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Volumn 12, Issue 12, 2012, Pages 798-799

Metabolism: Warburg behind the butyrate paradox?

(1)  Burgess, Darren J a  

a NONE

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID; LACTATE DEHYDROGENASE;

EID: 84870248862     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3401     Document Type: Note
Times cited : (26)

References (170)
  • 4
    • 79951910309 scopus 로고    scopus 로고
    • Survival and prognostic factors of early childhood medulloblastoma: An international meta-analysis
    • Rutkowski, S. et al. Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis. J. Clin. Oncol. 28, 4961-4968 (2010
    • (2010) J. Clin. Oncol. , vol.28 , pp. 4961-4968
    • Rutkowski, S.1
  • 5
    • 32944461274 scopus 로고    scopus 로고
    • β-catenin status predicts a favorable outcome in childhood medulloblastoma: The United Kingdom Children's Cancer Study Group Brain Tumour Committee
    • DOI 10.1200/JCO.2005.01.5479
    • Ellison, D. W. et al. ß-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee. J. Clin. Oncol. 23, 7951-7957 (2005). This study was the first to show that CTNNB1 mutated medulloblastomas, which would subsequently define the WNT subgroup, have an excellent prognosis compared with non-CTNNB1-mutated cases. (Pubitemid 46657395)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.31 , pp. 7951-7957
    • Ellison, D.W.1    Onilude, O.E.2    Lindsey, J.C.3    Lusher, M.E.4    Weston, C.L.5    Taylor, R.E.6    Pearson, A.D.7    Clifford, S.C.8
  • 6
    • 55949132115 scopus 로고    scopus 로고
    • Management of and prognosis with medulloblastoma: Therapy at a crossroads
    • Packer, R. J. & Vezina, G. Management of and prognosis with medulloblastoma: therapy at a crossroads. Arch. Neurol. 65, 1419-1424 (2008
    • (2008) Arch. Neurol. , vol.65 , pp. 1419-1424
    • Packer, R.J.1    Vezina, G.2
  • 7
    • 42449125240 scopus 로고    scopus 로고
    • Core Neurocognitive Functions in Children Treated for Posterior Fossa Tumors
    • DOI 10.1037/0894-4105.22.2.159, PII S0894410508600170
    • Mabbott, D. J., Penkman, L., Witol, A., Strother, D. & Bouffet, E. Core neurocognitive functions in children treated for posterior fossa tumors. Neuropsychology 22, 159-168 (2008 (Pubitemid 351626504)
    • (2008) Neuropsychology , vol.22 , Issue.2 , pp. 159-168
    • Mabbott, D.J.1    Penkman, L.2    Witol, A.3    Strother, D.4    Bouffet, E.5
  • 9
    • 1442307846 scopus 로고    scopus 로고
    • Change in neurocognitive functioning after treatment with cranial radiation in childhood
    • DOI 10.1200/JCO.2004.05.186
    • Spiegler, B. J., Bouffet, E., Greenberg, M. L., Rutka, J. T. & Mabbott, D. J. Change in neurocognitive functioning after treatment with cranial radiation in childhood. J. Clin. Oncol. 22, 706-713 (2004 (Pubitemid 41095075)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.4 , pp. 706-713
    • Spiegler, B.J.1    Bouffet, E.2    Greenberg, M.L.3    Rutka, J.T.4    Mabbott, D.J.5
  • 10
    • 79951904426 scopus 로고    scopus 로고
    • Clinical experience with hedgehog pathway inhibitors
    • Low, J. A. & de Sauvage, F. J. Clinical experience with Hedgehog pathway inhibitors. J. Clin. Oncol. 28, 5321-5326 (2010
    • (2010) J. Clin. Oncol. , vol.28 , pp. 5321-5326
    • Low, J.A.1    De Sauvage, F.J.2
  • 11
    • 80955181031 scopus 로고    scopus 로고
    • The hedgehog's tale: Developing strategies for targeting cancer
    • Ng, J. M. & Curran, T. The Hedgehog's tale: developing strategies for targeting cancer. Nature Rev. Cancer 11, 493-501 (2011
    • (2011) Nature Rev. Cancer , vol.11 , pp. 493-501
    • Ng, J.M.1    Curran, T.2
  • 12
    • 0034493199 scopus 로고    scopus 로고
    • Molecular insight into medulloblastoma and central nervous system primitive neuroectodermal tumor biology from hereditary syndromes: A review
    • Taylor, M. D., Mainprize, T. G. & Rutka, J. T. Molecular insight into medulloblastoma and central nervous system primitive neuroectodermal tumor biology from hereditary syndromes: a review. Neurosurgery 47, 888-901 (2000 (Pubitemid 32103665)
    • (2000) Neurosurgery , vol.47 , Issue.4 , pp. 888-901
    • Taylor, M.D.1    Mainprize, T.G.2    Rutka, J.T.3
  • 15
    • 0026627965 scopus 로고
    • Developmental defects in gorlin syndrome related to a putative tumor suppressor gene on chromosome 9
    • Gailani, M. R. et al. Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9. Cell 69, 111-117 (1992
    • (1992) Cell , vol.69 , pp. 111-117
    • Gailani, M.R.1
  • 18
    • 0030738693 scopus 로고    scopus 로고
    • Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
    • Wolter, M., Reifenberger, J., Sommer, C., Ruzicka, T. & Reifenberger, G. Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res. 57, 2581-2585 (1997 (Pubitemid 27283761)
    • (1997) Cancer Research , vol.57 , Issue.13 , pp. 2581-2585
    • Wolter, M.1    Reifenberger, J.2    Sommer, C.3    Ruzicka, T.4    Reifenberger, G.5
  • 19
    • 84863393028 scopus 로고    scopus 로고
    • Molecular subgroups of medulloblastoma: An international meta-analysis of transcriptome, genetic aberrations, and clinical data of wnt, shh, group 3, and group 4 medulloblastomas
    • This study combined all published genomic data of medulloblastomas and effectivley summarized the main clinical and genomic features defining the medulloblastoma subgroups.
    • Kool, M. et al. Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas. Acta Neuropathol. 123, 473-484 (2012). This study combined all published genomic data of medulloblastomas and effectivley summarized the main clinical and genomic features defining the medulloblastoma subgroups.
    • (2012) Acta Neuropathol. , vol.123 , pp. 473-484
    • Kool, M.1
  • 20
    • 0028970197 scopus 로고
    • The molecular basis of turcot's syndrome
    • Hamilton, S. R. et al. The molecular basis of Turcot's syndrome. New Engl. J. Med. 332, 839-847 (1995
    • (1995) New Engl. J. Med. , vol.332 , pp. 839-847
    • Hamilton, S.R.1
  • 21
    • 0032030894 scopus 로고    scopus 로고
    • Sporadic medulloblastomas contain oncogenic β-catenin mutations
    • Zurawel, R. H., Chiappa, S. A., Allen, C. & Raffel, C. Sporadic medulloblastomas contain oncogenic ß-catenin mutations. Cancer Res. 58, 896-899 (1998 (Pubitemid 28182454)
    • (1998) Cancer Research , vol.58 , Issue.5 , pp. 896-899
    • Zurawel, R.H.1    Chiappa, S.A.2    Allen, C.3    Raffel, C.4
  • 23
    • 67649869544 scopus 로고    scopus 로고
    • Identification of a sufu germline mutation in a family with gorlin syndrome
    • Pastorino, L. et al. Identification of a SUFU germline mutation in a family with Gorlin syndrome. Am. J. Med. Genet. A 149A, 1539-1543 (2009
    • (2009) Am. J. Med. Genet. A , vol.149 A , pp. 1539-1543
    • Pastorino, L.1
  • 24
    • 0036648241 scopus 로고    scopus 로고
    • Mutations in sufu predispose to medulloblastoma
    • This study identified germline and somatic mutations of SUFU in patients with medulloblastoma, establishing it as an important TSG in the SHH pathway.
    • Taylor, M. D. et al. Mutations in SUFU predispose to medulloblastoma. Nature Genet. 31, 306-310 (2002). This study identified germline and somatic mutations of SUFU in patients with medulloblastoma, establishing it as an important TSG in the SHH pathway.
    • (2002) Nature Genet. , vol.31 , pp. 306-310
    • Taylor, M.D.1
  • 26
    • 0037473082 scopus 로고    scopus 로고
    • AXIN1 mutations but not deletions in cerebellar medulloblastomas
    • DOI 10.1038/sj.onc.1206156
    • Baeza, N., Masuoka, J., Kleihues, P. & Ohgaki, H. AXIN1 mutations but not deletions in cerebellar medulloblastomas. Oncogene 22, 632-636 (2003 (Pubitemid 36188620)
    • (2003) Oncogene , vol.22 , Issue.4 , pp. 632-636
    • Baeza, N.1    Masuoka, J.2    Kleihues, P.3    Ohgaki, H.4
  • 29
    • 0033590605 scopus 로고    scopus 로고
    • A frequent activated smoothened mutation in sporadic basal cell carcinomas
    • Lam, C. W. et al. A frequent activated smoothened mutation in sporadic basal cell carcinomas. Oncogene 18, 833-836 (1999
    • (1999) Oncogene , vol.18 , pp. 833-836
    • Lam, C.W.1
  • 30
    • 77956838065 scopus 로고    scopus 로고
    • Advances in understanding cancer genomes through second-generation sequencing
    • Meyerson, M., Gabriel, S. & Getz, G. Advances in understanding cancer genomes through second-generation sequencing. Nature Rev. Genet. 11, 685-696 (2010
    • (2010) Nature Rev. Genet. , vol.11 , pp. 685-696
    • Meyerson, M.1    Gabriel, S.2    Getz, G.3
  • 31
    • 79953158399 scopus 로고    scopus 로고
    • Exploring the genomes of cancer cells: Progress and promise
    • Stratton, M. R. Exploring the genomes of cancer cells: progress and promise. Science 331, 1553-1558 (2011
    • (2011) Science , vol.331 , pp. 1553-1558
    • Stratton, M.R.1
  • 32
    • 84864444165 scopus 로고    scopus 로고
    • Novel mutations target distinct subgroups of medulloblastoma
    • Robinson, G. et al. Novel mutations target distinct subgroups of medulloblastoma. Nature 488, 43-48 (2012
    • (2012) Nature , vol.488 , pp. 43-48
    • Robinson, G.1
  • 33
    • 84864419974 scopus 로고    scopus 로고
    • Dissecting the genomic complexity underlying medulloblastoma
    • Jones, D. T. et al. Dissecting the genomic complexity underlying medulloblastoma. Nature 488,100-105 (2012
    • (2012) Nature , vol.488 , pp. 100-105
    • Jones, D.T.1
  • 34
    • 84864492215 scopus 로고    scopus 로고
    • Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
    • References 32 to 34 were the first studies to apply next-generation sequencing to large cohorts of medulloblastoma samples in order to catalogue the prevalent somatic mutations in the disease.
    • Pugh, T. J. et al. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature 488, 106-110 (2012). References 32 to 34 were the first studies to apply next-generation sequencing to large cohorts of medulloblastoma samples in order to catalogue the prevalent somatic mutations in the disease.
    • (2012) Nature , vol.488 , pp. 106-110
    • Pugh, T.J.1
  • 35
    • 84862907577 scopus 로고    scopus 로고
    • Genome sequencing of pediatric medulloblastoma links catastrophic dna rearrangements with tp53 mutations
    • This study used WGS to describe the genomic landscape of medulloblastomas arising in patients with LFS, uncovering chromothripsis as a signature event in this subset of patients.
    • Rausch, T. et al. Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell 148, 59-71 (2012). This study used WGS to describe the genomic landscape of medulloblastomas arising in patients with LFS, uncovering chromothripsis as a signature event in this subset of patients.
    • (2012) Cell , vol.148 , pp. 59-71
    • Rausch, T.1
  • 36
    • 65249186793 scopus 로고    scopus 로고
    • The mir 17/92 polycistron is up regulated in sonic hedgehog-driven medulloblastomas and induced by n myc in sonic hedgehog-treated cerebellar neural precursors
    • Northcott, P. A. et al. The miR 17/92 polycistron is up regulated in sonic hedgehog-driven medulloblastomas and induced by N myc in sonic hedgehog-treated cerebellar neural precursors. Cancer Res. 69, 3249-3255 (2009
    • (2009) Cancer Res. , vol.69 , pp. 3249-3255
    • Northcott, P.A.1
  • 38
    • 52449119078 scopus 로고    scopus 로고
    • Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features
    • References 37 and 38 were the first to report the existence of distinct molecular subgroups of medulloblastoma based on unsupervised analyses of transcriptional profiles.
    • Kool, M. et al. Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS ONE 3, e3088 (2008). References 37 and 38 were the first to report the existence of distinct molecular subgroups of medulloblastoma based on unsupervised analyses of transcriptional profiles.
    • (2008) PLoS ONE , vol.3
    • Kool, M.1
  • 39
    • 79954991010 scopus 로고    scopus 로고
    • Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome
    • Cho, Y. J. et al. Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. J. Clin. Oncol. 29, 1424-1430 (2011
    • (2011) J. Clin. Oncol. , vol.29 , pp. 1424-1430
    • Cho, Y.J.1
  • 40
    • 79955034739 scopus 로고    scopus 로고
    • Medulloblastoma comprises four distinct molecular variants
    • References 39 and 40 are highly complementary studies on the genomic and clinical characteristics of medulloblastoma subgroups and instigated the definition of the currently recognized consensus subgroups.
    • Northcott, P. A. et al. Medulloblastoma comprises four distinct molecular variants. J. Clin. Oncol. 29, 1408-1414 (2011). References 39 and 40 are highly complementary studies on the genomic and clinical characteristics of medulloblastoma subgroups and instigated the definition of the currently recognized consensus subgroups.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 1408-1414
    • Northcott, P.A.1
  • 41
    • 80053980912 scopus 로고    scopus 로고
    • Fstl5 is a marker of poor prognosis in non-wnt/non-shh medulloblastoma
    • Remke, M. et al. FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma. J. Clin. Oncol. 29, 3852-3861 (2011
    • (2011) J. Clin. Oncol. , vol.29 , pp. 3852-3861
    • Remke, M.1
  • 42
    • 84860821444 scopus 로고    scopus 로고
    • Molecular subgroups of medulloblastoma: The current consensus
    • This report is the consensus statement on the four subgroup structure of medulloblastoma agreed on by the medulloblastoma community.
    • Taylor, M. D. et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol. 123, 465-472 (2012). This report is the consensus statement on the four subgroup structure of medulloblastoma agreed on by the medulloblastoma community.
    • (2012) Acta Neuropathol. , vol.123 , pp. 465-472
    • Taylor, M.D.1
  • 45
    • 79954428982 scopus 로고    scopus 로고
    • Risk stratification of medulloblastoma: A paradigm for future childhood brain tumor management strategies
    • Packer, R. J. Risk stratification of medulloblastoma: a paradigm for future childhood brain tumor management strategies. Curr. Neurol. Neurosci. Rep. 11, 124-126 (2011
    • (2011) Curr. Neurol. Neurosci. Rep. , vol.11 , pp. 124-126
    • Packer, R.J.1
  • 46
    • 84856120371 scopus 로고    scopus 로고
    • The molecular classification of medulloblastoma: Driving the next generation clinical trials
    • Leary, S. E. & Olson, J. M. The molecular classification of medulloblastoma: driving the next generation clinical trials. Curr. Opin. Pediatr. 24, 33-39 (2012
    • (2012) Curr. Opin. Pediatr. , vol.24 , pp. 33-39
    • Leary, S.E.1    Olson, J.M.2
  • 48
    • 33751234205 scopus 로고    scopus 로고
    • Wnt/wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis
    • Clifford, S. C. et al. Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis. Cell Cycle 5, 2666-2670 (2006
    • (2006) Cell Cycle , vol.5 , pp. 2666-2670
    • Clifford, S.C.1
  • 49
    • 79951934386 scopus 로고    scopus 로고
    • Tp53 mutation is frequently associated with ctnnb1 mutation or mycn amplification and is compatible with long-term survival in medulloblastoma
    • Pfaff, E. et al. TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma. J. Clin. Oncol. 28, 5188-5196 (2010
    • (2010) J. Clin. Oncol. , vol.28 , pp. 5188-5196
    • Pfaff, E.1
  • 50
    • 79955020755 scopus 로고    scopus 로고
    • Tp53 mutations in favorable-risk wnt/wingless-subtype medulloblastomas
    • Lindsey, J. C. et al. TP53 mutations in favorable-risk Wnt/Wingless-subtype medulloblastomas. J. Clin. Oncol. 29, e344-e348 (2011
    • (2011) J. Clin. Oncol. , vol.29
    • Lindsey, J.C.1
  • 51
    • 84862680481 scopus 로고    scopus 로고
    • Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples
    • Northcott, P. A. et al. Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples. Acta Neuropathol. 123, 615-626 (2012
    • (2012) Acta Neuropathol. , vol.123 , pp. 615-626
    • Northcott, P.A.1
  • 52
    • 78650811198 scopus 로고    scopus 로고
    • Subtypes of medulloblastoma have distinct developmental origins
    • This study described the first mouse model to faithfully recapitulate human WNT medulloblastoma and proposed LRPs as their putative cell of origin.
    • Gibson, P. et al. Subtypes of medulloblastoma have distinct developmental origins. Nature 468, 1095-1099 (2010). This study described the first mouse model to faithfully recapitulate human WNT medulloblastoma and proposed LRPs as their putative cell of origin.
    • (2010) Nature , vol.468 , pp. 1095-1099
    • Gibson, P.1
  • 53
    • 79960842253 scopus 로고    scopus 로고
    • Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct
    • Northcott, P. A. et al. Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct. Acta Neuropathol. 122, 231-240 (2011
    • (2011) Acta Neuropathol. , vol.122 , pp. 231-240
    • Northcott, P.A.1
  • 54
    • 79954444747 scopus 로고    scopus 로고
    • Medulloblastoma: Clinicopathological correlates of shh wnt and non-shhwnt molecular subgroups
    • Ellison, D. W. et al. Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups. Acta Neuropathol. 121, 381-396 (2011
    • (2011) Acta Neuropathol. , vol.121 , pp. 381-396
    • Ellison, D.W.1
  • 55
    • 84863979877 scopus 로고    scopus 로고
    • High frequency of germline sufu mutations in children with desmoplastic/nodular medulloblastoma younger than 3 years of age
    • Brugieres, L. et al. High frequency of germline SUFU mutations in children with desmoplastic/nodular medulloblastoma younger than 3 years of age. J. Clin. Oncol. 30, 2087-2093 (2012
    • (2012) J. Clin. Oncol. , vol.30 , pp. 2087-2093
    • Brugieres, L.1
  • 56
    • 77349101119 scopus 로고    scopus 로고
    • Incomplete penetrance of the predisposition to medulloblastoma associated with germ-line sufu mutations
    • Brugieres, L. et al. Incomplete penetrance of the predisposition to medulloblastoma associated with germ-line SUFU mutations. J. Med. Genet. 47, 142-144 (2010
    • (2010) J. Med. Genet. , vol.47 , pp. 142-144
    • Brugieres, L.1
  • 57
    • 65249184393 scopus 로고    scopus 로고
    • Medulloblastoma variants: Age-dependent occurrence and relation to gorlin syndrome-A new clinical perspective
    • Garre, M. L. et al. Medulloblastoma variants: age-dependent occurrence and relation to Gorlin syndrome-a new clinical perspective. Clin. Cancer Res. 15, 2463-2471 (2009
    • (2009) Clin. Cancer Res. , vol.15 , pp. 2463-2471
    • Garre, M.L.1
  • 58
    • 57449096198 scopus 로고    scopus 로고
    • Genetically engineered mouse models of brain cancer and the promise of preclinical testing
    • Huse, J. T. & Holland, E. C. Genetically engineered mouse models of brain cancer and the promise of preclinical testing. Brain Pathol. 19, 132-143 (2009
    • (2009) Brain Pathol. , vol.19 , pp. 132-143
    • Huse, J.T.1    Holland, E.C.2
  • 60
    • 0030866154 scopus 로고    scopus 로고
    • Altered neural cell fates and medulloblastoma in mouse patched mutants
    • DOI 10.1126/science.277.5329.1109
    • Goodrich, L. V., Milenkovic, L., Higgins, K. M. & Scott, M. P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277, 1109-1113 (1997). This article introduced the first sporadic mouse model of medulloblastoma generated through germline deletion of one allele of the Ptch1 TSG. (Pubitemid 27371635)
    • (1997) Science , vol.277 , Issue.5329 , pp. 1109-1113
    • Goodrich, L.V.1    Milenkovic, L.2    Higgins, K.M.3    Scott, M.P.4
  • 61
    • 0034655270 scopus 로고    scopus 로고
    • The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched
    • Wetmore, C., Eberhart, D. E. & Curran, T. The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched. Cancer Res. 60, 2239-2246 (2000 (Pubitemid 30225189)
    • (2000) Cancer Research , vol.60 , Issue.8 , pp. 2239-2246
    • Wetmore, C.1    Eberhart, D.E.2    Curran, T.3
  • 65
    • 48449101742 scopus 로고    scopus 로고
    • Medulloblastoma can be initiated by deletion of patched in lineage-restricted progenitors or stem cells
    • Yang, Z. J. et al. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell 14, 135-145 (2008
    • (2008) Cancer Cell , vol.14 , pp. 135-145
    • Yang, Z.J.1
  • 66
    • 48449105147 scopus 로고    scopus 로고
    • Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form shh-induced medulloblastoma
    • Schuller, U. et al. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell 14, 123-134 (2008
    • (2008) Cancer Cell , vol.14 , pp. 123-134
    • Schuller, U.1
  • 67
    • 84862646026 scopus 로고    scopus 로고
    • Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem
    • Grammel, D. et al. Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem. Acta Neuropathol. 123, 601-614 (2012
    • (2012) Acta Neuropathol. , vol.123 , pp. 601-614
    • Grammel, D.1
  • 68
    • 70349244812 scopus 로고    scopus 로고
    • Treatment of medulloblastoma with hedgehog pathway inhibitor gdc 0449
    • This study demonstrated proof of principle for targeted therapy of medulloblastoma through administration of a pharmacological inhibitor of SMO to a single patient with metastatic medulloblastoma, resulting in a profound but transient response and subsequent therapeutic resistance.
    • Rudin, C. M. et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC 0449. New Engl. J. Med. 361, 1173-1178 (2009). This study demonstrated proof of principle for targeted therapy of medulloblastoma through administration of a pharmacological inhibitor of SMO to a single patient with metastatic medulloblastoma, resulting in a profound but transient response and subsequent therapeutic resistance.
    • (2009) New Engl. J. Med. , vol.361 , pp. 1173-1178
    • Rudin, C.M.1
  • 69
    • 70350496540 scopus 로고    scopus 로고
    • Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma
    • Yauch, R. L. et al. Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science 326, 572-574 (2009
    • (2009) Science , vol.326 , pp. 572-574
    • Yauch, R.L.1
  • 70
    • 77958060845 scopus 로고    scopus 로고
    • Interfering with resistance to smoothened antagonists by inhibition of the pi3k pathway in medulloblastoma
    • Buonamici, S. et al. Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma. Sci. Transl. Med. 2, 51ra70 (2010
    • (2010) Sci. Transl. Med. , vol.2
    • Buonamici, S.1
  • 71
    • 78751520029 scopus 로고    scopus 로고
    • Small molecule inhibition of gdc 0449 refractory smoothened mutants and downstream mechanisms of drug resistance
    • Dijkgraaf, G. J. et al. Small molecule inhibition of GDC 0449 refractory smoothened mutants and downstream mechanisms of drug resistance. Cancer Res. 71, 435-444 (2011
    • (2011) Cancer Res. , vol.71 , pp. 435-444
    • Dijkgraaf, G.J.1
  • 72
    • 79960935826 scopus 로고    scopus 로고
    • Hedgehog fights back: Mechanisms of acquired resistance against smoothened antagonists
    • Metcalfe, C. & de Sauvage, F. J. Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists. Cancer Res. 71, 5057-5061 (2011
    • (2011) Cancer Res. , vol.71 , pp. 5057-5061
    • Metcalfe, C.1    De Sauvage, F.J.2
  • 73
    • 63449115501 scopus 로고    scopus 로고
    • Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
    • This study used SNP arrays to identify significant copy number aberrations in the medulloblastoma genome and was the first to implicate deregulation of chromatin modifiers as an important theme in medulloblastoma biology.
    • Northcott, P. A. et al. Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nature Genet. 41, 465-472 (2009). This study used SNP arrays to identify significant copy number aberrations in the medulloblastoma genome and was the first to implicate deregulation of chromatin modifiers as an important theme in medulloblastoma biology.
    • (2009) Nature Genet. , vol.41 , pp. 465-472
    • Northcott, P.A.1
  • 74
    • 40149091426 scopus 로고    scopus 로고
    • Transient Inhibition of the Hedgehog Pathway in Young Mice Causes Permanent Defects in Bone Structure
    • DOI 10.1016/j.ccr.2008.01.027, PII S1535610808000378
    • Kimura, H., Ng, J. M. & Curran, T. Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure. Cancer Cell 13, 249-260 (2008 (Pubitemid 351324879)
    • (2008) Cancer Cell , vol.13 , Issue.3 , pp. 249-260
    • Kimura, H.1    Ng, J.M.Y.2    Curran, T.3
  • 75
    • 84863012675 scopus 로고    scopus 로고
    • An animal model of myc-driven medulloblastoma
    • Pei, Y. et al. An animal model of MYC-driven medulloblastoma. Cancer Cell 21, 155-167 (2012
    • (2012) Cancer Cell , vol.21 , pp. 155-167
    • Pei, Y.1
  • 76
    • 84857013044 scopus 로고    scopus 로고
    • A mouse model of the most aggressive subgroup of human medulloblastoma
    • References 75 and 76 describe the successful generation of in vivo models of MYC-driven Group 3 medulloblastoma.
    • Kawauchi, D. et al. A mouse model of the most aggressive subgroup of human medulloblastoma. Cancer Cell 21, 168-180 (2012). References 75 and 76 describe the successful generation of in vivo models of MYC-driven Group 3 medulloblastoma.
    • (2012) Cancer Cell , vol.21 , pp. 168-180
    • Kawauchi, D.1
  • 77
    • 79960119129 scopus 로고    scopus 로고
    • Adult medulloblastoma comprises three major molecular variants
    • Remke, M. et al. Adult medulloblastoma comprises three major molecular variants. J. Clin. Oncol. 29, 2717-2723 (2011
    • (2011) J. Clin. Oncol. , vol.29 , pp. 2717-2723
    • Remke, M.1
  • 78
    • 84856986590 scopus 로고    scopus 로고
    • Three down and one to go: Modeling medulloblastoma subgroups
    • Eberhart, C. G. Three down and one to go: modeling medulloblastoma subgroups. Cancer Cell 21, 137-138 (2012
    • (2012) Cancer Cell , vol.21 , pp. 137-138
    • Eberhart, C.G.1
  • 79
    • 84861399134 scopus 로고    scopus 로고
    • Distinct neural stem cell populations give rise to disparate brain tumors in response to n myc
    • Swartling, F. J. et al. Distinct neural stem cell populations give rise to disparate brain tumors in response to N MYC. Cancer Cell 21, 601-613 (2012
    • (2012) Cancer Cell , vol.21 , pp. 601-613
    • Swartling, F.J.1
  • 80
    • 77952375097 scopus 로고    scopus 로고
    • Pleiotropic role for mycn in medulloblastoma
    • This article introduced an elegant mouse model of MYCN-driven medulloblastoma relying on a bidirectional transgenic promoter expressing both MYCN and luciferase in the developing mouse cerebellum that generated highly penetrant mouse medulloblastomas with similar features of the human disease.
    • Swartling, F. J. et al. Pleiotropic role for MYCN in medulloblastoma. Genes Dev. 24, 1059-1072 (2010). This article introduced an elegant mouse model of MYCN-driven medulloblastoma relying on a bidirectional transgenic promoter expressing both MYCN and luciferase in the developing mouse cerebellum that generated highly penetrant mouse medulloblastomas with similar features of the human disease.
    • (2010) Genes Dev. , vol.24 , pp. 1059-1072
    • Swartling, F.J.1
  • 81
    • 76549086016 scopus 로고    scopus 로고
    • Genomics of medulloblastoma: From giemsa-banding to next-generation sequencing in 20 years
    • Northcott, P. A., Rutka, J. T. & Taylor, M. D. Genomics of medulloblastoma: from Giemsa-banding to next-generation sequencing in 20 years. Neurosurg. Focus 28, e6 (2010
    • (2010) Neurosurg. Focus , vol.28
    • Northcott, P.A.1    Rutka, J.T.2    Taylor, M.D.3
  • 82
    • 77953020607 scopus 로고    scopus 로고
    • Heterozygous germ-line mutations in the nbn gene predispose to medulloblastoma in pediatric patients
    • Ciara, E. et al. Heterozygous germ-line mutations in the NBN gene predispose to medulloblastoma in pediatric patients. Acta Neuropathol. 119, 325-334 (2010
    • (2010) Acta Neuropathol. , vol.119 , pp. 325-334
    • Ciara, E.1
  • 83
    • 0038748216 scopus 로고    scopus 로고
    • Fatal toxicity following radio- and chemotherapy of medulloblastoma in a child with unrecognized Nijmegen breakage syndrome
    • DOI 10.1002/mpo.10275
    • Distel, L., Neubauer, S., Varon, R., Holter, W. & Grabenbauer, G. Fatal toxicity following radio- and chemotherapy of medulloblastoma in a child with unrecognized Nijmegen breakage syndrome. Med. Pediatr. Oncol. 41, 44-48 (2003 (Pubitemid 41103253)
    • (2003) Medical and Pediatric Oncology , vol.41 , Issue.1 , pp. 44-48
    • Distel, L.1    Neubauer, S.2    Varon, R.3    Holter, W.4    Grabenbauer, G.5
  • 85
    • 79251629946 scopus 로고    scopus 로고
    • The genetic landscape of the childhood cancer medulloblastoma
    • This study was the first unbiased exome-wide sequencing study of medulloblastoma and identified novel recurrent somatic mutations in the chromatin modifiers MLL2 and MLL3.
    • Parsons, D. W. et al. The genetic landscape of the childhood cancer medulloblastoma. Science 331, 435-439 (2011). This study was the first unbiased exome-wide sequencing study of medulloblastoma and identified novel recurrent somatic mutations in the chromatin modifiers MLL2 and MLL3.
    • (2011) Science , vol.331 , pp. 435-439
    • Parsons, D.W.1
  • 86
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons, D. W. et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807-1812 (2008
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1
  • 87
    • 84864258996 scopus 로고    scopus 로고
    • A landscape of driver mutations in melanoma
    • Hodis, E. et al. A landscape of driver mutations in melanoma. Cell 150, 251-263 (2012
    • (2012) Cell , vol.150 , pp. 251-263
    • Hodis, E.1
  • 88
    • 84862523863 scopus 로고    scopus 로고
    • Sequence analysis of mutations and translocations across breast cancer subtypes
    • Banerji, S. et al. Sequence analysis of mutations and translocations across breast cancer subtypes. Nature 486, 405-409 (2012
    • (2012) Nature , vol.486 , pp. 405-409
    • Banerji, S.1
  • 89
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • Cancer Genome Atlas Research Network.
    • Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature 474, 609-615 (2011
    • (2011) Nature , vol.474 , pp. 609-615
  • 90
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas Research Network.
    • Cancer Genome Atlas Research Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330-337 (2012
    • (2012) Nature , vol.487 , pp. 330-337
  • 91
    • 84861581164 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent spop foxa1 and med12 mutations in prostate cancer
    • Barbieri, C. E. et al. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nature Genet. 44, 685-689 (2012
    • (2012) Nature Genet. , vol.44 , pp. 685-689
    • Barbieri, C.E.1
  • 92
    • 79961057508 scopus 로고    scopus 로고
    • Dead-box rna helicase belle/ddx3 and the rna interference pathway promote mitotic chromosome segregation
    • Pek, J. W. & Kai, T. DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation. Proc. Natl Acad. Sci. USA 108, 12007-12012 (2011
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 12007-12012
    • Pek, J.W.1    Kai, T.2
  • 93
    • 78649532406 scopus 로고    scopus 로고
    • Ddx3 regulates cell growth through translational control of cyclin e1
    • Lai, M. C., Chang, W. C., Shieh, S. Y. & Tarn, W. Y. DDX3 regulates cell growth through translational control of cyclin E1. Mol. Cell. Biol. 30, 5444-5453 (2010
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 5444-5453
    • Lai, M.C.1    Chang, W.C.2    Shieh, S.Y.3    Tarn, W.Y.4
  • 94
    • 70449674212 scopus 로고    scopus 로고
    • Human dead-box protein 3 has multiple functions in gene regulation and cell cycle control and is a prime target for viral manipulation
    • Schroder, M. Human DEAD-box protein 3 has multiple functions in gene regulation and cell cycle control and is a prime target for viral manipulation. Biochem. Pharmacol. 79, 297-306 (2010
    • (2010) Biochem. Pharmacol. , vol.79 , pp. 297-306
    • Schroder, M.1
  • 95
    • 49249132005 scopus 로고    scopus 로고
    • Human ddx3 functions in translation and interacts with the translation initiation factor eif3
    • Lee, C. S. et al. Human DDX3 functions in translation and interacts with the translation initiation factor eIF3. Nucleic Acids Res. 36, 4708-4718 (2008
    • (2008) Nucleic Acids Res. , vol.36 , pp. 4708-4718
    • Lee, C.S.1
  • 96
    • 55549107531 scopus 로고    scopus 로고
    • The dead-box rna helicase ddx3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control
    • Lai, M. C., Lee, Y. H. & Tarn, W. Y. The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control. Mol. Biol. Cell 19, 3847-3858 (2008
    • (2008) Mol. Biol. Cell , vol.19 , pp. 3847-3858
    • Lai, M.C.1    Lee, Y.H.2    Tarn, W.Y.3
  • 97
    • 35449007714 scopus 로고    scopus 로고
    • The DDX3 subfamily of the DEAD box helicases: Divergent roles as unveiled by studying different organisms and in vitro assays
    • DOI 10.2174/092986707782023677
    • Rosner, A. & Rinkevich, B. The DDX3 subfamily of the DEAD box helicases: divergent roles as unveiled by studying different organisms and in vitro assays. Curr. Med. Chem. 14, 2517-2525 (2007 (Pubitemid 47618039)
    • (2007) Current Medicinal Chemistry , vol.14 , Issue.23 , pp. 2517-2525
    • Rosner, A.1    Rinkevich, B.2
  • 99
    • 84864425646 scopus 로고    scopus 로고
    • Subgroup-specific structural variation across 1,000 medulloblastoma genomes
    • This study described the SCNAs present in a series of >1,000 primary medulloblastomas and led to the discovery of several novel medulloblastoma subgroup-specific alterations, including PVT1-MYC fusion genes in Group 3 medulloblastoma and tandem duplication of SNCAIP in Group 4 medulloblastoma.
    • Northcott, P. A. et al. Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature 488, 49-56 (2012). This study described the SCNAs present in a series of >1,000 primary medulloblastomas and led to the discovery of several novel medulloblastoma subgroup-specific alterations, including PVT1-MYC fusion genes in Group 3 medulloblastoma and tandem duplication of SNCAIP in Group 4 medulloblastoma.
    • (2012) Nature , vol.488 , pp. 49-56
    • Northcott, P.A.1
  • 100
    • 80455140217 scopus 로고    scopus 로고
    • Structural basis for histone h3 lys 27 demethylation by utx/kdm6a
    • Sengoku, T. & Yokoyama, S. Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A. Genes Dev. 25, 2266-2277 (2011
    • (2011) Genes Dev. , vol.25 , pp. 2266-2277
    • Sengoku, T.1    Yokoyama, S.2
  • 101
    • 84861813539 scopus 로고    scopus 로고
    • Diverse ways to be specific: A novel zn binding domain confers substrate specificity to utx/kdm6a histone h3 lys 27 demethylase
    • Kim, E. & Song, J. J. Diverse ways to be specific: a novel Zn binding domain confers substrate specificity to UTX/KDM6A histone H3 Lys 27 demethylase. Genes Dev. 25, 2223-2226 (2011
    • (2011) Genes Dev. , vol.25 , pp. 2223-2226
    • Kim, E.1    Song, J.J.2
  • 102
    • 84860215207 scopus 로고    scopus 로고
    • Molecular mechanisms and potential functions of histone demethylases
    • Kooistra, S. M. & Helin, K. Molecular mechanisms and potential functions of histone demethylases. Nature Rev. Mol. Cell Biol. 13, 297-311 (2012
    • (2012) Nature Rev. Mol. Cell Biol. , vol.13 , pp. 297-311
    • Kooistra, S.M.1    Helin, K.2
  • 103
    • 25144519737 scopus 로고    scopus 로고
    • An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation
    • DOI 10.1038/nature04021, PII N04021
    • Lee, M. G., Wynder, C., Cooch, N. & Shiekhattar, R. An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature 437, 432-435 (2005 (Pubitemid 41613507)
    • (2005) Nature , vol.437 , Issue.7057 , pp. 432-435
    • Lee, M.G.1    Wynder, C.2    Cooch, N.3    Shiekhattar, R.4
  • 104
    • 77957344798 scopus 로고    scopus 로고
    • Chd7 targets active gene enhancer elements to modulate es cell-specific gene expression
    • Schnetz, M. P. et al. CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. PLoS Genet. 6, e1001023 (2010
    • (2010) PLoS Genet. , vol.6
    • Schnetz, M.P.1
  • 105
    • 77249117148 scopus 로고    scopus 로고
    • Chd7 cooperates with pbaf to control multipotent neural crest formation
    • Bajpai, R. et al. CHD7 cooperates with PBAF to control multipotent neural crest formation. Nature 463, 958-962 (2010
    • (2010) Nature , vol.463 , pp. 958-962
    • Bajpai, R.1
  • 106
    • 64149122182 scopus 로고    scopus 로고
    • Genomic distribution of chd7 on chromatin tracks h3k4 methylation patterns
    • Schnetz, M. P. et al. Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns. Genome Res. 19, 590-601 (2009
    • (2009) Genome Res. , vol.19 , pp. 590-601
    • Schnetz, M.P.1
  • 107
    • 84859893371 scopus 로고    scopus 로고
    • Histone methylation: A dynamic mark in health, disease and inheritance
    • Greer, E. L. & Shi, Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nature Rev. Genet. 13, 343-357 (2012
    • (2012) Nature Rev. Genet. , vol.13 , pp. 343-357
    • Greer, E.L.1    Shi, Y.2
  • 108
    • 78751662908 scopus 로고    scopus 로고
    • The polycomb complex prc2 and its mark in life
    • Margueron, R. & Reinberg, D. The Polycomb complex PRC2 and its mark in life. Nature 469, 343-349 (2011
    • (2011) Nature , vol.469 , pp. 343-349
    • Margueron, R.1    Reinberg, D.2
  • 109
    • 84865339061 scopus 로고    scopus 로고
    • Targeting the enhancer of zeste homologue 2 in medulloblastoma. International journal of cancer
    • Alimova, I. et al. Targeting the enhancer of zeste homologue 2 in medulloblastoma. International journal of cancer. J. Inter. Cancer 131,1800-1809 (2012
    • (2012) J. Inter. Cancer , vol.131 , pp. 1800-1809
    • Alimova, I.1
  • 110
    • 79551626803 scopus 로고    scopus 로고
    • Structural basis for the assembly of the smrt/ncor core transcriptional repression machinery
    • Oberoi, J. et al. Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery. Nature Struct. Mol. Biol. 18, 177-184 (2011
    • (2011) Nature Struct. Mol. Biol. , vol.18 , pp. 177-184
    • Oberoi, J.1
  • 111
    • 79952610870 scopus 로고    scopus 로고
    • Making sense of cancer genomic data
    • Chin, L., Hahn, W. C., Getz, G. & Meyerson, M. Making sense of cancer genomic data. Genes Dev. 25, 534-555 (2011
    • (2011) Genes Dev. , vol.25 , pp. 534-555
    • Chin, L.1    Hahn, W.C.2    Getz, G.3    Meyerson, M.4
  • 112
    • 33751320113 scopus 로고    scopus 로고
    • Dullard Promotes Degradation and Dephosphorylation of BMP Receptors and Is Required for Neural Induction
    • DOI 10.1016/j.devcel.2006.10.001, PII S1534580706004539
    • Satow, R., Kurisaki, A., Chan, T. C., Hamazaki, T. S. & Asashima, M. Dullard promotes degradation and dephosphorylation of BMP receptors and is required for neural induction. Dev. Cell 11, 763-774 (2006 (Pubitemid 44804276)
    • (2006) Developmental Cell , vol.11 , Issue.6 , pp. 763-774
    • Satow, R.1    Kurisaki, A.2    Chan, T.-c.3    Hamazaki, T.S.4    Asashima, M.5
  • 114
    • 84856296166 scopus 로고    scopus 로고
    • Nuclear envelope phosphatase 1 regulatory subunit 1 (formerly tmem188) is the metazoan spo7p ortholog and functions in the lipin activation pathway
    • Han, S. et al. Nuclear envelope phosphatase 1 regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. J. Biol. Chem. 287, 3123-3137 (2012
    • (2012) J. Biol. Chem. , vol.287 , pp. 3123-3137
    • Han, S.1
  • 115
    • 0026513426 scopus 로고
    • Involvement of multiple chromosome 17p loci in medulloblastoma tumorigenesis
    • Cogen, P. H. et al. Involvement of multiple chromosome 17p loci in medulloblastoma tumorigenesis. Am. J. Hum. Genet. 50, 584-589 (1992
    • (1992) Am. J. Hum. Genet. , vol.50 , pp. 584-589
    • Cogen, P.H.1
  • 116
    • 0024998205 scopus 로고
    • Deletion mapping of the medulloblastoma locus on chromosome 17p
    • Cogen, P. H., Daneshvar, L., Metzger, A. K. & Edwards, M. S. Deletion mapping of the medulloblastoma locus on chromosome 17p. Genomics 8, 279-285 (1990 (Pubitemid 20335619)
    • (1990) Genomics , vol.8 , Issue.2 , pp. 279-285
    • Cogen, P.H.1    Daneshvar, L.2    Metzger, A.K.3    Edwards, M.S.B.4
  • 117
    • 0026634161 scopus 로고
    • Evidence for a 17p tumor related locus distinct from p53 in pediatric primitive neuroectodermal tumors
    • Biegel, J. A., Burk, C. D., Barr, F. G. & Emanuel, B. S. Evidence for a 17p tumor related locus distinct from p53 in pediatric primitive neuroectodermal tumors. Cancer Res. 52, 3391-3395 (1992
    • (1992) Cancer Res. , vol.52 , pp. 3391-3395
    • Biegel, J.A.1    Burk, C.D.2    Barr, F.G.3    Emanuel, B.S.4
  • 118
    • 75149149855 scopus 로고    scopus 로고
    • Otx2 is critical for the maintenance and progression of shh-independent medulloblastomas
    • Adamson, D. C. et al. OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas. Cancer Res. 70, 181-191 (2010
    • (2010) Cancer Res. , vol.70 , pp. 181-191
    • Adamson, D.C.1
  • 119
    • 63749118521 scopus 로고    scopus 로고
    • Outcome prediction in pediatric medulloblastoma based on dna copy-number aberrations of chromosomes 6q and 17q and the myc and mycn loci
    • Pfister, S. et al. Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci. J. Clin. Oncol. 27, 1627-1636 (2009
    • (2009) J. Clin. Oncol. , vol.27 , pp. 1627-1636
    • Pfister, S.1
  • 121
    • 84865358363 scopus 로고    scopus 로고
    • Multiple cdk/cyclind genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor
    • Li, M. et al. Multiple CDK/CYCLIND genes are amplified in medulloblastoma and supratentorial primitive neuroectodermal brain tumor. Cancer Genet. 205, 220-231 (2012
    • (2012) Cancer Genet. , vol.205 , pp. 220-231
    • Li, M.1
  • 122
    • 75949097839 scopus 로고    scopus 로고
    • Wip1 phosphatase at the crossroads of cancer and aging
    • Le Guezennec, X. & Bulavin, D. V. WIP1 phosphatase at the crossroads of cancer and aging. Trends Biochem. Sci. 35, 109-114 (2010
    • (2010) Trends Biochem. Sci. , vol.35 , pp. 109-114
    • Le Guezennec, X.1    Bulavin, D.V.2
  • 123
    • 38049074854 scopus 로고    scopus 로고
    • Medulloblastomas overexpress the p53 inactivating oncogene wip1/ppm1d
    • Castellino, R. C. et al. Medulloblastomas overexpress the p53 inactivating oncogene WIP1/PPM1D. J. Neurooncol. 86, 245-256 (2008
    • (2008) J. Neurooncol. , vol.86 , pp. 245-256
    • Castellino, R.C.1
  • 124
    • 84858747888 scopus 로고    scopus 로고
    • Wip1 enhances tumor formation in a sonic hedgehog-dependent model of medulloblastoma
    • Doucette, T. A. et al. WIP1 enhances tumor formation in a sonic hedgehog-dependent model of medulloblastoma. Neurosurgery 70, 1003-1010 (2012
    • (2012) Neurosurgery , vol.70 , pp. 1003-1010
    • Doucette, T.A.1
  • 126
    • 40149092646 scopus 로고    scopus 로고
    • Pvt1 encoded micrornas in oncogenesis
    • Beck-Engeser, G. B. et al. Pvt1 encoded microRNAs in oncogenesis. Retrovirology 5, 4 (2008
    • (2008) Retrovirology , vol.5 , pp. 4
    • Beck-Engeser, G.B.1
  • 129
  • 130
    • 33749666185 scopus 로고    scopus 로고
    • Synphilin isoforms and the search for a cellular model of lewy body formation in Parkinson's disease
    • Eyal, A. & Engelender, S. Synphilin isoforms and the search for a cellular model of lewy body formation in Parkinson's disease. Cell Cycle 5, 2082-2086 (2006 (Pubitemid 44553743)
    • (2006) Cell Cycle , vol.5 , Issue.18 , pp. 2082-2086
    • Eyal, A.1    Engelender, S.2
  • 132
    • 55349107544 scopus 로고    scopus 로고
    • Tandem duplication producing a novel oncogenic braf fusion gene defines the majority of pilocytic astrocytomas
    • Jones, D. T. et al. Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas. Cancer Res. 68, 8673-8677 (2008
    • (2008) Cancer Res. , vol.68 , pp. 8673-8677
    • Jones, D.T.1
  • 134
    • 0025648762 scopus 로고
    • Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome
    • Srivastava, S., Zou, Z. Q., Pirollo, K., Blattner, W. & Chang, E. H. Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li Fraumeni syndrome. Nature 348, 747-749 (1990). References 133 and 134 established germline TP53 mutations as the underlying cause of LFS. (Pubitemid 120015153)
    • (1990) Nature , vol.348 , Issue.6303 , pp. 747-749
    • Srivastava, S.1    Zou, Z.2    Pirollo, K.3    Blattner, W.4    Chang, E.H.5
  • 135
    • 78650959663 scopus 로고    scopus 로고
    • Massive genomic rearrangement acquired in a single catastrophic event during cancer development
    • Stephens, P. J. et al. Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell 144, 27-40 (2011
    • (2011) Cell , vol.144 , pp. 27-40
    • Stephens, P.J.1
  • 136
    • 74049135504 scopus 로고    scopus 로고
    • Concerning the origin of malignant tumours by theodor boveri. Translated and annotated by henry harris
    • Boveri, T. Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris. J. Cell Sci. 121, 1-84 (2008
    • (2008) J. Cell Sci. , vol.121 , pp. 1-84
    • Boveri, T.1
  • 137
    • 84857192718 scopus 로고    scopus 로고
    • Causes and consequences of aneuploidy in cancer
    • Gordon, D. J., Resio, B. & Pellman, D. Causes and consequences of aneuploidy in cancer. Nature Rev. Genet. 13, 189-203 (2012
    • (2012) Nature Rev. Genet. , vol.13 , pp. 189-203
    • Gordon, D.J.1    Resio, B.2    Pellman, D.3
  • 138
    • 0347762556 scopus 로고    scopus 로고
    • From polyploidy to aneuploidy, genome instability and cancer
    • DOI 10.1038/nrm1276
    • Storchova, Z. & Pellman, D. From polyploidy to aneuploidy, genome instability and cancer. Nature Rev. Mol. Cell Biol. 5, 45-54 (2004 (Pubitemid 38089840)
    • (2004) Nature Reviews Molecular Cell Biology , vol.5 , Issue.1 , pp. 45-54
    • Storchova, Z.1    Pellman, D.2
  • 139
    • 0028029456 scopus 로고
    • Chromosome analysis of brain tumors in childhood
    • DOI 10.1002/gcc.2870110402
    • Fujii, Y., Hongo, T. & Hayashi, Y. Chromosome analysis of brain tumors in childhood. Genes Chromosomes Cancer 11, 205-215 (1994 (Pubitemid 24372144)
    • (1994) Genes Chromosomes and Cancer , vol.11 , Issue.4 , pp. 205-215
    • Fujii, Y.1    Hongo, T.2    Hayashi, Y.3
  • 140
    • 0025050466 scopus 로고
    • Bone metastases of medulloblastoma in childhood; correlation with flow cytometric DNA analysis
    • Tomita, T., Das, L. & Radkowski, M. A. Bone metastases of medulloblastoma in childhood; correlation with flow cytometric DNA analysis. J. Neurooncol. 8, 113-120 (1990 (Pubitemid 20250778)
    • (1990) Journal of Neuro-Oncology , vol.8 , Issue.2 , pp. 113-120
    • Tomita, T.1    Das, L.2    Radkowski, M.A.3
  • 141
    • 0025971967 scopus 로고
    • Desmoplastic versus "classic" medulloblastoma: Comparison of dna content, histopathology and differentiation. Virchows archiv
    • Giangaspero, F. et al. "Desmoplastic" versus "classic" medulloblastoma: comparison of DNA content, histopathology and differentiation. Virchows Archiv. A Pathol. Anat. Histopathol. 418, 207-214 (1991
    • (1991) A Pathol. Anat. Histopathol. , vol.418 , pp. 207-214
    • Giangaspero, F.1
  • 145
    • 84862127178 scopus 로고    scopus 로고
    • Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells
    • Davoli, T. & de Lange, T. Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells. Cancer Cell 21, 765-776 (2012
    • (2012) Cancer Cell , vol.21 , pp. 765-776
    • Davoli, T.1    De Lange, T.2
  • 146
    • 27144507868 scopus 로고    scopus 로고
    • Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
    • DOI 10.1038/nature04217, PII N04217
    • Fujiwara, T. et al. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53 null cells. Nature 437, 1043-1047 (2005 (Pubitemid 41486987)
    • (2005) Nature , vol.437 , Issue.7061 , pp. 1043-1047
    • Fujiwara, T.1    Bandi, M.2    Nitta, M.3    Ivanova, E.V.4    Bronson, R.T.5    Pellman, D.6
  • 148
    • 65949119123 scopus 로고    scopus 로고
    • Preferential killing of tetraploid tumor cells by targeting the mitotic kinesin eg5
    • Rello-Varona, S. et al. Preferential killing of tetraploid tumor cells by targeting the mitotic kinesin Eg5. Cell Cycle 8, 1030-1035 (2009
    • (2009) Cell Cycle , vol.8 , pp. 1030-1035
    • Rello-Varona, S.1
  • 149
    • 42749091176 scopus 로고    scopus 로고
    • Inhibition of chk1 kills tetraploid tumor cells through a p53 dependent pathway
    • Vitale, I. et al. Inhibition of Chk1 kills tetraploid tumor cells through a p53 dependent pathway. PLoS ONE 2, e1337 (2007
    • (2007) PLoS ONE , vol.2
    • Vitale, I.1
  • 150
    • 33748870748 scopus 로고    scopus 로고
    • Hereditary cancer predisposition in children: Genetic basis and clinical implications
    • DOI 10.1002/ijc.21962
    • Strahm, B. & Malkin, D. Hereditary cancer predisposition in children: genetic basis and clinical implications. Int. J. Cancer 119, 2001-2006 (2006 (Pubitemid 44423655)
    • (2006) International Journal of Cancer , vol.119 , Issue.9 , pp. 2001-2006
    • Strahm, B.1    Malkin, D.2
  • 151
    • 46449099445 scopus 로고    scopus 로고
    • Family cancer history and risk of brain tumors in children: Results of the search international brain tumor study
    • Searles Nielsen, S. et al. Family cancer history and risk of brain tumors in children: results of the SEARCH international brain tumor study. Cancer Causes Control 19, 641-648 (2008
    • (2008) Cancer Causes Control , vol.19 , pp. 641-648
    • Searles Nielsen, S.1
  • 152
    • 80052825195 scopus 로고    scopus 로고
    • The functional spectrum of low-frequency coding variation
    • Marth, G. T. et al. The functional spectrum of low-frequency coding variation. Genome Biol. 12, R84 (2011
    • (2011) Genome Biol. , vol.12
    • Marth, G.T.1
  • 153
    • 84975742565 scopus 로고    scopus 로고
    • A map of human genome variation from population-scale sequencing
    • 1000 Genomes Project Consortium.
    • 1000 Genomes Project Consortium. A map of human genome variation from population-scale sequencing. Nature 467, 1061-1073 (2010
    • (2010) Nature , vol.467 , pp. 1061-1073
  • 154
    • 84863621527 scopus 로고    scopus 로고
    • Cancer epigenetics: From mechanism to therapy
    • Dawson, M. A. & Kouzarides, T. Cancer epigenetics: from mechanism to therapy. Cell 150, 12-27 (2012
    • (2012) Cell , vol.150 , pp. 12-27
    • Dawson, M.A.1    Kouzarides, T.2
  • 155
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome - Biological and translational implications
    • Baylin, S. B. & Jones, P. A. A decade of exploring the cancer epigenome - biological and translational implications. Nature Rev. Cancer 11, 726-734 (2011
    • (2011) Nature Rev. Cancer , vol.11 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 156
    • 78751570979 scopus 로고    scopus 로고
    • Rna sequencing: Advances, challenges and opportunities
    • Ozsolak, F. & Milos, P. M. RNA sequencing: advances, challenges and opportunities. Nature Rev. Genet. 12, 87-98 (2011
    • (2011) Nature Rev. Genet. , vol.12 , pp. 87-98
    • Ozsolak, F.1    Milos, P.M.2
  • 157
    • 84861527388 scopus 로고    scopus 로고
    • The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
    • Curtis, C. et al. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature 486, 346-352 (2012
    • (2012) Nature , vol.486 , pp. 346-352
    • Curtis, C.1
  • 158
    • 57049128193 scopus 로고    scopus 로고
    • Design and analysis issues in genome-wide somatic mutation studies of cancer
    • Parmigiani, G. et al. Design and analysis issues in genome-wide somatic mutation studies of cancer. Genomics 93, 17-21 (2009
    • (2009) Genomics , vol.93 , pp. 17-21
    • Parmigiani, G.1
  • 160
    • 79952696452 scopus 로고    scopus 로고
    • A rapid and scalable system for studying gene function in mice using conditional rna interference
    • Premsrirut, P. K. et al. A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell 145, 145-158 (2011
    • (2011) Cell , vol.145 , pp. 145-158
    • Premsrirut, P.K.1
  • 161
    • 78651312134 scopus 로고    scopus 로고
    • Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated rnai
    • Zuber, J. et al. Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. Nature Biotechnol. 29, 79-83 (2011
    • (2011) Nature Biotechnol. , vol.29 , pp. 79-83
    • Zuber, J.1
  • 162
    • 77957132245 scopus 로고    scopus 로고
    • Harnessing transposons for cancer gene discovery
    • Copeland, N. G. & Jenkins, N. A. Harnessing transposons for cancer gene discovery. Nature Rev. Cancer 10, 696-706 (2010
    • (2010) Nature Rev. Cancer , vol.10 , pp. 696-706
    • Copeland, N.G.1    Jenkins, N.A.2
  • 163
    • 84862776537 scopus 로고    scopus 로고
    • Clonal selection drives genetic divergence of metastatic medulloblastoma
    • This study used the SB transposon system to mutagenize the developing mouse cerebellum and generate highly penetrant metastatic mouse medulloblastomas that allowed for a direct comparison of the genes suspected to drive the primary tumours with those targeted in the matched metastases.
    • Wu, X. et al. Clonal selection drives genetic divergence of metastatic medulloblastoma. Nature 482, 529-533 (2012). This study used the SB transposon system to mutagenize the developing mouse cerebellum and generate highly penetrant metastatic mouse medulloblastomas that allowed for a direct comparison of the genes suspected to drive the primary tumours with those targeted in the matched metastases.
    • (2012) Nature , vol.482 , pp. 529-533
    • Wu, X.1
  • 164
    • 79954992066 scopus 로고    scopus 로고
    • Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables
    • Ellison, D. W. et al. Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables. J. Clin. Oncol. 29, 1400-1407 (2011
    • (2011) J. Clin. Oncol. , vol.29 , pp. 1400-1407
    • Ellison, D.W.1
  • 165
    • 64049087816 scopus 로고    scopus 로고
    • Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial hit'91
    • von Hoff, K. et al. Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT'91. Eur. J. Cancer 45, 1209-1217 (2009
    • (2009) Eur. J. Cancer , vol.45 , pp. 1209-1217
    • Von Hoff, K.1
  • 167
    • 53549083765 scopus 로고    scopus 로고
    • Childhood brain tumors: Accomplishments and ongoing challenges
    • Packer, R. J. Childhood brain tumors: accomplishments and ongoing challenges. J. Child Neurol. 23, 1122-1127 (2008
    • (2008) J. Child Neurol. , vol.23 , pp. 1122-1127
    • Packer, R.J.1
  • 168
    • 79953281617 scopus 로고    scopus 로고
    • Mapping cancer origins
    • Gilbertson, R. J. Mapping cancer origins. Cell 145, 25-29 (2011
    • (2011) Cell , vol.145 , pp. 25-29
    • Gilbertson, R.J.1
  • 169
    • 0034656212 scopus 로고    scopus 로고
    • Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
    • Marino, S., Vooijs, M., van Der Gulden, H., Jonkers, J. & Berns, A. Induction of medulloblastomas in p53 null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 14, 994-1004 (2000 (Pubitemid 30253007)
    • (2000) Genes and Development , vol.14 , Issue.8 , pp. 994-1004
    • Marino, S.1    Vooijs, M.2    Van Der Gulden, H.3    Jonkers, J.4    Berns, A.5
  • 170
    • 0032959871 scopus 로고    scopus 로고
    • Control of neuronal precursor proliferation in the cerebellum by sonic hedgehog
    • DOI 10.1016/S0896-6273(00)80682-0
    • Wechsler-Reya, R. J. & Scott, M. P. Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22, 103-114 (1999). This study identified the link between SHH signalling and cerebellar development. (Pubitemid 29070097)
    • (1999) Neuron , vol.22 , Issue.1 , pp. 103-114
    • Wechsler-Reya, R.J.1    Scott, M.P.2


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