Dissecting the total transition state stabilization provided by amino acid side chains at orotidine 5′-monophosphate decarboxylase: A two-part substrate approach

Biochemistry

Volumn 47, Issue 30, 2008, Pages 7785-7787

  Barnett, Shonoi A ^a   Amyes, Tina L ^a   Wood, Bryant M ^b   Gerlt, John A ^b   Richard, John P ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; AMINES; AMINO ACIDS; CARBOXYLATION; HEALTH; HYDROGEN; HYDROGEN BONDS; NONMETALS; ORGANIC ACIDS;

AMERICAN CHEMICAL SOCIETY (ACS); AMIDE SIDE CHAIN; DECARBOXYLASE; DI ANIONS; KINETIC ANALYSES; MONOPHOSPHATE; SIDE CHAINS; TRANSITION STATE (TS); TRANSITION STATE STABILIZATION;

CHAINS;

1 (BETA DEXTRO ERYTHROFURANOSYL)OROTIC ACID; AMINO ACID; MUTANT PROTEIN; NUCLEOSIDE; OROTIC ACID DERIVATIVE; OROTIDINE 5' PHOSPHATE DECARBOXYLASE; PHOSPHITE; PYRIMIDINE DERIVATIVE;

ARTICLE; DECARBOXYLATION; ENZYME ANALYSIS; ENZYME STRUCTURE; KINETICS; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; SPECTROPHOTOMETRY; STRUCTURE ANALYSIS; YEAST;

AMINO ACIDS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; KINETICS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; OROTIDINE-5'-PHOSPHATE DECARBOXYLASE; SUBSTRATE SPECIFICITY; URIDINE MONOPHOSPHATE;

EID: 48249090425     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800939k     Document Type: Article

References (16)

1. Miller, B. G., and Wolfenden, R. (2002) Annu. Rev. Biochem. 71, 847-885.
2. Amyes, T. L., Wood, B. M., Chan, K., Gerlt, J. A., and Richard, J. P. (2008) J. Am. Chem. Soc. 130, 1574-1575.
3. Miller, B. G., Hassell, A. M., Wolfenden, R., Milburn, M. V., and Short, S. A. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 2011-2016.
4. Wu, N., Mo, Y., Gao, J., and Pai, E. F. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 2017-2022.
5. Appleby, T. C., Kinsland, C., Begley, T. P., and Ealick, S. E. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 2005-2010.
6. Harris, P., Poulsen, J.-C. N., Jensen, K. F., and Larsen, S. (2000) Biochemistry 39, 4217-4224.
7. Callahan, B. P., and Miller, B. G. (2007) Bioorg. Chem. 35, 465-469.
8. Gao, J., Byun, K. L., and Kluger, R. (2004) Top. Curr. Chem. 238, 113-136.
9. Amyes, T. L., Richard, J. P., and Tait, J. J. (2005) J. Am. Chem. Soc. 127, 15708-15709.
10. Jencks, W. P. (1981) Proc. Natl. Acad. Sci. U.S.A. 78, 4046-4050.
11. Amyes, T. L., and Richard, J. P. (2007) Biochemistry 46, 5841-5854.
12. Tsang, W.-Y., Amyes, T. L., and Richard, J. P. (2008) Biochemistry 47, 4575-4582.
13. Miller, B. G., Snider, M. J., Wolfenden, R., and Short, S. A. (2001) J. Biol. Chem. 276, 15174-15176.
14. First, E. A., and Fersht, A. R. (1995) Biochemistry 34, 5030-5043.
15. Horovitz, A., and Fersht, A. R. (1990) J. Mol. Biol. 214, 613-617.
16. Porter, D. J. T., and Short, S. A. (2000) Biochemistry 39, 11788-11800.