Wnt/wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis

Cell Cycle

Volumn 5, Issue 22, 2006, Pages

  Clifford, Steve C ^a,d   Lusher, Meryl E ^a   Lindsey, Janet C ^a   Langdon, Jacqueline A ^b   Gilbertson, Richard J ^c   Straughton, Debbie ^a   Ellison, Debbie W ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Chromosome 6; Medulloblastoma; Prognosis; Wnt Wg; catenin

Indexed keywords

BETA CATENIN; WNT PROTEIN; WNT1 PROTEIN;

ADOLESCENT; ARTICLE; CHILD; CHROMOSOME 6; CHROMOSOME ABERRATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC DISORDER; GENOME ANALYSIS; HUMAN; MALE; MEDULLOBLASTOMA; PATHOGENESIS; PROGNOSIS;

EID: 33751234205     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Ellison DW, Clifford SC, Gajjar A, Gilbertson RJ. What's new in neuro-oncology? Recent advances in medulloblastoma. Eur J Paediatr Neurol 2003; 7:53-66.
2. Ellison DW, Onilude OE, Lindsey JC, Lusher ME, Weston CL, Taylor RE, Pearson AD, Clifford SC. beta-Catenin status predicts a favourable outcome in childhood medulloblastoma: The United Kingdom children's cancer study group brain tumour committee. J Clin Oncol 2005; 23:7951-7.
3. Eberhart CG, Tihan T, Burger PC. Nuclear localization and mutation of beta-catenin in medulloblastomas. J Neuropathol Exp Neurol 2000; 59:333-7.
4. Thompson MC, Fuller C, Hogg TL, Dalton J, Finkelstein D, Lau CC, Chintagumpala M, Adesina A, Ashley DM, Kellie SJ, Taylor MD, Curran T, Gajjar A, Gilbertson RJ. Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol 2006; 24:1924-31.
5. Snijders AM, Nowak N, Segraves R, Blackwood S, Brown N, Conroy J, Hamilton G, Hindle AK, Huey B, Kimura K, Law S, Myambo K, Palmer J, Ylstra B, Yue JP, Gray JW, Jain AN, Pinkel D, Albertson DG. Assembly of microarrays for genome-wide measurement of DNA copy number. Nat Genet 2001; 29:263-4.
6. Jain AN, Tokuyasu TA, Snijders AM, Segraves R, Albertson DG, Pinkel D. Fully automatic quantification of microarray image data. Genome Res 2002; 12:325-32.
7. Olshen AB, Venkatraman ES, Lucito R, Wigler M. Circular binary segmentation for the analysis of array-based DNA copy number data. Biostatistics 2004; 5:557-72.
8. Fridlyand J, Snijders AM, Ylstra B, Li H, Olshen A, Segraves R, Dairkee S, Tokuyasu T, Ljung BM, Jain AN, McLennan J, Ziegler J, Chin K, Devries S, Feiler H, Gray JW, Waldman F, Pinkel D, Albertson DG. Breast tumor copy number aberration phenotypes and genomic instability. BMC Cancer 2006; 6:96.
9. Taylor MD, Poppleton H, Fuller C, Su X, Liu Y, Jensen P, Magdaleno S, Dalton J, Calabrese C, Board J, Macdonald T, Rutka J, Guha A, Gajjar A, Curran T, Gilbertson RJ. Radial glia cells are candidate stem cells of ependymoma. Cancer Cell 2005; 8:323-35.
10. Langdon JA, Lamont JM, Scott DK, Dyer S, Prebble E, Bown N, Grundy RG, Ellison DW, Clifford SC. Combined genome-wide allelotyping and copy number analysis identify frequent genetic losses without copy number reduction in medulloblastoma. Genes Chromosomes Cancer 2006; 45:47-60.
11. Lamont JM, McManamy CS, Pearson AD, Clifford SC, Ellison DW. Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients. Clin Cancer Res 2004; 10:5482-93.
12. Taipale J, Beachy PA. The Hedgehog and Wnt signalling pathways in cancer. Nature 2001; 411:349-54.
13. McManamy CS, Lamont JM, Taylor RE, Cole M, Pearson AD, Clifford SC, Ellison DW. Morphophenotypic variation predicts clinical behavior in childhood nondesmoplastic medulloblastomas. J Neuropathol Exp Neurol 2003; 62:627-32.