Effects of dietary antioxidants on the immune function of middle-aged adults

Proceedings of the Nutrition Society

Volumn 58, Issue 1, 1999, Pages 79-84

  Hughes, David A ^a  

^a INSTITUTE OF FOOD RESEARCH   (United Kingdom)

Author keywords

Antioxidants; Immune function; Vitamin C; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CAROTENOID; CATALASE; FLAVONOID; FREE RADICAL; GLUTATHIONE PEROXIDASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ADULT; AGE; ANTIOXIDANT ACTIVITY; CANCER PREVENTION; CELLULAR IMMUNITY; CONFERENCE PAPER; DEGENERATIVE DISEASE; DIET SUPPLEMENTATION; FOOD COMPOSITION; HUMAN; IMMUNOSTIMULATION; OXIDATIVE STRESS;

ADULT; ANTIOXIDANTS; ASCORBIC ACID; DIET; FREE RADICALS; HUMANS; IMMUNITY; MIDDLE AGED; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SELENIUM; VITAMIN E;

EID: 0032937774     PISSN: 00296651     EISSN: None     Source Type: Journal    
DOI: 10.1079/PNS19990012     Document Type: Conference Paper

References (45)

1. Anderson R (1982) Effects of ascorbate on normal and abnormal leucocyte functions. International Journal for Vitamin and Nutrition Research 23, Suppl., 23-34.
2. Anderson R & Lukey PT (1987) A biological role for ascorbate in the selective neutralisation of extracellular phagocyte-derived oxidants. Annals of the New York Academy of Sciences 498, 229-247.
3. Anderson R, Oosthuigen R, Maritz R, Theron A & Van Rensburg A (1980) The effect of increasing weekly doses of ascorbate on certain cellular and humoral immune functions in normal volunteers. American Journal of Clinical Nutrition 33, 71-76.
4. Anderson R, Smith MJ, Joone GK & Van Straden AM (1990) Vitamin C and cellular immune functions. Protection against hypochlorous acid-mediated inactivation of glyceraldehyde-3-phosphate dehydrogenase and ATP generation in human leukocytes as a possible mechanism of ascorbate-mediated immunostimulation. Annals of the New York Academy of Sciences 587, 34-48.
5. Baker KR & Meydani M (1994) Beta-carotene in immunity and cancer. Journal of Optimal Nutrition 3, 39-50.
6. Beach RS, Mantero-Atienza E, Shor-Posner G, Javier JJ, Szapocznik J, Morgan R, Sauberlich HE, Cornwell PE, Eisdorfer C & Baum MK (1992) Specific nutrient abnormalities in asymptomatic HIV-1 infection. AIDS 6, 701-708.
7. Beck MA (1998) The influence of antioxidant nutrients on viral infection. Nutrition Reviews 56, S140-S146.
8. Bendich A (1994) Recent advances in clinical research involving carotenoids. Pure and Applied Chemistry 66, 1017-1024.
9. Bendich A (1996) Antioxidant vitamins and human immune responses. Vitamins and Hormones 52, 35-62.
10. Bendich A, Burton GW, Machlin LJ, Scandurra O & Wayner DDM (1986) The antioxidant role of vitamin C. Advances in Free Radical Biology and Medicine 2, 419-444.
11. Blackwell TS & Christman JW (1997) The role of nuclear factor-κB in cytokine gene regulation. American Journal of Respiratory and Cell Molecular Biology 17, 3-9.
12. Boxer LA (1986) Regulation of phagocyte function by α-tocopherol. Proceedings of the Nutrition Society 45, 333-334.
13. Boxer LA, Watanabe AM, Rister M & Besch HR (1976) Correction of leucocyte function in Chediak-Higashi syndrome by ascorbate. New England Journal of Medicine 295, 1041-1045.
14. Chavance M, Brubacher G, Herbeth B, Vernes G, Mistacki T, Deti F, Fournier C & Janot C (1985) Immunological and nutritional status among the elderly. In Nutrition, Immunity, and Illness in the Elderly, pp. 137-145 [RK Chandra, editor]. New York: Pergamon Press.
15. Coulehan JL, Reisinger KS, Rogers KD & Bradley DW (1974) Vitamin C prophylaxis in a boarding school. New England Journal of Medicine 290, 6-10.
16. Devaraj S & Jialal I (1997) Alpha-tocopherol inhibits IL-1β from human monocytes. FASEB Journal 11, 3753.
17. Devaraj S, Li D & Jialal I (1996) The effects of α-tocopherol supplementation on monocyte function. Journal of Clinical Investigation 98, 756-763.
18. Favier A, Sappey C, Leclerc P, Faure P & Micoud M (1994) Antioxidant status and lipid peroxidation in patients infected with HIV. Chemico-Biological Interactions 91, 165-180.
19. Frei B, England L & Ames BN (1989) Ascorbate is an outstanding antioxidant in human blood plasma. Proceedings of the National Academy of Sciences USA 86, 6377-6381.
20. Gruner S, Volk H-D, Falck P & Baehr RV (1986) The influence of phagocytic stimuli on the expression of HLA-DR antigens; role of reactive oxygen intermediates. European Journal of Immunology 16, 212-215.
21. Halliwell B & Aruoma OI (1991) DNA damage by oxygen-derived species: Its mechanisms and measurement in mammalian systems. FEBS Letters 281, 9-19.
22. Hughes DA, Haslam PL, Townsend PJ & Turner-Warwick M (1985) Numerical and functional alterations in circulatory lymphocytes in cigarette smokers. Clinical and Experimental Immunology 61, 459-466.
23. Hughes DA, Wright AJA, Finglas PM, Peerless ACJ, Bailey AL, Astley SB, Pinder AC & Southon S (1997) The effect of beta-carotene supplementation on the immune function of blood monocytes from healthy male non-smokers. Journal of Laboratory and Clinical Medicine 129, 309-317.
24. Jackson MJ, McArdle A & McArdle F (1998) Antioxidant micronutrients and gene expression. Proceedings of the Nutrition Society 57, 301-305.
25. Jacob RA, Kelley DS, Pianalto FS, Swendsein ME, Henning SM, Zhang JZ, Ames BN, Fraga CG & Peters JH (1991) Immunocompetence and oxidant defense during ascorbate depletion of healthy men. American Journal of Clinical Nutrition 54, 1302S-1309S.
26. Jacques PF, Taylor A, Hankinson SE, Willett WC, Mahnken B, Lee Y, Vaid K & Lahav M (1997) Long-term vitamin C supplement use and prevalence of early age-related lens opacities. American Journal of Clinical Nutrition 66, 911-916.
27. Johnson JD, Houchens DP, Kluwe WM, Craig DK & Fisher GL (1990) Effects of mainstream and environmental tobacco smoke on the immune system in animals and humans: A review. CRC Critical Reviews in Toxicology 134, 356-361.
28. Lesourd BM (1999) Immune response during disease and recovery in the elderly. Proceedings of the Nutrition Society 58, 85-98.
29. McKenzie RC, Rafferty TS & Beckett GJ (1998) Selenium: an essential element for immune function. Immunology Today 19, 342-345.
30. Mangels AR, Holden JM, Beecher GR, Forman MR & Lanza E (1993) Carotenoid content of fruits and vegetables: an evaluation of analytical data. Journal of the American Dietetic Association 93, 284-296.
31. Meydani SN & Beharka AA (1996) Recent developments in vitamin E and immune response. Nutrition Reviews 66, S49-S58.
32. Pacht ER, Kasek H, Mohammad JR, Cromwell DG & Davis WB (1986) Deficiency of vitamin E in the alveolar fluid of cigarette smokers: Influence on alveolar macrophage cytotoxicity. Journal of Clinical Investigation 77, 789-796.
33. Passi S, Picardo M & Morrone A (1993) Study on plasma polyunsaturated phospholipids and vitamin E, and on erythrocyte glutathione peroxidase in high risk HIV infection categories and AIDS patients. Clinical Chemistry and Enzymology Communications 5, 169-177.
34. Pauling L (1970) Vitamin C and the Common Cold. San Francisco, CA: W.H. Freeman.
35. Prasad JS (1980) Effect of vitamin E supplementation on leukocyte function. American Journal of Clinical Nutrition 33, 606-608.
36. Pryor WA & Stone K (1993) Oxidants in cigarette smoke. Annals of the New York Academy of Sciences 686, 12-28.
37. Rebora A, Dallegri F & Patrone F (1980) Neutrophil dysfunction and repeated infections: influence of levamisole and ascorbic acid. British Journal of Dermatology 21, 49-56.
38. Rice-Evans C (1995) Plant polyphenols: free radical scavengers or chain-breaking antioxidants? Biochemical Society Symposium 61, 103-116.
39. Richards GA, Theron AJ, Van Rensburg CEJ, Van Rensberg AJ, Van Der Merwe CA, Kuyl JM & Anderson R (1990) Investigation of the effects of oral administration of vitamin E and beta-carotene on the chemiluminescence responses and the frequency of sister chromatid exchanges in circulating leukocytes from cigarette smokers. American Review of Respiratory Disease 142, 648-654.
40. Roy M, Kiremidjian-Schumacher L, Wishe HI, Cohen MW & Stotzky G (1994) Supplementation with selenium and human immune functions. I. Effect on lymphocyte proliferation and interleukin-2 receptor expression. Biological Trace Elements Research 41, 103-114.
41. Sen CK & Packer L (1996) Antioxidant and redox regulation of gene transcription. FASEB Journal 10, 709-720.
42. Serfass RE & Ganther HE (1975) Defective microbicidal activity in glutathione peroxidase-deficient neutrophils of selenium-deficient rats. Nature 255, 640-641.
43. Siegel BV (1993) Vitamin C and the immune response in health and disease. In Nutrition and Immunology, pp. 167-196 [DM Klurfeld, editor]. New York: Plenum Press.
44. Spallholz JE, Boylan LM & Larsen HS (1990) Advances in understanding selenium's role in the immune system. Annals of the New York Academy of Sciences 587, 123-139.
45. Thomas WR & Holt PG (1978) Vitamin C and immunity: An assessment of the evidence. Clinical and Experimental Immunology 32, 370-379.