HA14-1 sensitizes TNF-α-induced apoptosis via inhibition of the NF-κB signaling pathway: Involvement of reactive oxygen species and JNK

Cancer Letters

Volumn 292, Issue 1, 2010, Pages 111-118

  Moon, Dong Oh ^a   Kim, Mun Ock ^a   Kang, Sang Hyuck ^a   Choi, Yung Hyun ^b   Park, Sung Yong ^c   Kim, Gi Young ^a  

^a Jeju National University   (South Korea)

^b Dong Eui University   (South Korea)

^c OTTOGI Research Institute   (South Korea)

Author keywords

HA14 1; JNK; NF B; ROS; TNF

Indexed keywords

2 AMINO 6 BROMO 4 (1 CYANO 2 ETHOXY 2 OXOETHYL) 4H CHROMENE 3 CARBOXYLIC ACID ETHYL ESTER; ACTIN; CASPASE 3; CYCLIN D1; CYCLOOXYGENASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 1; MYC PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; BENZOPYRAN DERIVATIVE; DNA; ETHYL 2-AMINO-6-BROMO-4-(1-CYANO-2-ETHOXY-2-OXOETHYL)-4H-CHROMENE-3-CARBOXYLATE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; NITRILE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CHEMOSENSITIVITY; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; LEUKEMIA CELL; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; DRUG ANTAGONISM; DRUG EFFECT; LEUKEMIA; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; BENZOPYRANS; CELL LINE, TUMOR; DNA, NEOPLASM; ENZYME ACTIVATION; HUMANS; LEUKEMIA; MAP KINASE KINASE 4; NF-KAPPA B; NITRILES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77951222935     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.11.014     Document Type: Article

References (39)

1. Tracey K.J., Cerami A. Tumor necrosis factor: an updated review of its biology. Crit. Care Med. 1993, 21:S415-S422.
2. Wajant H., Pfizenmaier K., Scheurich P. Tumor necrosis factor signaling. Cell Death Differ. 2003, 10:45-65.
3. Jiang Y., Woronicz J.D., Liu W., Goeddel D.V. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. Science 1999, 283:543-546.
4. Poyet J.L., Srinivasula S.M., Lin J.H., Fernandes-Alnemri T., Yamaoka S., Tsichlis P.N., Alnemri E.S. Activation of the IκB kinases by RIP via IKKγ/NEMO-mediated oligomerization. J. Biol. Chem. 2000, 275:37966-37977.
5. Muppidi J.R., Tschopp J., Siegel R.M. Life and death decisions: secondary complexes and lipid rafts in TNF receptor family signal transduction. Immunity 2004, 21:461-465.
6. Hennet T., Richter C., Peterhans E. Tumour necrosis factor-α induces superoxide anion generation in mitochondria of L929 cells. Biochem. J. 1993, 289:587-592.
7. Meier B., Radeke H.H., Selle S., Younes M., Sies H., Resch K., Habermehl G.G. Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-α. Biochem. J. 1989, 263:539-545.
8. O'Donnell V.B., Spycher S., Azzi A. Involvement of oxidants and oxidant-generating enzyme(s) in tumour-necrosis-factor-α-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain. Biochem. J. 1995, 310:133-141.
9. Wallach D., Boldin M., Varfolomeev E., Beyaert R., Vandenabeele P., Fiers W. Cell death induction by receptors of the TNF family: towards a molecular understanding. FEBS Lett. 1997, 410:96-106.
10. 2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor α-induced but not interleukin-1β-induced IκB kinase complex/nuclear factor-κB activation. J. Biol. Chem. 2005, 280:2912-2923.
11. Shen H.M., Pervaiz S. TNF receptor superfamily-induced cell death: redoxdependent execution. FASEB J. 2006, 20:1589-1598.
12. Lin Y., Choksi S., Shen H.M., Yang Q.F., Hur G.M., Kim Y.S., Tran J.H., Nedospasov S.A., Liu Z.G. Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J. Biol. Chem. 2004, 279:10822-10828.
13. Kamata H., Honda S., Maeda S., Chang L., Hirata H., Karin M. Reactive oxygen species promote TNFα-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005, 120:649-661.
14. Wang J.L., Liu D., Zhang Z.J., Shan S., Han X., Srinivasula S.M., Croce C.M., Alnemri E.S., Huang Z. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc. Natl. Acad. Sci. USA 2000, 97:7124-7129.
15. An J., Chen Y., Huang Z. Critical upstream signals of cytochrome c release induced by a novel Bcl-2 inhibitor. J. Biol. Chem. 2004, 279:19133-19140.
16. Lickliter J.D., Wood N.J., Johnson L., McHugh G., Tan J., Wood F., Cox J., Wickham N.W. HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death. Leukemia 2003, 17:2074-2080.
17. Hao J.H., Yu M., Liu F.T., Newland A.C., Jia L. Bcl-2 inhibitors sensitize tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by uncoupling of mitochondrial respiration in human leukemic CEM cells. Cancer Res. 2004, 64:3607-3616.
18. Tang R., Faussat A.M., Majdak P., Perrot J.Y., Chaoui D., Legrand O., Marie J.P. Valproic acid inhibits proliferation and induces apoptosis in acute myeloid leukemia cells expressing P-gp and MRP1. Leukemia 2004, 18:1246-1251.
19. An J., Chervin A.S., Nie A., Ducoff H.S., Huang Z. Overcoming the radioresistance of prostate cancer cells with a novel Bcl-2 inhibitor. Oncogene 2007, 26:652-661.
20. Hsu H., Shu H.B., Pan M.G., Goeddel D.V. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 1996, 84:299-308.
21. Ozes O.N., Mayo L.D., Gustin J.A., Pfeffer S.R., Pfeffer L.M., Donner D.B. NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 1999, 401:82-85.
22. Mukhopadhyay A., Banerjee S., Stafford L.J., Xia C., Liu M., Aggarwal B.B. Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Oncogene 2002, 21:8852-8861.
23. Yamamoto K., Arakawa T., Ueda N., Yamamoto S. Transcriptional roles of nuclear factor κB and nuclear factor-interleukin-6 in the tumor necrosis factor α-dependent induction of cyclooxygenase-2 in MC3T3-1 cells. J. Biol. Chem. 1995, 270:31315-31320.
24. Chu Z.L., McKinsey T.A., Liu L., Gentry J.J., Malim M.H., Ballard D.W. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control. Proc. Natl. Acad. Sci. USA 1997, 94:10057-10062.
25. Stehlik C., de Martin R., Kumabashiri I., Schmid J.A., Binder B.R., Lipp J. Nuclear factor (NF)-κB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor α-induced apoptosis. J. Exp. Med. 1998, 188:211-216.
26. Catz S.D., Johnson J.L. Transcriptional regulation of bcl-2 by nuclear factor κB and its significance in prostate cancer. Oncogene 2001, 20:7342-7351.
27. Nishitoh H., Saitoh M., Mochida Y., Takeda K., Nakano H., Rothe M., Miyazono K., Ichijo H. ASK1 is essential for JNK/SAPK activation by TRAF2. Mol. Cell. 1998, 2:389-395.
28. Aggarwal B.B. Nuclear factor-κB: the enemy within. Cancer Cell 2004, 6:203-208.
29. Silverman N., Maniatis T. NF-κB signaling pathways in mammalian and insect innate immunity. Genes Dev. 2001, 15:2321-2342.
30. Zhang S.Q., Kovalenko A., Cantarella G., Wallach D. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKγ) upon receptor stimulation. Immunity 2000, 12:301-311.
31. Sakon S., Xue X., Takekawa M., Sasazuki T., Okazaki T., Kojima Y., Piao J.H., Yagita H., Okumura K., Doi T., Nakano H. NF-κB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J. 2003, 22:3898-3909.
32. Pham C.G., Bubici C., Zazzeroni F., Papa S., Jones J., Alvarez K., Jayawardena S., De Smaele E., Cong R., Beaumont C., Torti F.M., Torti S.V., Franzoso G. Ferritin heavy chain upregulation by NF-κB inhibits TNF-α-induced apoptosis by suppressing reactive oxygen species. Cell 2004, 119:529-542.
33. Kamata H., Honda S., Maeda S., Chang L., Hirata H., Karin M. Reactive oxygen species promote TNF-α-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005, 120:649-661.
34. Schreck R., Rieber P., Baeuerle P.A. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO J. 1991, 10:2247-2258.
35. Anderson M.T., Staal F.J., Gitler C., Herzenberg L.A. Separation of oxidant-initiated and redox-regulated steps in the NF-κB signal transduction pathway. Proc. Natl. Acad. Sci. USA 1994, 91:11527-11531.
36. Schreck R., Meier B., Mannel D.N., Droge W., Baeuerle P.A. Dithiocarbamates as potent inhibitors of nuclear B activation in intact cells. J. Exp. Med. 1992, 175:1181-1194.
37. Schubert S.Y., Neeman I., Resnick N. A novel mechanism for the inhibition of NF-κB activation in vascular endothelial cells by natural antioxidants. FASEB J. 2002, 16:1931-1933.
38. Shrivastava A., Aggarwal B.B. Antioxidants differentially regulate activation of nuclear factor-kappa B, activator protein-1, C-jun amino-terminal kinases, and apoptosis induced by tumor necrosis factor: evidence that JNK and NF-κB activation are not linked to apoptosis. Antioxid. Redox Signal 1999, 1:181-191.
39. Varfolomeev E.E., Ashkenazi A. Tumor necrosis factor: an apoptosis JuNKie?. Cell 2004, 116:491-497.