-
1
-
-
0034648757
-
Thrombin signalling and protease-activated receptors
-
Coughlin SR. Thrombin signalling and protease-activated receptors. Nature. 2000;407:258-264.
-
(2000)
Nature
, vol.407
, pp. 258-264
-
-
Coughlin, S.R.1
-
2
-
-
0034933683
-
Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor
-
Riewald M, Ruf W. Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor. Proc Natl Acad Sci U S A. 2001;98:7742-7747.
-
(2001)
Proc. Natl. Acad. Sci. U S A
, vol.98
, pp. 7742-7747
-
-
Riewald, M.1
Ruf, W.2
-
3
-
-
0034624973
-
Tissue factor-and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
-
Camerer E, Huang W, Coughlin SR. Tissue factor-and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci U S A. 2000;97:5255-5260.
-
(2000)
Proc. Natl. Acad. Sci. U S A
, vol.97
, pp. 5255-5260
-
-
Camerer, E.1
Huang, W.2
Coughlin, S.R.3
-
4
-
-
74049143122
-
Local protease signaling contributes to neural tube closure in the mouse embryo
-
Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, Cornelissen I, Darragh MR, Hussain A, Zheng YW, Srinivasan Y, Brown C, Xu SM, Regard JB, Lin CY, Craik CS, Kirchhofer D, Coughlin SR. Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell. 2010;18:25-38.
-
(2010)
Dev. Cell.
, vol.18
, pp. 25-38
-
-
Camerer, E.1
Barker, A.2
Duong, D.N.3
Ganesan, R.4
Kataoka, H.5
Cornelissen, I.6
Darragh, M.R.7
Hussain, A.8
Zheng, Y.W.9
Srinivasan, Y.10
Brown, C.11
Xu, S.M.12
Regard, J.B.13
Lin, C.Y.14
Craik, C.S.15
Kirchhofer, D.16
Coughlin, S.R.17
-
5
-
-
11244297746
-
The cardiovascular actions of protease-activated receptors
-
Steinberg SF. The cardiovascular actions of protease-activated receptors. Mol Pharmacol. 2005;67:2-11.
-
(2005)
Mol. Pharmacol.
, vol.67
, pp. 2-11
-
-
Steinberg, S.F.1
-
6
-
-
0034717192
-
Signaling properties and functions of two distinct cardiomyocyte protease-activated receptors
-
Sabri A, Muske G, Zhang H, Pak E, Darrow A, Andrade-Gordon P, Steinberg SF. Signaling properties and functions of two distinct cardiomyocyte protease-activated receptors. Circ Res. 2000;86:1054-1061.
-
(2000)
Circ. Res.
, vol.86
, pp. 1054-1061
-
-
Sabri, A.1
Muske, G.2
Zhang, H.3
Pak, E.4
Darrow, A.5
Andrade-Gordon, P.6
Steinberg, S.F.7
-
7
-
-
0034547916
-
Delayed onset of inflammation in protease-activated receptor-2-deficient mice
-
Lindner JR, Kahn ML, Coughlin SR, Sambrano GR, Schauble E, Bernstein D, Foy D, Hafezi-Moghadam A, Ley K. Delayed onset of inflammation in protease-activated receptor-2-deficient mice. J Immunol. 2000;165:6504-6510.
-
(2000)
J. Immunol.
, vol.165
, pp. 6504-6510
-
-
Lindner, J.R.1
Kahn, M.L.2
Coughlin, S.R.3
Sambrano, G.R.4
Schauble, E.5
Bernstein, D.6
Foy, D.7
Hafezi-Moghadam, A.8
Ley, K.9
-
8
-
-
0037247658
-
Essential role for proteinase-activated receptor-2 in arthritis
-
Ferrell WR, Lockhart JC, Kelso EB, Dunning L, Plevin R, Meek SE, Smith AJ, Hunter GD, McLean JS, McGarry F, Ramage R, Jiang L, Kanke T, Kawagoe J. Essential role for proteinase-activated receptor-2 in arthritis. J Clin Invest. 2003;111:35-41.
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 35-41
-
-
Ferrell, W.R.1
Lockhart, J.C.2
Kelso, E.B.3
Dunning, L.4
Plevin, R.5
Meek, S.E.6
Smith, A.J.7
Hunter, G.D.8
McLean, J.S.9
McGarry, F.10
Ramage, R.11
Jiang, L.12
Kanke, T.13
Kawagoe, J.14
-
9
-
-
0034927070
-
Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway
-
Vergnolle N, Bunnett NW, Sharkey KA, Brussee V, Compton SJ, Grady EF, Cirino G, Gerard N, Basbaum AI, Andrade-Gordon P, Hollenberg MD, Wallace JL. Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway. Nat Med. 2001;7:821-826.
-
(2001)
Nat. Med.
, vol.7
, pp. 821-826
-
-
Vergnolle, N.1
Bunnett, N.W.2
Sharkey, K.A.3
Brussee, V.4
Compton, S.J.5
Grady, E.F.6
Cirino, G.7
Gerard, N.8
Basbaum, A.I.9
Andrade-Gordon, P.10
Hollenberg, M.D.11
Wallace, J.L.12
-
10
-
-
33847342529
-
Role for protease activity in visceral pain in irritable bowel syndrome
-
Cenac N, Andrews CN, Holzhausen M, Chapman K, Cottrell G, Andrade-Gordon P, Steinhoff M, Barbara G, Beck P, Bunnett NW, Sharkey KA, Ferraz JG, Shaffer E, Vergnolle N. Role for protease activity in visceral pain in irritable bowel syndrome. J Clin Invest. 2007;117:636-647.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 636-647
-
-
Cenac, N.1
Andrews, C.N.2
Holzhausen, M.3
Chapman, K.4
Cottrell, G.5
Andrade-Gordon, P.6
Steinhoff, M.7
Barbara, G.8
Beck, P.9
Bunnett, N.W.10
Sharkey, K.A.11
Ferraz, J.G.12
Shaffer, E.13
Vergnolle, N.14
-
11
-
-
0036840959
-
Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway
-
Schmidlin F, Amadesi S, Dabbagh K, Lewis DE, Knott P, Bunnett NW, Gater PR, Geppetti P, Bertrand C, Stevens ME. Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway. J Immunol. 2002;169:5315-5321.
-
(2002)
J. Immunol.
, vol.169
, pp. 5315-5321
-
-
Schmidlin, F.1
Amadesi, S.2
Dabbagh, K.3
Lewis, D.E.4
Knott, P.5
Bunnett, N.W.6
Gater, P.R.7
Geppetti, P.8
Bertrand, C.9
Stevens, M.E.10
-
12
-
-
0038720558
-
Proteinase-activated receptor-2 mediates itch: A novel pathway for pruritus in human skin
-
Steinhoff M, Neisius U, Ikoma A, Fartasch M, Heyer G, Skov PS, Luger TA, Schmelz M. Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J Neurosci. 2003;23:6176-6180.
-
(2003)
J. Neurosci.
, vol.23
, pp. 6176-6180
-
-
Steinhoff, M.1
Neisius, U.2
Ikoma, A.3
Fartasch, M.4
Heyer, G.5
Skov, P.S.6
Luger, T.A.7
Schmelz, M.8
-
13
-
-
0033545627
-
A protective role for protease-activated receptors in the airways
-
Cocks TM, Fong B, Chow JM, Anderson GP, Frauman AG, Goldie RG, Henry PJ, Carr MJ, Hamilton JR, Moffatt JD. A protective role for protease-activated receptors in the airways. Nature. 1999;398:156-160.
-
(1999)
Nature
, vol.398
, pp. 156-160
-
-
Cocks, T.M.1
Fong, B.2
Chow, J.M.3
Anderson, G.P.4
Frauman, A.G.5
Goldie, R.G.6
Henry, P.J.7
Carr, M.J.8
Hamilton, J.R.9
Moffatt, J.D.10
-
14
-
-
14644442960
-
Deficiency of PAR-2 gene increases acute focal ischemic brain injury
-
Jin G, Hayashi T, Kawagoe J, Takizawa T, Nagata T, Nagano I, Syoji M, Abe K. Deficiency of PAR-2 gene increases acute focal ischemic brain injury. J Cereb Blood Flow Metab. 2005;25:302-313.
-
(2005)
J. Cereb. Blood Flow Metab.
, vol.25
, pp. 302-313
-
-
Jin, G.1
Hayashi, T.2
Kawagoe, J.3
Takizawa, T.4
Nagata, T.5
Nagano, I.6
Syoji, M.7
Abe, K.8
-
15
-
-
67649198507
-
Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway
-
Khoufache K, LeBouder F, Morello E, Laurent F, Riffault S, Andrade-Gordon P, Boullier S, Rousset P, Vergnolle N, Riteau B. Protective role for protease-activated receptor-2 against influenza virus pathogenesis via an IFN-gamma-dependent pathway. J Immunol. 2009;182:7795-7802.
-
(2009)
J. Immunol.
, vol.182
, pp. 7795-7802
-
-
Khoufache, K.1
LeBouder, F.2
Morello, E.3
Laurent, F.4
Riffault, S.5
Andrade-Gordon, P.6
Boullier, S.7
Rousset, P.8
Vergnolle, N.9
Riteau, B.10
-
16
-
-
38449113059
-
Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease
-
Afkhami-Goli A, Noorbakhsh F, Keller AJ, Vergnolle N, Westaway D, Jhamandas JH, Andrade-Gordon P, Hollenberg MD, Arab H, Dyck RH, Power C. Proteinase-activated receptor-2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease. J Immunol. 2007;179:5493-5503.
-
(2007)
J. Immunol.
, vol.179
, pp. 5493-5503
-
-
Afkhami-Goli, A.1
Noorbakhsh, F.2
Keller, A.J.3
Vergnolle, N.4
Westaway, D.5
Jhamandas, J.H.6
Andrade-Gordon, P.7
Hollenberg, M.D.8
Arab, H.9
Dyck, R.H.10
Power, C.11
-
17
-
-
49449104281
-
Acute myocardial infarction
-
White HD, Chew DP. Acute myocardial infarction. Lancet. 2008;372:570-584.
-
(2008)
Lancet
, vol.372
, pp. 570-584
-
-
White, H.D.1
Chew, D.P.2
-
18
-
-
0022402059
-
Myocardial reperfusion: A double-edged sword?
-
Braunwald E, Kloner RA. Myocardial reperfusion: a double-edged sword? J Clin Invest. 1985;76:1713-1719.
-
(1985)
J. Clin. Invest.
, vol.76
, pp. 1713-1719
-
-
Braunwald, E.1
Kloner, R.A.2
-
19
-
-
55849112296
-
Neutrophil activation by the tissue factor/factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome
-
Redecha P, Franzke CW, Ruf W, Mackman N, Girardi G. Neutrophil activation by the tissue factor/factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome. J Clin Invest. 2008;118:3453-3461.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3453-3461
-
-
Redecha, P.1
Franzke, C.W.2
Ruf, W.3
Mackman, N.4
Girardi, G.5
-
20
-
-
0034724445
-
Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart
-
Napoli C, Cicala C, Wallace JL, de Nigris F, Santagada V, Caliendo G, Franconi F, Ignarro LJ, Cirino G. Protease-activated receptor-2 modulates myocardial ischemia-reperfusion injury in the rat heart. Proc Natl Acad Sci U S A. 2000;97:3678-3683.
-
(2000)
Proc. Natl. Acad. Sci. U S A
, vol.97
, pp. 3678-3683
-
-
Napoli, C.1
Cicala, C.2
Wallace, J.L.3
De Nigris, F.4
Santagada, V.5
Caliendo, G.6
Franconi, F.7
Ignarro, L.J.8
Cirino, G.9
-
21
-
-
0037040862
-
Protease-activated receptor-2 activation causes EDHF-like coronary vasodilation: Selective preservation in ischemia/reperfusion injury: Involvement of lipoxygenase products, VR1 receptors, and C-fibers
-
McLean PG, Aston D, Sarkar D, Ahluwalia A. Protease-activated receptor-2 activation causes EDHF-like coronary vasodilation: selective preservation in ischemia/reperfusion injury: involvement of lipoxygenase products, VR1 receptors, and C-fibers. Circ Res. 2002;90:465-472.
-
(2002)
Circ. Res.
, vol.90
, pp. 465-472
-
-
McLean, P.G.1
Aston, D.2
Sarkar, D.3
Ahluwalia, A.4
-
22
-
-
36148993325
-
PAR-2 activation at the time of reperfusion salvages myocardium via an ERK1/2 pathway in in vivo rat hearts
-
Jiang R, Zatta A, Kin H, Wang N, Reeves JG, Mykytenko J, Deneve J, Zhao ZQ, Guyton RA, Vinten-Johansen J. PAR-2 activation at the time of reperfusion salvages myocardium via an ERK1/2 pathway in in vivo rat hearts. Am J Physiol Heart Circ Physiol. 2007;293:H2845-H2852.
-
(2007)
Am. J. Physiol. Heart Circ. Physiol.
, vol.293
-
-
Jiang, R.1
Zatta, A.2
Kin, H.3
Wang, N.4
Reeves, J.G.5
Mykytenko, J.6
Deneve, J.7
Zhao, Z.Q.8
Guyton, R.A.9
Vinten-Johansen, J.10
-
23
-
-
0032988474
-
Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1
-
Damiano BP, Cheung WM, Santulli RJ, Fung-Leung WP, Ngo K, Ye RD, Darrow AL, Derian CK, de Garavilla L, Andrade-Gordon P. Cardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1. J Pharmacol Exp Ther. 1999;288:671-678.
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.288
, pp. 671-678
-
-
Damiano, B.P.1
Cheung, W.M.2
Santulli, R.J.3
Fung-Leung, W.P.4
Ngo, K.5
Ye, R.D.6
Darrow, A.L.7
Derian, C.K.8
De Garavilla, L.9
Andrade-Gordon, P.10
-
24
-
-
36048945107
-
Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy
-
Pawlinski R, Tencati M, Hampton CR, Shishido T, Bullard TA, Casey LM, Andrade-Gordon P, Kotzsch M, Spring D, Luther T, Abe J, Pohlman TH, Verrier ED, Blaxall BC, Mackman N. Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy. Circulation. 2007;116:2298-2306.
-
(2007)
Circulation
, vol.116
, pp. 2298-2306
-
-
Pawlinski, R.1
Tencati, M.2
Hampton, C.R.3
Shishido, T.4
Bullard, T.A.5
Casey, L.M.6
Andrade-Gordon, P.7
Kotzsch, M.8
Spring, D.9
Luther, T.10
Abe, J.11
Pohlman, T.H.12
Verrier, E.D.13
Blaxall, B.C.14
Mackman, N.15
-
25
-
-
0034284310
-
Egr-1 gene is induced by the systemic administration of the vascular endothelial growth factor and the epidermal growth factor
-
Liu L, Tsai JC, Aird WC. Egr-1 gene is induced by the systemic administration of the vascular endothelial growth factor and the epidermal growth factor. Blood. 2000;96:1772-1781.
-
(2000)
Blood
, vol.96
, pp. 1772-1781
-
-
Liu, L.1
Tsai, J.C.2
Aird, W.C.3
-
26
-
-
34147163464
-
Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress
-
Tao L, Gao E, Jiao X, Yuan Y, Li S, Christopher TA, Lopez BL, Koch W, Chan L, Goldstein BJ, Ma XL. Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress. Circulation. 2007;115:1408-1416.
-
(2007)
Circulation
, vol.115
, pp. 1408-1416
-
-
Tao, L.1
Gao, E.2
Jiao, X.3
Yuan, Y.4
Li, S.5
Christopher, T.A.6
Lopez, B.L.7
Koch, W.8
Chan, L.9
Goldstein, B.J.10
Ma, X.L.11
-
27
-
-
77949783907
-
Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress
-
Ji L, Fu F, Zhang L, Liu W, Cai X, Zheng Q, Zhang H, Gao F. Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress. Am J Physiol Endocrinol Metab. 2010;298:E871-E880.
-
(2010)
Am. J. Physiol. Endocrinol. Metab.
, vol.298
-
-
Ji, L.1
Fu, F.2
Zhang, L.3
Liu, W.4
Cai, X.5
Zheng, Q.6
Zhang, H.7
Gao, F.8
-
28
-
-
77950366415
-
Simvastatin in contrast to postconditioning reduces infarct size in hyperlipidemic rabbits: Possible role of oxidative/nitrosative stress attenuation
-
Iliodromitis EK, Andreadou I, Prokovas E, Zoga A, Farmakis D, Fotopoulou T, Ioannidis K, Paraskevaidis IA, Kremastinos DT. Simvastatin in contrast to postconditioning reduces infarct size in hyperlipidemic rabbits: possible role of oxidative/nitrosative stress attenuation. Basic Res Cardiol. 2010;105:193-203.
-
(2010)
Basic Res. Cardiol.
, vol.105
, pp. 193-203
-
-
Iliodromitis, E.K.1
Andreadou, I.2
Prokovas, E.3
Zoga, A.4
Farmakis, D.5
Fotopoulou, T.6
Ioannidis, K.7
Paraskevaidis, I.A.8
Kremastinos, D.T.9
-
29
-
-
33748349642
-
Inflame my heart (by p38-MAPK)
-
Clerk A, Sugden PH. Inflame my heart (by p38-MAPK). Circ Res. 2006;99:455-458.
-
(2006)
Circ. Res.
, vol.99
, pp. 455-458
-
-
Clerk, A.1
Sugden, P.H.2
-
30
-
-
3843090683
-
Inhibition of c-Jun. N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats
-
Ferrandi C, Ballerio R, Gaillard P, Giachetti C, Carboni S, Vitte PA, Gotteland JP, Cirillo R. Inhibition of c-Jun. N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats. Br J Pharmacol. 2004;142:953-960.
-
(2004)
Br. J. Pharmacol.
, vol.142
, pp. 953-960
-
-
Ferrandi, C.1
Ballerio, R.2
Gaillard, P.3
Giachetti, C.4
Carboni, S.5
Vitte, P.A.6
Gotteland, J.P.7
Cirillo, R.8
-
31
-
-
0037293568
-
Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia-reperfusion injury and preconditioning
-
Ferdinandy P, Schulz R. Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia-reperfusion injury and preconditioning. Br J Pharmacol. 2003;138:532-543.
-
(2003)
Br. J. Pharmacol.
, vol.138
, pp. 532-543
-
-
Ferdinandy, P.1
Schulz, R.2
-
32
-
-
59549106445
-
Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: Mitochondria as the major target
-
Liu B, Tewari AK, Zhang L, Green-Church KB, Zweier JL, Chen YR, He G. Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: mitochondria as the major target. Biochim Biophys Acta. 2009;1794:476-485.
-
(2009)
Biochim. Biophys. Acta
, vol.1794
, pp. 476-485
-
-
Liu, B.1
Tewari, A.K.2
Zhang, L.3
Green-Church, K.B.4
Zweier, J.L.5
Chen, Y.R.6
He, G.7
-
33
-
-
68249151075
-
Essential role of mitogen-activated protein kinase pathways in protease activated receptor 2-mediated nitric-oxide production from rat primary astrocytes
-
Park GH, Jeon SJ, Ryu JR, Choi MS, Han SH, Yang SI, Ryu JH, Cheong JH, Shin CY, Ko KH. Essential role of mitogen-activated protein kinase pathways in protease activated receptor 2-mediated nitric-oxide production from rat primary astrocytes. Nitric Oxide. 2009;21:110-119.
-
(2009)
Nitric Oxide
, vol.21
, pp. 110-119
-
-
Park, G.H.1
Jeon, S.J.2
Ryu, J.R.3
Choi, M.S.4
Han, S.H.5
Yang, S.I.6
Ryu, J.H.7
Cheong, J.H.8
Shin, C.Y.9
Ko, K.H.10
-
34
-
-
33750492571
-
Activation of mouse protease-activated receptor-2 induces lymphocyte adhesion and generation of reactive oxygen species
-
Lim SY, Tennant GM, Kennedy S, Wainwright CL, Kane KA. Activation of mouse protease-activated receptor-2 induces lymphocyte adhesion and generation of reactive oxygen species. Br J Pharmacol. 2006;149:591-599.
-
(2006)
Br. J. Pharmacol.
, vol.149
, pp. 591-599
-
-
Lim, S.Y.1
Tennant, G.M.2
Kennedy, S.3
Wainwright, C.L.4
Kane, K.A.5
-
35
-
-
33750909999
-
Reactive oxygen speciesinduced activation of the MAP kinase signaling pathways
-
McCubrey JA, Lahair MM, Franklin RA. Reactive oxygen speciesinduced activation of the MAP kinase signaling pathways. Antioxid Redox Signal. 2006;8:1775-1789.
-
(2006)
Antioxid Redox Signal
, vol.8
, pp. 1775-1789
-
-
McCubrey, J.A.1
Lahair, M.M.2
Franklin, R.A.3
-
36
-
-
33744958661
-
Cyclooxygenase-2 induction and prostacyclin release by protease-activated receptors in endothelial cells require cooperation between mitogen-activated protein kinase and NF-kappaB pathways
-
Syeda F, Grosjean J, Houliston RA, Keogh RJ, Carter TD, Paleolog E, Wheeler-Jones CP. Cyclooxygenase-2 induction and prostacyclin release by protease-activated receptors in endothelial cells require cooperation between mitogen-activated protein kinase and NF-kappaB pathways. J Biol Chem. 2006;281:11792-11804.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 11792-11804
-
-
Syeda, F.1
Grosjean, J.2
Houliston, R.A.3
Keogh, R.J.4
Carter, T.D.5
Paleolog, E.6
Wheeler-Jones, C.P.7
-
37
-
-
2442534165
-
Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemiareperfusion in vivo
-
Kaiser RA, Bueno OF, Lips DJ, Doevendans PA, Jones F, Kimball TF, Molkentin JD. Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemiareperfusion in vivo. J Biol Chem. 2004;279:15524-15530.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 15524-15530
-
-
Kaiser, R.A.1
Bueno, O.F.2
Lips, D.J.3
Doevendans, P.A.4
Jones, F.5
Kimball, T.F.6
Molkentin, J.D.7
-
38
-
-
37549046852
-
LOX-1 abrogation reduces myocardial ischemia-reperfusion injury in mice
-
Hu C, Chen J, Dandapat A, Fujita Y, Inoue N, Kawase Y, Jishage K, Suzuki H, Li D, Hermonat PL, Sawamura T, Mehta JL. LOX-1 abrogation reduces myocardial ischemia-reperfusion injury in mice. J Mol Cell Cardiol. 2008;44:76-83.
-
(2008)
J. Mol. Cell. Cardiol.
, vol.44
, pp. 76-83
-
-
Hu, C.1
Chen, J.2
Dandapat, A.3
Fujita, Y.4
Inoue, N.5
Kawase, Y.6
Jishage, K.7
Suzuki, H.8
Li, D.9
Hermonat, P.L.10
Sawamura, T.11
Mehta, J.L.12
-
39
-
-
36649008514
-
Induction of inflammatory cytokine release from human umbilical vein endothelial cells by agonists of proteinase-activated receptor-2
-
Niu QX, Chen HQ, Chen ZY, Fu YL, Lin JL, He SH. Induction of inflammatory cytokine release from human umbilical vein endothelial cells by agonists of proteinase-activated receptor-2. Clin Exp Pharmacol Physiol. 2008;35:89-96.
-
(2008)
Clin. Exp. Pharmacol. Physiol.
, vol.35
, pp. 89-96
-
-
Niu, Q.X.1
Chen, H.Q.2
Chen, Z.Y.3
Fu, Y.L.4
Lin, J.L.5
He, S.H.6
-
40
-
-
0036174696
-
Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappaB in human dermal microvascular endothelial cells
-
Shpacovitch VM, Brzoska T, Buddenkotte J, Stroh C, Sommerhoff CP, Ansel JC, Schulze-Osthoff K, Bunnett NW, Luger TA, Steinhoff M. Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappaB in human dermal microvascular endothelial cells. J Invest Dermatol. 2002;118:380-385.
-
(2002)
J. Invest. Dermatol.
, vol.118
, pp. 380-385
-
-
Shpacovitch, V.M.1
Brzoska, T.2
Buddenkotte, J.3
Stroh, C.4
Sommerhoff, C.P.5
Ansel, J.C.6
Schulze-Osthoff, K.7
Bunnett, N.W.8
Luger, T.A.9
Steinhoff, M.10
-
41
-
-
16944366340
-
Complement C5a, TGF-beta 1, and MCP-1, in sequence, induce migration of monocytes into ischemic canine myocardium within the first one to five hours after reperfusion
-
Birdsall HH, Green DM, Trial J, Youker KA, Burns AR, MacKay CR, LaRosa GJ, Hawkins HK, Smith CW, Michael LH, Entman ML, Rossen RD. Complement C5a, TGF-beta 1, and MCP-1, in sequence, induce migration of monocytes into ischemic canine myocardium within the first one to five hours after reperfusion. Circulation. 1997;95:684-692.
-
(1997)
Circulation
, vol.95
, pp. 684-692
-
-
Birdsall, H.H.1
Green, D.M.2
Trial, J.3
Youker, K.A.4
Burns, A.R.5
MacKay, C.R.6
LaRosa, G.J.7
Hawkins, H.K.8
Smith, C.W.9
Michael, L.H.10
Entman, M.L.11
Rossen, R.D.12
-
42
-
-
25644443223
-
Human peripheral blood monocytes express protease receptor-2 and respond to receptor activation by production of IL-6, IL-8, and IL-1{beta}
-
Johansson U, Lawson C, Dabare M, Syndercombe-Court D, Newland AC, Howells GL, Macey MG. Human peripheral blood monocytes express protease receptor-2 and respond to receptor activation by production of IL-6, IL-8, and IL-1{beta}. J Leukoc Biol. 2005;78:967-975.
-
(2005)
J. Leukoc Biol.
, vol.78
, pp. 967-975
-
-
Johansson, U.1
Lawson, C.2
Dabare, M.3
Syndercombe-Court, D.4
Newland, A.C.5
Howells, G.L.6
Macey, M.G.7
-
43
-
-
77951992340
-
Beta-Arrestins scaffold cofilin with chronophin to direct localized actin filament severing and membrane protrusions downstream of protease-activated receptor-2
-
Zoudilova M, Min J, Richards HL, Carter D, Huang T, De Fea KA. beta-Arrestins scaffold cofilin with chronophin to direct localized actin filament severing and membrane protrusions downstream of protease-activated receptor-2. J Biol Chem. 2010;285:14318-14329.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 14318-14329
-
-
Zoudilova, M.1
Min, J.2
Richards, H.L.3
Carter, D.4
Huang, T.5
De Fea, K.A.6
-
44
-
-
0027815143
-
Polymorphonuclear leukocytes as a significant source of tumor necrosis factor-alpha in endotoxin-challenged lung tissue
-
Xing Z, Kirpalani H, Torry D, Jordana M, Gauldie J. Polymorphonuclear leukocytes as a significant source of tumor necrosis factor-alpha in endotoxin-challenged lung tissue. Am J Pathol. 1993;143:1009-1015.
-
(1993)
Am. J. Pathol.
, vol.143
, pp. 1009-1015
-
-
Xing, Z.1
Kirpalani, H.2
Torry, D.3
Jordana, M.4
Gauldie, J.5
-
45
-
-
0029162756
-
Neutrophils express tumor necrosis factor-alpha during mouse skin wound healing
-
Feiken E, Romer J, Eriksen J, Lund LR. Neutrophils express tumor necrosis factor-alpha during mouse skin wound healing. J Invest Dermatol. 1995;105:120-123.
-
(1995)
J. Invest. Dermatol.
, vol.105
, pp. 120-123
-
-
Feiken, E.1
Romer, J.2
Eriksen, J.3
Lund, L.R.4
-
46
-
-
0036533648
-
The proinflammatory CD14 + CD16 + DR++ monocytes are a major source of TNF
-
Belge KU, Dayyani F, Horelt A, Siedlar M, Frankenberger M, Frankenberger B, Espevik T, Ziegler-Heitbrock L. The proinflammatory CD14 + CD16 + DR++ monocytes are a major source of TNF. J Immunol. 2002;168:3536-3542.
-
(2002)
J. Immunol.
, vol.168
, pp. 3536-3542
-
-
Belge, K.U.1
Dayyani, F.2
Horelt, A.3
Siedlar, M.4
Frankenberger, M.5
Frankenberger, B.6
Espevik, T.7
Ziegler-Heitbrock, L.8
-
47
-
-
33750515851
-
Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-kappaB dependent inflammatory response
-
Boyd JH, Mathur S, Wang Y, Bateman RM, Walley KR. Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-kappaB dependent inflammatory response. Cardiovasc Res. 2006;72:384-393.
-
(2006)
Cardiovasc. Res.
, vol.72
, pp. 384-393
-
-
Boyd, J.H.1
Mathur, S.2
Wang, Y.3
Bateman, R.M.4
Walley, K.R.5
-
48
-
-
3242769906
-
Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart
-
Chong AJ, Shimamoto A, Hampton CR, Takayama H, Spring DJ, Rothnie CL, Yada M, Pohlman TH, Verrier ED. Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart. J Thorac Cardiovasc Surg. 2004;128:170-179.
-
(2004)
J. Thorac. Cardiovasc. Surg.
, vol.128
, pp. 170-179
-
-
Chong, A.J.1
Shimamoto, A.2
Hampton, C.R.3
Takayama, H.4
Spring, D.J.5
Rothnie, C.L.6
Yada, M.7
Pohlman, T.H.8
Verrier, E.D.9
-
49
-
-
54049117260
-
Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: A novel paradigm for receptor cooperativity
-
Rallabhandi P, Nhu QM, Toshchakov VY, Piao W, Medvedev AE, Hollenberg MD, Fasano A, Vogel SN. Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity. J Biol Chem. 2008;283:24314-24325.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 24314-24325
-
-
Rallabhandi, P.1
Nhu, Q.M.2
Toshchakov, V.Y.3
Piao, W.4
Medvedev, A.E.5
Hollenberg, M.D.6
Fasano, A.7
Vogel, S.N.8
-
50
-
-
40349085619
-
Proteinases and signalling: Pathophysiological and therapeutic implications via PARs and more
-
Ramachandran R, Hollenberg MD. Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more. Br J Pharmacol. 2008;153(suppl 1):S263-S282.
-
(2008)
Br. J. Pharmacol.
, vol.153
, Issue.1 SUPPL.
-
-
Ramachandran, R.1
Hollenberg, M.D.2
-
51
-
-
0033639115
-
Inhibition of the tissue factor-thrombin pathway limits infarct size after myocardial ischemia-reperfusion injury by reducing inflammation
-
Erlich JH, Boyle EM, Labriola J, Kovacich JC, Santucci RA, Fearns C, Morgan EN, Yun W, Luther T, Kojikawa O, Martin TR, Pohlman TH, Verrier ED, Mackman N. Inhibition of the tissue factor-thrombin pathway limits infarct size after myocardial ischemia-reperfusion injury by reducing inflammation. Am J Pathol. 2000;157:1849-1862.
-
(2000)
Am. J. Pathol.
, vol.157
, pp. 1849-1862
-
-
Erlich, J.H.1
Boyle, E.M.2
Labriola, J.3
Kovacich, J.C.4
Santucci, R.A.5
Fearns, C.6
Morgan, E.N.7
Yun, W.8
Luther, T.9
Kojikawa, O.10
Martin, T.R.11
Pohlman, T.H.12
Verrier, E.D.13
Mackman, N.14
-
52
-
-
0034042062
-
Recombinant human, active site-blocked factor VIIa reduces infarct size and no-reflow phenomenon in rabbits
-
Golino P, Ragni M, Cirillo P, Scognamiglio A, Ravera A, Buono C, Guarino A, Piro O, Lambiase C, Botticella F, Ezban M, Condorelli M, Chiariello M. Recombinant human, active site-blocked factor VIIa reduces infarct size and no-reflow phenomenon in rabbits. Am J Physiol Heart Circ Physiol. 2000;278:H1507-H1516.
-
(2000)
Am. J. Physiol. Heart Circ. Physiol.
, vol.278
-
-
Golino, P.1
Ragni, M.2
Cirillo, P.3
Scognamiglio, A.4
Ravera, A.5
Buono, C.6
Guarino, A.7
Piro, O.8
Lambiase, C.9
Botticella, F.10
Ezban, M.11
Condorelli, M.12
Chiariello, M.13
-
53
-
-
59049093517
-
Active site inhibited factor VIIa attenuates myocardial ischemia/reperfusion injury in mice
-
Loubele ST, Spek CA, Leenders P, van Oerle R, Aberson HL, van der Voort D, Hamulyak K, Petersen LC, Spronk HM, ten Cate H. Active site inhibited factor VIIa attenuates myocardial ischemia/reperfusion injury in mice. J Thromb Haemost. 2009;7:290-298.
-
(2009)
J. Thromb. Haemost.
, vol.7
, pp. 290-298
-
-
Loubele, S.T.1
Spek, C.A.2
Leenders, P.3
Van Oerle, R.4
Aberson, H.L.5
Van Der Voort, D.6
Hamulyak, K.7
Petersen, L.C.8
Spronk, H.M.9
Cate, H.T.10
-
54
-
-
16244367746
-
The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemiareperfusion injury
-
Petzelbauer P, Zacharowski PA, Miyazaki Y, Friedl P, Wickenhauser G, Castellino FJ, Groger M, Wolff K, Zacharowski K. The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemiareperfusion injury. Nat Med. 2005;11:298-304.
-
(2005)
Nat. Med.
, vol.11
, pp. 298-304
-
-
Petzelbauer, P.1
Zacharowski, P.A.2
Miyazaki, Y.3
Friedl, P.4
Wickenhauser, G.5
Castellino, F.J.6
Groger, M.7
Wolff, K.8
Zacharowski, K.9
-
55
-
-
0032539897
-
Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy
-
Patella V, Marino I, Arbustini E, Lamparter-Schummert B, Verga L, Adt M, Marone G. Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy. Circulation. 1998;97:971-978.
-
(1998)
Circulation
, vol.97
, pp. 971-978
-
-
Patella, V.1
Marino, I.2
Arbustini, E.3
Lamparter-Schummert, B.4
Verga, L.5
Adt, M.6
Marone, G.7
-
56
-
-
33947732711
-
Mast cell deficient W/Wv mice have lower serum IL-6 and less cardiac tissue necrosis than their normal littermates following myocardial ischemia-reperfusion
-
Bhattacharya K, Farwell K, Huang M, Kempuraj D, Donelan J, Papaliodis D, Vasiadi M, Theoharides TC. Mast cell deficient W/Wv mice have lower serum IL-6 and less cardiac tissue necrosis than their normal littermates following myocardial ischemia-reperfusion. Int J Immunopathol Pharmacol. 2007;20:69-74.
-
(2007)
Int. J. Immunopathol. Pharmacol.
, vol.20
, pp. 69-74
-
-
Bhattacharya, K.1
Farwell, K.2
Huang, M.3
Kempuraj, D.4
Donelan, J.5
Papaliodis, D.6
Vasiadi, M.7
Theoharides, T.C.8
-
57
-
-
70349324342
-
Agonist-biased signaling via proteinase activated receptor-2: Differential activation of calcium and mitogen-activated protein kinase pathways
-
Ramachandran R, Mihara K, Mathur M, Rochdi MD, Bouvier M, Defea K, Hollenberg MD. Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways. Mol Pharmacol. 2009;76:791-801.
-
(2009)
Mol. Pharmacol.
, vol.76
, pp. 791-801
-
-
Ramachandran, R.1
Mihara, K.2
Mathur, M.3
Rochdi, M.D.4
Bouvier, M.5
Defea, K.6
Hollenberg, M.D.7
-
58
-
-
50249124682
-
Protease-activated receptor-2 activation: A major actor in intestinal inflammation
-
Hyun E, Andrade-Gordon P, Steinhoff M, Vergnolle N. Protease-activated receptor-2 activation: a major actor in intestinal inflammation. Gut. 2008;57:1222-1229.
-
(2008)
Gut
, vol.57
, pp. 1222-1229
-
-
Hyun, E.1
Andrade-Gordon, P.2
Steinhoff, M.3
Vergnolle, N.4
-
59
-
-
0035923526
-
Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis
-
Fiorucci S, Mencarelli A, Palazzetti B, Distrutti E, Vergnolle N, Hollenberg MD, Wallace JL, Morelli A, Cirino G. Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proc Natl Acad Sci USA. 2001;98:13936-13941.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 13936-13941
-
-
Fiorucci, S.1
Mencarelli, A.2
Palazzetti, B.3
Distrutti, E.4
Vergnolle, N.5
Hollenberg, M.D.6
Wallace, J.L.7
Morelli, A.8
Cirino, G.9
|