Crystal structures of orotidine monophosphate decarboxylase: Does the structure reveal the mechanism of nature's most proficient enzyme?

ChemBioChem

Volumn 2, Issue 2, 2001, Pages 113-118

  Houk, Kendall N ^a   Lee, Jeehiun K ^b   Tantillo, Dean J ^a   Bahmanyar, Sogole ^a   Hietbrink, Bruce N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Enzyme catalysis; Lyases; Orotidine 5 phosphate decarboxylase; Protein structures; Reaction mechanisms

Indexed keywords

OROTIDINE 5' PHOSPHATE DECARBOXYLASE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; KINETICS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; KINETICS; MODELS, MOLECULAR; OROTIDINE-5'-PHOSPHATE DECARBOXYLASE;

EID: 0035793646     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/1439-7633(20010202)2:2<113::AID-CBIC113>3.0.CO;2-T     Document Type: Article

References (3)

1. T. C. Bruice, S. Benkovic, Bioorganic Mechanisms, Vol. 2, Benjamin, New York, 1966.
2. M. L. Bender, Mechanisms of Homogeneous Catalysis from Protons to Proteins, Wiley-Interscience, New York, 1971.
3. A. Radzicka, R. Wolfenden, Science 1995, 267, 90-93.