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Volumn 66, Issue , 2012, Pages 67-77

BH3 mimetics as a strategy to complement anticancer therapies;Mimetyki BH3 jako terapia wspomagaja̧ca konwencjonalne leki przeciwnowotworowe

Author keywords

Anticancer therapy; Apoptosis; Bcl 2 proteins; BH3 mimetics; BH3 only proteins

Indexed keywords

ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; BAX PROTEIN (53 86); BAX PROTEIN (53-86); ONCOPROTEIN; PEPTIDE FRAGMENT;

EID: 84867978350     PISSN: 00325449     EISSN: 17322693     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (6)

References (100)
  • 1
    • 33847328289 scopus 로고    scopus 로고
    • The Bcl-2 apoptotic switch in cancer development and therapy
    • Adams J. M., Cory S.: The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene, 2007;26:1324-1337
    • (2007) Oncogene , vol.26 , pp. 1324-1337
    • Adams, J.M.1    Cory, S.2
  • 2
    • 74849090776 scopus 로고    scopus 로고
    • Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells
    • Arisan E. D., Kutuk O., Tezil T., Bodur C., Telci D., Basaga H.: Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells. Breast Cancer Res. Treat., 2010;119:271-281
    • (2010) Breast Cancer Res. Treat. , vol.119 , pp. 271-281
    • Arisan, E.D.1    Kutuk, O.2    Tezil, T.3    Bodur, C.4    Telci, D.5    Basaga, H.6
  • 4
    • 59449095496 scopus 로고    scopus 로고
    • AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance
    • Balakrishnan K., Burger J. A., Wierda W. G., Gandhi V.: AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Blood, 2009;113:149-153
    • (2009) Blood , vol.113 , pp. 149-153
    • Balakrishnan, K.1    Burger, J.A.2    Wierda, W.G.3    Gandhi, V.4
  • 8
    • 33646354381 scopus 로고    scopus 로고
    • Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
    • Certo M., del Gaizo Moore V., Nishino M., Wei G., Korsmeyer S., Armstrong S. A., Letai A.: Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell, 2006;9:351-365
    • (2006) Cancer Cell , vol.9 , pp. 351-365
    • Certo, M.1    Del Gaizo Moore, V.2    Nishino, M.3    Wei, G.4    Korsmeyer, S.5    Armstrong, S.A.6    Letai, A.7
  • 9
    • 9144257919 scopus 로고    scopus 로고
    • Upregulation of Fas/Fas ligand-mediated apoptosis by gossypol in an immortalized human alveolar lung cancer cell line
    • Chang J. S., Hsu Y. L., Kuo P. L., Chiang L. C., Lin C. C.: Upregulation of Fas/Fas ligand-mediated apoptosis by gossypol in an immortalized human alveolar lung cancer cell line. Clin. Exp. Pharmacol. Physiol., 2004;31:716-722
    • (2004) Clin. Exp. Pharmacol. Physiol. , vol.31 , pp. 716-722
    • Chang, J.S.1    Hsu, Y.L.2    Kuo, P.L.3    Chiang, L.C.4    Lin, C.C.5
  • 10
    • 3042766027 scopus 로고    scopus 로고
    • The apoptotic effect of HA14-1, a Bcl-2-interacting small molecular compound, requires Bax translocation and is enhanced by PK11195
    • Chen J., Freeman A., Liu J., Dai Q., Lee R. M.: The apoptotic effect of HA14-1, a Bcl-2-interacting small molecular compound, requires Bax translocation and is enhanced by PK11195. Mol. Cancer Ther., 2002;1:961-967
    • (2002) Mol. Cancer Ther. , vol.1 , pp. 961-967
    • Chen, J.1    Freeman, A.2    Liu, J.3    Dai, Q.4    Lee, R.M.5
  • 11
    • 33846674886 scopus 로고    scopus 로고
    • Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation
    • Chen S., Dai Y., Harada H., Dent P., Grant S.: Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation. Cancer Res., 2007;67:782-791
    • (2007) Cancer Res. , vol.67 , pp. 782-791
    • Chen, S.1    Dai, Y.2    Harada, H.3    Dent, P.4    Grant, S.5
  • 13
    • 68149112387 scopus 로고    scopus 로고
    • Mimicking the BH3 domain to kill cancer cells
    • Chonghaile T. N., Letai A.: Mimicking the BH3 domain to kill cancer cells. Oncogene, 2008;27(Suppl.1):S149-S157
    • (2008) Oncogene , vol.27 , Issue.SUPPL.1
    • Chonghaile, T.N.1    Letai, A.2
  • 14
    • 84867939422 scopus 로고    scopus 로고
    • 29.11.2011
    • Clinical trials. http://clinicaltrials.gov/ct2/home (29.11.2011)
  • 15
    • 55849139095 scopus 로고    scopus 로고
    • Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic
    • Cragg M. S., Jansen E. S., Cook M., Harris C., Strasser A., Scott C. L.: Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic. J. Clin. Invest., 2008;118:3651-3659
    • (2008) J. Clin. Invest. , vol.118 , pp. 3651-3659
    • Cragg, M.S.1    Jansen, E.S.2    Cook, M.3    Harris, C.4    Strasser, A.5    Scott, C.L.6
  • 16
    • 79953727302 scopus 로고    scopus 로고
    • Optimization of circulating biomarkers of obatoclax-induced cell death in patients with small cell lung cancer
    • Dean E. J., Cummings J., Roulston A., Berger M., Ranson M., Blackhall F., Dive C.: Optimization of circulating biomarkers of obatoclax-induced cell death in patients with small cell lung cancer. Neoplasia, 2011;13:339-347
    • (2011) Neoplasia , vol.13 , pp. 339-347
    • Dean, E.J.1    Cummings, J.2    Roulston, A.3    Berger, M.4    Ranson, M.5    Blackhall, F.6    Dive, C.7
  • 18
    • 33845994359 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737
    • Del Gaizo Moore V., Brown J. R., Certo M., Love T. M., Novina C. D., Letai A.: Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. J. Clin. Invest., 2007;117:112-121
    • (2007) J. Clin. Invest. , vol.117 , pp. 112-121
    • Del Gaizo Moore, V.1    Brown, J.R.2    Certo, M.3    Love, T.M.4    Novina, C.D.5    Letai, A.6
  • 19
    • 84865857533 scopus 로고    scopus 로고
    • BH3 profiling - Measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions
    • w druku
    • Del Gaizo Moore V., Letai A.: BH3 profiling - measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions. Cancer Lett., 2012 (w druku)
    • (2012) Cancer Lett.
    • Del Gaizo Moore, V.1    Letai, A.2
  • 20
    • 0030750062 scopus 로고    scopus 로고
    • Effect of gossypol on hepatic and serum γ-glutamyltransferase activity in rats
    • Deoras D. P., Young-Curtis P., Dalvi R. R., Tippett F. E.: Effect of gossypol on hepatic and serum γ-glutamyltransferase activity in rats. Vet. Res. Commun., 1997;21:317-323
    • (1997) Vet. Res. Commun. , vol.21 , pp. 317-323
    • Deoras, D.P.1    Young-Curtis, P.2    Dalvi, R.R.3    Tippett, F.E.4
  • 21
    • 70350025502 scopus 로고    scopus 로고
    • Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis
    • Dewson G., Kluck R. M.: Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis. J. Cell Sci., 2009;122:2801-2808
    • (2009) J. Cell Sci. , vol.122 , pp. 2801-2808
    • Dewson, G.1    Kluck, R.M.2
  • 22
    • 80053018164 scopus 로고    scopus 로고
    • The role of BH3-only proteins in tumor cell development, signaling and treatment
    • Elkholi R., Floros K. V., Chipuk J. E.: The role of BH3-only proteins in tumor cell development, signaling and treatment. Genes Cancer, 2011;2:523-537
    • (2011) Genes Cancer , vol.2 , pp. 523-537
    • Elkholi, R.1    Floros, K.V.2    Chipuk, J.E.3
  • 23
    • 56149092147 scopus 로고    scopus 로고
    • Regulation of antiapoptotic MCL-1 function by gossypol: Mechanistic insights from in vitro reconstituted systems
    • Etxebarria A., Landeta O., Antonsson B., Basañez G.: Regulation of antiapoptotic MCL-1 function by gossypol: mechanistic insights from in vitro reconstituted systems. Biochem. Pharmacol., 2008;76:1563-1576
    • (2008) Biochem. Pharmacol. , vol.76 , pp. 1563-1576
    • Etxebarria, A.1    Landeta, O.2    Antonsson, B.3    Basañez, G.4
  • 24
    • 79958753992 scopus 로고    scopus 로고
    • Phosphorylation of Puma modulates its apoptotic function by regulating protein stability
    • Fricker M., O'Prey J., Tolkovsky A. M., Ryan K. M.: Phosphorylation of Puma modulates its apoptotic function by regulating protein stability. Cell Death Dis., 2010;1:e59
    • (2010) Cell Death Dis. , vol.1
    • Fricker, M.1    O'Prey, J.2    Tolkovsky, A.M.3    Ryan, K.M.4
  • 27
    • 0029031013 scopus 로고
    • Antiproliferative activity of gossypol and gossypolone on human breast cancer cells
    • Gilbert N. E., O'Reilly J. E., Chang C. J., Lin Y. C., Brueggemeier R. W.: Antiproliferative activity of gossypol and gossypolone on human breast cancer cells. Life Sci., 1995;57:61-67
    • (1995) Life Sci. , vol.57 , pp. 61-67
    • Gilbert, N.E.1    O'Reilly, J.E.2    Chang, C.J.3    Lin, Y.C.4    Brueggemeier, R.W.5
  • 31
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D., Weinberg R. A.: Hallmarks of cancer: the next generation. Cell, 2011;144:646-674
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 32
    • 2442685708 scopus 로고    scopus 로고
    • Bcl-2 inhibitors sensitize tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by uncoupling of mitochondrial respiration in human leukemic CEM cells
    • Hao J. H., Yu M., Liu F. T., Newland A. C., Jia L.: Bcl-2 inhibitors sensitize tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by uncoupling of mitochondrial respiration in human leukemic CEM cells. Cancer Res., 2004;64:3607-3616
    • (2004) Cancer Res. , vol.64 , pp. 3607-3616
    • Hao, J.H.1    Yu, M.2    Liu, F.T.3    Newland, A.C.4    Jia, L.5
  • 33
    • 77949261504 scopus 로고    scopus 로고
    • Increased expression of the pro-apoptotic Bcl2 family member PUMA and apoptosis by the muscle regulatory transcription factor MyoD in response to a variety of stimuli
    • Harford T. J., Shaltouki A., Weyman C. M.: Increased expression of the pro-apoptotic Bcl2 family member PUMA and apoptosis by the muscle regulatory transcription factor MyoD in response to a variety of stimuli. Apoptosis, 2010;15:71-82
    • (2010) Apoptosis , vol.15 , pp. 71-82
    • Harford, T.J.1    Shaltouki, A.2    Weyman, C.M.3
  • 36
    • 42349098051 scopus 로고    scopus 로고
    • BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells
    • Huang S., Sinicrope F. A.: BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells. Cancer Res., 2008;68:2944-2951
    • (2008) Cancer Res. , vol.68 , pp. 2944-2951
    • Huang, S.1    Sinicrope, F.A.2
  • 37
    • 67650866708 scopus 로고    scopus 로고
    • Gossypol reduces invasiveness in metastatic prostate cancer cells
    • Huang Y. W., Wang L. S., Dowd M. K., Wan P. J., Lin Y. C.: (-)-Gossypol reduces invasiveness in metastatic prostate cancer cells. Anticancer Res., 2009;29:2179-2188
    • (2009) Anticancer Res. , vol.29 , pp. 2179-2188
    • Huang, Y.W.1    Wang, L.S.2    Dowd, M.K.3    Wan, P.J.4    Lin, Y.C.5
  • 38
    • 0032418283 scopus 로고    scopus 로고
    • Induction of c-fos, and cytochrome c oxidase subunits I and II by gossypol acetic acid in rat liver cells
    • Hutchinson R. W., Ing N. H., Burghardt R. C.: Induction of c-fos, and cytochrome c oxidase subunits I and II by gossypol acetic acid in rat liver cells. Cell Biol. Toxicol., 1998;14:391-399
    • (1998) Cell Biol. Toxicol. , vol.14 , pp. 391-399
    • Hutchinson, R.W.1    Ing, N.H.2    Burghardt, R.C.3
  • 39
    • 80052840489 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor entinostat (SNDX-275) induces apoptosis in Hodgkin lymphoma cells and synergizes with Bcl-2 family inhibitors
    • e1
    • Jóna A., Khaskhely N., Buglio D., Shafer J. A., Derenzini E., Bollard C. M., Medeiros L. J., Illés A., Ji Y., Younes A.: The histone deacetylase inhibitor entinostat (SNDX-275) induces apoptosis in Hodgkin lymphoma cells and synergizes with Bcl-2 family inhibitors. Exp. Hematol., 2011;39:1007-1017.e1
    • (2011) Exp. Hematol. , vol.39 , pp. 1007-1017
    • Jóna, A.1    Khaskhely, N.2    Buglio, D.3    Shafer, J.A.4    Derenzini, E.5    Bollard, C.M.6    Medeiros, L.J.7    Illés, A.8    Ji, Y.9    Younes, A.10
  • 40
    • 70350565471 scopus 로고    scopus 로고
    • P53 - A Jack of all trades but master of none
    • Junttila M. R., Evan G. I.: p53 - a Jack of all trades but master of none. Nat. Rev. Cancer, 2009;9:821-829
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 821-829
    • Junttila, M.R.1    Evan, G.I.2
  • 41
    • 34548814971 scopus 로고    scopus 로고
    • Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo
    • Kang M. H., Kang Y. H., Szymanska B., Wilczynska-Kalak U., Sheard M. A., Harned T. M., Lock R. B., Reynolds C. P.: Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo. Blood, 2007;110:2057-2066
    • (2007) Blood , vol.110 , pp. 2057-2066
    • Kang, M.H.1    Kang, Y.H.2    Szymanska, B.3    Wilczynska-Kalak, U.4    Sheard, M.A.5    Harned, T.M.6    Lock, R.B.7    Reynolds, C.P.8
  • 42
    • 77952559110 scopus 로고    scopus 로고
    • Inhibition of p38 MAPK enhances ABT-737-induced cell death in melanoma cell lines: Novel regulation of PUMA
    • Keuling A. M., Andrew S. E., Tron V. A.: Inhibition of p38 MAPK enhances ABT-737-induced cell death in melanoma cell lines: novel regulation of PUMA. Pigment Cell Melanoma Res., 2010;23:430-440
    • (2010) Pigment Cell Melanoma Res. , vol.23 , pp. 430-440
    • Keuling, A.M.1    Andrew, S.E.2    Tron, V.A.3
  • 44
    • 13544266560 scopus 로고    scopus 로고
    • Antimycin A-induced killing of HL-60 cells: Apoptosis initiated from within mitochondria does not necessarily proceed via caspase 9
    • King M. A.: Antimycin A-induced killing of HL-60 cells: apoptosis initiated from within mitochondria does not necessarily proceed via caspase 9. Cytometry A, 2005;63:69-76
    • (2005) Cytometry A , vol.63 , pp. 69-76
    • King, M.A.1
  • 45
    • 42449147919 scopus 로고    scopus 로고
    • Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048)
    • Kitada S., Kress C. L., Krajewska M., Jia L., Pellecchia M., Reed J. C.: Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). Blood, 2008;111:3211-3219
    • (2008) Blood , vol.111 , pp. 3211-3219
    • Kitada, S.1    Kress, C.L.2    Krajewska, M.3    Jia, L.4    Pellecchia, M.5    Reed, J.C.6
  • 47
    • 67649388154 scopus 로고    scopus 로고
    • Involvement of BH3-only proteins in hematologic malignancies
    • Kuroda J., Taniwaki M.: Involvement of BH3-only proteins in hematologic malignancies. Crit. Rev. Oncol. Hematol., 2009;71:89-101
    • (2009) Crit. Rev. Oncol. Hematol. , vol.71 , pp. 89-101
    • Kuroda, J.1    Taniwaki, M.2
  • 49
    • 0036728834 scopus 로고    scopus 로고
    • Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
    • Letai A., Bassik M. C., Walensky L. D., Sorcinelli M. D., Weiler S., Korsmeyer S. J.: Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell, 2002;2:183-192
    • (2002) Cancer Cell , vol.2 , pp. 183-192
    • Letai, A.1    Bassik, M.C.2    Walensky, L.D.3    Sorcinelli, M.D.4    Weiler, S.5    Korsmeyer, S.J.6
  • 50
    • 37249057877 scopus 로고    scopus 로고
    • A small molecule pan-Bcl-2 family inhibitor, GX15-070, induces apoptosis and enhances cisplatin-induced apoptosis in non-small cell lung cancer cells
    • Li J., Viallet J., Haura E. B.: A small molecule pan-Bcl-2 family inhibitor, GX15-070, induces apoptosis and enhances cisplatin-induced apoptosis in non-small cell lung cancer cells. Cancer Chemother. Pharmacol., 2008;61:525-534
    • (2008) Cancer Chemother. Pharmacol. , vol.61 , pp. 525-534
    • Li, J.1    Viallet, J.2    Haura, E.B.3
  • 52
    • 68249106060 scopus 로고    scopus 로고
    • BH3-only proteins in apoptosis and beyond: An overview
    • Lomonosova E., Chinnadurai G.: BH3-only proteins in apoptosis and beyond: an overview. Oncogene, 2008;27(Suppl.1):S2-S19
    • (2008) Oncogene , vol.27 , Issue.SUPPL.1
    • Lomonosova, E.1    Chinnadurai, G.2
  • 56
    • 36048943429 scopus 로고    scopus 로고
    • Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells
    • Meng Y., Li Y., Li J., Li H., Fu J., Liu Y., Liu H., Chen X.: (-) Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells. Leuk. Lymphoma, 2007;48:2204-2212
    • (2007) Leuk. Lymphoma , vol.48 , pp. 2204-2212
    • Meng, Y.1    Li, Y.2    Li, J.3    Li, H.4    Fu, J.5    Liu, Y.6    Liu, H.7    Chen, X.8
  • 60
    • 67651100626 scopus 로고    scopus 로고
    • Bcl-2 inhibitor HA14-1 and genistein together adeptly down regulated survival factors and activated cysteine proteases for apoptosis in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells
    • Mohan N., Karmakar S., Choudhury S. R., Banik N. L., Ray S. K.: Bcl-2 inhibitor HA14-1 and genistein together adeptly down regulated survival factors and activated cysteine proteases for apoptosis in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells. Brain Res., 2009;1283:155-166
    • (2009) Brain Res. , vol.1283 , pp. 155-166
    • Mohan, N.1    Karmakar, S.2    Choudhury, S.R.3    Banik, N.L.4    Ray, S.K.5
  • 61
    • 79952445986 scopus 로고    scopus 로고
    • Gossypol decreases tumor necrosis factor-α-induced intercellular adhesion molecule-1 expression via suppression of NF-κB activity
    • Moon D. O., Choi Y. H., Moon S. K., Kim W. J., Kim G. Y.: Gossypol decreases tumor necrosis factor-α-induced intercellular adhesion molecule-1 expression via suppression of NF-κB activity. Food Chem. Toxicol., 2011;49:999-1005
    • (2011) Food Chem. Toxicol. , vol.49 , pp. 999-1005
    • Moon, D.O.1    Choi, Y.H.2    Moon, S.K.3    Kim, W.J.4    Kim, G.Y.5
  • 62
    • 77951222935 scopus 로고    scopus 로고
    • HA14-1 sensitizes TNF-α-induced apoptosis via inhibition of the NF-κB signaling pathway: Involvement of reactive oxygen species and JNK
    • Moon D. O., Kim M. O., Kang S. H., Choi Y. H., Park S. Y., Kim G. Y.: HA14-1 sensitizes TNF-α-induced apoptosis via inhibition of the NF-κB signaling pathway: involvement of reactive oxygen species and JNK. Cancer Lett., 2010;292:111-118
    • (2010) Cancer Lett. , vol.292 , pp. 111-118
    • Moon, D.O.1    Kim, M.O.2    Kang, S.H.3    Choi, Y.H.4    Park, S.Y.5    Kim, G.Y.6
  • 63
    • 53349097246 scopus 로고    scopus 로고
    • BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis
    • Mott J. L., Bronk S. F., Mesa R. A., Kaufmann S. H., Gores G. J.: BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis. Mol. Cancer Ther., 2008;7:2339-2347
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 2339-2347
    • Mott, J.L.1    Bronk, S.F.2    Mesa, R.A.3    Kaufmann, S.H.4    Gores, G.J.5
  • 64
    • 27944486757 scopus 로고    scopus 로고
    • Frequent HRK inactivation associated with low apoptotic index in secondary glioblastomas
    • Nakamura M., Ishida E., Shimada K., Nakase H., Sakaki T., Konishi N.: Frequent HRK inactivation associated with low apoptotic index in secondary glioblastomas. Acta Neuropathol., 2005;110:402-410
    • (2005) Acta Neuropathol. , vol.110 , pp. 402-410
    • Nakamura, M.1    Ishida, E.2    Shimada, K.3    Nakase, H.4    Sakaki, T.5    Konishi, N.6
  • 67
    • 58849164097 scopus 로고    scopus 로고
    • Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia
    • O'Brien S. M., Claxton D. F., Crump M., Faderl S., Kipps T., Keating M. J., Viallet J., Cheson B. D.: Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia. Blood, 2009;113:299-305
    • (2009) Blood , vol.113 , pp. 299-305
    • O'Brien, S.M.1    Claxton, D.F.2    Crump, M.3    Faderl, S.4    Kipps, T.5    Keating, M.J.6    Viallet, J.7    Cheson, B.D.8
  • 68
    • 13944262237 scopus 로고    scopus 로고
    • Gossypol acts directly on the mitochondria to overcome Bcl-2-and Bcl-XL-mediated apoptosis resistance
    • Oliver C. L., Miranda M. B., Shangary S., Land S., Wang S., Johnson D. E.: (-)-Gossypol acts directly on the mitochondria to overcome Bcl-2-and Bcl-XL-mediated apoptosis resistance. Mol. Cancer Ther., 2005;4:23-31
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 23-31
    • Oliver, C.L.1    Miranda, M.B.2    Shangary, S.3    Land, S.4    Wang, S.5    Johnson, D.E.6
  • 70
    • 77952525706 scopus 로고    scopus 로고
    • The BH3-mimetic GX15-070 induces autophagy, potentiates the cytotoxicity of carboplatin and 5-fluorouracil in esophageal carcinoma cells
    • Pan J., Cheng C., Verstovsek S., Chen Q., Jin Y., Cao Q.: The BH3-mimetic GX15-070 induces autophagy, potentiates the cytotoxicity of carboplatin and 5-fluorouracil in esophageal carcinoma cells. Cancer Lett., 2010;293:167-174
    • (2010) Cancer Lett. , vol.293 , pp. 167-174
    • Pan, J.1    Cheng, C.2    Verstovsek, S.3    Chen, Q.4    Jin, Y.5    Cao, Q.6
  • 71
    • 45949094910 scopus 로고    scopus 로고
    • Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma
    • Paoluzzi L., Gonen M., Gardner J. R., Mastrella J., Yang D., Holmlund J., Sorensen M., Leopold L., Manova K., Marcucci G., Heaney M. L., O'Connor O. A.: Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma. Blood, 2008;111:5350-5358
    • (2008) Blood , vol.111 , pp. 5350-5358
    • Paoluzzi, L.1    Gonen, M.2    Gardner, J.R.3    Mastrella, J.4    Yang, D.5    Holmlund, J.6    Sorensen, M.7    Leopold, L.8    Manova, K.9    Marcucci, G.10    Heaney, M.L.11    O'Connor, O.A.12
  • 74
    • 30944438284 scopus 로고    scopus 로고
    • Sensitization of prostate carcinoma cells to Apo2L/TRAIL by a Bcl-2 family protein inhibitor
    • Ray S., Bucur O., Almasan A.: Sensitization of prostate carcinoma cells to Apo2L/TRAIL by a Bcl-2 family protein inhibitor. Apoptosis, 2005;10:1411-1418
    • (2005) Apoptosis , vol.10 , pp. 1411-1418
    • Ray, S.1    Bucur, O.2    Almasan, A.3
  • 75
    • 16244375885 scopus 로고    scopus 로고
    • Susceptibility of myelomonocytic leukemia U937 cells to the induction of apoptosis by the non-peptidic Bcl-2 ligand HA14-1 is cell cycle phase-dependent
    • Reiners J. J. Jr., Kassel D.: Susceptibility of myelomonocytic leukemia U937 cells to the induction of apoptosis by the non-peptidic Bcl-2 ligand HA14-1 is cell cycle phase-dependent. Cancer Lett., 2005;221:153-163
    • (2005) Cancer Lett. , vol.221 , pp. 153-163
    • Reiners Jr., J.J.1    Kassel, D.2
  • 78
    • 30144441345 scopus 로고    scopus 로고
    • HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells
    • Skommer J., Wlodkowic D., Mättö M., Eray M., Pelkonen J.: HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells. Leuk. Res., 2006;30:322-331
    • (2006) Leuk. Res. , vol.30 , pp. 322-331
    • Skommer, J.1    Wlodkowic, D.2    Mättö, M.3    Eray, M.4    Pelkonen, J.5
  • 80
    • 74049087545 scopus 로고    scopus 로고
    • BNIP3 jako nietypowy przedstawiciel rodziny Bcl-2. Czȩś ć 1: BNIP3 - Regulator nieapoptycznej programowanej śmierci komórek
    • Swoboda E., Strza̧dała L.: BNIP3 jako nietypowy przedstawiciel rodziny Bcl-2. Czȩść 1: BNIP3 - regulator nieapoptycznej programowanej śmierci komórek. Postȩpy Hig. Med. Dośw., 2009;63:409-417
    • (2009) Postȩpy Hig. Med. Dośw. , vol.63 , pp. 409-417
    • Swoboda, E.1    Strza̧dała, L.2
  • 82
    • 37049008863 scopus 로고    scopus 로고
    • SHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell
    • Tian D., Das S. G., Doshi J. M., Peng J., Lin J., Xing C.: sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell. Cancer Lett., 2008;259:198-208
    • (2008) Cancer Lett. , vol.259 , pp. 198-208
    • Tian, D.1    Das, S.G.2    Doshi, J.M.3    Peng, J.4    Lin, J.5    Xing, C.6
  • 83
    • 34249982915 scopus 로고    scopus 로고
    • Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma
    • Trudel S., Li Z. H., Rauw J., Tiedemann R. E., Wen X. Y., Stewart A. K.: Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma. Blood, 2007;109:5430-5438
    • (2007) Blood , vol.109 , pp. 5430-5438
    • Trudel, S.1    Li, Z.H.2    Rauw, J.3    Tiedemann, R.E.4    Wen, X.Y.5    Stewart, A.K.6
  • 85
    • 0021355071 scopus 로고
    • Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines
    • Tuszynski G. P., Cossu G.: Differential cytotoxic effect of gossypol on human melanoma, colon carcinoma, and other tissue culture cell lines. Cancer Res., 1984;44:768-771
    • (1984) Cancer Res. , vol.44 , pp. 768-771
    • Tuszynski, G.P.1    Cossu, G.2
  • 90
    • 77955748052 scopus 로고    scopus 로고
    • Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood
    • Vogler M., Furdas S. D., Jung M., Kuwana T., Dyer M. J., Cohen G. M.: Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood. Clin. Cancer Res., 2010;16:4217-4225
    • (2010) Clin. Cancer Res. , vol.16 , pp. 4217-4225
    • Vogler, M.1    Furdas, S.D.2    Jung, M.3    Kuwana, T.4    Dyer, M.J.5    Cohen, G.M.6
  • 93
    • 66149090396 scopus 로고    scopus 로고
    • TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: Involvement of Notch-1 signaling pathway
    • Wang Z., Azmi A. S., Ahmad A., Banerjee S., Wang S., Sarkar F. H., Mohammad R. M.: TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway. Cancer Res., 2009;69:2757-2765
    • (2009) Cancer Res. , vol.69 , pp. 2757-2765
    • Wang, Z.1    Azmi, A.S.2    Ahmad, A.3    Banerjee, S.4    Wang, S.5    Sarkar, F.H.6    Mohammad, R.M.7
  • 94
    • 77952575844 scopus 로고    scopus 로고
    • Endogenous Noxa determines the strong proapoptotic synergism of the BH3-mimetic ABT-737 with chemotherapeutic agents in human melanoma cells
    • Weber A., Kirejczyk Z., Potthoff S., Ploner C., Häcker G.: Endogenous Noxa determines the strong proapoptotic synergism of the BH3-mimetic ABT-737 with chemotherapeutic agents in human melanoma cells. Transl. Oncol., 2009;2:73-83
    • (2009) Transl. Oncol. , vol.2 , pp. 73-83
    • Weber, A.1    Kirejczyk, Z.2    Potthoff, S.3    Ploner, C.4    Häcker, G.5
  • 97
    • 1542285114 scopus 로고    scopus 로고
    • Synthesis and helical structure of lactam bridged BH3 peptides derived from pro-apoptotic Bcl-2 family proteins
    • Yang B., Liu D., Huang Z.: Synthesis and helical structure of lactam bridged BH3 peptides derived from pro-apoptotic Bcl-2 family proteins. Bioorg. Med. Chem. Lett., 2004;14:1403-1406
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 1403-1406
    • Yang, B.1    Liu, D.2    Huang, Z.3
  • 98
    • 77951442337 scopus 로고    scopus 로고
    • Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1
    • Yecies D., Carlson N. E., Deng J., Letai A.: Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1. Blood, 2010;115:3304-3313
    • (2010) Blood , vol.115 , pp. 3304-3313
    • Yecies, D.1    Carlson, N.E.2    Deng, J.3    Letai, A.4
  • 100
    • 79959828710 scopus 로고    scopus 로고
    • GDC-0941 sensitizes breast cancer to ABT-737 in vitro and in vivo through promoting the degradation of Mcl-1
    • Zheng L., Yang W., Zhang C., Ding W. J., Zhu H., Lin N. M., Wu H. H., He Q. J., Yang B.: GDC-0941 sensitizes breast cancer to ABT-737 in vitro and in vivo through promoting the degradation of Mcl-1. Cancer Lett., 2011;309:27-36
    • (2011) Cancer Lett. , vol.309 , pp. 27-36
    • Zheng, L.1    Yang, W.2    Zhang, C.3    Ding, W.J.4    Zhu, H.5    Lin, N.M.6    Wu, H.H.7    He, Q.J.8    Yang, B.9


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