Bcl-2 inhibitor HA14-1 and genistein together adeptly down regulated survival factors and activated cysteine proteases for apoptosis in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells

Brain Research

Volumn 1283, Issue , 2009, Pages 155-166

  Mohan, Nishant ^a   Karmakar, Surajit ^a   Choudhury, Subhasree Roy ^a   Banik, Naren L ^b   Ray, Swapan K ^a  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Apoptosis; Bcl 2; Caspase; Genistein; HA14 1

Indexed keywords

120 KD SPECTRIN BREAKDOWN PRODUCT; 145 KD SPECTRIN BREAKDOWN PRODUCT; 2 AMINO 6 BROMO 4 (1 CYANO 2 ETHOXY 2 OXOETHYL) 4H CHROMENE 3 CARBOXYLIC ACID ETHYL ESTER; CALPAIN; CASPASE 3; CASPASE 8; CYTOCHROME C; FODRIN; GENISTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN C MYB; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SURVIVIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; IMAGE ANALYSIS; NEUROBLASTOMA; NEUROBLASTOMA CELL; PRIORITY JOURNAL;

ANNEXIN A5; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BENZOPYRANS; CELL CYCLE; CYSTEINE ENDOPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; GENISTEIN; HUMANS; NEUROBLASTOMA; NITRILES; PROTEIN KINASE INHIBITORS;

EID: 67651100626     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.05.097     Document Type: Article

References (46)

1. Adrain C., Creagh E.M., and Martin S.J. Apoptosis-associated release of Smac/Diablo from mitochondria requires active caspases and is blocked by Bcl-2. EMBO J. 20 (2001) 6627-6636
2. Akiyama T., Ishida J., Nakagawa S., Ogawara H., Watanabe S., Itoh N., Shibuya M., and Fukami Y. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262 (1987) 5592-5595
3. Ambrosini G., Aidida C., and Altieri D.C. A novel antiapoptosis gene, survivin, expressed in cancer and lymphoma. Nature Med. 3 (1997) 917-921
4. Azuhata T., Scott D., Takamizawa S., Wen J., Davidoff A., Fukuzawa M., and Sandler A. The inhibitor of apoptosis protein survivin is associated with high-risk behavior of neuroblastoma. J. Pediatr. Surg. 36 (2001) 1785-1791
5. Beg A.A., and Baltimore D. An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274 (1996) 782-784
6. Biedler J.L., Helson L., and Spengler B.A. Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture. Cancer Res. 33 (1973) 2643-2652
7. Biedler J.L., Roffler-Tarlov S., Schachner M., and Freedman L.S. Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res. 38 (1978) 3751-3757
8. Brodeur G.M. Neuroblastoma: biological insights into a clinical enigma. Nat. Rev. Cancer 3 (2003) 203-216
9. Chen J., Freeman A., Liu J., Dai Q., and Lee R.M. The apoptotic effect of HA14-1, a Bcl-2-interacting small molecular compound, requires Bax translocation and is enhanced by PK11195. Mol. Cancer Ther. 1 (2002) 961-967
10. Cheng E.H., Wei M.C., Weiler S., Flavel R.A., Mak T.W., Lindsten T., and Korsmeyer S.J. Bcl-2, Bcl-xL sequester BH3 domain-only molecules preventing Bax- and Bak-mediated mitochondrial apoptosis. Mol. Cell 8 (2001) 705-711
11. Chou T.C. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol. Rev. 58 (2006) 621-681
12. Danial N.N. Bcl-2 family proteins: critical checkpoints of apoptotic cell death. Clin. Cancer Res. 13 (2007) 7254-7263
13. Das A., Banik N.L., and Ray S.K. Mechanism of apoptosis with the involvement of calpain and caspase cascades in human malignant neuroblastoma SH-SY5Y cells exposed to flavonoids. Int. J. Cancer 119 (2006) 2575-2585
14. Das A., Banik N.L., and Ray S.K. Retinoids induce differentiation and downregulate telomerase activity and N-Myc to increase sensitivity to flavonoids for apoptosis in human malignant neuroblastoma SH-SY5Y cells. Int. J. Oncol. 34 (2009) 757-765
15. Daugas E., Nochy D., Ravagnan L., Loeffler M., Susin S.A., Zamzami N., and Kroemer G. Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. FEBS Lett. 476 (2000) 118-123
16. Davis J.N., Singh B., Bhuiyan M., and Sarkar F.H. Genistein induced upregulation of p21WAF1, downregulation of cyclin B, and induction of apoptosis in prostate cancer cells. Nutr. Cancer 32 (1998) 123-131
17. Dole M., Nuñez G., Merchant A.K., Maybaum J., Rode C.K., Bloch C.A., and Castle V.P. Bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma. Cancer Res. 54 (1994) 3253-3259
18. Green D.R., and Reed J.C. Mitochondria and apoptosis. Science 281 (1998) 1309-1312
19. Hanada M., Krajewski S., Tanaka S., Cazals-Hatem D., Spengler B.A., Ross R.A., Biedler J.L., and Reed J.C. Regulation of Bcl-2 oncoprotein levels with differentiation of human neuroblastoma cells1. Cancer Res. 53 (1993) 4978-4986
20. Ho R., Eggert A., Hishiki T., Minturn J.E., Ikegaki N., Foster P., Camoratto A.M., Evans A.E., and Brodeur G.M. Resistance to chemotherapy mediated by TrkB in neuroblastomas. Cancer Res. 62 (2002) 6462-6466
21. Hossain M.S., Ozaki T., Wang H., Nakagawa A., Takenobu H., Ohira M., Kamijo T., and Nakagawara A. N-Myc promotes cell proliferation through a direct transactivation of neuronal leucine-rich repeat protein-1 (NLRR1) gene in neuroblastoma. Oncogene 27 (2008) 6075-6082
22. Ikeda H., Hirato J., Akami M., Matsumaya S., Suzuku N., Takahashi A., and Kuroiwa M. Bcl-2 oncoprotein expression and apoptosis in neuroblastoma. J. Pediatr. Surg. 30 (1995) 805-808
23. Ismail I.A., Kang K.S., Lee H.A., Kim J.W., and Sohn Y.K. Genistein-induced neuronal apoptosis and G2/M cell cycle arrest is associated with MDC1 upregulation and PLK1 down regulation. Eur. J. Pharmacol. 575 (2007) 12-20
24. Jeremias I., Kupatt C., Baumann B., Herr I., Wirth T., and Debatin K.M. Inhibition of nuclear factor-κB activation attenuates apoptosis resistance in lymphoid cells. Blood 91 (1998) 4624-4631
25. Jin C.Y., Park C., Lee J.H., Chung K.T., Kwon T.K., Kim G.Y., Choi B.T., and Choi Y.H. Naringenin-induced apoptosis is attenuated by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human leukemia U937 cells. Toxicol. In Vitro 23 (2009) 259-265
26. Karmakar S., Weinberg M.S., Banik N.L., Patel S.J., and Ray S.K. Activation of multiple molecular mechanisms for apoptosis in human malignant glioblastoma T98G and U87MG cells treated with sulforaphane. Neuroscience 141 (2006) 1265-1280
27. Karmakar S., Banik N.L., Patel S.J., and Ray S.K. Garlic compounds induced calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells. Apoptosis 12 (2007) 671-684
28. Karmakar S., Banik N.L., Patel S.J., and Ray S.K. Combination of all-trans retinoic acid and taxol regressed glioblastoma T98G xenografts in nude mice. Apoptosis 12 (2007) 2077-2087
29. Karmakar S., Banik N.L., and Ray S.K. Combination of all-trans retinoic acid and paclitaxel-induced differentiation and apoptosis in human glioblastoma U87MG xenografts in nude mice. Cancer 112 (2008) 596-607
30. Li H., Zhu H., Xu C.J., and Yuan J. Cleavage of BID by caspase-8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94 (1998) 491-501
31. Li Y., Upadhyay S., Bhuiyan M., and Sarkar F.H. Induction of apoptosis in breast cancer cells MDA-MB-231 by genistein. Oncogene 18 (1999) 3166-3172
32. Manero F., Gautier F., Gallenne T., Cauquil N., Grée D., Cartron P., Olivier Geneste O., Grée R., Vallette F.M., and Juin P. The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death. Cancer Res. 66 (2006) 2757-2764
33. Mitsiades N., Mitsiades C.S., Poulaki V., Chauhan D., Richardson P.G., Hideshima T., Munshi N., Treon S.P., and Anderson K.C. Biologic sequelae of nuclear factor-κB blockade in multiple myeloma: therapeutic applications. Blood 99 (2002) 4079-4086
34. Notarbartolo M., Poma P., Perri D., Dusonchet L., Cervello M., and D'Alessandro N. Antitumor effects of curcumin, alone or in combination with cisplatin or doxorubicin, on human hepatic cancer cells. Analysis of their possible relationship to changes in NF-κB activation levels and in IAP gene expression. Cancer Lett. 224 (2005) 53-65
35. 2+ influx upregulate calpain and induce apoptosis in PC12 cells. Brain Res. 852 (2000) 326-333
36. Reed J.C., Jurgensmeier J.M., and Matsuyama S. Bcl-2 family proteins and mitochondria. Biochim. Biophys. Acta 1366 (1998) 127-137
37. Sánchez Y., Amrán D., Fernández C., de Blas E., and Aller P. Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK). Int. J. Cancer 123 (2008) 1205-1214
38. Schwab M., Harold E.V., and Bishop J.M. Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture. Nature 316 (1985) 160-162
39. Shimizu S., Narita M., and Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399 (1999) 483-487
40. Spinozzi F., Pagliacci M.C., Migliorati G., Moraca R., Grignani F., Riccardi C., and Nicoletti I. The natural tyrosine kinase inhibitor genistein produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. Leuk. Res. 18 (1994) 431-439
41. Susin S.A., Lorenzo H.K., Zamzami N., Marzo I., Snow B.E., Brothers G.M., Mangion J., and Jacotot E. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397 (1999) 441-446
42. Tajiri T., Tanaka S., Shono K., Kinoshita Y., Fujii Y., Suita S., Ihara K., and Hara T. Quick quantitative analysis of gene dosages associated with prognosis in neuroblastoma. Cancer Lett. 166 (2001) 89-94
43. Tweddle D.A., Malcolm A.J., Bown N., Pearson A.D., and Lunec J. Evidence for the development of p53 mutations after cytotoxic therapy in a neuroblastoma cell line. Cancer Res. 61 (2001) 8-13
44. Wang J.L., Liu D., Zhang Z.J., Shan S., Han X., Srinivasula S.M., Croce C.M., Alnemri E.S., and Huang Z. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 7124-7129
45. Weinstein J.L., Katzenstein H.M., and Cohn S.L. Advances in the diagnosis and treatment of neuroblastoma. Oncologist 8 (2003) 278-292
46. Wilkinson J.C., Wilkinson A.S., Scott F.L., Csomos R.A., Salvesen G.S., and Duckett C.S. Neutralization of Smac/Diablo by inhibitors of apoptosis (IAPs). A caspase-independent mechanism for apoptotic inhibition. J. Biol. Chem. 279 (2004) 51082-51090