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Volumn 39, Issue 11, 2012, Pages 9931-9939

Haematococcus as a promising cell factory to produce recombinant pharmaceutical proteins

Author keywords

Cell factory; Codon usage optimization; Haematococcus; Protein expression system; Transgenic photobioreactor

Indexed keywords

ASTAXANTHIN; EDIBLE VACCINE; RECOMBINANT PROTEIN;

EID: 84869503514     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-012-1861-z     Document Type: Article
Times cited : (13)

References (112)
  • 1
    • 0035313153 scopus 로고    scopus 로고
    • Advances in Escherichia coli production of therapeutic proteins
    • Swartz JR (2001) Advances in Escherichia coli production of therapeutic proteins. Curr Opin Biotechnol 12: 195-201
    • (2001) Curr Opin Biotechnol , vol.12 , pp. 195-201
    • Swartz, J.R.1
  • 2
    • 0024017415 scopus 로고
    • Formation of recombinant protein inclusion bodies in Escherichia coli
    • Kane JF, Hartley DL (1988) Formation of recombinant protein inclusion bodies in Escherichia coli. Trend Biotechnol 6: 95-101
    • (1988) Trend Biotechnol , vol.6 , pp. 95-101
    • Kane, J.F.1    Hartley, D.L.2
  • 3
    • 66949126546 scopus 로고    scopus 로고
    • Strategies for successful recombinant expression of disulfide bond-dependent proteins in Escherichia coli
    • de Marco A (2009) Strategies for successful recombinant expression of disulfide bond-dependent proteins in Escherichia coli. Microb Cell Fact 8:26
    • (2009) Microb Cell Fact , vol.8 , pp. 26
    • De Marco, A.1
  • 4
    • 33747666218 scopus 로고    scopus 로고
    • Overview of bacterial expression systems for heterologous protein production: From molecular and biochemical fundamentals to commercial systems
    • Terpe K (2006) Overview of bacterial expression systems for heterologous protein production: from molecular and biochemical fundamentals to commercial systems. Appl Microbiol Biotechnol 72: 211-222
    • (2006) Appl Microbiol Biotechnol , vol.72 , pp. 211-222
    • Terpe, K.1
  • 5
    • 13444262282 scopus 로고    scopus 로고
    • The humanization of N-glycosylation pathways in yeast
    • Wildt S, Gerngross TU (2005) The humanization of N-glycosylation pathways in yeast. Nat Rev Microbiol 3: 119-128
    • (2005) Nat Rev Microbiol , vol.3 , pp. 119-128
    • Wildt, S.1    Gerngross, T.U.2
  • 6
    • 77950143374 scopus 로고    scopus 로고
    • Engineering considerations for process development in mammalian cell cultivation
    • Zhang H, Wang W, Quan C, Fan S (2010) Engineering considerations for process development in mammalian cell cultivation. Curr Pharm Biotechnol 11: 103-112
    • (2010) Curr Pharm Biotechnol , vol.11 , pp. 103-112
    • Zhang, H.1    Wang, W.2    Quan, C.3    Fan, S.4
  • 8
    • 0033672657 scopus 로고    scopus 로고
    • Transgenic animal bioreactors
    • Houdebine LM (2000) Transgenic animal bioreactors. Transgenic Res 9: 305-320
    • (2000) Transgenic Res , vol.9 , pp. 305-320
    • Houdebine, L.M.1
  • 11
    • 84855190526 scopus 로고    scopus 로고
    • Microalgae as platforms for production of recombinant proteins and valuable compounds: Progress and prospects
    • Gong Y, Hu H, Gao Y, Xu X, Gao H (2011) Microalgae as platforms for production of recombinant proteins and valuable compounds: progress and prospects. J Ind Microbiol Biotechnol 38: 1879-1890
    • (2011) J Ind Microbiol Biotechnol , vol.38 , pp. 1879-1890
    • Gong, Y.1    Hu, H.2    Gao, Y.3    Xu, X.4    Gao, H.5
  • 12
    • 77956747852 scopus 로고    scopus 로고
    • Micro-algae come of age as a platform for recombinant protein production
    • Specht E, Miyake-Stoner S, Mayfield S (2010) Micro-algae come of age as a platform for recombinant protein production. Biotechnol Lett 32: 1373-1383
    • (2010) Biotechnol Lett , vol.32 , pp. 1373-1383
    • Specht, E.1    Miyake-Stoner, S.2    Mayfield, S.3
  • 15
    • 8644242931 scopus 로고    scopus 로고
    • Valuable products from biotechnology of microalgae
    • Pulz O, Gross W (2004) Valuable products from biotechnology of microalgae. Appl Microbiol Biotechnol 65: 635-648
    • (2004) Appl Microbiol Biotechnol , vol.65 , pp. 635-648
    • Pulz, O.1    Gross, W.2
  • 16
  • 19
    • 1542321146 scopus 로고    scopus 로고
    • Prospects for molecular farming in the green alga Chlamydomonas
    • Franklin SE, Mayfield SP (2004) Prospects for molecular farming in the green alga Chlamydomonas. Curr Opin Plant Biol 7: 159-165
    • (2004) Curr Opin Plant Biol , vol.7 , pp. 159-165
    • Franklin, S.E.1    Mayfield, S.P.2
  • 20
    • 73749088691 scopus 로고    scopus 로고
    • Heat-stable oral alga-based vaccine protects mice from Staphylococcus aureus infection
    • Dreesen IA, Charpin-El HG, Fussenegger M (2010) Heat-stable oral alga-based vaccine protects mice from Staphylococcus aureus infection. J Biotechnol 145: 273-280
    • (2010) J Biotechnol , vol.145 , pp. 273-280
    • Dreesen, I.A.1    Charpin-El, H.G.2    Fussenegger, M.3
  • 21
    • 58249116675 scopus 로고    scopus 로고
    • A novel expression platform for the production of diabetes-associated autoantigen human glutamic acid decarboxylase (hGAD65)
    • Wang X, Brandsma M, Tremblay R, Maxwell D, Jevnikar AM, Huner N, Ma S (2008) A novel expression platform for the production of diabetes-associated autoantigen human glutamic acid decarboxylase (hGAD65). BMC Biotechnol 8:87
    • (2008) BMC Biotechnol , vol.8 , pp. 87
    • Wang, X.1    Brandsma, M.2    Tremblay, R.3    Maxwell, D.4    Jevnikar, A.M.5    Huner, N.6    Ma, S.7
  • 22
    • 0042862830 scopus 로고    scopus 로고
    • Foot-andmouth disease virus VP1 protein fused with cholera toxin B subunit expressed in Chlamydomonas reinhardtii chloroplast
    • Sun M, Qian K, Su N, Chang H, Liu J, Shen G (2003) Foot-andmouth disease virus VP1 protein fused with cholera toxin B subunit expressed in Chlamydomonas reinhardtii chloroplast. Biotechnol Lett 25: 1087-1092
    • (2003) Biotechnol Lett , vol.25 , pp. 1087-1092
    • Sun, M.1    Qian, K.2    Su, N.3    Chang, H.4    Liu, J.5    Shen, G.6
  • 23
    • 33846809293 scopus 로고    scopus 로고
    • Recombination and expression of classical swine fever virus (CSFV) structural protein E2 gene in Chlamydomonas reinhardtii chloroplasts
    • He DM, Qian KX, Shen GF, Zhang ZF, Li YN, Su ZL, Shao HB (2007) Recombination and expression of classical swine fever virus (CSFV) structural protein E2 gene in Chlamydomonas reinhardtii chloroplasts. Colloids Surf B 55: 26-30
    • (2007) Colloids Surf B , vol.55 , pp. 26-30
    • He, D.M.1    Qian, K.X.2    Shen, G.F.3    Zhang, Z.F.4    Li, Y.N.5    Su, Z.L.6    Shao, H.B.7
  • 25
    • 0347380967 scopus 로고    scopus 로고
    • Stable expression of hepatitis B surface antigen in Dunaliella salina (Chlorophyta)
    • Geng D, Wang Y, Li W, Sun Y (2003) Stable expression of hepatitis B surface antigen in Dunaliella salina (Chlorophyta). J Appl Phycol 15: 451-456
    • (2003) J Appl Phycol , vol.15 , pp. 451-456
    • Geng, D.1    Wang, Y.2    Li, W.3    Sun, Y.4
  • 26
    • 0036204864 scopus 로고    scopus 로고
    • Stable integration and functional expression of flounder growth hormone gene in transformed microalga, Chlorella ellipsoidea
    • Kim DH, Kim YT, Cho JJ, Bae JH, Hur SB, Hwang I, Choi TJ (2002) Stable integration and functional expression of flounder growth hormone gene in transformed microalga, Chlorella ellipsoidea. Mar Biotechnol (NY) 4: 63-73
    • (2002) Mar Biotechnol (NY) , vol.4 , pp. 63-73
    • Kim, D.H.1    Kim, Y.T.2    Cho, J.J.3    Bae, J.H.4    Hur, S.B.5    Hwang, I.6    Choi, T.J.7
  • 27
    • 44349083609 scopus 로고    scopus 로고
    • Expression of exogenous genes under the control of endogenous HSP70 and CAB promoters in the Closterium peracerosum- strigosum-littorale complex
    • Abe J, Hiwatashi Y, Ito M, Hasebe M, Sekimoto H (2008) Expression of exogenous genes under the control of endogenous HSP70 and CAB promoters in the Closterium peracerosum- strigosum-littorale complex. Plant Cell Physiol 49: 625-632
    • (2008) Plant Cell Physiol , vol.49 , pp. 625-632
    • Abe, J.1    Hiwatashi, Y.2    Ito, M.3    Hasebe, M.4    Sekimoto, H.5
  • 28
    • 68849093745 scopus 로고    scopus 로고
    • Stable nuclear transformation of Gonium pectorale
    • Lerche K, Hallmann A (2009) Stable nuclear transformation of Gonium pectorale. BMC Biotechnol 9:64
    • (2009) BMC Biotechnol , vol.9 , pp. 64
    • Lerche, K.1    Hallmann, A.2
  • 29
    • 44349183061 scopus 로고    scopus 로고
    • Transient transformation of a chlorarachniophyte alga, Lotharella amoebiformis (Chlorarachniophyceae), with uidA and egfp reporter genes
    • Hirakawa Y, Kofuji R, Ishida K (2008) Transient transformation of a chlorarachniophyte alga, Lotharella amoebiformis (Chlorarachniophyceae), with uidA and egfp reporter genes. J Phycol 44: 814-820
    • (2008) J Phycol , vol.44 , pp. 814-820
    • Hirakawa, Y.1    Kofuji, R.2    Ishida, K.3
  • 30
    • 67849133218 scopus 로고    scopus 로고
    • Isolation and characterization of the rbcS genes from a sterile mutant of Ulva pertusa (Ulvales, Chlorophyta) and transient gene expression using the rbcS gene promoter
    • Kakinuma M, Ikeda M, Deal Coury (2009) Isolation and characterization of the rbcS genes from a sterile mutant of Ulva pertusa (Ulvales, Chlorophyta) and transient gene expression using the rbcS gene promoter. Fish Sci 75: 1015-1028
    • (2009) Fish Sci , vol.75 , pp. 1015-1028
    • Kakinuma, M.1    Ikeda, M.2    Coury, D.3
  • 31
    • 82555187161 scopus 로고    scopus 로고
    • Algae as protein factories: Expression of a human antibody and the respective antigen in the diatom Phaeodactylum tricornutum
    • Hempel F, Lau J, Klingl A, Maier UG (2011) Algae as protein factories: expression of a human antibody and the respective antigen in the diatom Phaeodactylum tricornutum. PLoS One 6:e28424
    • (2011) PLoS One , vol.6
    • Hempel, F.1    Lau, J.2    Klingl, A.3    Maier, U.G.4
  • 32
    • 38349163639 scopus 로고    scopus 로고
    • Polyethylene glycol (PEG)-mediated transient gene expression in a red alga, Cyanidioschyzon merolae 10D
    • Ohnuma M, Yokoyama T, Inouye T, Sekine Y, Tanaka K (2008) Polyethylene glycol (PEG)-mediated transient gene expression in a red alga, Cyanidioschyzon merolae 10D. Plant Cell Physiol 49: 117-120
    • (2008) Plant Cell Physiol , vol.49 , pp. 117-120
    • Ohnuma, M.1    Yokoyama, T.2    Inouye, T.3    Sekine, Y.4    Tanaka, K.5
  • 33
    • 0033746113 scopus 로고    scopus 로고
    • Commercial production of astaxanthin from Haematococcus pluvialis using 25,000-liter outdoor photobioreactors
    • Olaizola M (2000) Commercial production of astaxanthin from Haematococcus pluvialis using 25,000-liter outdoor photobioreactors. J Appl Phycol 12: 499-506
    • (2000) J Appl Phycol , vol.12 , pp. 499-506
    • Olaizola, M.1
  • 34
    • 41549158783 scopus 로고    scopus 로고
    • High efficiency production of astaxanthin by autotrophic cultivation of Haematococcus pluvialis in a bubble column photobioreactor
    • Ranjbar R, Inoue R, Shiraishi H, Katsuda T, Katoh S (2008) High efficiency production of astaxanthin by autotrophic cultivation of Haematococcus pluvialis in a bubble column photobioreactor. Biochem Eng J 39: 575-580
    • (2008) Biochem Eng J , vol.39 , pp. 575-580
    • Ranjbar, R.1    Inoue, R.2    Shiraishi, H.3    Katsuda, T.4    Katoh, S.5
  • 35
    • 80054715203 scopus 로고    scopus 로고
    • Studies on the growth behavior of Chlorella, Haematococcus and Scenedesmus sp. in culture media with different concentrations of sodium bicarbonate and carbon dioxide gas
    • Devgoswami ChR, Kalita MC, Talukdar J, Bora R, Sharma P (2011) Studies on the growth behavior of Chlorella, Haematococcus and Scenedesmus sp. in culture media with different concentrations of sodium bicarbonate and carbon dioxide gas. Afr J Biotechnol 10: 13128-13138
    • (2011) Afr J Biotechnol , vol.10 , pp. 13128-13138
    • Chr, D.1    Kalita, M.C.2    Talukdar, J.3    Bora, R.4    Sharma, P.5
  • 36
    • 0017759929 scopus 로고
    • The enzymic interconversion of acetate and acetyl-coenzyme A in Escherichia coli
    • Brown TDK (1977) The enzymic interconversion of acetate and acetyl-coenzyme A in Escherichia coli. J Gen Microbiol 102: 327-336
    • (1977) J Gen Microbiol , vol.102 , pp. 327-336
    • Brown, T.D.K.1
  • 37
    • 0031893765 scopus 로고    scopus 로고
    • High-efficiency transformation of Chlamydomonas reinhardtii by electroporation
    • Shimogawara K, Fujiwara S, Grossman A, Usuda H (1998) High-efficiency transformation of Chlamydomonas reinhardtii by electroporation. Genetics 148: 1821-1828
    • (1998) Genetics , vol.148 , pp. 1821-1828
    • Shimogawara, K.1    Fujiwara, S.2    Grossman, A.3    Usuda, H.4
  • 38
    • 43649098283 scopus 로고    scopus 로고
    • High quality metabolomic data for Chlamydomonas reinhardtii
    • Lee dY, Fiehn O (2008) High quality metabolomic data for Chlamydomonas reinhardtii. Plant Methods 4:7
    • (2008) Plant Methods , vol.4 , pp. 7
    • Dy, L.1    Fiehn, O.2
  • 39
    • 0035706167 scopus 로고    scopus 로고
    • Presence of a nonhydrolyzable biopolymer in the cell wall of vegetative cells and astaxanthin-rich cysts of Haematococcus pluvialis (Chlorophyceae)
    • Montsant A, Zarka A, Boussiba S (2001) Presence of a nonhydrolyzable biopolymer in the cell wall of vegetative cells and astaxanthin-rich cysts of Haematococcus pluvialis (Chlorophyceae). Mar Biotechnol (NY) 3: 515-521
    • (2001) Mar Biotechnol (NY) , vol.3 , pp. 515-521
    • Montsant, A.1    Zarka, A.2    Boussiba, S.3
  • 41
    • 0034040720 scopus 로고    scopus 로고
    • Optimization of culture medium for the continuous cultivation of the microalga Haematococcus pluvialis
    • Fabregas J, Dominguez A, Regueiro M, Maseda A, Otero A (2000) Optimization of culture medium for the continuous cultivation of the microalga Haematococcus pluvialis. Appl Microbiol Biotechnol 53: 530-535
    • (2000) Appl Microbiol Biotechnol , vol.53 , pp. 530-535
    • Fabregas, J.1    Dominguez, A.2    Regueiro, M.3    Maseda, A.4    Otero, A.5
  • 42
    • 0041881832 scopus 로고
    • Some controlling factors in the distribution of Haematococcus pluvialis
    • Proctor VW (1975) Some controlling factors in the distribution of Haematococcus pluvialis. Ecology 38: 457-462
    • (1975) Ecology , vol.38 , pp. 457-462
    • Proctor, V.W.1
  • 43
    • 67849122688 scopus 로고    scopus 로고
    • Chloroplast-derived vaccine antigens and biopharmaceuticals: Expression, folding, assembly and functionality
    • Chebolu S, Daniell H (2009) Chloroplast-derived vaccine antigens and biopharmaceuticals: expression, folding, assembly and functionality. Curr Top Microbiol Immunol 332: 33-54
    • (2009) Curr Top Microbiol Immunol , vol.332 , pp. 33-54
    • Chebolu, S.1    Daniell, H.2
  • 44
    • 39549119513 scopus 로고    scopus 로고
    • An improved implementation of codon adaptation index
    • Xia X (2007) An improved implementation of codon adaptation index. Evol Bioinform Online 3: 53-58
    • (2007) Evol Bioinform Online , vol.3 , pp. 53-58
    • Xia, X.1
  • 45
    • 34547579086 scopus 로고    scopus 로고
    • OPTIMIZER: A web server for optimizing the codon usage of DNA sequences
    • Puigbo P, Guzman E, Romeu A, Garcia-Vallve S (2007) OPTIMIZER: a web server for optimizing the codon usage of DNA sequences. Nucleic Acids Res 35:W126-W131
    • (2007) Nucleic Acids Res , vol.35
    • Puigbo, P.1    Guzman, E.2    Romeu, A.3    Garcia-Vallve, S.4
  • 46
    • 39549104948 scopus 로고    scopus 로고
    • E-CAI: A novel server to estimate an expected value of Codon Adaptation Index (eCAI)
    • Puigbo P, Bravo IG, Garcia-Vallve S (2008) E-CAI: a novel server to estimate an expected value of Codon Adaptation Index (eCAI). BMC Bioinformatics 9:65
    • (2008) BMC Bioinformatics , vol.9 , pp. 65
    • Puigbo, P.1    Bravo, I.G.2    Garcia-Vallve, S.3
  • 47
    • 14744293443 scopus 로고    scopus 로고
    • Expression of human antibodies in eukaryotic micro-algae
    • Mayfield SP, Franklin SE (2005) Expression of human antibodies in eukaryotic micro-algae. Vaccine 23: 1828-1832
    • (2005) Vaccine , vol.23 , pp. 1828-1832
    • Mayfield, S.P.1    Franklin, S.E.2
  • 48
  • 49
    • 84857454593 scopus 로고    scopus 로고
    • Optimal design of scalable photo-bioreactor for phototropic culturing of Haematococcus pluvialis
    • Yoo JJ, Choi SP, Kim BW, Sim SJ (2012) Optimal design of scalable photo-bioreactor for phototropic culturing of Haematococcus pluvialis. Bioprocess Biosyst Eng 35: 309-315
    • (2012) Bioprocess Biosyst Eng , vol.35 , pp. 309-315
    • Yoo, J.J.1    Choi, S.P.2    Kim, B.W.3    Sim, S.J.4
  • 50
    • 33846931624 scopus 로고    scopus 로고
    • Biosynthesis of astaxanthin in Haematococcus pluvialis caused by suppression on nitrogen and carbon metabolisms
    • doi:CNKI:ISSN: 1005-9954.0.2006-12-012
    • Dong QL, Zhao XM, Xing XY, Gong JX, Hu JZ (2006) Biosynthesis of astaxanthin in Haematococcus pluvialis caused by suppression on nitrogen and carbon metabolisms. Chem Eng 12. doi:CNKI:ISSN: 1005-9954.0.2006-12-012
    • (2006) Chem Eng , vol.12
    • Dong, Q.L.1    Zhao, X.M.2    Xing, X.Y.3    Gong, J.X.4    Hu, J.Z.5
  • 51
    • 84863064753 scopus 로고    scopus 로고
    • Variation in Rubisco and other photosynthetic parameters in the life cycle of Haematococcus pluvialis
    • Chen Z, Wang G, Niu J (2012) Variation in Rubisco and other photosynthetic parameters in the life cycle of Haematococcus pluvialis. Chin J Oceanol Limnol 30: 136-145
    • (2012) Chin J Oceanol Limnol , vol.30 , pp. 136-145
    • Chen, Z.1    Wang, G.2    Niu, J.3
  • 52
    • 0027095972 scopus 로고
    • Effect of carbon/nitrogen ratio on encystment accompanied with astaxanthin formation in a green alga, Haematococcus pluvialis
    • Kakizono T, Kobayashi M, Nagai S (1992) Effect of carbon/nitrogen ratio on encystment accompanied with astaxanthin formation in a green alga, Haematococcus pluvialis. J Ferment Bioeng 74: 403-405
    • (1992) J Ferment Bioeng , vol.74 , pp. 403-405
    • Kakizono, T.1    Kobayashi, M.2    Nagai, S.3
  • 53
    • 0031855262 scopus 로고    scopus 로고
    • Induction of astaxanthin accumulation by nitrogen and magnesium deficiencies in Haematococcus pluvialis
    • Fabregas J, Dominquez A, Garcia Alvarez D, Lamela T, Otero A (2012) Induction of astaxanthin accumulation by nitrogen and magnesium deficiencies in Haematococcus pluvialis. Biotechnol Lett 20: 623-626
    • (2012) Biotechnol Lett , vol.20 , pp. 623-626
    • Fabregas, J.1    Dominquez, A.2    Garcia Alvarez, D.3    Lamela, T.4    Otero, A.5
  • 54
    • 0026687612 scopus 로고
    • Effects of light intensity, light quality, and illumination cycle on astaxanthin formation in a green alga, Haematococcus pluvialis
    • Kobayashi M, Kakizono T, Nishio N, Nagai S (1992) Effects of light intensity, light quality, and illumination cycle on astaxanthin formation in a green alga, Haematococcus pluvialis. J Ferment Bioeng 74: 61-63
    • (1992) J Ferment Bioeng , vol.74 , pp. 61-63
    • Kobayashi, M.1    Kakizono, T.2    Nishio, N.3    Nagai, S.4
  • 55
    • 0347622385 scopus 로고    scopus 로고
    • Astaxanthin accumulation in Haematococcus pluvialis (Chlorophyceae) as an active photoprotective process under high irradiance
    • Wang B, Zarka A, Trebst A, Boussiba S (2003) Astaxanthin accumulation in Haematococcus pluvialis (Chlorophyceae) as an active photoprotective process under high irradiance. J Phycol 39: 1116-1124
    • (2003) J Phycol , vol.39 , pp. 1116-1124
    • Wang, B.1    Zarka, A.2    Trebst, A.3    Boussiba, S.4
  • 56
    • 0037898832 scopus 로고    scopus 로고
    • Light induction of carotenoid biosynthesis genes in the green alga Haematococcus pluvialis: Regulation by photosynthetic redox control
    • Steinbrenner J, Linden H (2003) Light induction of carotenoid biosynthesis genes in the green alga Haematococcus pluvialis: regulation by photosynthetic redox control. Plant Mol Biol 52: 343-356
    • (2003) Plant Mol Biol , vol.52 , pp. 343-356
    • Steinbrenner, J.1    Linden, H.2
  • 57
    • 0028211736 scopus 로고
    • Hyper-accumulation of astaxanthin in a green alga Haematococcus pluvialis at elevated temperatures
    • Tjahjono AE, Hayama Y, Kakizono T, Terada Y, Nishio N, Nagai S (1994) Hyper-accumulation of astaxanthin in a green alga Haematococcus pluvialis at elevated temperatures. Biotechnol Lett 16: 133-138
    • (1994) Biotechnol Lett , vol.16 , pp. 133-138
    • Tjahjono, A.E.1    Hayama, Y.2    Kakizono, T.3    Terada, Y.4    Nishio, N.5    Nagai, S.6
  • 58
    • 0030919685 scopus 로고    scopus 로고
    • Light-independent, astaxanthin production by the green microalga Haematococcus pluvialis under salt stress
    • Kobayashi M, Kurimura Y, Tsuji Y (1997) Light-independent, astaxanthin production by the green microalga Haematococcus pluvialis under salt stress. Biotechnol Lett 19: 507-509
    • (1997) Biotechnol Lett , vol.19 , pp. 507-509
    • Kobayashi, M.1    Kurimura, Y.2    Tsuji, Y.3
  • 59
    • 0025878518 scopus 로고
    • Astaxanthin production by a green algae, Haematococcus pluvialis accompanied with morphological changes in acetate media
    • Kobayashi M, Kakizono T, Nagai S (1991) Astaxanthin production by a green algae, Haematococcus pluvialis accompanied with morphological changes in acetate media. J Ferment Bioeng 71: 335-339
    • (1991) J Ferment Bioeng , vol.71 , pp. 335-339
    • Kobayashi, M.1    Kakizono, T.2    Nagai, S.3
  • 60
    • 0027513039 scopus 로고
    • Enhanced carotenoid biosynthesis by oxidative stress in acetate-induced cyst cells of a green unicellular alga, Haematococcus pluvialis
    • Kobayashi M, Kakizono T, Nagai S (1993) Enhanced carotenoid biosynthesis by oxidative stress in acetate-induced cyst cells of a green unicellular alga, Haematococcus pluvialis. Appl Environ Microbiol 59: 867-873
    • (1993) Appl Environ Microbiol , vol.59 , pp. 867-873
    • Kobayashi, M.1    Kakizono, T.2    Nagai, S.3
  • 61
    • 57349161891 scopus 로고    scopus 로고
    • Enhanced protection against oxidative stress in an astaxanthin- overproduction Haematococcus mutant (Chlorophyceae)
    • Hu Z, Li Y, Sommerfeld M, Chen F, Hu Q (2008) Enhanced protection against oxidative stress in an astaxanthin-overproduction Haematococcus mutant (Chlorophyceae). Eur J Phycol 43: 365-376
    • (2008) Eur J Phycol , vol.43 , pp. 365-376
    • Hu, Z.1    Li, Y.2    Sommerfeld, M.3    Chen, F.4    Hu, Q.5
  • 62
    • 34147158443 scopus 로고    scopus 로고
    • Plastid biotechnology: Prospects for herbicide and insect resistance, metabolic engineering and molecular farming
    • Bock R (2007) Plastid biotechnology: prospects for herbicide and insect resistance, metabolic engineering and molecular farming. Curr Opin Biotechnol 18: 100-106
    • (2007) Curr Opin Biotechnol , vol.18 , pp. 100-106
    • Bock, R.1
  • 63
    • 62149107922 scopus 로고    scopus 로고
    • Generation of Chlamydomonas strains that efficiently express nuclear transgenes
    • Neupert J, Karcher D, Bock R (2009) Generation of Chlamydomonas strains that efficiently express nuclear transgenes. Plant J 57: 1140-1150
    • (2009) Plant J , vol.57 , pp. 1140-1150
    • Neupert, J.1    Karcher, D.2    Bock, R.3
  • 64
    • 77957019344 scopus 로고    scopus 로고
    • Strategies for high-level recombinant protein expression in transgenic microalgae: A review
    • Potvin G, Zhang Z (2010) Strategies for high-level recombinant protein expression in transgenic microalgae: a review. Biotechnol Adv 28: 910-918
    • (2010) Biotechnol Adv , vol.28 , pp. 910-918
    • Potvin, G.1    Zhang, Z.2
  • 66
    • 33645664198 scopus 로고    scopus 로고
    • Nuclear suppressors define three factors that participate in both 50 and 30 end processing of mRNAs in Chlamydomonas chloroplasts
    • Rymarquis LA, Higgs DC, Stern DB (2006) Nuclear suppressors define three factors that participate in both 50 and 30 end processing of mRNAs in Chlamydomonas chloroplasts. Plant J 46: 448-461
    • (2006) Plant J , vol.46 , pp. 448-461
    • Rymarquis, L.A.1    Higgs, D.C.2    Stern, D.B.3
  • 67
    • 33645520500 scopus 로고    scopus 로고
    • Novel pathways for glycoprotein import into chloroplasts
    • Faye L, Daniell H (2006) Novel pathways for glycoprotein import into chloroplasts. Plant Biotechnol J 4: 275-279
    • (2006) Plant Biotechnol J , vol.4 , pp. 275-279
    • Faye, L.1    Daniell, H.2
  • 68
    • 0037454638 scopus 로고    scopus 로고
    • Enclosed outdoor photobioreactors: Light regime, photosynthetic efficiency, scale-up, and future prospects
    • Janssen M, Tramper J, Mur LR, Wijffels RH (2003) Enclosed outdoor photobioreactors: light regime, photosynthetic efficiency, scale-up, and future prospects. Biotechnol Bioeng 81: 193-210
    • (2003) Biotechnol Bioeng , vol.81 , pp. 193-210
    • Janssen, M.1    Tramper, J.2    Mur, L.R.3    Wijffels, R.H.4
  • 69
    • 0025117612 scopus 로고
    • High-frequency nuclear transformation of Chlamydomonas reinhardtii
    • Kindle KL (1990) High-frequency nuclear transformation of Chlamydomonas reinhardtii. Proc Natl Acad Sci USA 87: 1228-1232
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1228-1232
    • Kindle, K.L.1
  • 71
    • 0026058315 scopus 로고
    • Introduction of exogenous DNA into Chlamydomonas reinhardtii by electroporation
    • Brown LE, Sprecher SL, Keller LR (1991) Introduction of exogenous DNA into Chlamydomonas reinhardtii by electroporation. Mol Cell Biol 11: 2328-2332
    • (1991) Mol Cell Biol , vol.11 , pp. 2328-2332
    • Brown, L.E.1    Sprecher, S.L.2    Keller, L.R.3
  • 72
    • 1242276376 scopus 로고    scopus 로고
    • Genetic transformation of the green alga-Chlamydomonas reinhardtii by Agrobacterium tumefaciens
    • Kumar SV, Misquitta RW, Reddy VS, Rao BJ, Rajam MV (2004) Genetic transformation of the green alga-Chlamydomonas reinhardtii by Agrobacterium tumefaciens. Plant Sci 166: 731-738
    • (2004) Plant Sci , vol.166 , pp. 731-738
    • Kumar, S.V.1    Misquitta, R.W.2    Reddy, V.S.3    Rao, B.J.4    Rajam, M.V.5
  • 73
    • 33845546367 scopus 로고    scopus 로고
    • Transformation of the green alga Haematococcus pluvialis with a phytoene desaturase for accelerated astaxanthin biosynthesis
    • Steinbrenner J, Sandmann G (2006) Transformation of the green alga Haematococcus pluvialis with a phytoene desaturase for accelerated astaxanthin biosynthesis. Appl Environ Microbiol 72: 7477-7484
    • (2006) Appl Environ Microbiol , vol.72 , pp. 7477-7484
    • Steinbrenner, J.1    Sandmann, G.2
  • 74
    • 0036926525 scopus 로고    scopus 로고
    • Transient expression of lacZ in bombarded unicellular green alga Haematococcus pluvialis
    • Teng C, Qin S, Liu J, Yu D, Liang C, Tseng C (2002) Transient expression of lacZ in bombarded unicellular green alga Haematococcus pluvialis. J Appl Phycol 14: 495-500
    • (2002) J Appl Phycol , vol.14 , pp. 495-500
    • Teng, C.1    Qin, S.2    Liu, J.3    Yu, D.4    Liang, C.5    Tseng, C.6
  • 75
    • 66749102794 scopus 로고    scopus 로고
    • Agrobacterium-mediated transformation in the green alga Haematococcus pluvialis (Chlorophyceae, volvocales)
    • Kathiresan S, Chandrashekar A, Ravishankar GA, Sarada R (2009) Agrobacterium-mediated transformation in the green alga Haematococcus pluvialis (Chlorophyceae, volvocales). J Phycol 45: 642-649
    • (2009) J Phycol , vol.45 , pp. 642-649
    • Kathiresan, S.1    Chandrashekar, A.2    Ravishankar, G.A.3    Sarada, R.4
  • 77
    • 50549086332 scopus 로고    scopus 로고
    • Safety assessment of astaxanthin-rich microalgae biomass: Acute and subchronic toxicity studies in rats
    • Stewart JS, Lignell A, Pettersson A, Elfving E, Soni MG (2008) Safety assessment of astaxanthin-rich microalgae biomass: acute and subchronic toxicity studies in rats. Food Chem Toxicol 46: 3030-3036
    • (2008) Food Chem Toxicol , vol.46 , pp. 3030-3036
    • Stewart, J.S.1    Lignell, A.2    Pettersson, A.3    Elfving, E.4    Soni, M.G.5
  • 78
    • 0038288903 scopus 로고    scopus 로고
    • Safety of an astaxanthin-rich Haematococcus pluvialis algal extract: A randomized clinical trial
    • Spiller GA, Dewell A (2003) Safety of an astaxanthin-rich Haematococcus pluvialis algal extract: a randomized clinical trial. J Med Food 6: 51-56
    • (2003) J Med Food , vol.6 , pp. 51-56
    • Spiller, G.A.1    Dewell, A.2
  • 79
    • 0035369779 scopus 로고    scopus 로고
    • The regulation of biologic products derived from bioengineered plants
    • Stein KE, Webber KO (2001) The regulation of biologic products derived from bioengineered plants. Curr Opin Biotechnol 12: 308-311
    • (2001) Curr Opin Biotechnol , vol.12 , pp. 308-311
    • Stein, K.E.1    Webber, K.O.2
  • 80
    • 0036156754 scopus 로고    scopus 로고
    • Microbial contamination of medicinal plants - A review
    • Kneifel W, Czech E, Kopp B (2002) Microbial contamination of medicinal plants - a review. Plant Med 68: 5-15
    • (2002) Plant Med , vol.68 , pp. 5-15
    • Kneifel, W.1    Czech, E.2    Kopp, B.3
  • 81
    • 0036098736 scopus 로고    scopus 로고
    • Ultrastructural and chemical changes in the cell wall of Haematococcus pluvialis (Volvocales, Chlorophyta) during aplanospore formation
    • Hagen C, Siegmund S, Braune W (2002) Ultrastructural and chemical changes in the cell wall of Haematococcus pluvialis (Volvocales, Chlorophyta) during aplanospore formation. Eur J Phycol 37: 217-226
    • (2002) Eur J Phycol , vol.37 , pp. 217-226
    • Hagen, C.1    Siegmund, S.2    Braune, W.3
  • 82
    • 33751564866 scopus 로고    scopus 로고
    • Ultrastructure of the cyst wall of Haematococcus pluvialis (Chlorophyceae): Wall development and behaviour during cyst germination
    • Cecilia Damiani M, Leonardi PI, Pieroni OI, Caseres EJ (2006) Ultrastructure of the cyst wall of Haematococcus pluvialis (Chlorophyceae): wall development and behaviour during cyst germination. Phycologia 45: 616-623
    • (2006) Phycologia , vol.45 , pp. 616-623
    • Cecilia Damiani, M.1    Leonardi, P.I.2    Pieroni, O.I.3    Caseres, E.J.4
  • 83
    • 12444273668 scopus 로고    scopus 로고
    • Recent advances in commercial production of astaxanthin from microalgae
    • Fingerman M, Nagabhushanam R (eds). Science Publishers, London
    • Olaizola M, Huntley ME (2003) Recent advances in commercial production of astaxanthin from microalgae. In: Fingerman M, Nagabhushanam R (eds) Biomaterials and bioprocessing. Science Publishers, London
    • (2003) Biomaterials and Bioprocessing
    • Olaizola, M.1    Huntley, M.E.2
  • 84
    • 0034175978 scopus 로고    scopus 로고
    • Commercial potential for Haematococcus microalgae as a natural source of astaxanthin
    • Lorenz RT, Cysewski GR (2000) Commercial potential for Haematococcus microalgae as a natural source of astaxanthin. Trends Biotechnol 18: 160-167
    • (2000) Trends Biotechnol , vol.18 , pp. 160-167
    • Lorenz, R.T.1    Cysewski, G.R.2
  • 85
    • 0027948638 scopus 로고
    • Chemoprevention of mouse urinary bladder carcinogenesis by the naturally occurring carotenoid astaxanthin
    • Tanaka T, Morishita Y, Suzui M, Kojima T, Okumura A, Mori H (1994) Chemoprevention of mouse urinary bladder carcinogenesis by the naturally occurring carotenoid astaxanthin. Carcinogenesis 15: 15-19
    • (1994) Carcinogenesis , vol.15 , pp. 15-19
    • Tanaka, T.1    Morishita, Y.2    Suzui, M.3    Kojima, T.4    Okumura, A.5    Mori, H.6
  • 86
    • 0032801585 scopus 로고    scopus 로고
    • A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo
    • Chew BP, Park JS, Wong MW, Wong TS (1999) A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo. Anticancer Res 19: 1849-1853
    • (1999) Anticancer Res , vol.19 , pp. 1849-1853
    • Chew, B.P.1    Park, J.S.2    Wong, M.W.3    Wong, T.S.4
  • 87
    • 0026957205 scopus 로고
    • Hypercholesterolemic effect of canthaxanthin and astaxanthin in rats
    • Murillo E (1992) [Hypercholesterolemic effect of canthaxanthin and astaxanthin in rats]. Arch Latinoam Nutr 42: 409-413
    • (1992) Arch Latinoam Nutr , vol.42 , pp. 409-413
    • Murillo, E.1
  • 88
    • 0028107320 scopus 로고
    • Immunomodulating actions of carotenoids: Enhancement of in vivo and in vitro antibody production to T-dependent antigens
    • Jyonouchi H, Zhang L, Gross M, Tomita Y (1994) Immunomodulating actions of carotenoids: enhancement of in vivo and in vitro antibody production to T-dependent antigens. Nutr Cancer 21: 47-58
    • (1994) Nutr Cancer , vol.21 , pp. 47-58
    • Jyonouchi, H.1    Zhang, L.2    Gross, M.3    Tomita, Y.4
  • 89
    • 0032937774 scopus 로고    scopus 로고
    • Effects of dietary antioxidants on the immune function of middle-aged adults
    • Hughes DA (1999) Effects of dietary antioxidants on the immune function of middle-aged adults. Proc Nutr Soc 58: 79-84
    • (1999) Proc Nutr Soc , vol.58 , pp. 79-84
    • Hughes, D.A.1
  • 90
    • 0037407158 scopus 로고    scopus 로고
    • Haematococcus astaxanthin: Applications for human health and nutrition
    • Guerin M, Huntley ME, Olaizola M (2003) Haematococcus astaxanthin: applications for human health and nutrition. Trends Biotechnol 21: 210-216
    • (2003) Trends Biotechnol , vol.21 , pp. 210-216
    • Guerin, M.1    Huntley, M.E.2    Olaizola, M.3
  • 91
    • 33646709465 scopus 로고    scopus 로고
    • The effects of oral Cardax (disodium disuccinate astaxanthin) on multiple independent oxidative stress markers in a mouse peritoneal inflammation model: Influence on 5-lipoxygenase in vitro and in vivo
    • Lockwood SF, Penn MS, Hazen SL, Bikadi Z, Zsila F (2006) The effects of oral Cardax (disodium disuccinate astaxanthin) on multiple independent oxidative stress markers in a mouse peritoneal inflammation model: influence on 5-lipoxygenase in vitro and in vivo. Life Sci 79: 162-174
    • (2006) Life Sci , vol.79 , pp. 162-174
    • Lockwood, S.F.1    Penn, M.S.2    Hazen, S.L.3    Bikadi, Z.4    Zsila, F.5
  • 92
    • 2342431807 scopus 로고    scopus 로고
    • Cardioprotection and myocardial salvage by a disodium disuccinate astaxanthin derivative (Cardax)
    • Gross GJ, Lockwood SF (2004) Cardioprotection and myocardial salvage by a disodium disuccinate astaxanthin derivative (Cardax). Life Sci 75: 215-224
    • (2004) Life Sci , vol.75 , pp. 215-224
    • Gross, G.J.1    Lockwood, S.F.2
  • 93
    • 61349114218 scopus 로고    scopus 로고
    • Strategies to facilitate transgene expression in Chlamydomonas reinhardtii
    • Eichler-Stahlberg A, Weisheit W, Ruecker O, Heitzer M (2009) Strategies to facilitate transgene expression in Chlamydomonas reinhardtii. Planta 229: 873-883
    • (2009) Planta , vol.229 , pp. 873-883
    • Eichler-Stahlberg, A.1    Weisheit, W.2    Ruecker, O.3    Heitzer, M.4
  • 94
    • 0031830846 scopus 로고    scopus 로고
    • Efficient foreign gene expression in Chlamydomonas reinhardtii mediated by an endogenous intron
    • Lumbreras V, Stevens DR, Purton S (1998) Efficient foreign gene expression in Chlamydomonas reinhardtii mediated by an endogenous intron. Plant J 14: 441-447
    • (1998) Plant J , vol.14 , pp. 441-447
    • Lumbreras, V.1    Stevens, D.R.2    Purton, S.3
  • 95
    • 0036967786 scopus 로고    scopus 로고
    • An engineered Streptomyces hygroscopicus aph 700 gene mediates dominant resistance against hygromycin B in Chlamydomonas reinhardtii
    • Berthold P, Schmitt R, Mages W (2002) An engineered Streptomyces hygroscopicus aph 700 gene mediates dominant resistance against hygromycin B in Chlamydomonas reinhardtii. Protist 153: 401-412
    • (2002) Protist , vol.153 , pp. 401-412
    • Berthold, P.1    Schmitt, R.2    Mages, W.3
  • 96
    • 65349109237 scopus 로고    scopus 로고
    • Accumulation and processing of a recombinant protein designed as a cleavable fusion to the endogenous Rubisco LSU protein in Chlamydomonas chloroplast
    • Muto M, Henry RE, Mayfield SP (2009) Accumulation and processing of a recombinant protein designed as a cleavable fusion to the endogenous Rubisco LSU protein in Chlamydomonas chloroplast. BMC Biotechnol 9:26
    • (2009) BMC Biotechnol , vol.9 , pp. 26
    • Muto, M.1    Henry, R.E.2    Mayfield, S.P.3
  • 97
    • 0032168897 scopus 로고    scopus 로고
    • Compartment-specific accumulation of recombinant immunoglobulins in plant cells: An essential tool for antibody production and immunomodulation of physiological functions and pathogen activity
    • Conrad U, Fiedler U (1998) Compartment-specific accumulation of recombinant immunoglobulins in plant cells: an essential tool for antibody production and immunomodulation of physiological functions and pathogen activity. Plant Mol Biol 38: 101-109
    • (1998) Plant Mol Biol , vol.38 , pp. 101-109
    • Conrad, U.1    Fiedler, U.2
  • 98
    • 1242265510 scopus 로고    scopus 로고
    • Expression of active human epidermal growth factor (hEGF) in tobacco plants by integrative and non-integrative systems
    • Wirth S, Calamante G, Mentaberry A, Bussmann L, Lattanzi M, Baranao L, Bravo-Almonacid F (2004) Expression of active human epidermal growth factor (hEGF) in tobacco plants by integrative and non-integrative systems. Mol Breed 13: 23-35
    • (2004) Mol Breed , vol.13 , pp. 23-35
    • Wirth, S.1    Calamante, G.2    Mentaberry, A.3    Bussmann, L.4    Lattanzi, M.5    Baranao, L.6    Bravo-Almonacid, F.7
  • 99
    • 18744378812 scopus 로고    scopus 로고
    • ER-resident chaperone interactions with recombinant antibodies in transgenic plants
    • Nuttall J, Vine L, Hadlington JL, Drake P, Frigerio L, Ma JKC (2002) ER-resident chaperone interactions with recombinant antibodies in transgenic plants. Eur J Biochem 269: 6042-6051
    • (2002) Eur J Biochem , vol.269 , pp. 6042-6051
    • Nuttall, J.1    Vine, L.2    Hadlington, J.L.3    Drake, P.4    Frigerio, L.5    Ma, J.K.C.6
  • 100
    • 1542279127 scopus 로고    scopus 로고
    • Oryzacystatin i expression in transformed tobacco produces a conditional growth phenotype and enhances chilling tolerance
    • Van der Vyver C, Schneidereit J, Driscoll S, Turner J, Kunert K, Foyer CH (2003) Oryzacystatin I expression in transformed tobacco produces a conditional growth phenotype and enhances chilling tolerance. Plant Cell Environ 1: 101-112
    • (2003) Plant Cell Environ , vol.1 , pp. 101-112
    • Van Der Vyver, C.1    Schneidereit, J.2    Driscoll, S.3    Turner, J.4    Kunert, K.5    Foyer, C.H.6
  • 101
    • 0035929242 scopus 로고    scopus 로고
    • Transgenic plastids in basic research and plant biotechnology
    • Bock R (2001) Transgenic plastids in basic research and plant biotechnology. J Mol Biol 312: 425-438
    • (2001) J Mol Biol , vol.312 , pp. 425-438
    • Bock, R.1
  • 102
    • 17844410082 scopus 로고    scopus 로고
    • Dual targeting of the protein disulfide isomerase RB60 to the chloroplast and the endoplasmic reticulum
    • Levitan A, Trebitsh T, Kiss V, Pereg Y, Dangoor I, Danan A (2005) Dual targeting of the protein disulfide isomerase RB60 to the chloroplast and the endoplasmic reticulum. Proc Natl Acad Sci USA 102: 6225-6230
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 6225-6230
    • Levitan, A.1    Trebitsh, T.2    Kiss, V.3    Pereg, Y.4    Dangoor, I.5    Danan, A.6
  • 104
    • 33746368041 scopus 로고    scopus 로고
    • Evidence for an ER to Golgi to chloroplast protein transport pathway
    • Radhamony RN, Theg SM (2006) Evidence for an ER to Golgi to chloroplast protein transport pathway. Trends Cell Biol 16: 385-387
    • (2006) Trends Cell Biol , vol.16 , pp. 385-387
    • Radhamony, R.N.1    Theg, S.M.2
  • 108
    • 0030571551 scopus 로고    scopus 로고
    • A tightly regulated high level expression vector that utilizes a thermosensitive lac repressor: Production of the human T cell receptor Vb5.3 in Escherichia coli
    • Andrews B, Adari H, Hannig G, Lahue E, Gosselin M, Martin S, Ahmed A, Ford PJ, Hayman EG, Makrides SC (1996) A tightly regulated high level expression vector that utilizes a thermosensitive lac repressor: production of the human T cell receptor Vb5.3 in Escherichia coli. Gene 182: 101-109
    • (1996) Gene , vol.182 , pp. 101-109
    • Andrews, B.1    Adari, H.2    Hannig, G.3    Lahue, E.4    Gosselin, M.5    Martin, S.6    Ahmed, A.7    Ford, P.J.8    Hayman, E.G.9    Makrides, S.C.10
  • 109
    • 0024825088 scopus 로고
    • High-level expression of recombinant genes in Escherichia coli is dependent on the availability of the dnaY gene product
    • Brinkmann U, Mattes RE, Buckel P (1989) High-level expression of recombinant genes in Escherichia coli is dependent on the availability of the dnaY gene product. Gene 85: 109-114
    • (1989) Gene , vol.85 , pp. 109-114
    • Brinkmann, U.1    Mattes, R.E.2    Buckel, P.3
  • 110
    • 38549102642 scopus 로고    scopus 로고
    • Influence of codon bias on the expression of foreign genes in microalgae
    • Heitzer M, Eckert A, Fuhrmann M, Griesbeck C (2007) Influence of codon bias on the expression of foreign genes in microalgae. Adv Exp Med Biol 616: 46-53
    • (2007) Adv Exp Med Biol , vol.616 , pp. 46-53
    • Heitzer, M.1    Eckert, A.2    Fuhrmann, M.3    Griesbeck, C.4
  • 111
    • 0348013051 scopus 로고    scopus 로고
    • Hierarchy of sequence-dependent features associated with prokaryotic translation
    • Lithwick G, Margalit H (2003) Hierarchy of sequence-dependent features associated with prokaryotic translation. Genome Res 13: 2665-2673
    • (2003) Genome Res , vol.13 , pp. 2665-2673
    • Lithwick, G.1    Margalit, H.2


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