Immune complex-mediated co-ligation of the BCR with FcγRIIB results in homeostatic apoptosis of B cells involving Fas signalling that is defective in the MRL/Lpr model of systemic lupus erythematosus

Journal of Autoimmunity

Volumn 39, Issue 4, 2012, Pages 332-346

  Paunovic, Verica ^a   Carter, Natalie A ^a   Thalhamer, Theresa ^a   Blair, Derek ^a   Gordon, Brian ^a   Lacey, Erica ^a   Michie, Alison M ^b   Harnett, Margaret M ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Apoptosis; B lymphocytes; Caspases; Fas; Fc RIIB

Indexed keywords

B LYMPHOCYTE RECEPTOR; BCR ABL PROTEIN; CASPASE 8; CASPASE INHIBITOR; DEATH RECEPTOR; FAS ANTIGEN; FAS LIGAND; FC RECEPTOR IIB; PROTEIN BAD; PROTEIN BID; PROTEIN P53; PROTEINASE;

ANIMAL EXPERIMENT; ANTIGEN ANTIBODY COMPLEX; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; ENDOSOME; FLOW CYTOMETRY; LYSOSOME; MITOCHONDRION; MOUSE; MURPHY ROTHS LARGE LYMPHOPROLIFERATIVE MOUSE; NONHUMAN; NUCLEAR EXPORT SIGNAL; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; UPREGULATION;

ANIMALS; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS, CD95; APOPTOSIS; B-LYMPHOCYTES; BCL-ASSOCIATED DEATH PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASPASE 8; DISEASE MODELS, ANIMAL; FAS LIGAND PROTEIN; GENE EXPRESSION REGULATION; HUMANS; LUPUS NEPHRITIS; LYSOSOMES; MALE; MICE; MICE, INBRED MRL LPR; MICE, KNOCKOUT; MITOCHONDRIA; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, IGG; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84869875827     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2012.04.006     Document Type: Article

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