Effect of CC chemokine receptor 2 CCR2 blockade on serum C-reactive protein in individuals at atherosclerotic risk and with a single nucleotide polymorphism of the monocyte chemoattractant protein-1 promoter region

American Journal of Cardiology

Volumn 107, Issue 6, 2011, Pages 906-911

  Gilbert, Jim ^a   Lekstrom Himes, Julie ^b   Donaldson, Debra ^c   Lee, Yih ^d   Hu, Mingxiu ^d   Xu, Jing ^d   Wyant, Tim ^d   Davidson, Michael ^e,f  

^a Archemix Corporation   (United States)

^b Xiphos Pharmaceuticals Inc   (United States)

^c GENENTECH INC   (United States)

^d MILLENNIUM PHARMACEUTICALS INC   (United States)

^e UNIVERSITY OF CHICAGO   (United States)

^f RADIANT RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ADENINE; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTILIPEMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; C REACTIVE PROTEIN; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR2; CLOPIDOGREL; CORTICOSTEROID DERIVATIVE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GUANINE; MLN 1202; MONOCYTE CHEMOTACTIC PROTEIN 1; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG INDUCED HEADACHE; DRUG MECHANISM; DRUG TOLERABILITY; FEMALE; GENE; GENOTYPE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MCP 1 GENE; MULTICENTER STUDY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; RHINOPHARYNGITIS; RISK ASSESSMENT; SINGLE DRUG DOSE; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT DURATION; TREATMENT RESPONSE; UPPER RESPIRATORY TRACT INFECTION; WILD TYPE;

ANTIBODIES, MONOCLONAL; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CHEMOKINE CCL2; CORONARY ARTERY DISEASE; DOUBLE-BLIND METHOD; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PLACEBOS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RECEPTORS, CCR2; RISK FACTORS; STATISTICS, NONPARAMETRIC;

EID: 79952316203     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2010.11.005     Document Type: Article

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