Multiple facets of NF-?B in the heart: to be or not to NF-?B. Circ Res. 2011;108:1122-32. This study provides evidence of the duality of beneficial and deleterious effects of NF-?B in the heart such as potentially harmful inflammation as well as promoting cardiomyocyte survival.
    • (2011) Circ Res , vol.108 , pp. 1122-32
    • Gordon, J.W.1    Shaw, J.A.2    Kirshenbaum, L.A.3
  • 28
    • 84855384344 scopus 로고    scopus 로고
    • The fire within: Cardiac inflammatory signaling in health and disease
    • This article introduces inflammatory pathways in the heart, as well as their interactions with signaling pathways regulating cell survival and metabolism
    • Coggins M, Rosenzweig A. The fire within: cardiac inflammatory signaling in health and disease. Circ Res. 2012;110:116-25. This article introduces inflammatory pathways in the heart, as well as their interactions with signaling pathways regulating cell survival and metabolism.
    • (2012) Circ Res. , Issue.110 , pp. 116-25
    • Coggins, M.1    Rosenzweig, A.2
  • 29
    • 77954036224 scopus 로고    scopus 로고
    • Role of nuclear factor b in cardiovascular health and disease
    • This article introduces inflammatory pathways in the heart, as well as their interactions with signaling pathways regulating cell survival and metabolism. 29. Van der Heiden K, Cuhlmann S, le Luong A, et al. Role of nuclear factor ?B in cardiovascular health and disease. Clin Sci (Lond). 2010;118:593-605.
    • (2010) Clin Sci (Lond) , vol.118 , pp. 593-605
    • Van Der Heiden, K.1    Cuhlmann, S.2    Le Luong, A.3
  • 31
    • 34548427894 scopus 로고    scopus 로고
    • The inflammatory cytokine oncostatin m induces pai-1 in human vascular smooth muscle cells in vitro via pi 3-kinase and erk1/2-dependent pathways
    • Demyanets S, Kaun C, Rychli K, et al. The inflammatory cytokine oncostatin M induces PAI-1 in human vascular smooth muscle cells in vitro via PI 3-kinase and ERK1/2-dependent pathways. Am J Physiol Heart Circ Physiol. 2007;293:H1962-8.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293
    • Demyanets, S.1    Kaun, C.2    Rychli, K.3
  • 32
    • 41149172247 scopus 로고    scopus 로고
    • Remote vs. Ischaemic preconditioning: The differential role of mitogen-activated protein kinase pathways
    • Heidbreder M, Naumann A, Tempel K, et al. Remote vs. ischaemic preconditioning: the differential role of mitogen-activated protein kinase pathways. Circ Res. 2008;78:108-15.
    • (2008) Circ Res , vol.78 , pp. 108-15
    • Heidbreder, M.1    Naumann, A.2    Tempel, K.3
  • 33
    • 0037155837 scopus 로고    scopus 로고
    • Direct activation of mitochondrial apoptosis machinery by c-jun n-terminal kinase in adult cardiac myocytes
    • Aoki H, Kang PM, Hampe J, et al. Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes. J Biol Chem. 2002;277:10244-50.
    • (2002) J Biol Chem , vol.277 , pp. 10244-50
    • Aoki, H.1    Kang, P.M.2    Hampe, J.3
  • 34
    • 0037423550 scopus 로고    scopus 로고
    • ß-adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathway
    • Remondino A, Kwon SH, Communal C, et al. ß-adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathway. Circ Res. 2003;92:136-8.
    • (2003) Circ Res , vol.92 , pp. 136-8
    • Remondino, A.1    Kwon, S.H.2    Communal, C.3
  • 35
    • 0035895651 scopus 로고    scopus 로고
    • Cytoprotection by jun kinase during nitric oxide-induced cardiac myocyte apoptosis
    • Andreka P, Zang J, Dougherty C, et al. Cytoprotection by Jun kinase during nitric oxide-induced cardiac myocyte apoptosis. Circ Res. 2001;88:305-12.
    • (2001) Circ Res , vol.88 , pp. 305-12
    • Andreka, P.1    Zang, J.2    Dougherty, C.3
  • 36
    • 0037086678 scopus 로고    scopus 로고
    • Activation of c-jun n-terminal kinase promotes survival of cardiac myocytes after oxidative stress
    • Dougherty CJ, Kubasiak LA, Prentice H, et al. Activation of c-Jun N-terminal kinase promotes survival of cardiac myocytes after oxidative stress. Biochem J. 2002;362:561-71.
    • (2002) Biochem J , vol.362 , pp. 561-71
    • Dougherty, C.J.1    Kubasiak, L.A.2    Prentice, H.3
  • 37
    • 0034705626 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase pathway protects adult rat ventricular myocytes against ß-adrenergic receptor-stimulated apoptosis. Evidence for gidependent activation
    • Communal C, Colucci WS, Singh K. p38 mitogen-activated protein kinase pathway protects adult rat ventricular myocytes against ß-adrenergic receptor-stimulated apoptosis. Evidence for Gidependent activation. J Biol Chem. 2000;275:19395-400.
    • (2000) J Biol Chem , vol.275 , pp. 19395-400
    • Communal, C.1    Colucci, W.S.2    Singh, K.3
  • 38
    • 0035008371 scopus 로고    scopus 로고
    • Inhibition of p38 mapk a/ß reduces ischemic injury and does not block protective effects of preconditioning
    • Schneider S, Chen W, Hou J, et al. Inhibition of p38 MAPK a/ß reduces ischemic injury and does not block protective effects of preconditioning. Am J Physiol Heart Circ Physiol. 2001;280: H499-508.
    • (2001) Am J Physiol Heart Circ Physiol , vol.280
    • Schneider, S.1    Chen, W.2    Hou, J.3
  • 39
    • 0032510743 scopus 로고    scopus 로고
    • Signal transduction and activator of transcription (stat) protein-dependent activation of angiotensinogen promoter: A cellular signal for hypertrophy in cardiac muscle
    • Mascareno E, Dhar M, Siddiqui MA. Signal transduction and activator of transcription (STAT) protein-dependent activation of angiotensinogen promoter: a cellular signal for hypertrophy in cardiac muscle. Proc Natl Acad Sci U S A. 1998;95:5590-4.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 5590-4
    • Mascareno, E.1    Dhar, M.2    Siddiqui, M.A.3
  • 40
    • 53749100817 scopus 로고    scopus 로고
    • The myocardial jak/stat pathway: From protection to failure
    • Boengler K, Hilfiker-Kleiner D, Drexler H, et al. The myocardial JAK/STAT pathway: from protection to failure. Pharmacol Ther. 2008;120:172-85.
    • (2008) Pharmacol Ther , vol.120 , pp. 172-85
    • Boengler, K.1    Hilfiker-Kleiner, D.2    Drexler, H.3
  • 41
    • 0034651983 scopus 로고    scopus 로고
    • Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart
    • Fujio Y, Nguyen T, Wencker D, et al. Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation. 2000;101:660-7.
    • (2000) Circulation , vol.101 , pp. 660-7
    • Fujio, Y.1    Nguyen, T.2    Wencker, D.3
  • 42
    • 20344388514 scopus 로고    scopus 로고
    • Proapoptotic effects of caspase-1/interleukin-converting enzyme dominate in myocardial ischemia
    • Syed FM, Hahn HS, Odley A, et al. Proapoptotic effects of caspase-1/interleukin-converting enzyme dominate in myocardial ischemia. Circ Res. 2005;96:1103-9.
    • (2005) Circ Res , vol.96 , pp. 1103-9
    • Syed, F.M.1    Hahn, H.S.2    Odley, A.3
  • 43
    • 77649179433 scopus 로고    scopus 로고
    • Nlrp3 inflammasome activation: The convergence of multiple signalling pathways on ros production?
    • Tschopp J, Schroder K. NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production? Nat Rev Immunol. 2010;10:210-5.
    • (2010) Nat Rev Immunol , vol.10 , pp. 210-5
    • Tschopp, J.1    Schroder, K.2
  • 44
    • 79951679204 scopus 로고    scopus 로고
    • Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/reperfusion injury
    • Kawaguchi M, Takahashi M, Hata T, et al. Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/reperfusion injury. Circulation. 2011;123:594-604.
    • (2011) Circulation , vol.123 , pp. 594-604
    • Kawaguchi, M.1    Takahashi, M.2    Hata, T.3
  • 45
    • 0028990133 scopus 로고
    • Interleukin-1ß induces cardiac myocyte growth but inhibits cardiac fibroblast proliferation in culture
    • Palmer JN, Hartogensis WE, Patten M, et al. Interleukin-1ß induces cardiac myocyte growth but inhibits cardiac fibroblast proliferation in culture. J Clin Invest. 1995;95:2555-64.
    • (1995) J Clin Invest , vol.95 , pp. 2555-64
    • Palmer, J.N.1    Hartogensis, W.E.2    Patten, M.3
  • 46
    • 84858405983 scopus 로고    scopus 로고
    • Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure
    • Van Tassell BW, Arena RA, Toldo S, et al. Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure. PLoS One. 2012;7:e33438.
    • (2012) PLoS One , vol.7
    • Van Tassell, B.W.1    Arena, R.A.2    Toldo, S.3
  • 47
    • 14244249930 scopus 로고    scopus 로고
    • Increased expression of il-6 and lif in the hypertrophied left ventricle of tgr(mren2)27 and shr rats
    • Kurdi M, Randon J, Cerutti C, et al. Increased expression of IL-6 and LIF in the hypertrophied left ventricle of TGR(mRen2)27 and SHR rats. Mol Cell Biochem. 2005;269:95-101.
    • (2005) Mol Cell Biochem , vol.269 , pp. 95-101
    • Kurdi, M.1    Randon, J.2    Cerutti, C.3
  • 48
    • 0034703035 scopus 로고    scopus 로고
    • Interleukin-6 family of cytokines mediate angiotensin ii-induced cardiac hypertrophy in rodent cardiomyocytes
    • Sano M, Fukuda K, Kodama H, et al. Interleukin-6 family of cytokines mediate angiotensin II-induced cardiac hypertrophy in rodent cardiomyocytes. J Biol Chem. 2000;275:29717-23.
    • (2000) J Biol Chem , vol.275 , pp. 29717-23
    • Sano, M.1    Fukuda, K.2    Kodama, H.3
  • 50
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey DL, Timms E, Tan HL, et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 1998;93:165-76.
    • (1998) Cell , vol.93 , pp. 165-76
    • Lacey, D.L.1    Timms, E.2    Tan, H.L.3
  • 51
    • 0036510762 scopus 로고    scopus 로고
    • Tnf-related activation-induced cytokine (trance) induces angiogenesis through the activation of src and phospholipase c (plc) in human endothelial cells
    • Kim YM, Kim YM, Lee YM, et al. TNF-related activation-induced cytokine (TRANCE) induces angiogenesis through the activation of Src and phospholipase C (PLC) in human endothelial cells. J Biol Chem. 2002;277:6799-805.
    • (2002) J Biol Chem , vol.277 , pp. 6799-805
    • Kim, Y.M.1    Kim, Y.M.2    Lee, Y.M.3
  • 52
    • 21244499298 scopus 로고    scopus 로고
    • Tnf-related activation-induced cytokine enhances leukocyte adhesiveness: Induction of icam-1and vcam-1 via tnf receptor-associated factor and protein kinase c-dependent nf-?b activation in endothelial cells
    • Min JK, Kim YM, Kim SW, et al. TNF-related activation-induced cytokine enhances leukocyte adhesiveness: induction of ICAM-1and VCAM-1 via TNF receptor-associated factor and protein kinase C-dependent NF-?B activation in endothelial cells. J Immunol. 2005;175:531-40.
    • (2005) J Immunol , vol.175 , pp. 531-40
    • Min, J.K.1    Kim, Y.M.2    Kim, S.W.3
  • 53
    • 33846925850 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor (nf)-?b ligand (rankl) increases vascular permeability: Impaired permeability and angiogenesis in enos-deficient mice
    • Min JK, Cho YL, Choi JH, et al. Receptor activator of nuclear factor (NF)-?B ligand (RANKL) increases vascular permeability: impaired permeability and angiogenesis in eNOS-deficient mice. Blood. 2007;109:1495-502.
    • (2007) Blood , vol.109 , pp. 1495-502
    • Min, J.K.1    Cho, Y.L.2    Choi, J.H.3
  • 54
    • 21044452012 scopus 로고    scopus 로고
    • Dysregulated osteoprotegerin/rank ligand/rank axis in clinical and experimental heart failure
    • Ueland T, Yndestad A, Øie E, et al. Dysregulated osteoprotegerin/RANK ligand/RANK axis in clinical and experimental heart failure. Circulation. 2005;111:2461-8.
    • (2005) Circulation , vol.111 , pp. 2461-8
    • Ueland, T.1    Yndestad, A.2    Øie, E.3
  • 55
    • 84859038834 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor-?b ligand is a novel inducer of myocardial inflammation
    • Ock S, Ahn J, Lee SH, et al. Receptor activator of nuclear factor-?B ligand is a novel inducer of myocardial inflammation. Cardiovasc Res. 2012;94:105-14.
    • (2012) Cardiovasc Res , vol.94 , pp. 105-14
    • Ock, S.1    Ahn, J.2    Lee, S.H.3
  • 56
    • 70149111743 scopus 로고    scopus 로고
    • Role of mcp-1 in cardiovascular disease: Molecular mechanisms and clinical implications
    • Niu J, Kolattukudy PE. Role of MCP-1 in cardiovascular disease: molecular mechanisms and clinical implications. Clin Sci (Lond). 2009;117:95-109.
    • (2009) Clin Sci (Lond) , vol.117 , pp. 95-109
    • Niu, J.1    Kolattukudy, P.E.2
  • 57
    • 0242286636 scopus 로고    scopus 로고
    • Anti-monocyte chemoattractant protein-1 gene therapy attenuates left ventricular remodeling and failure after experimental myocardial infarction
    • Hayashidani S, Tsutsui H, Shiomi T, et al. Anti-monocyte chemoattractant protein-1 gene therapy attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation. 2003;108:2134-40.
    • (2003) Circulation , vol.108 , pp. 2134-40
    • Hayashidani, S.1    Tsutsui, H.2    Shiomi, T.3
  • 58
    • 84855371090 scopus 로고    scopus 로고
    • Regulation of the inflammatory response in cardiac repair
    • This review introduces recently identified endogenous inhibitors induced as part of the core inflammatory reaction that serve to reduce post-infarct inflammation.
    • Frangogiannis NG. Regulation of the inflammatory response in cardiac repair. Circ Res. 2012;110:159-73. This review introduces recently identified endogenous inhibitors induced as part of the core inflammatory reaction that serve to reduce post-infarct inflammation.
    • (2012) Circ Res , vol.110 , pp. 159-73
    • Frangogiannis, N.G.1
  • 59
    • 81855184881 scopus 로고    scopus 로고
    • Repair after myocardial infarction, between fantasy and reality: The role of chemokines
    • Liehn EA, Postea O, Curaj A, et al. Repair after myocardial infarction, between fantasy and reality: the role of chemokines. J Am Coll Cardiol. 2011;58:2357-62.
    • (2011) J Am Coll Cardiol , vol.58 , pp. 2357-62
    • Liehn, E.A.1    Postea, O.2    Curaj, A.3
  • 60
    • 72449147738 scopus 로고    scopus 로고
    • The multifunctional role of mtor in innate immunity: Implications for transplant immunity
    • Säemann MD, Haidinger M, Hecking M, et al. The multifunctional role of mTOR in innate immunity: implications for transplant immunity. Am J Transplant. 2009;9:2655-61.
    • (2009) Am J Transplant , vol.9 , pp. 2655-61
    • Säemann, M.D.1    Haidinger, M.2    Hecking, M.3
  • 61
    • 54949109311 scopus 로고    scopus 로고
    • The tsc-mtor signaling pathway regulates the innate inflammatory response
    • Weichhart T, Costantino G, Poglitsch M, et al. The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity. 2008;29:565-77.
    • (2008) Immunity , vol.29 , pp. 565-77
    • Weichhart, T.1    Costantino, G.2    Poglitsch, M.3
  • 62
    • 78649668307 scopus 로고    scopus 로고
    • Mtor attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy
    • Song X, Kusakari Y, Xiao CY, et al. mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy. Am J Physiol Cell Physiol. 2010;299:C1256-66.
    • (2010) Am J Physiol Cell Physiol , vol.299
    • Song, X.1    Kusakari, Y.2    Xiao, C.Y.3
  • 63
    • 0034956481 scopus 로고    scopus 로고
    • Changes in extracellular matrix and in transforming growth factor beta isoforms after coronary artery ligation in rats
    • Deten A, Hölzl A, Leicht M, et al. Changes in extracellular matrix and in transforming growth factor beta isoforms after coronary artery ligation in rats. J Mol Cell Cardiol. 2001;33:1191-207.
    • (2001) J Mol Cell Cardiol , vol.33 , pp. 1191-207
    • Deten, A.1    Hölzl, A.2    Leicht, M.3
  • 64
    • 0036645337 scopus 로고    scopus 로고
    • Transforming growth factor-ß function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats
    • Kuwahara F, Kai H, Tokuda K, et al. Transforming growth factor-ß function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats. Circulation. 2002;106:130-5.
    • (2002) Circulation , vol.106 , pp. 130-5
    • Kuwahara, F.1    Kai, H.2    Tokuda, K.3
  • 65
    • 59449107442 scopus 로고    scopus 로고
    • Myocardial repair/remodelling following infarction: Roles of local factors
    • Sun Y. Myocardial repair/remodelling following infarction: roles of local factors. Cardiovasc Res. 2009;81:482-90.
    • (2009) Cardiovasc Res , vol.81 , pp. 482-90
    • Sun, Y.1
  • 66
    • 3242806007 scopus 로고    scopus 로고
    • Tgf-ß1 and angiotensin networking in cardiac remodeling
    • Rosenkranz S. TGF-ß1 and angiotensin networking in cardiac remodeling. Cardiovasc Res. 2004;63:423-32.
    • (2004) Cardiovasc Res , vol.63 , pp. 423-32
    • Rosenkranz, S.1
  • 67
    • 0346368261 scopus 로고    scopus 로고
    • Extracellular protease activation and unraveling of the myocardial interstitium: Critical steps toward clinical applications
    • Chapman RE, Spinale FG. Extracellular protease activation and unraveling of the myocardial interstitium: critical steps toward clinical applications. Am J Physiol Heart Circ Physiol. 2004;286:H1-10.
    • (2004) Am J Physiol Heart Circ Physiol , vol.286
    • Chapman, R.E.1    Spinale, F.G.2
  • 69
    • 84862537276 scopus 로고    scopus 로고
    • Anti-inflammatory mechanisms and therapeutic opportunities in myocardial infarct healing
    • This article reviews anti-inflammatory and pro-inflammatory pathways during myocardial infarct healing.
    • Kempf T, Zarbock A, Vestweber D, et al. Anti-inflammatory mechanisms and therapeutic opportunities in myocardial infarct healing. J Mol Med (Berl). 2012;90:361-9. This article reviews anti-inflammatory and pro-inflammatory pathways during myocardial infarct healing.
    • (2012) J Mol Med (Berl) , vol.90 , pp. 361-9
    • Kempf, T.1    Zarbock, A.2    Vestweber, D.3
  • 70
    • 0020055656 scopus 로고
    • Effects of methylprednisolone on the ischemic damage in patients with acute myocardial infarction
    • Madias JE, Hood Jr. WB. Effects of methylprednisolone on the ischemic damage in patients with acute myocardial infarction. Circulation. 1982;65:1106-13.
    • (1982) Circulation. , vol.65 , pp. 1106-13
    • Madias, J.E.1    Hood Jr., W.B.2
  • 71
    • 11144355760 scopus 로고    scopus 로고
    • Targeted anticytokine therapy in patients with chronic heart failure: Results of the randomized etanercept worldwide evaluation (renewal)
    • Mann DL, McMurray JJ, Packer M, et al. Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL). Circulation. 2004;109:1594-602.
    • (2004) Circulation , vol.109 , pp. 1594-602
    • Mann, D.L.1    McMurray, J.J.2    Packer, M.3
  • 72
    • 70449333577 scopus 로고    scopus 로고
    • Effect of the soluble tnf-antagonist etanercept on tumor necrosis factor bioactivity and stability
    • Mann DL, Bozkurt B, Torreamione G, et al. Effect of the soluble TNF-antagonist etanercept on tumor necrosis factor bioactivity and stability. Clin Transl Sci. 2008;1:142-5.
    • (2008) Clin Transl Sci , vol.1 , pp. 142-5
    • Mann, D.L.1    Bozkurt, B.2    Torreamione, G.3
  • 73
    • 0038755661 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-a, in patients with moderate-tosevere heart failure: Results of the anti-tnf therapy against congestive heart failure (attach) trial
    • Chung ES, Packer M, Lo KH, et al. Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-a, in patients with moderate-tosevere heart failure: results of the anti-TNF Therapy Against Congestive Heart Failure (ATTACH) trial. Circulation. 2003;107:3133-40.
    • (2003) Circulation , vol.107 , pp. 3133-40
    • Chung, E.S.1    Packer, M.2    Lo, K.H.3
  • 74
    • 84859459736 scopus 로고    scopus 로고
    • Infliximab treatment increases left ventricular ejection fraction in patients with rheumatoid arthritis: Assessment of heart function by echocardiography, endothelin 1, interleukin 6, and nt-pro brain natriuretic peptide
    • Kotyla PJ, Owczarek A, Rakoczy J, et al. Infliximab treatment increases left ventricular ejection fraction in patients with rheumatoid arthritis: assessment of heart function by echocardiography, endothelin 1, interleukin 6, and NT-pro brain natriuretic peptide. J Rheumatol. 2012;39:701-6.
    • (2012) J Rheumatol , vol.39 , pp. 701-6
    • Kotyla, P.J.1    Owczarek, A.2    Rakoczy, J.3
  • 75
    • 64549101645 scopus 로고    scopus 로고
    • Immunological mechanisms of pentoxifylline in chronic heart failure
    • Shaw SM, Shah MK, Williams SG, et al. Immunological mechanisms of pentoxifylline in chronic heart failure. Eur J Heart Fail. 2009;11:113-8.
    • (2009) Eur J Heart Fail , vol.11 , pp. 113-8
    • Shaw, S.M.1    Shah, M.K.2    Williams, S.G.3
  • 76
    • 1342324113 scopus 로고    scopus 로고
    • Pentoxifylline in ischemic, hypertensive and idiopathic-dilated cardiomyopathy: Effects on left-ventricular function, inflammatory cytokines and symptoms
    • Bahrmann P, Hengst UM, Richartz BM, et al. Pentoxifylline in ischemic, hypertensive and idiopathic-dilated cardiomyopathy: effects on left-ventricular function, inflammatory cytokines and symptoms. Eur J Heart Fail. 2004;6:195-201.
    • (2004) Eur J Heart Fail , vol.6 , pp. 195-201
    • Bahrmann, P.1    Hengst, U.M.2    Richartz, B.M.3
  • 77
    • 51749096897 scopus 로고    scopus 로고
    • Intravenous immunoglobulin -Indications and mechanisms in cardiovascular diseases
    • Nussinovitch U, Shoenfeld Y. Intravenous immunoglobulin -indications and mechanisms in cardiovascular diseases. Autoimmun Rev. 2008;7:445-52.
    • (2008) Autoimmun Rev , vol.7 , pp. 445-52
    • Nussinovitch, U.1    Shoenfeld, Y.2
  • 78
    • 77957597713 scopus 로고    scopus 로고
    • Lupus myocarditis: Marked improvement in cardiac function after intravenous immunoglobulin therapy
    • Suri V, Varma S, Joshi K, et al. Lupus myocarditis: marked improvement in cardiac function after intravenous immunoglobulin therapy. Rheumatol Int. 2010;30:1503-5.
    • (2010) Rheumatol Int , vol.30 , pp. 1503-5
    • Suri, V.1    Varma, S.2    Joshi, K.3
  • 79
    • 0006518635 scopus 로고    scopus 로고
    • Controlled trial of intravenous immune globulin in recent-onset dilated cardiomyopathy
    • McNamara DM, Holubkov R, Starling RC, et al. Controlled trial of intravenous immune globulin in recent-onset dilated cardiomyopathy. Circulation. 2001;103:2254-9.
    • (2001) Circulation , vol.103 , pp. 2254-9
    • McNamara, D.M.1    Holubkov, R.2    Starling, R.C.3
  • 80
    • 38149017709 scopus 로고    scopus 로고
    • Fluvastatin reduces increased blood monocyte toll-like receptor 4 expression in whole blood from patients with chronic heart failure
    • Földes G, von Haehling S, Okonko DO, et al. Fluvastatin reduces increased blood monocyte Toll-like receptor 4 expression in whole blood from patients with chronic heart failure. Int J Cardiol. 2008;124:80-5.
    • (2008) Int J Cardiol , vol.124 , pp. 80-5
    • Földes, G.1    Von Haehling, S.2    Okonko, D.O.3
  • 81
    • 80052432773 scopus 로고    scopus 로고
    • The cardioprotective effect of fluvastatin on ischemic injury via down-regulation of toll-like receptor 4
    • Yang J, Zhang XD, Yang J, et al. The cardioprotective effect of fluvastatin on ischemic injury via down-regulation of toll-like receptor 4. Mol Biol Rep. 2011;38:3037-44.
    • (2011) Mol Biol Rep , vol.38 , pp. 3037-44
    • Yang, J.1    Zhang, X.D.2    Yang, J.3
  • 82
    • 22744457125 scopus 로고    scopus 로고
    • Monocyte suppressing action of fenofibrate
    • Okopien B, Kowalski J, Krysiak R, et al. Monocyte suppressing action of fenofibrate. Pharmacol Rep. 2005;57:367-72.
    • (2005) Pharmacol Rep , vol.57 , pp. 367-72
    • Okopien, B.1    Kowalski, J.2    Krysiak, R.3
  • 83
    • 68349142979 scopus 로고    scopus 로고
    • Fenofibrate attenuates endothelial monocyte adhesion in chronic heart failure: An in vitro study
    • Huang WP, Yin WH, Chen JW, et al. Fenofibrate attenuates endothelial monocyte adhesion in chronic heart failure: an in vitro study. Eur J Clin Invest. 2009;39:775-83.
    • (2009) Eur J Clin Invest , vol.39 , pp. 775-83
    • Huang, W.P.1    Yin, W.H.2    Chen, J.W.3
  • 84
    • 72349090953 scopus 로고    scopus 로고
    • Immunoregulatory effects of carvedilol on rat experimental autoimmune myocarditis
    • Liu H, Li W, Gu W, et al. Immunoregulatory effects of carvedilol on rat experimental autoimmune myocarditis. Scand J Immunol. 2010;71:38-44.
    • (2010) Scand J Immunol , vol.71 , pp. 38-44
    • Liu, H.1    Li, W.2    Gu, W.3
  • 85
    • 33745662138 scopus 로고    scopus 로고
    • Eplerenone inhibits tumour necrosis factor a shedding process by tumour necrosis factor a converting enzyme in monocytes from patients with congestive heart failure
    • Satoh M, Ishikawa Y, Minami Y, et al. Eplerenone inhibits tumour necrosis factor a shedding process by tumour necrosis factor a converting enzyme in monocytes from patients with congestive heart failure. Heart. 2006;92:979-80.
    • (2006) Heart , vol.92 , pp. 979-80
    • Satoh, M.1    Ishikawa, Y.2    Minami, Y.3
  • 86
    • 33846867740 scopus 로고    scopus 로고
    • Critical role of monocyte chemoattractant protein-1/cc chemokine ligand 2 in the pathogenesis of ischemic cardiomyopathy
    • Frangogiannis NG, Dewald O, Xia Y, et al. Critical role of monocyte chemoattractant protein-1/CC chemokine ligand 2 in the pathogenesis of ischemic cardiomyopathy. Circulation. 2007;115:584-92.
    • (2007) Circulation , vol.115 , pp. 584-592
    • Frangogiannis, N.G.1    Dewald, O.2    Xia, Y.3
  • 87
    • 79952316203 scopus 로고    scopus 로고
    • Effect of cc chemokine receptor 2 ccr2 blockade on serum c-reactive protein in individuals at atherosclerotic risk and with a single nucleotide polymorphism of the monocyte chemoattractant protein-1 promoter region
    • Gilbert J, Lekstrom-Himes J, Donaldson D, et al. Effect of CC chemokine receptor 2 CCR2 blockade on serum C-reactive protein in individuals at atherosclerotic risk and with a single nucleotide polymorphism of the monocyte chemoattractant protein-1 promoter region. Am J Cardiol. 2011;107:906-11.
    • (2011) Am J Cardiol , vol.107 , pp. 906-11
    • Gilbert, J.1    Lekstrom-Himes, J.2    Donaldson, D.3
  • 88
    • 80955158815 scopus 로고    scopus 로고
    • Synthetic peptide fragment (65-76) of monocyte chemotactic protein-1 (mcp-1) inhibits mcp-1 binding to heparin and possesses antiinflammatory activity in stable angina patients after coronary stenting
    • Arefieva TI, Krasnikova TL, Potekhina AV, et al. Synthetic peptide fragment (65-76) of monocyte chemotactic protein-1 (MCP-1) inhibits MCP-1 binding to heparin and possesses antiinflammatory activity in stable angina patients after coronary stenting. Inflamm Res. 2011;60:955-64.
    • (2011) Inflamm Res , vol.60 , pp. 955-64
    • Arefieva, T.I.1    Krasnikova, T.L.2    Potekhina, A.V.3
  • 89
    • 17844377356 scopus 로고    scopus 로고
    • Inflammatory and antiinflammatory cytokines in chronic heart failure: Potential therapeutic implications
    • Aukrust P, Gullestad L, Ueland T, et al. Inflammatory and antiinflammatory cytokines in chronic heart failure: potential therapeutic implications. Ann Med. 2005;37:74-85.
    • (2005) Ann Med , vol.37 , pp. 74-85
    • Aukrust, P.1    Gullestad, L.2    Ueland, T.3


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