Medulloblastoma variants: Age-dependent occurrence and relation to gorlin syndrome-a new clinical perspective

Clinical Cancer Research

Volumn 15, Issue 7, 2009, Pages 2463-2471

  Garrè, Maria Luisa ^b,c   Cama, Armando ^b   Bagnasco, Francesca ^a   Morana, Giovanni ^b   Giangaspero, Felice ^f   Brisigotti, Massimo ^h   Gambini, Claudio ^b   Forni, Marco ⁱ   Rossi, Andrea ^b   Haupt, Riccardo ^a   Nozza, Paolo ^b   Barra, Salvina ^d   Piatelli, Gianluca ^b   Viglizzo, Gian Maria ^b   Capra, Valeria ^b   Bruno, William ^e   Pastorino, Lorenza ^e   Massimino, Maura ^j   Tumolo, Miriam ^c   Fidani, Paola ^g   Dallorso, Sandro ^b   Schumacher, Riccardo Fabian ^b   Milanaccio, Claudia ^b   Pietsch, Torsten ^k   more..

^a Biostatistics Unit   (Italy)

^b Department of Haemato Oncology ^*  (Italy)

^c G GASLINI INSTITUTE   (Italy)

^d UNIVERSITY OF GENOA   (Italy)

^e UNIVERSITY OF GENOA   (Italy)

^f SAPIENZA UNIVERSITY OF ROME   (Italy)

^g BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^h Hospital of Rimini   (Italy)

ⁱ REGINA MARGHERITA CHILDREN S HOSPITAL   (Italy)

^j NATIONAL CANCER INSTITUTE   (Italy)

^k UNIVERSITY HOSPITAL BONN   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; ETOPOSIDE; KI 67 ANTIGEN; NEURON SPECIFIC ENOLASE; NEURON SPECIFIC NUCLEAR PROTEIN; NEUROTROPHIN RECEPTOR P75; PROTEIN PATCHED 1; SYNAPTOPHYSIN;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; ANAPLASTIC CARCINOMA; ARTICLE; BASAL CELL NEVUS SYNDROME; CANCER CHEMOTHERAPY; CANCER RELAPSE; CANCER SURVIVAL; CEREBELLUM VERMIS; CHILD; COMPUTER ASSISTED TOMOGRAPHY; DESMOPLASTIC MEDULLOBLASTOMA; DISEASE ASSOCIATION; FAMILIAL CANCER; FEMALE; GENE; GENETIC PREDISPOSITION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ITALY; LARGE CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MEDULLOBLASTOMA; MEDULLOBLASTOMA WITH EXTENSIVE NODULARITY; METASTASIS; NEUROFIBROMATOSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; OVERALL SURVIVAL; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGNOSIS; PTCH 1 GENE; SCHOOL CHILD; SOMATIC MUTATION; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR LOCALIZATION;

AGE DISTRIBUTION; AGE FACTORS; AGE OF ONSET; BASAL CELL NEVUS SYNDROME; CEREBELLAR NEOPLASMS; CHILD, PRESCHOOL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MEDULLOBLASTOMA; RISK FACTORS; SURVIVAL ANALYSIS;

EID: 65249184393     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-08-2023     Document Type: Article

References (48)

1. Giangaspero F, Eberhart CG, Haapasalo H, PietschT, Wiestler OD, Ellison DW. Medulloblastoma. In: Louis DN, Ohgaki H, Wiestler D, Cavenee WK, editors. WHO classification of tumours of the central nervous system. Lyon:IARC; 2007.p. 132-40.
2. Giangaspero F, Perilongo G, Fondelli MP, et al. Medulloblastoma with extensive nodularity: a variant with favorable prognosis. J Neurosurg 1999;91:971 - 7.
3. McManami CS,Pears J, Weston CL,et al. Nodule formation and desmoplasia in medulloblastomas - defining the nodular/desmoplastic variant and its biological behaviour. Brain Pathol 2007;17:151 -64.
4. Duffner PK, Horowitz ME, KrischerJP,et al.The treatment of malignant brain tumors in infants and very young children: an update of the Pediatric Oncology Group experience. Neuro-oncol 1999;1:152-61.
5. Geyer JR, Sposto R, Jennings M, et al. Multiagent chemotherapy and deferred radiotherapy in infants with malignant brain tumours: a report from theChild- ren's Cancer Group. J Clin Oncol 2005;23:7621 -31.
6. Grill J, Sainte-Rose C, Jouvet A, et al. Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial in young children. Lancet Oncol 2005;6:573-80.
7. Eberhart CG, Kepner JL, Goldthwaite PT, et al. Histo- pathologic grading of medulloblastomas: a Pediatric Oncology Group study. Cancer 2002;94:552 -60.
8. RutkowskiS,BodeU,Deinlein F,et al. Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med 2005;352: 978-86.
9. Gorlin RJ. Nevoid basal cell carcinoma syndrome. Dermatol Clin1995;13:113-25.
10. Gorlin RJ. Nevoid basal cell carcinoma (Gorlin) syndrome: unanswered issues. J Lab Clin Med1999;134: 551 -2.
11. Evans DG, Famdon PA, Burnell LD, et al. Theincidence of Gorlin syndrome in 173 consecutive cases of medulloblastoma. Br J Cancer 1991;64:959-61.
12. Amlashi SFA, Riffaud L, Brassier G, et al. Nevoid Basal Cell Carcinoma Syndrome: relation with desmo- plastic medulloblastoma in infancy. A population- based study and review of the literature. Cancer 2003;98:618-24.
13. 13.Taylor MD, LiuL, Raffael C, et al. Mutationsin SUFU predispose to medulloblastoma. Nat Genet 2002;31: 306-10.
14. PietschT,Waha A, Koch A, et al. Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. Cancer Res 1997;57:2085-8.
15. Aliani S, Brunner J, Graf N, et al. Medulloblastoma with extensive nodularity in nevoid basal cell carcinoma syndrome. Med Pediatr Oncol 2003;40:266-7.
16. Schuller U, Koch A, Hartmann W, et al. Subtype- specific expression and genetic alterations of the che- mokine receptor gene CXCR4 in medulloblastomas. Int J Cancer 2005;117:82-9.
17. Grundy RG,Wilne SA, Weston CL, et al. Primary postoperative chemotherapy without radiotherapy for intracranial ependymoma in children: the UKCCSG/SIOP prospective study. Lancet Oncol 2007;8:696-705.
18. Garre ML, Massimino M, Cefalo G, et al. High-risk malignant CNS tumours in infants: standard vs myeloablative chemotherapy: the experience of theItalian cooperative study for children <3 years of age. Neurooncol 2003;1:40.
19. Packer RJ, Gajjar A, Vezina G, et al. Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J Clin Oncol 2006;24:4202-8.
20. Corrias A, Einaudi S, Ricardi U, et al. Thyroid diseases in patients treated during pre-puberty for medulloblastoma with different radiotherapic protocols. J Endocrinol Invest 2001;24:387 -92.
21. Dallorso S, Dini G, Ladenstein R, et al. Evolving role of myeloablative chemotherapy in the treatment of childhood brain tumours. Bone Marrow Transplant 2005;35:S31 -4.
22. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
23. Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 1966;50:163-70.
24. Marubini E, Valsecchi MG. Analysing Survival Data from Clinical Trials and observational Studies. Chichester (England): John Wiley & Sons; 1995.
25. Tortori-Donati P, Rossi A, Biancheri R, et al. Brain Tumors. In: Tortori Donati P, editor. Pediatric Neurora- diology Brain. Vol. 1. Berlin/Heidelberg Springer; 2005. p. 329-436.
26. Garre ML, Cama A, Milanaccio, et al. New concepts in the treatment of brain tumours in very young children. Expert Rev Neurother 2006;6:489-500.
27. Packer RJ, Rood BR, MacDonald TJ. Medulloblastoma: present concepts of stratification into risk groups. Pediatr Neurosurg 2003;39:60-7.
28. Pomeroy SL,Tamayo P, Gaasenbeek M, et al. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 2002;415:436-42.
29. Raffel C, Jenkins RB, Frederick L, et al. Sporadic medulloblastomas contain PTCH mutations. Cancer Res1997;57:842-5.
30. Ellison D. Classifying the medulloblastoma: insights from morphology and molecular genetics. Neuropathol Appl Neurobiol 2002;28:257-82.
31. Gilbertson R, Wickramasinghe C, Hernan R, et al. Clinical and molecular stratification of disease risk in medulloblastoma. Br J Cancer 2001;85:705-12.
32. Ellison DW, Onilude OE, Lindsey JC, et al. β-catenin status predicts a favourable out come in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee. J Clin Oncol 2005;23:7951 -7.
33. Rutkowski S,von Bueren A,von HoffK,et al. Prognostic relevance of clinical and biological risk factors in childhood medulloblastoma: results of patients treated in the prospective multicenter trial HIT'91. Clin Cancer Res 2007;13:2651 -7.
34. Tabori U, SungL,HukinJ,et al. Medulloblastomain the second decade of life: a specific group with respect to toxicity and management. Cancer 2005;103: 1874-80.
35. Salsano E, Pollo B, Eoli M, et al. Expression of MATH1, a marker of cerebellar granule cell progenitors, identifies different medulloblastoma sub-types. Neu-rosci Lett 2004;370:180-5.
36. Giangaspero F, Rigobello L, Badiali M, et al. Large cell medulloblastomas. a distinct variant with highly aggressive behavior. Am J Surg Pathol 1992;16: 687-93.
37. Buhren J, Christoph AH, Buslei R, et al. Expression of the neutrophin receptor p75NTR in medulloblasto- mas is correlated with distinct histological and clinical features: evidence of a medulloblastoma subtype derived from the external granule cell layer. J Neuropathol ExpNeurol 2000;59:229-40.
38. Agrawal D, Singhal A, Hendson G at al. Gyriform differentiation in medulloblastoma. Pediatr Neurosurg 2007;43:142-5.
39. Hamilton SR,Liu B, Parsons RE, et al. The molecular basis of Turcot's syndrome. N Eng J Med1995;332: 839-47.
40. Biegel JA. Cytogenetics and molecular genetics of childhoodbrain tumours.Neuro-oncol1999;1:139-51.
41. Vortmeyer AO, Stavrou T, Selby D, et al. Deletion analysis of the Adenomatous Polyposis Coli and PTCH gene loci in patients with sporadic and nevoid basal cell carcinoma syndrome-associated medulloblastoma. Cancer1999;85:2662-7.
42. Mulhern RK, Palmer SL, Merchant TE, et al. Neurocognitive consequences of risk adapted therapy for childhood medulloblastoma. J Clin Oncol 2005;23: 5511 -9.
43. Evans DGR, Birch JM, Ramsden RT, et al. Malignant transformation and new primary tumours after therapeutic radiation for benign disease: substantial risks in certain tumour prone syndromes. J Med Genet 2006;43:289-94.
44. Broniscer A, KeW, Fuller CE, et al. Secondneoplasms in pediatric patients with primary central nervous system tumours. The St. Jude Children's Research Hospital Experience. Cancer 2004;100:2246-52.
45. Campbell RM, Mader RD, Dufresne RG. Meningio- mas after medulloblastoma irradiation treatment in a patient with basal cell nevus syndrome. J Am Acad Dermatol 2005;53:S256-9.
46. Fukushima Y, Oka H, Utsuki S, et al. Nevoid Basal cell carcinoma syndrome with medulloblastoma and meningioma. Case Report. Neurol Med Chir (Tokyo) 2004;44:665-8.
47. Pastorino L, Cusano R, Baldo C, et al. Nevoid basal cell carcinoma syndrome in infants: improving diagnosis. Child Care Health Dev 2005;31:351 -4.
48. Ng D, Stavrou T, Liu L, et al. Retrospective family study of childhood medulloblastoma. Am J Med Genet A 2005;134:399-403.