Orotic acid decarboxylation in water and nonpolar solvents: A potential role for desolvation in the action of OMP decarboxylase

Biochemistry

Volumn 48, Issue 36, 2009, Pages 8738-8745

  Lewis Jr , Charles A ^a   Wolfenden, Richard ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AMMONIUM GROUPS; CARBOXYLATE GROUPS; COFACTORS; DECARBOXYLASES; DESOLVATION; DIPOLAR APROTIC SOLVENT; ELECTROSTATIC CHARGES; MONOANIONS; NON-ENZYMATIC; NON-POLAR SOLVENTS; POLAR SOLVENTS; PROTON DONORS; RATE ENHANCEMENT; TETRABUTYLAMMONIUM SALTS;

ACIDS; AMMONIUM COMPOUNDS; CARBOXYLATION; CARBOXYLIC ACIDS; ELECTROSTATICS; ENZYMES; METAL RECOVERY; PROTONS; SUBSTRATES;

SOLVENTS;

1 CYCLOHEXYLOROTATE; AMMONIUM DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; OROTIC ACID; OROTIC ACID DERIVATIVE; OROTIDINE 5' PHOSPHATE DECARBOXYLASE; PROTON; PYRIMIDINE NUCLEOSIDE; SOLVENT; TETRABUTYLAMMONIUM; UNCLASSIFIED DRUG; UROPORPHYRINOGEN DECARBOXYLASE; WATER;

ARTICLE; CHEMICAL BINDING; CHEMICAL PHENOMENA; CONTROLLED STUDY; DECARBOXYLATION; DESOLVATION; ELECTRICITY; ENZYME ACTIVE SITE; ENZYME STABILITY; ENZYME SUBSTRATE; HIGH TEMPERATURE; HYDROLYSIS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ACETIC ACID; DECARBOXYLATION; HYDROGEN-ION CONCENTRATION; OROTIC ACID; OROTIDINE-5'-PHOSPHATE DECARBOXYLASE; SOLUBILITY; SOLVENTS; TEMPERATURE; URACIL; WATER;

EID: 70149114606     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901085m     Document Type: Article

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