Cardioprotection and myocardial salvage by a disodium disuccinate astaxanthin derivative (Cardax™)

Life Sciences

Volumn 75, Issue 2, 2004, Pages 215-224

  Gross, Garrett J ^a   Lockwood, Samuel F ^b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b HAWAII BIOTECH INC   (United States)

Author keywords

Astaxanthin; Cardax Area at risk; Cardioprotection; Carotenoid derivatives; Disodium disuccinate astaxanthin; Infarct size; Ischemia reperfusion (I R) injury; Myocardial salvage; Rodent infarct model; Sprague Dawley rats

Indexed keywords

CARDAX; CAROTENOID; DISODIUM DISUCCINATE ASTAXANTHIN; DISULFINE BLUE; TRIPHENYLTETRAZOLIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE REPERFUSION; HEART PROTECTION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LINEAR SYSTEM; NONHUMAN; PROPHYLAXIS; QUANTITATIVE ANALYSIS; RAT; SALVAGE THERAPY; STAINING; STATISTICAL SIGNIFICANCE;

ANALYSIS OF VARIANCE; ANIMALS; BETA CAROTENE; CARDIOTONIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, INTRAVENOUS; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; RATS; RATS, SPRAGUE-DAWLEY; SUCCINATES; TETRAZOLIUM SALTS; XANTHOPHYLLS;

ANIMALIA; RODENTIA;

EID: 2342431807     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2003.12.006     Document Type: Article

References (28)

1. Aoi W., Naito Y., Sakuma K., Kuchide M., Tokuda H., Maoka T., Toyokuni S., Oka S., Yasuhara M., Yoshikawa T. Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice. Antioxid Redox Signal. 5(1):2003;139-144
2. Baldus S., Heeschen C., Meinertz T., Zeiher A.M., Eiserich J.P., Munzel T., Simoons M.L., Hamm C.W. Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation. 108(12):2003;1440-1445
3. Bertram J.S. Carotenoids and gene regulation. Nutrition Reviews. 57:1999;182-191
4. Beutner S., Bloedorn B., Frixel S., Blanco I.H., Hoffmann T., Martin H.-D., Mayer B., Noack P., Ruck C., Schmidt M., Schülke I., Sell S., Ernst H., Haremza S., Seybold G.n., Sies H., Stahl W., Walsh R. Quantitative assessment of antioxidant properties of natural colorants and phytochemicals: Carotenoids. Avonoids, phenols and indigoids. The role of β-carotene in antioxidant functions† Journal of the Science of Food and Agriculture. 81:2001;559-568
5. Bikádi Z., Zsila F., Deli J., Mady G., Simonyi M. The supramolecular structure of self-assembly formed by capsanthin derivatives. Enantiomer. 7(2-3):2002;67-76
6. Britton G. Structure and properties of carotenoids in relation to function. FASEB Journal. 9:1995;1551-1558
7. Buchwald P., Bodor N. Physicochemical aspects of the enzymatic hydrolysis of carboxylic esters. Pharmazie. 57(2):2002;87-93
8. Burton G.W., Ingold K.U. Beta-carotene: An unusual type of lipid antioxidant. Science. 224(4649):1984;569-573
9. Cardounel A.J., Dumitrescu C., Zweier J.L., Lockwood S.F. Direct superoxide anion scavenging by a disodium disuccinate astaxanthin derivative: Relative efficacy of individual stereoisomers versus the statistical mixture of stereoisomers by electron paramagnetic resonance imaging. Biochemical and Biophysical Research Communications. 307:2003;704-712
10. Clark R.M., Yao L., She L., Furr H.C. A comparison of lycopene and astaxanthin absorption from corn oil and olive oil emulsions. Lipids. 35(7):2000;803-806
11. Curry S., Brick P., Franks N.P. Fatty acid binding to human serum albumin: New insights from crystallographic studies. Biochimica et Biophysica Acta. 1441(2-3):1999;131-140
12. Goto S., Kogure K., Abe K., Kimata Y., Kitahama K., Yamashita E., Terada H. Efficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antiperoxidative activity of the carotenoid astaxanthin. Biochimica et Biophysica Acta. 1512(2):2001;251-258
13. Guerin M., Huntley M.E., Olaizola M. Haematococcus astaxanthin: Applications for human health and nutrition. Trends in Biotechnology. 21(5):2003;210-216
14. Hertzberg S., Liaaen-Jensen S. Carotenoid sulfates. 4.*syntheses and properties of carotenoid sulfates. Acta Chemica Scandinavica B. 39:1985;629-638
15. Jensen S.K., Engberg R.M., Hedemann M.S. All-rac-alpha-tocopherol acetate is a better vitamin e source than all-rac-alpha-tocopherol succinate for broilers. Journal of Nutrition. 129(7):1999;1355-1360
16. Kurihara H., Koda H., Asami S., Kiso Y., Tanaka T. Contribution of the antioxidative property of astaxanthin to its protective effect on the promotion of cancer metastasis in mice treated with restraint stress. Life Sciences. 70(21):2002;2509-2520
17. Lockwood S.F., O'Malley S., Mosher G.L. Improved aqueous solubility of crystalline astaxanthin (3, 3′-dihydroxy-beta, beta-carotene-4, 4′-dione) by captisol (sulfobutyl ether beta-cyclodextrin). Journal of Pharmaceutical Sciences. 92(4):2003;922-926
18. Ludwig L.M., Patel H.H., Gross G.J., Kersten J.R., Pagel P.S., Warltier D.C. Morphine enhances pharmacological preconditioning by isoflurane: Role of mitochondrial K(ATP) channels and opioid receptors. Anesthesiology. 98(3):2003;705-711
19. Maxwell S.R.J., Lip G.Y.H. Reperfusion injury: A review of the pathophysiology, clinical manifestations and therapeutic options. International Journal of Cardiology. 58:1997;95-117
20. Miki W. Biological functions and activities of animal carotenoids. Pure and Applied Chemistry. 63(1):1991;141-146
21. Ohgami K., Shiratori K., Kotake S., Nishida T., Mizuki N., Yazawa K., Ohno S. Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Investigative Ophthalmology and Visual Science. 44(6):2003;2694-2701
22. Oliveros E., Braun A.M., Aminian-Saghafi T., Sliwka H.R. Quenching of singlet oxygen by carotenoid derivatives: Kinetic analysis by near-infrared luminescence. New Journal of Chemistry. 18:1994;535-539
23. Østerlie M., Bjerkeng B., Liaaen-Jensen S., 2000. Plasma appearance and distribution of astaxanthin e/z and r/s isomers in plasma lipoproteins of men after single dose administration of astaxanthin(1). 11 (10), 482-490.
24. Papas A.M. Antioxidant status: Diet, health and disease; part i: Factors affecting antioxidant status and its role. Mature Medicine November/December. 1999;315-319
25. Patel H.H., Hsu A., Moore J., Gross G.J. BW373U86, a δ opioid agonist, partially mediates delayed cardioprotection via a free radical mechanism that is independent of opioid receptor stimulation. Journal of Molecular Cellular Cardiology. 33:2001;1455-1465
26. Simonyi M., Bikadi Z., Zsila F., Deli J. Supramolecular exciton chirality of carotenoid aggregates. Chirality. 15(8):2003;680-698
27. Stephens N.G., Parsons A., Schofield P.M., Kelly F., Cheeseman K., Mitchinson M.J. Randomised controlled trial of vitamin e in patients with coronary disease: Cambridge heart antioxidant study. Lancet. 347:1996;781-786
28. Zsila F., Simonyi M., Lockwood S.F. Interaction of the disodium disuccinate derivative of meso-astaxanthin with human serum albumin: From chiral complexation to self-assembly. Bioorganic and Medicinal Chemistry Letters. 13(22):2003;4093-4100