메뉴 건너뛰기




Volumn 4, Issue 8, 2012, Pages 535-546

Sarcopenia, obesity, and natural killer cell immune senescence in aging: Altered cytokine levels as a common mechanism

Author keywords

Adipose tissue; Aging; Immunity; Natural killer lymphocytes; Obesity; Sarcopenia; Skeletal muscle

Indexed keywords


EID: 84868029429     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100482     Document Type: Review
Times cited : (255)

References (141)
  • 1
    • 0034084305 scopus 로고    scopus 로고
    • Sarcopenic obesity: does muscle loss cause fat gain?: lessons from rheumatoid arthritis and osteoarthritis
    • Roubenoff R. Sarcopenic obesity: does muscle loss cause fat gain?: lessons from rheumatoid arthritis and osteoarthritis. Ann NY Acad Sci. 2000; 904:553-557.
    • (2000) Ann NY Acad Sci , vol.904 , pp. 553-557
    • Roubenoff, R.1
  • 2
    • 74549144396 scopus 로고    scopus 로고
    • Fifth phase of the epidemiologic transition: the age of obesity and inactivity
    • Gaziano JM. Fifth phase of the epidemiologic transition: the age of obesity and inactivity. JAMA. 2010; 303:275-276.
    • (2010) JAMA , vol.303 , pp. 275-276
    • Gaziano, J.M.1
  • 3
    • 71249157791 scopus 로고    scopus 로고
    • The diseasome of physical inactivity - and the role of myokines in muscle-fat cross talk
    • Pedersen BK. The diseasome of physical inactivity - and the role of myokines in muscle-fat cross talk. J Physiol. 2009; 587:5559-5568.
    • (2009) J Physiol , vol.587 , pp. 5559-5568
    • Pedersen, B.K.1
  • 5
    • 77956248079 scopus 로고    scopus 로고
    • Sarcopenia: characteristics, mechanisms and functional significance
    • Narici MV and Maffulli N. Sarcopenia: characteristics, mechanisms and functional significance. Br Med Bull. 2010:ldq008.
    • Br Med Bull , vol.2010
    • Narici, M.V.1    Maffulli, N.2
  • 8
    • 84859514751 scopus 로고    scopus 로고
    • One size may not fit all: anti-aging therapies and sarcopenia
    • Burks TN and Cohn RD. One size may not fit all: anti-aging therapies and sarcopenia. Aging (Albany NY). 2011; 3:1142-1153.
    • (2011) Aging (Albany NY) , vol.3 , pp. 1142-1153
    • Burks, T.N.1    Cohn, R.D.2
  • 15
    • 71249106254 scopus 로고    scopus 로고
    • Chronic high fat feeding attenuates load-induced hypertrophy in mice
    • Sitnick M, Bodine SC and Rutledge JC. Chronic high fat feeding attenuates load-induced hypertrophy in mice. J Physiol. 2009; 587:5753-5765.
    • (2009) J Physiol , vol.587 , pp. 5753-5765
    • Sitnick, M.1    Bodine, S.C.2    Rutledge, J.C.3
  • 16
    • 79959539851 scopus 로고    scopus 로고
    • Normalizing a hyperactive mTOR initiates muscle growth during obesity
    • Williamson DL and Drake JC. Normalizing a hyperactive mTOR initiates muscle growth during obesity. Aging (Albany NY). 2011; 3:83-84.
    • (2011) Aging (Albany NY) , vol.3 , pp. 83-84
    • Williamson, D.L.1    Drake, J.C.2
  • 18
    • 0037012021 scopus 로고    scopus 로고
    • Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study
    • Wikby A, Johansson B, Olsson J, Löfgren S, Nilsson B-O and Ferguson F. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp Gerontol. 2002; 37:445-453.
    • (2002) Exp Gerontol , vol.37 , pp. 445-453
    • Wikby, A.1    Johansson, B.2    Olsson, J.3    Löfgren, S.4    Nilsson, B.-O.5    Ferguson, F.6
  • 21
    • 79955011677 scopus 로고    scopus 로고
    • Human NK cells proliferate and die in vivo more rapidly than T cells in healthy young and elderly adults
    • Lutz CT, Karapetyan A, Al-Attar A, Shelton BJ, Holt KJ, Tucker JH and Presnell SR. Human NK cells proliferate and die in vivo more rapidly than T cells in healthy young and elderly adults. J Immunol. 2011; 186:4590-4598.
    • (2011) J Immunol , vol.186 , pp. 4590-4598
    • Lutz, C.T.1    Karapetyan, A.2    Al-Attar, A.3    Shelton, B.J.4    Holt, K.J.5    Tucker, J.H.6    Presnell, S.R.7
  • 22
    • 0023225697 scopus 로고
    • Increased number of circulating Leu 11+ (CD 16) large granular lymphocytes and decreased NK activity during human ageing
    • Facchini A, Mariani E, Mariani AR, Papa S, Vitale M and Manzoli FA. Increased number of circulating Leu 11+ (CD 16) large granular lymphocytes and decreased NK activity during human ageing. Clin Exp Immunol. 1987; 68:340-347.
    • (1987) Clin Exp Immunol , vol.68 , pp. 340-347
    • Facchini, A.1    Mariani, E.2    Mariani, A.R.3    Papa, S.4    Vitale, M.5    Manzoli, F.A.6
  • 23
    • 0034715948 scopus 로고    scopus 로고
    • Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population
    • Imai K, Matsuyama S, Miyake S, Suga K and Nakachi K. Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population. Lancet. 2000; 356:1795-1799.
    • (2000) Lancet , vol.356 , pp. 1795-1799
    • Imai, K.1    Matsuyama, S.2    Miyake, S.3    Suga, K.4    Nakachi, K.5
  • 24
    • 0033951533 scopus 로고    scopus 로고
    • NK and NK/T cells in human senescence
    • Solana R and Mariani E. NK and NK/T cells in human senescence. Vaccine. 2000; 18:1613-1620.
    • (2000) Vaccine , vol.18 , pp. 1613-1620
    • Solana, R.1    Mariani, E.2
  • 25
    • 78651379305 scopus 로고    scopus 로고
    • Muscles and their myokines
    • Pedersen BK. Muscles and their myokines. J Exp Biol. 2011; 214:337-346.
    • (2011) J Exp Biol , vol.214 , pp. 337-346
    • Pedersen, B.K.1
  • 26
    • 77951498530 scopus 로고    scopus 로고
    • The interaction between adipokines, diet and exercise on muscle insulin sensitivity
    • Stefanyk LE and Dyck DJ. The interaction between adipokines, diet and exercise on muscle insulin sensitivity. Curr Opin Clin Nutr Metab Care. 2010; 13:255-259.
    • (2010) Curr Opin Clin Nutr Metab Care , vol.13 , pp. 255-259
    • Stefanyk, L.E.1    Dyck, D.J.2
  • 27
    • 33748992313 scopus 로고    scopus 로고
    • Adipocytokines: mediators linking adipose tissue, inflammation and immunity
    • Tilg H and Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol. 2006; 6:772-783.
    • (2006) Nat Rev Immunol , vol.6 , pp. 772-783
    • Tilg, H.1    Moschen, A.R.2
  • 28
    • 38949106690 scopus 로고    scopus 로고
    • Role of adiponectin and PBEF/visfatin as regulators of inflammation: involvement in obesity-associated diseases
    • Tilg H and Moschen AR. Role of adiponectin and PBEF/visfatin as regulators of inflammation: involvement in obesity-associated diseases. Clin Sci. 2008; 114:275-288.
    • (2008) Clin Sci , vol.114 , pp. 275-288
    • Tilg, H.1    Moschen, A.R.2
  • 30
    • 65649117802 scopus 로고    scopus 로고
    • Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity
    • Duffaut C, Galitzky J, Lafontan M and Bouloumié A. Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity. Biochem Biophys Res Commun. 2009; 384:482-485.
    • (2009) Biochem Biophys Res Commun , vol.384 , pp. 482-485
    • Duffaut, C.1    Galitzky, J.2    Lafontan, M.3    Bouloumié, A.4
  • 39
    • 0036431034 scopus 로고    scopus 로고
    • Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation
    • Tian Z, Sun R, Wei H and Gao B. Impaired natural killer (NK) cell activity in leptin receptor deficient mice: leptin as a critical regulator in NK cell development and activation. Biochem Biophys Res Commun. 2002; 298:297-302.
    • (2002) Biochem Biophys Res Commun , vol.298 , pp. 297-302
    • Tian, Z.1    Sun, R.2    Wei, H.3    Gao, B.4
  • 41
    • 74949143243 scopus 로고    scopus 로고
    • Narrative review: the role of leptin in human physiology: emerging clinical applications
    • Kelesidis T, Kelesidis I, Chou S and Mantzoros CS. Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med. 2010; 152:93-100.
    • (2010) Ann Intern Med , vol.152 , pp. 93-100
    • Kelesidis, T.1    Kelesidis, I.2    Chou, S.3    Mantzoros, C.S.4
  • 44
    • 0035162054 scopus 로고    scopus 로고
    • The role of leptin resistance in the lipid abnormalities of aging
    • Wang ZW, Pan WT, Lee Y, Kakuma T, Zhou YT and Unger RH. The role of leptin resistance in the lipid abnormalities of aging. FASEB J. 2001; 15:108-114.
    • (2001) FASEB J , vol.15 , pp. 108-114
    • Wang, Z.W.1    Pan, W.T.2    Lee, Y.3    Kakuma, T.4    Zhou, Y.T.5    Unger, R.H.6
  • 45
    • 82955203470 scopus 로고    scopus 로고
    • Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism
    • Bondue B, Wittamer V and Parmentier M. Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism. Cytokine Growth Factor Rev. 2011; 22:331-338.
    • (2011) Cytokine Growth Factor Rev , vol.22 , pp. 331-338
    • Bondue, B.1    Wittamer, V.2    Parmentier, M.3
  • 47
    • 17844392652 scopus 로고    scopus 로고
    • Resistin, an adipokine with potent proinflammatory properties
    • Bokarewa M, Nagaev I, Dahlberg L, Smith U and Tarkowski A. Resistin, an adipokine with potent proinflammatory properties. J Immunol. 2005; 174:5789-5795.
    • (2005) J Immunol , vol.174 , pp. 5789-5795
    • Bokarewa, M.1    Nagaev, I.2    Dahlberg, L.3    Smith, U.4    Tarkowski, A.5
  • 50
    • 4043073614 scopus 로고    scopus 로고
    • Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis
    • Jia SH, Li Y, Parodo J, Kapus A, Fan L, Rotstein OD and Marshall JC. Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. J Clin Invest. 2004; 114:141-141.
    • (2004) J Clin Invest , vol.114 , pp. 141-1141
    • Jia, S.H.1    Li, Y.2    Parodo, J.3    Kapus, A.4    Fan, L.5    Rotstein, O.D.6    Marshall, J.C.7
  • 51
    • 41549095950 scopus 로고    scopus 로고
    • Is visfatin an adipokine or myokine? Evidence for greater visfatin expression in skeletal muscle than visceral fat in chickens
    • Krzysik-Walker SM, Ocon-Grove OM, Maddineni SR, Hendricks GL, III and Ramachandran R. Is visfatin an adipokine or myokine? Evidence for greater visfatin expression in skeletal muscle than visceral fat in chickens. Endocrinology. 2008; 149:1543-1550.
    • (2008) Endocrinology , vol.149 , pp. 1543-1550
    • Krzysik-Walker, S.M.1    Ocon-Grove, O.M.2    Maddineni, S.R.3    Hendricks III, G.L.4    Ramachandran, R.5
  • 55
    • 0027333425 scopus 로고
    • Tumor necrosis factor, other cytokines and disease
    • Tracey KJ and Cerami A. Tumor necrosis factor, other cytokines and disease. Ann Rev Cell Biol. 1993; 9:317-343.
    • (1993) Ann Rev Cell Biol , vol.9 , pp. 317-343
    • Tracey, K.J.1    Cerami, A.2
  • 56
    • 0030028606 scopus 로고    scopus 로고
    • The expression of TNFa by human muscle Relationship to insulin resistance
    • Saghizadeh M, Ong JM, Garvey WT, Henry RR and Kern PA. The expression of TNFa by human muscle. Relationship to insulin resistance. J Clin Invest. 1996; 97:1111-1116.
    • (1996) J Clin Invest , vol.97 , pp. 1111-1116
    • Saghizadeh, M.1    Ong, J.M.2    Garvey, W.T.3    Henry, R.R.4    Kern, P.A.5
  • 57
    • 0033842592 scopus 로고    scopus 로고
    • Cytokines and chemokines are both expressed by human myoblasts: possible relevance for the immune pathogenesis of muscle inflammation
    • De Rossi M, Bernasconi P, Baggi F, de Waal Malefyt R and Mantegazza R. Cytokines and chemokines are both expressed by human myoblasts: possible relevance for the immune pathogenesis of muscle inflammation. International Immunol. 2000; 12:1329-1335.
    • (2000) International Immunol , vol.12 , pp. 1329-1335
    • De Rossi, M.1    Bernasconi, P.2    Baggi, F.3    de Waal Malefyt, R.4    Mantegazza, R.5
  • 58
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng CN, Bodzin JL and Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007; 117:175-184.
    • (2007) J Clin Invest , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 59
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-a: direct role in obesitylinked insulin resistance
    • Hotamisligil GS, Shargill NS and Spiegelman BM. Adipose expression of tumor necrosis factor-a: direct role in obesitylinked insulin resistance. Science. 1993; 259:87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 60
    • 79955973916 scopus 로고    scopus 로고
    • Inflammatory markers in population studies of aging
    • Singh T and Newman AB. Inflammatory markers in population studies of aging. Ageing Res Rev. 2011; 10:319-329.
    • (2011) Ageing Res Rev , vol.10 , pp. 319-329
    • Singh, T.1    Newman, A.B.2
  • 62
    • 0031573089 scopus 로고    scopus 로고
    • Pivotal role of endogenous TNF-a in the induction of functional inactivation and apoptosis in NK cells
    • Jewett A, Cavalcanti M and Bonavida B. Pivotal role of endogenous TNF-a in the induction of functional inactivation and apoptosis in NK cells. J Immunol. 1997; 159:4815-4822.
    • (1997) J Immunol , vol.159 , pp. 4815-4822
    • Jewett, A.1    Cavalcanti, M.2    Bonavida, B.3
  • 63
    • 0030981927 scopus 로고    scopus 로고
    • Cytokine-induced apoptosis of human natural killer cells identifies a novel mechanism to regulate the innate immune response
    • Ross ME and Caligiuri MA. Cytokine-induced apoptosis of human natural killer cells identifies a novel mechanism to regulate the innate immune response. Blood. 1997; 89:910-918.
    • (1997) Blood , vol.89 , pp. 910-918
    • Ross, M.E.1    Caligiuri, M.A.2
  • 64
    • 29744468405 scopus 로고    scopus 로고
    • TNF-a-induced apoptosis in human naïve and memory CD8+ T cells in aged humans
    • Gupta S and Gollapudi S. TNF-a-induced apoptosis in human naïve and memory CD8+ T cells in aged humans. Exp Gerontol. 2006; 41:69-77.
    • (2006) Exp Gerontol , vol.41 , pp. 69-77
    • Gupta, S.1    Gollapudi, S.2
  • 68
    • 77958010525 scopus 로고    scopus 로고
    • Interleukin 6 as a key regulator of muscle mass during cachexia
    • Carson JA and Baltgalvis KA. Interleukin 6 as a key regulator of muscle mass during cachexia. Exerc Sport Sci Rev. 2010; 38:168-176.
    • (2010) Exerc Sport Sci Rev , vol.38 , pp. 168-176
    • Carson, J.A.1    Baltgalvis, K.A.2
  • 71
    • 0038322493 scopus 로고    scopus 로고
    • Exercise and IL-6 infusion inhibit endotoxin-induced TNF-a production in humans
    • Starkie R, Ostrowski SR, Jauffred S, Febbraio M and Pedersen BK. Exercise and IL-6 infusion inhibit endotoxin-induced TNF-a production in humans. FASEB J. 2003; 17:884-886.
    • (2003) FASEB J , vol.17 , pp. 884-886
    • Starkie, R.1    Ostrowski, S.R.2    Jauffred, S.3    Febbraio, M.4    Pedersen, B.K.5
  • 73
    • 62649139025 scopus 로고    scopus 로고
    • Immunological and inflammatory functions of the interleukin-1 family
    • Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol. 2009; 27:519-550.
    • (2009) Annu Rev Immunol , vol.27 , pp. 519-550
    • Dinarello, C.A.1
  • 76
    • 77954627022 scopus 로고    scopus 로고
    • Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity
    • Cella M, Otero K and Colonna M. Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity. Proc Natl Acad Sci U S A. 2010; 107:10961-10966.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 10961-10966
    • Cella, M.1    Otero, K.2    Colonna, M.3
  • 79
    • 16844363815 scopus 로고    scopus 로고
    • The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function
    • Chelvarajan RL, Collins SM, Van Willigen JM and Bondada S. The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function. J Leukoc Biol. 2005; 77:503-512.
    • (2005) J Leukoc Biol , vol.77 , pp. 503-512
    • Chelvarajan, R.L.1    Collins, S.M.2    Van Willigen, J.M.3    Bondada, S.4
  • 80
    • 51549109600 scopus 로고    scopus 로고
    • Mononuclear phagocyte-derived IL-10 suppresses the innate IL-12/IFN-gamma axis in lung-challenged aged mice
    • Chiu BC, Stolberg VR and Chensue SW. Mononuclear phagocyte-derived IL-10 suppresses the innate IL-12/IFN-gamma axis in lung-challenged aged mice. J Immunol. 2008; 181:3156-3166.
    • (2008) J Immunol , vol.181 , pp. 3156-3166
    • Chiu, B.C.1    Stolberg, V.R.2    Chensue, S.W.3
  • 83
    • 80053069818 scopus 로고    scopus 로고
    • IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection
    • Stacey MA, Marsden M, Wang EC, Wilkinson GW and Humphreys IR. IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection. J Immunol. 2011; 187:2944-2952.
    • (2011) J Immunol , vol.187 , pp. 2944-2952
    • Stacey, M.A.1    Marsden, M.2    Wang, E.C.3    Wilkinson, G.W.4    Humphreys, I.R.5
  • 87
    • 3543072385 scopus 로고    scopus 로고
    • Natural killer cell activity and sensitivity to positive and negative modulation in uncomplicated obese subjects: relationships to leptin and diet composition
    • Dovio A, Caramello V, Masera RG, Sartori ML, Saba L, Tinivella M, Prolo P, Termine A, Avagnina P and Angeli A. Natural killer cell activity and sensitivity to positive and negative modulation in uncomplicated obese subjects: relationships to leptin and diet composition. Int J Obes. 2004; 28:894-901.
    • (2004) Int J Obes , vol.28 , pp. 894-901
    • Dovio, A.1    Caramello, V.2    Masera, R.G.3    Sartori, M.L.4    Saba, L.5    Tinivella, M.6    Prolo, P.7    Termine, A.8    Avagnina, P.9    Angeli, A.10
  • 89
    • 78651256740 scopus 로고    scopus 로고
    • Bariatric surgery reverses natural killer (NK) cell activity and NKrelated cytokine synthesis impairment induced by morbid obesity
    • Moulin CM, Marguti I, Peron JP, Halpern A and Rizzo LV. Bariatric surgery reverses natural killer (NK) cell activity and NKrelated cytokine synthesis impairment induced by morbid obesity. Obes Surg. 2011; 21:112-118.
    • (2011) Obes Surg , vol.21 , pp. 112-118
    • Moulin, C.M.1    Marguti, I.2    Peron, J.P.3    Halpern, A.4    Rizzo, L.V.5
  • 90
    • 78449288956 scopus 로고    scopus 로고
    • The association between the ratio of visceral fat to thigh muscle area and metabolic syndrome: the Korean Sarcopenic Obesity Study (KSOS)
    • Lim KI, Yang SJ, Kim TN, Yoo HJ, Kang HJ, Song W, Baik SH, Choi DS and Choi KM. The association between the ratio of visceral fat to thigh muscle area and metabolic syndrome: the Korean Sarcopenic Obesity Study (KSOS). Clin Endocrinol (Oxf). 2010; 73:588-594.
    • (2010) Clin Endocrinol (Oxf) , vol.73 , pp. 588-594
    • Lim, K.I.1    Yang, S.J.2    Kim, T.N.3    Yoo, H.J.4    Kang, H.J.5    Song, W.6    Baik, S.H.7    Choi, D.S.8    Choi, K.M.9
  • 95
    • 0033046593 scopus 로고    scopus 로고
    • The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
    • Waldmann TA and Tagaya Y. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu Rev Immunol. 1999; 17:19-49.
    • (1999) Annu Rev Immunol , vol.17 , pp. 19-49
    • Waldmann, T.A.1    Tagaya, Y.2
  • 97
    • 43549096677 scopus 로고    scopus 로고
    • IL-15Ra chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation
    • Mortier E, Woo T, Advincula R, Gozalo S and Ma A. IL-15Ra chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J Exp Med. 2008; 205:1213-1225.
    • (2008) J Exp Med , vol.205 , pp. 1213-1225
    • Mortier, E.1    Woo, T.2    Advincula, R.3    Gozalo, S.4    Ma, A.5
  • 98
    • 3242776039 scopus 로고    scopus 로고
    • Natural, proteolytic release of a soluble form of human IL-15 receptor achain that behaves as a specific, high affinity IL-15 antagonist
    • Mortier E, Bernard J, Plet A and Jacques Y. Natural, proteolytic release of a soluble form of human IL-15 receptor achain that behaves as a specific, high affinity IL-15 antagonist. J Immunol. 2004; 173:1681-1688.
    • (2004) J Immunol , vol.173 , pp. 1681-1688
    • Mortier, E.1    Bernard, J.2    Plet, A.3    Jacques, Y.4
  • 100
    • 49549098143 scopus 로고    scopus 로고
    • The exon-3- encoded domain of IL-15Ra contributes to IL-15 high-affinity binding and is crucial for the IL-15 antagonistic effect of soluble IL-15Ra
    • Bouchaud G, Garrigue-Antar L, Solé V, Quéméner A, Boublik Y, Mortier E, Perdreau H, Jacques Y and Plet A. The exon-3- encoded domain of IL-15Ra contributes to IL-15 high-affinity binding and is crucial for the IL-15 antagonistic effect of soluble IL-15Ra. J Mol Biol. 2008; 382:1-12.
    • (2008) J Mol Biol , vol.382 , pp. 1-12
    • Bouchaud, G.1    Garrigue-Antar, L.2    Solé, V.3    Quéméner, A.4    Boublik, Y.5    Mortier, E.6    Perdreau, H.7    Jacques, Y.8    Plet, A.9
  • 103
    • 33750335080 scopus 로고    scopus 로고
    • Combined IL- 15/IL-15Ra immunotherapy maximizes IL-15 activity in vivo
    • Stoklasek TA, Schluns KS and Lefrancois L. Combined IL- 15/IL-15Ra immunotherapy maximizes IL-15 activity in vivo. J Immunol. 2006; 177:6072-6080.
    • (2006) J Immunol , vol.177 , pp. 6072-6080
    • Stoklasek, T.A.1    Schluns, K.S.2    Lefrancois, L.3
  • 104
    • 0015380362 scopus 로고
    • The renal handling of low molecular weight proteins II. Disorders of serum protein catabolism in patients with tubular proteinuria, the nephrotic syndrome, or uremia
    • Waldmann TA, Strober W and Mogielnicki RP. The renal handling of low molecular weight proteins II. Disorders of serum protein catabolism in patients with tubular proteinuria, the nephrotic syndrome, or uremia. J Clin Invest. 1972; 51:2162-2174.
    • (1972) J Clin Invest , vol.51 , pp. 2162-2174
    • Waldmann, T.A.1    Strober, W.2    Mogielnicki, R.P.3
  • 106
    • 45949095096 scopus 로고    scopus 로고
    • Interleukin-15: a muscle-derived cytokine regulating fat-to-lean body composition
    • Quinn LS. Interleukin-15: a muscle-derived cytokine regulating fat-to-lean body composition. J Anim Sci. 2008; 86:E75-83.
    • (2008) J Anim Sci , vol.86
    • Quinn, L.S.1
  • 107
    • 9244242571 scopus 로고    scopus 로고
    • Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses
    • Riechman SE, Balasekaran G, Roth SM and Ferrell RE. Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses. J Appl Physiol. 2004; 97:2214-2219.
    • (2004) J Appl Physiol , vol.97 , pp. 2214-2219
    • Riechman, S.E.1    Balasekaran, G.2    Roth, S.M.3    Ferrell, R.E.4
  • 108
    • 79953307941 scopus 로고    scopus 로고
    • Upregulation of circulating IL-15 by treadmill running in healthy individuals: Is IL-15 an endocrine mediator of the beneficial effects of endurance exercise?
    • Tamura Y, Watanabe K, Kantani T, Hayashi J, Ishida N and Kaneki M. Upregulation of circulating IL-15 by treadmill running in healthy individuals: Is IL-15 an endocrine mediator of the beneficial effects of endurance exercise? Endocr J. 2011; 58:211-215.
    • (2011) Endocr J , vol.58 , pp. 211-215
    • Tamura, Y.1    Watanabe, K.2    Kantani, T.3    Hayashi, J.4    Ishida, N.5    Kaneki, M.6
  • 109
    • 74649084925 scopus 로고    scopus 로고
    • Serum and muscle interleukin-15 levels decrease in aging mice: Correlation with declines in soluble interleukin-15 receptor alpha expression
    • Quinn LS, Anderson BG, Strait-Bodey L and Wolden-Hanson T. Serum and muscle interleukin-15 levels decrease in aging mice: Correlation with declines in soluble interleukin-15 receptor alpha expression. Exp Gerontol. 2010; 45:106-112.
    • (2010) Exp Gerontol , vol.45 , pp. 106-112
    • Quinn, L.S.1    Anderson, B.G.2    Strait-Bodey, L.3    Wolden-Hanson, T.4
  • 110
  • 113
    • 0036031875 scopus 로고    scopus 로고
    • Overexpression of interleukin-15 induces skeletal muscle hypertrophy in vitro: implications for treatment of muscle wasting disorders
    • Quinn LS, Anderson BG, Drivdahl RH, Alvarez B and Argiles JM. Overexpression of interleukin-15 induces skeletal muscle hypertrophy in vitro: implications for treatment of muscle wasting disorders. Exp Cell Res. 2002; 280:55-63.
    • (2002) Exp Cell Res , vol.280 , pp. 55-63
    • Quinn, L.S.1    Anderson, B.G.2    Drivdahl, R.H.3    Alvarez, B.4    Argiles, J.M.5
  • 116
    • 84855351190 scopus 로고    scopus 로고
    • Interleukin-15 treatment improves glucose homeostasis and insulin sensitivity in obese mice
    • Barra NG, Chew MV, Holloway AC and Ashkar AA. Interleukin-15 treatment improves glucose homeostasis and insulin sensitivity in obese mice. Diabetes Obes Metab. 2011; 14:190-193.
    • (2011) Diabetes Obes Metab , vol.14 , pp. 190-193
    • Barra, N.G.1    Chew, M.V.2    Holloway, A.C.3    Ashkar, A.A.4
  • 118
    • 0032211699 scopus 로고    scopus 로고
    • IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation
    • Lodolce JP, Boone DL, Chai S, Swain RE, Dassopoulos T, Trettin S and Ma A. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity. 1998; 9:669-676.
    • (1998) Immunity , vol.9 , pp. 669-676
    • Lodolce, J.P.1    Boone, D.L.2    Chai, S.3    Swain, R.E.4    Dassopoulos, T.5    Trettin, S.6    Ma, A.7
  • 120
    • 0037460067 scopus 로고    scopus 로고
    • In vivo survival and homeostatic proliferation of natural killer cells
    • Prlic M, Blazar BR, Farrar MA and Jameson SC. In vivo survival and homeostatic proliferation of natural killer cells. J Exp Med. 2003; 197:967-976.
    • (2003) J Exp Med , vol.197 , pp. 967-976
    • Prlic, M.1    Blazar, B.R.2    Farrar, M.A.3    Jameson, S.C.4
  • 121
    • 0037460058 scopus 로고    scopus 로고
    • Interleukin (IL)-15Ra-deficient natural killer cells survive in normal but not IL-15Ra-deficient mice
    • Koka R, Burkett PR, Chien M, Chai S, Chan F, Lodolce JP, Boone DL and Ma A. Interleukin (IL)-15Ra-deficient natural killer cells survive in normal but not IL-15Ra-deficient mice. J Exp Med. 2003; 197:977-984.
    • (2003) J Exp Med , vol.197 , pp. 977-984
    • Koka, R.1    Burkett, P.R.2    Chien, M.3    Chai, S.4    Chan, F.5    Lodolce, J.P.6    Boone, D.L.7    Ma, A.8
  • 125
    • 79955723001 scopus 로고    scopus 로고
    • Transcriptional control of natural killer cell development and function
    • Hesslein DG and Lanier LL. Transcriptional control of natural killer cell development and function. Adv Immunol. 2011; 109:45-85.
    • (2011) Adv Immunol , vol.109 , pp. 45-85
    • Hesslein, D.G.1    Lanier, L.L.2
  • 127
    • 0036826914 scopus 로고    scopus 로고
    • IL-15Ra recycles and presents IL-15 in trans to neighboring cells
    • Dubois S, Mariner J, Waldmann TA and Tagaya Y. IL-15Ra recycles and presents IL-15 in trans to neighboring cells. Immunity. 2002; 17:537-547.
    • (2002) Immunity , vol.17 , pp. 537-547
    • Dubois, S.1    Mariner, J.2    Waldmann, T.A.3    Tagaya, Y.4
  • 128
    • 71649100833 scopus 로고    scopus 로고
    • Trans-presentation: a novel mechanism regulating IL-15 delivery and responses
    • Stonier SW and Schluns KS. Trans-presentation: a novel mechanism regulating IL-15 delivery and responses. Immunol Lett. 2010; 127:85-92.
    • (2010) Immunol Lett , vol.127 , pp. 85-92
    • Stonier, S.W.1    Schluns, K.S.2
  • 129
    • 70449533145 scopus 로고    scopus 로고
    • Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets
    • Mortier E, Advincula R, Kim L, Chmura S, Barrera J, Reizis B, Malynn BA and Ma A. Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets. Immunity. 2009; 31:811-822.
    • (2009) Immunity , vol.31 , pp. 811-822
    • Mortier, E.1    Advincula, R.2    Kim, L.3    Chmura, S.4    Barrera, J.5    Reizis, B.6    Malynn, B.A.7    Ma, A.8
  • 130
    • 78650659948 scopus 로고    scopus 로고
    • No requirement of trans presentations of IL-15 for human CD8 T cell proliferation
    • Ota N, Takase M, Uchiyama H, Olsen SK and Kanagawa O. No requirement of trans presentations of IL-15 for human CD8 T cell proliferation. J Immunol. 2010; 185:6041-6048.
    • (2010) J Immunol , vol.185 , pp. 6041-6048
    • Ota, N.1    Takase, M.2    Uchiyama, H.3    Olsen, S.K.4    Kanagawa, O.5
  • 131
    • 0035399559 scopus 로고    scopus 로고
    • The sushi domain of soluble IL-15 receptor a is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivo
    • Wei X-q, Orchardson M, Gracie JA, Leung BP, Gao B-m, Guan H, Niedbala W, Paterson GK, McInnes IB and Liew FY. The sushi domain of soluble IL-15 receptor a is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivo. J Immunol. 2001; 167:277-282.
    • (2001) J Immunol , vol.167 , pp. 277-282
    • Wei X-q1    Orchardson, M.2    Gracie, J.A.3    Leung, B.P.4    Gao B-m5    Guan, H.6    Niedbala, W.7    Paterson, G.K.8    McInnes, I.B.9    Liew, F.Y.10
  • 132
    • 33644975335 scopus 로고    scopus 로고
    • Soluble interleukin-15 receptor a (IL-15Ra)-sushi as a selective and potent agonist of IL- 15 action through IL-15Rb/g
    • Mortier E, Quéméner A, Vusio P, Lorenzen I, Boublik Y, Grötzinger J, Plet A and Jacques Y. Soluble interleukin-15 receptor a (IL-15Ra)-sushi as a selective and potent agonist of IL- 15 action through IL-15Rb/g. J Biol Chem. 2006; 281:1612-1619.
    • (2006) J Biol Chem , vol.281 , pp. 1612-1619
    • Mortier, E.1    Quéméner, A.2    Vusio, P.3    Lorenzen, I.4    Boublik, Y.5    Grötzinger, J.6    Plet, A.7    Jacques, Y.8
  • 133
    • 71749113283 scopus 로고    scopus 로고
    • A programmed switch from IL-15- to IL-2-dependent activation in human NK cells
    • Pillet AH, Bugault F, Theze J, Chakrabarti LA and Rose T. A programmed switch from IL-15- to IL-2-dependent activation in human NK cells. J Immunol. 2009; 182:6267-6277.
    • (2009) J Immunol , vol.182 , pp. 6267-6277
    • Pillet, A.H.1    Bugault, F.2    Theze, J.3    Chakrabarti, L.A.4    Rose, T.5
  • 135
    • 0035216955 scopus 로고    scopus 로고
    • Decreased natural killer cell activity is associated with atherosclerosis in elderly humans
    • Bruunsgaard H, Pedersen AN, Schroll M, Skinhøj P and Pedersen BK. Decreased natural killer cell activity is associated with atherosclerosis in elderly humans. Exp Gerontol. 2001; 37:127-136.
    • (2001) Exp Gerontol , vol.37 , pp. 127-136
    • Bruunsgaard, H.1    Pedersen, A.N.2    Schroll, M.3    Skinhøj, P.4    Pedersen, B.K.5
  • 136
    • 0035110536 scopus 로고    scopus 로고
    • Characteristics of peripheral and peritoneal white blood cells in children with chronic renal failure, dialyzed or not
    • Bouts AH, Out TA, Schroder CH, Monnens LA, Nauta J, Krediet RT and Davin JC. Characteristics of peripheral and peritoneal white blood cells in children with chronic renal failure, dialyzed or not. Perit Dial Int. 2000; 20:748-756.
    • (2000) Perit Dial Int , vol.20 , pp. 748-756
    • Bouts, A.H.1    Out, T.A.2    Schroder, C.H.3    Monnens, L.A.4    Nauta, J.5    Krediet, R.T.6    Davin, J.C.7
  • 138
    • 33646674302 scopus 로고    scopus 로고
    • Cachexia: pathophysiology and clinical relevance
    • Morley JE, Thomas DR and Wilson MM. Cachexia: pathophysiology and clinical relevance. Am J Clin Nutr. 2006; 83:735-743.
    • (2006) Am J Clin Nutr , vol.83 , pp. 735-743
    • Morley, J.E.1    Thomas, D.R.2    Wilson, M.M.3
  • 141
    • 17144385790 scopus 로고    scopus 로고
    • Excess deaths associated with underweight, overweight, and obesity
    • Flegal KM, Graubard BI, Williamson DF and Gail MH. Excess deaths associated with underweight, overweight, and obesity. JAMA. 2005; 293:1861-1867.
    • (2005) JAMA , vol.293 , pp. 1861-1867
    • Flegal, K.M.1    Graubard, B.I.2    Williamson, D.F.3    Gail, M.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.