-
1
-
-
33646176246
-
Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex
-
Ali M.M., Roe S.M., Vaughan C.K., Meyer P., Panaretou B., Piper P.W., et al. Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex. Nature 2006, 440:1013-1017.
-
(2006)
Nature
, vol.440
, pp. 1013-1017
-
-
Ali, M.M.1
Roe, S.M.2
Vaughan, C.K.3
Meyer, P.4
Panaretou, B.5
Piper, P.W.6
-
2
-
-
33646371494
-
Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones
-
Arlander S.J., Felts S.J., Wagner J.M., Stensgard B., Toft D.O., Karnitz L.M. Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones. Journal of Biological Chemistry 2006, 281:2989-2998.
-
(2006)
Journal of Biological Chemistry
, vol.281
, pp. 2989-2998
-
-
Arlander, S.J.1
Felts, S.J.2
Wagner, J.M.3
Stensgard, B.4
Toft, D.O.5
Karnitz, L.M.6
-
3
-
-
84934439863
-
The cellular " networking" of mammalian Hsp27 and its functions in the control of protein folding, redox state and apoptosis
-
Arrigo A.P. The cellular " networking" of mammalian Hsp27 and its functions in the control of protein folding, redox state and apoptosis. Advances in Experimental Medicine and Biology 2007, 594:14-26.
-
(2007)
Advances in Experimental Medicine and Biology
, vol.594
, pp. 14-26
-
-
Arrigo, A.P.1
-
4
-
-
22844432021
-
Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: A novel basis for antileukemia activity of histone deacetylase inhibitors
-
Bali P., Pranpat M., Bradner J., Balasis M., Fiskus W., Guo F., et al. Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: A novel basis for antileukemia activity of histone deacetylase inhibitors. Journal of Biological Chemistry 2005, 280:26729-26734.
-
(2005)
Journal of Biological Chemistry
, vol.280
, pp. 26729-26734
-
-
Bali, P.1
Pranpat, M.2
Bradner, J.3
Balasis, M.4
Fiskus, W.5
Guo, F.6
-
5
-
-
33746541576
-
HDAC6-p97/VCP controlled polyubiquitin chain turnover
-
Boyault C., Gilquin B., Zhang Y., Rybin V., Garman E., Meyer-Klaucke W., et al. HDAC6-p97/VCP controlled polyubiquitin chain turnover. EMBO Journal 2006, 25:3357-3366.
-
(2006)
EMBO Journal
, vol.25
, pp. 3357-3366
-
-
Boyault, C.1
Gilquin, B.2
Zhang, Y.3
Rybin, V.4
Garman, E.5
Meyer-Klaucke, W.6
-
6
-
-
34547684065
-
HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination
-
Boyault C., Sadoul K., Pabion M., Khochbin S. HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination. Oncogene 2007, 26:5468-5476.
-
(2007)
Oncogene
, vol.26
, pp. 5468-5476
-
-
Boyault, C.1
Sadoul, K.2
Pabion, M.3
Khochbin, S.4
-
7
-
-
34548416641
-
HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates
-
Boyault C., Zhang Y., Fritah S., Caron C., Gilquin B., Kwon S.H., et al. HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes & Development 2007, 21:2172-2181.
-
(2007)
Genes & Development
, vol.21
, pp. 2172-2181
-
-
Boyault, C.1
Zhang, Y.2
Fritah, S.3
Caron, C.4
Gilquin, B.5
Kwon, S.H.6
-
8
-
-
78650791916
-
Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells
-
Brazelle W., Kreahling J.M., Gemmer J., Ma Y., Cress W.D., Haura E., et al. Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells. PLoS One 2010, 5:e14335.
-
(2010)
PLoS One
, vol.5
-
-
Brazelle, W.1
Kreahling, J.M.2
Gemmer, J.3
Ma, Y.4
Cress, W.D.5
Haura, E.6
-
10
-
-
33751172982
-
Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells
-
Catley L., Weisberg E., Kiziltepe T., Tai Y.T., Hideshima T., Neri P., et al. Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells. Blood 2006, 108:3441-3449.
-
(2006)
Blood
, vol.108
, pp. 3441-3449
-
-
Catley, L.1
Weisberg, E.2
Kiziltepe, T.3
Tai, Y.T.4
Hideshima, T.5
Neri, P.6
-
11
-
-
33746365169
-
Discovery and development of purine-scaffold Hsp90 inhibitors
-
Chiosis G. Discovery and development of purine-scaffold Hsp90 inhibitors. Current Topics in Medicinal Chemistry 2006, 6:1183-1191.
-
(2006)
Current Topics in Medicinal Chemistry
, vol.6
, pp. 1183-1191
-
-
Chiosis, G.1
-
12
-
-
68949212379
-
Lysine acetylation targets protein complexes and co-regulates major cellular functions
-
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., et al. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 2009, 325:834-840.
-
(2009)
Science
, vol.325
, pp. 834-840
-
-
Choudhary, C.1
Kumar, C.2
Gnad, F.3
Nielsen, M.L.4
Rehman, M.5
Walther, T.C.6
-
13
-
-
25844530060
-
Hsp90 potentiates the rapid evolution of new traits: Drug resistance in diverse fungi
-
Cowen L.E., Lindquist S. Hsp90 potentiates the rapid evolution of new traits: Drug resistance in diverse fungi. Science 2005, 309:2185-2189.
-
(2005)
Science
, vol.309
, pp. 2185-2189
-
-
Cowen, L.E.1
Lindquist, S.2
-
14
-
-
0031873752
-
The 90-kDa molecular chaperone family: Structure, function, and clinical applications. A comprehensive review
-
Csermely P., Schnaider T., Soti C., Prohaszka Z., Nardai G. The 90-kDa molecular chaperone family: Structure, function, and clinical applications. A comprehensive review. Pharmacology & Therapeutics 1998, 79:129-168.
-
(1998)
Pharmacology & Therapeutics
, vol.79
, pp. 129-168
-
-
Csermely, P.1
Schnaider, T.2
Soti, C.3
Prohaszka, Z.4
Nardai, G.5
-
15
-
-
77953937449
-
The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo
-
Dasmahapatra G., Lembersky D., Kramer L., Fisher R.I., Friedberg J., Dent P., et al. The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo. Blood 2010, 115:4478-4487.
-
(2010)
Blood
, vol.115
, pp. 4478-4487
-
-
Dasmahapatra, G.1
Lembersky, D.2
Kramer, L.3
Fisher, R.I.4
Friedberg, J.5
Dent, P.6
-
16
-
-
67649562565
-
Functions and pathologies of BiP and its interaction partners
-
Dudek J., Benedix J., Cappel S., Greiner M., Jalal C., Muller L., et al. Functions and pathologies of BiP and its interaction partners. Cellular and Molecular Life Sciences 2009, 66:1556-1569.
-
(2009)
Cellular and Molecular Life Sciences
, vol.66
, pp. 1556-1569
-
-
Dudek, J.1
Benedix, J.2
Cappel, S.3
Greiner, M.4
Jalal, C.5
Muller, L.6
-
18
-
-
2942716692
-
Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness
-
Eustace B.K., Sakurai T., Stewart J.K., Yimlamai D., Unger C., Zehetmeier C., et al. Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness. Nature Cell Biology 2004, 6:507-514.
-
(2004)
Nature Cell Biology
, vol.6
, pp. 507-514
-
-
Eustace, B.K.1
Sakurai, T.2
Stewart, J.K.3
Yimlamai, D.4
Unger, C.5
Zehetmeier, C.6
-
19
-
-
77953543377
-
The Beclin 1-VPS34 complex-At the crossroads of autophagy and beyond
-
Funderburk S.F., Wang Q.J., Yue Z. The Beclin 1-VPS34 complex-At the crossroads of autophagy and beyond. Trends in Cell Biology 2010, 20:355-362.
-
(2010)
Trends in Cell Biology
, vol.20
, pp. 355-362
-
-
Funderburk, S.F.1
Wang, Q.J.2
Yue, Z.3
-
20
-
-
84857169594
-
Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR
-
Gabai V.L., Meng L., Kim G., Mills T.A., Benjamin I.J., Sherman M.Y. Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR. Molecular and Cellular Biology 2012, 32:929-940.
-
(2012)
Molecular and Cellular Biology
, vol.32
, pp. 929-940
-
-
Gabai, V.L.1
Meng, L.2
Kim, G.3
Mills, T.A.4
Benjamin, I.J.5
Sherman, M.Y.6
-
21
-
-
80055077899
-
HDAC4 protein regulates HIF1alpha protein lysine acetylation and cancer cell response to hypoxia
-
Geng H., Harvey C.T., Pittsenbarger J., Liu Q., Beer T.M., Xue C., et al. HDAC4 protein regulates HIF1alpha protein lysine acetylation and cancer cell response to hypoxia. Journal of Biological Chemistry 2011, 286:38095-38102.
-
(2011)
Journal of Biological Chemistry
, vol.286
, pp. 38095-38102
-
-
Geng, H.1
Harvey, C.T.2
Pittsenbarger, J.3
Liu, Q.4
Beer, T.M.5
Xue, C.6
-
22
-
-
20844444898
-
Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3
-
George P., Bali P., Annavarapu S., Scuto A., Fiskus W., Guo F., et al. Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3. Blood 2005, 105:1768-1776.
-
(2005)
Blood
, vol.105
, pp. 1768-1776
-
-
George, P.1
Bali, P.2
Annavarapu, S.3
Scuto, A.4
Fiskus, W.5
Guo, F.6
-
23
-
-
34547897023
-
Histone deacetylases and cancer
-
Glozak M.A., Seto E. Histone deacetylases and cancer. Oncogene 2007, 26:5420-5432.
-
(2007)
Oncogene
, vol.26
, pp. 5420-5432
-
-
Glozak, M.A.1
Seto, E.2
-
24
-
-
0346727127
-
Protein degradation and protection against misfolded or damaged proteins
-
Goldberg A.L. Protein degradation and protection against misfolded or damaged proteins. Nature 2003, 426:895-899.
-
(2003)
Nature
, vol.426
, pp. 895-899
-
-
Goldberg, A.L.1
-
25
-
-
84867813853
-
-
Abstract No: 4698
-
Ha K., Fiskus W., Balusu R., Rao R., Venkannagari S., Bhalla K. Inhibition of histone deacetylase (HDAC) 3 induces hyperacetylation and inhibition of nuclear heat shock protein (hsp) 90 leading to depletion of ATR and CHK1 with sensitization to DNA damage in breast and cervical cancer cells 2012, Abstract No: 4698.
-
(2012)
Inhibition of histone deacetylase (HDAC) 3 induces hyperacetylation and inhibition of nuclear heat shock protein (hsp) 90 leading to depletion of ATR and CHK1 with sensitization to DNA damage in breast and cervical cancer cells
-
-
Ha, K.1
Fiskus, W.2
Balusu, R.3
Rao, R.4
Venkannagari, S.5
Bhalla, K.6
-
26
-
-
79960134213
-
Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage
-
Ha K., Fiskus W., Rao R., Balusu R., Venkannagari S., Nalabothula N.R., et al. Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage. Molecular Cancer Therapeutics 2011, 10:1194-1206.
-
(2011)
Molecular Cancer Therapeutics
, vol.10
, pp. 1194-1206
-
-
Ha, K.1
Fiskus, W.2
Rao, R.3
Balusu, R.4
Venkannagari, S.5
Nalabothula, N.R.6
-
27
-
-
75949094261
-
A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation
-
Hageman J., Rujano M.A., van Waarde M.A., Kakkar V., Dirks R.P., Govorukhina N., et al. A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation. Molecular Cell 2010, 37:355-369.
-
(2010)
Molecular Cell
, vol.37
, pp. 355-369
-
-
Hageman, J.1
Rujano, M.A.2
van Waarde, M.A.3
Kakkar, V.4
Dirks, R.P.5
Govorukhina, N.6
-
28
-
-
0344640906
-
Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation
-
Haggarty S.J., Koeller K.M., Wong J.C., Grozinger C.M., Schreiber S.L. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proceedings of the National Academy of Sciences of the United States of America 2003, 100:4389-4394.
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, pp. 4389-4394
-
-
Haggarty, S.J.1
Koeller, K.M.2
Wong, J.C.3
Grozinger, C.M.4
Schreiber, S.L.5
-
29
-
-
79960652801
-
Molecular chaperones in protein folding and proteostasis
-
Hartl F.U., Bracher A., Hayer-Hartl M. Molecular chaperones in protein folding and proteostasis. Nature 2011, 475:324-332.
-
(2011)
Nature
, vol.475
, pp. 324-332
-
-
Hartl, F.U.1
Bracher, A.2
Hayer-Hartl, M.3
-
30
-
-
0037040541
-
Molecular chaperones in the cytosol: From nascent chain to folded protein
-
Hartl F.U., Hayer-Hartl M. Molecular chaperones in the cytosol: From nascent chain to folded protein. Science 2002, 295:1852-1858.
-
(2002)
Science
, vol.295
, pp. 1852-1858
-
-
Hartl, F.U.1
Hayer-Hartl, M.2
-
31
-
-
20844435806
-
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma
-
Hideshima T., Bradner J.E., Wong J., Chauhan D., Richardson P., Schreiber S.L., et al. Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:8567-8572.
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, pp. 8567-8572
-
-
Hideshima, T.1
Bradner, J.E.2
Wong, J.3
Chauhan, D.4
Richardson, P.5
Schreiber, S.L.6
-
32
-
-
81055149914
-
Mechanism of action of proteasome inhibitors and deacetylase inhibitors and the biological basis of synergy in multiple myeloma
-
Hideshima T., Richardson P.G., Anderson K.C. Mechanism of action of proteasome inhibitors and deacetylase inhibitors and the biological basis of synergy in multiple myeloma. Molecular Cancer Therapeutics 2011, 10:2034-2042.
-
(2011)
Molecular Cancer Therapeutics
, vol.10
, pp. 2034-2042
-
-
Hideshima, T.1
Richardson, P.G.2
Anderson, K.C.3
-
33
-
-
34548037901
-
Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium
-
Hoyer-Hansen M., Jaattela M. Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. Cell Death and Differentiation 2007, 14:1576-1582.
-
(2007)
Cell Death and Differentiation
, vol.14
, pp. 1576-1582
-
-
Hoyer-Hansen, M.1
Jaattela, M.2
-
34
-
-
84874438834
-
The unfolded protein response at the crossroads of cellular life and death during ER stress
-
Jager R., Bertrand M.J., Gorman A.M., Vandenabeele P., Samali A. The unfolded protein response at the crossroads of cellular life and death during ER stress. Biology of the Cell 2012, 104:259-270.
-
(2012)
Biology of the Cell
, vol.104
, pp. 259-270
-
-
Jager, R.1
Bertrand, M.J.2
Gorman, A.M.3
Vandenabeele, P.4
Samali, A.5
-
36
-
-
0032488906
-
Hop modulates Hsp70/Hsp90 interactions in protein folding
-
Johnson B.D., Schumacher R.J., Ross E.D., Toft D.O. Hop modulates Hsp70/Hsp90 interactions in protein folding. Journal of Biological Chemistry 1998, 273:3679-3686.
-
(1998)
Journal of Biological Chemistry
, vol.273
, pp. 3679-3686
-
-
Johnson, B.D.1
Schumacher, R.J.2
Ross, E.D.3
Toft, D.O.4
-
37
-
-
0141484615
-
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
-
Kamal A., Thao L., Sensintaffar J., Zhang L., Boehm M.F., Fritz L.C., et al. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 2003, 425:407-410.
-
(2003)
Nature
, vol.425
, pp. 407-410
-
-
Kamal, A.1
Thao, L.2
Sensintaffar, J.3
Zhang, L.4
Boehm, M.F.5
Fritz, L.C.6
-
38
-
-
0346020435
-
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
-
Kawaguchi Y., Kovacs J.J., McLaurin A., Vance J.M., Ito A., Yao T.P. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 2003, 115:727-738.
-
(2003)
Cell
, vol.115
, pp. 727-738
-
-
Kawaguchi, Y.1
Kovacs, J.J.2
McLaurin, A.3
Vance, J.M.4
Ito, A.5
Yao, T.P.6
-
39
-
-
37849019672
-
Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors
-
Khan N., Jeffers M., Kumar S., Hackett C., Boldog F., Khramtsov N., et al. Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors. Biochemical Journal 2008, 409:581-589.
-
(2008)
Biochemical Journal
, vol.409
, pp. 581-589
-
-
Khan, N.1
Jeffers, M.2
Kumar, S.3
Hackett, C.4
Boldog, F.5
Khramtsov, N.6
-
40
-
-
21144444486
-
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
-
Kovacs J.J., Murphy P.J., Gaillard S., Zhao X., Wu J.T., Nicchitta C.V., et al. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Molecular Cell 2005, 18:601-607.
-
(2005)
Molecular Cell
, vol.18
, pp. 601-607
-
-
Kovacs, J.J.1
Murphy, P.J.2
Gaillard, S.3
Zhao, X.4
Wu, J.T.5
Nicchitta, C.V.6
-
41
-
-
49449113465
-
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: A new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6
-
Kozikowski A.P., Tapadar S., Luchini D.N., Kim K.H., Billadeau D.D. Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: A new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. Journal of Medicinal Chemistry 2008, 51:4370-4373.
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, pp. 4370-4373
-
-
Kozikowski, A.P.1
Tapadar, S.2
Luchini, D.N.3
Kim, K.H.4
Billadeau, D.D.5
-
42
-
-
78649338141
-
Autophagy and the integrated stress response
-
Kroemer G., Marino G., Levine B. Autophagy and the integrated stress response. Molecular Cell 2010, 40:280-293.
-
(2010)
Molecular Cell
, vol.40
, pp. 280-293
-
-
Kroemer, G.1
Marino, G.2
Levine, B.3
-
43
-
-
77956294299
-
Matrix metalloproteinase-9 is upregulated in nucleophosmin-anaplastic lymphoma kinase-positive anaplastic lymphomas and activated at the cell surface by the chaperone heat shock protein 90 to promote cell invasion
-
Lagarrigue F., Dupuis-Coronas S., Ramel D., Delsol G., Tronchere H., Payrastre B., et al. Matrix metalloproteinase-9 is upregulated in nucleophosmin-anaplastic lymphoma kinase-positive anaplastic lymphomas and activated at the cell surface by the chaperone heat shock protein 90 to promote cell invasion. Cancer Research 2010, 70:6978-6987.
-
(2010)
Cancer Research
, vol.70
, pp. 6978-6987
-
-
Lagarrigue, F.1
Dupuis-Coronas, S.2
Ramel, D.3
Delsol, G.4
Tronchere, H.5
Payrastre, B.6
-
44
-
-
54749101159
-
The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis
-
Lee Y.S., Lim K.H., Guo X., Kawaguchi Y., Gao Y., Barrientos T., et al. The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis. Cancer Research 2008, 68:7561-7569.
-
(2008)
Cancer Research
, vol.68
, pp. 7561-7569
-
-
Lee, Y.S.1
Lim, K.H.2
Guo, X.3
Kawaguchi, Y.4
Gao, Y.5
Barrientos, T.6
-
45
-
-
70349768075
-
A small molecule inhibitor of inducible heat shock protein 70
-
Leu J.I., Pimkina J., Frank A., Murphy M.E., George D.L. A small molecule inhibitor of inducible heat shock protein 70. Molecular Cell 2009, 36:15-27.
-
(2009)
Molecular Cell
, vol.36
, pp. 15-27
-
-
Leu, J.I.1
Pimkina, J.2
Frank, A.3
Murphy, M.E.4
George, D.L.5
-
46
-
-
79960694363
-
HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells
-
Leu J.I., Pimkina J., Pandey P., Murphy M.E., George D.L. HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells. Molecular Cancer Research 2011, 9:936-947.
-
(2011)
Molecular Cancer Research
, vol.9
, pp. 936-947
-
-
Leu, J.I.1
Pimkina, J.2
Pandey, P.3
Murphy, M.E.4
George, D.L.5
-
47
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine B., Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008, 132:27-42.
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
48
-
-
70349905357
-
Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis
-
Li G., Mongillo M., Chin K.T., Harding H., Ron D., Marks A.R., et al. Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. The Journal of Cell Biology 2009, 186:783-792.
-
(2009)
The Journal of Cell Biology
, vol.186
, pp. 783-792
-
-
Li, G.1
Mongillo, M.2
Chin, K.T.3
Harding, H.4
Ron, D.5
Marks, A.R.6
-
49
-
-
49949105827
-
The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells
-
Li J., Ni M., Lee B., Barron E., Hinton D.R., Lee A.S. The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells. Cell Death and Differentiation 2008, 15:1460-1471.
-
(2008)
Cell Death and Differentiation
, vol.15
, pp. 1460-1471
-
-
Li, J.1
Ni, M.2
Lee, B.3
Barron, E.4
Hinton, D.R.5
Lee, A.S.6
-
50
-
-
36049049392
-
IRE1 signaling affects cell fate during the unfolded protein response
-
Lin J.H., Li H., Yasumura D., Cohen H.R., Zhang C., Panning B., et al. IRE1 signaling affects cell fate during the unfolded protein response. Science 2007, 318:944-949.
-
(2007)
Science
, vol.318
, pp. 944-949
-
-
Lin, J.H.1
Li, H.2
Yasumura, D.3
Cohen, H.R.4
Zhang, C.5
Panning, B.6
-
51
-
-
79953659370
-
Autophagy blockade enhances HDAC inhibitors' pro-apoptotic effects: Potential implications for the treatment of a therapeutic-resistant malignancy
-
Lopez G., Torres K., Lev D. Autophagy blockade enhances HDAC inhibitors' pro-apoptotic effects: Potential implications for the treatment of a therapeutic-resistant malignancy. Autophagy 2011, 7:440-441.
-
(2011)
Autophagy
, vol.7
, pp. 440-441
-
-
Lopez, G.1
Torres, K.2
Lev, D.3
-
52
-
-
61449182121
-
Principles of cancer therapy: Oncogene and non-oncogene addiction
-
Luo J., Solimini N.L., Elledge S.J. Principles of cancer therapy: Oncogene and non-oncogene addiction. Cell 2009, 136:823-837.
-
(2009)
Cell
, vol.136
, pp. 823-837
-
-
Luo, J.1
Solimini, N.L.2
Elledge, S.J.3
-
53
-
-
84857053996
-
GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum
-
Marzec M., Eletto D., Argon Y. GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum. Biochimica et Biophysica Acta 2012, 1823:774-787.
-
(2012)
Biochimica et Biophysica Acta
, vol.1823
, pp. 774-787
-
-
Marzec, M.1
Eletto, D.2
Argon, Y.3
-
54
-
-
34347218245
-
Endoplasmic reticulum stress-induced death of mouse embryonic fibroblasts requires the intrinsic pathway of apoptosis
-
Masud A., Mohapatra A., Lakhani S.A., Ferrandino A., Hakem R., Flavell R.A. Endoplasmic reticulum stress-induced death of mouse embryonic fibroblasts requires the intrinsic pathway of apoptosis. The Journal of Biological Chemistry 2007, 282:14132-14139.
-
(2007)
The Journal of Biological Chemistry
, vol.282
, pp. 14132-14139
-
-
Masud, A.1
Mohapatra, A.2
Lakhani, S.A.3
Ferrandino, A.4
Hakem, R.5
Flavell, R.A.6
-
55
-
-
0035144493
-
Gadd153 sensitizes cells to endoplasmic reticulum stress by downregulating Bcl2 and perturbing the cellular redox state
-
McCullough K.D., Martindale J.L., Klotz L.O., Aw T.Y., Holbrook N.J. Gadd153 sensitizes cells to endoplasmic reticulum stress by downregulating Bcl2 and perturbing the cellular redox state. Molecular Cell Biology 2001, 21:1249-1259.
-
(2001)
Molecular Cell Biology
, vol.21
, pp. 1249-1259
-
-
McCullough, K.D.1
Martindale, J.L.2
Klotz, L.O.3
Aw, T.Y.4
Holbrook, N.J.5
-
56
-
-
78651479525
-
HDAC3 is a critical negative regulator of long-term memory formation
-
McQuown S.C., Barrett R.M., Matheos D.P., Post R.J., Rogge G.A., Alenghat T., et al. HDAC3 is a critical negative regulator of long-term memory formation. Journal of Neuroscience 2011, 31:764-774.
-
(2011)
Journal of Neuroscience
, vol.31
, pp. 764-774
-
-
McQuown, S.C.1
Barrett, R.M.2
Matheos, D.P.3
Post, R.J.4
Rogge, G.A.5
Alenghat, T.6
-
57
-
-
30344477367
-
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
-
Minucci S., Pelicci P.G. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nature Reviews. Cancer 2006, 1:38-51.
-
(2006)
Nature Reviews. Cancer
, vol.1
, pp. 38-51
-
-
Minucci, S.1
Pelicci, P.G.2
-
58
-
-
84857044092
-
Post-translational modifications of Hsp90 and their contributions to chaperone regulation
-
Mollapour M., Neckers L. Post-translational modifications of Hsp90 and their contributions to chaperone regulation. Biochimica et Biophysica Acta 2012, 1823:648-655.
-
(2012)
Biochimica et Biophysica Acta
, vol.1823
, pp. 648-655
-
-
Mollapour, M.1
Neckers, L.2
-
59
-
-
84866488172
-
The Heat Shock Response: Systems Biology of Proteotoxic Stress in Aging and Disease
-
Morimoto R.I. The Heat Shock Response: Systems Biology of Proteotoxic Stress in Aging and Disease. Cold Spring Harbor Symposia on Quantitative Biology 2012, 10.1101/sqb.2012.76.010637.
-
(2012)
Cold Spring Harbor Symposia on Quantitative Biology
-
-
Morimoto, R.I.1
-
60
-
-
80054851888
-
Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90
-
Moulick K., Ahn J.H., Zong H., Rodina A., Cerchietti L., Gomes DaGama E.M., et al. Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90. Nature Chemical Biology 2011, 7:818-826.
-
(2011)
Nature Chemical Biology
, vol.7
, pp. 818-826
-
-
Moulick, K.1
Ahn, J.H.2
Zong, H.3
Rodina, A.4
Cerchietti, L.5
Gomes DaGama, E.M.6
-
61
-
-
33645737411
-
Aggresome disruption: A novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells
-
Nawrocki S.T., Carew J.S., Pino M.S., Highshaw R.A., Andtbacka R.H., Dunner K., et al. Aggresome disruption: A novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells. Cancer Research 2006, 66:3773-3781.
-
(2006)
Cancer Research
, vol.66
, pp. 3773-3781
-
-
Nawrocki, S.T.1
Carew, J.S.2
Pino, M.S.3
Highshaw, R.A.4
Andtbacka, R.H.5
Dunner, K.6
-
62
-
-
79951537603
-
Beyond the endoplasmic reticulum: Atypical GRP78 in cell viability, signalling and therapeutic targeting
-
Ni M., Zhang Y., Lee A.S. Beyond the endoplasmic reticulum: Atypical GRP78 in cell viability, signalling and therapeutic targeting. The Biochemical Journal 2011, 434:181-188.
-
(2011)
The Biochemical Journal
, vol.434
, pp. 181-188
-
-
Ni, M.1
Zhang, Y.2
Lee, A.S.3
-
63
-
-
80054755362
-
Deacetylation of nonhistone proteins by HDACs and the implications in cancer
-
Peng L., Seto E. Deacetylation of nonhistone proteins by HDACs and the implications in cancer. Handbook of Experimental Pharmacology 2011, 206:39-56.
-
(2011)
Handbook of Experimental Pharmacology
, vol.206
, pp. 39-56
-
-
Peng, L.1
Seto, E.2
-
64
-
-
0036810352
-
Heat-shock protein 90, a chaperone for folding and regulation
-
Picard D. Heat-shock protein 90, a chaperone for folding and regulation. Cellular and Molecular Life Sciences 2002, 59:1640-1648.
-
(2002)
Cellular and Molecular Life Sciences
, vol.59
, pp. 1640-1648
-
-
Picard, D.1
-
65
-
-
34250758642
-
ER stress triggers apoptosis by activating BH3-only protein Bim
-
Puthalakath H., O'Reilly L.A., Gunn P., Lee L., Kelly P.N., Huntington N.D., et al. ER stress triggers apoptosis by activating BH3-only protein Bim. Cell 2007, 129:1337-1349.
-
(2007)
Cell
, vol.129
, pp. 1337-1349
-
-
Puthalakath, H.1
O'Reilly, L.A.2
Gunn, P.3
Lee, L.4
Kelly, P.N.5
Huntington, N.D.6
-
66
-
-
84861961464
-
Combination of Pan-Histone Deacetylase Inhibitor and Autophagy Inhibitor Exerts Superior Efficacy against Triple-Negative Human Breast Cancer Cells
-
Rao R., Balusu R., Fiskus W., Mudunuru U., Venkannagari S., Chauhan L., et al. Combination of Pan-Histone Deacetylase Inhibitor and Autophagy Inhibitor Exerts Superior Efficacy against Triple-Negative Human Breast Cancer Cells. Molecular Cancer Therapeutics 2012, 11:973-983.
-
(2012)
Molecular Cancer Therapeutics
, vol.11
, pp. 973-983
-
-
Rao, R.1
Balusu, R.2
Fiskus, W.3
Mudunuru, U.4
Venkannagari, S.5
Chauhan, L.6
-
67
-
-
52649133274
-
HDAC6 inhibition enhances 17-AAG-mediated abrogation of hsp90 chaperone function in human leukemia cells
-
Rao R., Fiskus W., Yang Y., Lee P., Joshi R., Fernandez P., et al. HDAC6 inhibition enhances 17-AAG-mediated abrogation of hsp90 chaperone function in human leukemia cells. Blood 2008, 112:1886-1893.
-
(2008)
Blood
, vol.112
, pp. 1886-1893
-
-
Rao, R.1
Fiskus, W.2
Yang, Y.3
Lee, P.4
Joshi, R.5
Fernandez, P.6
-
68
-
-
84875810929
-
Targeting autophagy induced by pan-HDAC inhibitor panobinostat and promoted by acetylated hsp70: A novel therapy for breast cancer
-
Rao R., Fiskus W., Yang Y., Mudunuru U., Wang Y., Atadja P., et al. Targeting autophagy induced by pan-HDAC inhibitor panobinostat and promoted by acetylated hsp70: A novel therapy for breast cancer. Molecular Cancer Therapeutics 2009, 8(Issue 12). Supplement 1.
-
(2009)
Molecular Cancer Therapeutics
, vol.8
, Issue.12 SUPPL. 1
-
-
Rao, R.1
Fiskus, W.2
Yang, Y.3
Mudunuru, U.4
Wang, Y.5
Atadja, P.6
-
69
-
-
77957584063
-
Role of CAAT/enhancer binding protein homologous protein in panobinostat-mediated potentiation of bortezomib-induced lethal endoplasmic reticulum stress in mantle cell lymphoma cells
-
Rao R., Nalluri S., Fiskus W., Savoie A., Buckley K.M., Ha K., et al. Role of CAAT/enhancer binding protein homologous protein in panobinostat-mediated potentiation of bortezomib-induced lethal endoplasmic reticulum stress in mantle cell lymphoma cells. Clinical Cancer Research 2010, 16:4742-4754.
-
(2010)
Clinical Cancer Research
, vol.16
, pp. 4742-4754
-
-
Rao, R.1
Nalluri, S.2
Fiskus, W.3
Savoie, A.4
Buckley, K.M.5
Ha, K.6
-
70
-
-
77950803990
-
Treatment with panobinostat induces glucose-regulated protein 78 acetylation and endoplasmic reticulum stress in breast cancer cells
-
Rao R., Nalluri S., Kolhe R., Yang Y., Fiskus W., Chen J., et al. Treatment with panobinostat induces glucose-regulated protein 78 acetylation and endoplasmic reticulum stress in breast cancer cells. Molecular Cancer Therapeutics 2010, 9:942-952.
-
(2010)
Molecular Cancer Therapeutics
, vol.9
, pp. 942-952
-
-
Rao, R.1
Nalluri, S.2
Kolhe, R.3
Yang, Y.4
Fiskus, W.5
Chen, J.6
-
71
-
-
0038080911
-
Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: Role of ATP binding site in suppression of caspase-7 activation
-
Reddy R.K., Mao C., Baumeister P., Austin R.C., Kaufman R.J., Lee A.S. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: Role of ATP binding site in suppression of caspase-7 activation. The Journal of Biological Chemistry 2003, 278:20915-20924.
-
(2003)
The Journal of Biological Chemistry
, vol.278
, pp. 20915-20924
-
-
Reddy, R.K.1
Mao, C.2
Baumeister, P.3
Austin, R.C.4
Kaufman, R.J.5
Lee, A.S.6
-
72
-
-
79151472958
-
HDAC6 is required for invadopodia activity and invasion by breast tumor cells
-
Rey M., Irondelle M., Waharte F., Lizarraga F., Chavrier P. HDAC6 is required for invadopodia activity and invasion by breast tumor cells. European Journal of Cell Biology 2011, 90:128-135.
-
(2011)
European Journal of Cell Biology
, vol.90
, pp. 128-135
-
-
Rey, M.1
Irondelle, M.2
Waharte, F.3
Lizarraga, F.4
Chavrier, P.5
-
73
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
Ron D., Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nature Reviews. Molecular Cell Biology 2007, 8:519-529.
-
(2007)
Nature Reviews. Molecular Cell Biology
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
74
-
-
22744446856
-
Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer
-
Saji S., Kawakami M., Hayashi S., Yoshida N., Hirose M., Horiguchi S., et al. Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer. Oncogene 2005, 24:4531-4539.
-
(2005)
Oncogene
, vol.24
, pp. 4531-4539
-
-
Saji, S.1
Kawakami, M.2
Hayashi, S.3
Yoshida, N.4
Hirose, M.5
Horiguchi, S.6
-
75
-
-
84858640254
-
Preclinical activity, pharmacodynamic and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma
-
Santo L., Hideshima T., Kung A.L., Tseng J.C., Tamang D., Yang M., et al. Preclinical activity, pharmacodynamic and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma. Blood 2012, 119:2579-2589.
-
(2012)
Blood
, vol.119
, pp. 2579-2589
-
-
Santo, L.1
Hideshima, T.2
Kung, A.L.3
Tseng, J.C.4
Tamang, D.5
Yang, M.6
-
76
-
-
77956165188
-
GRP78 signaling hub a receptor for targeted tumor therapy
-
Sato M., Yao V.J., Arap W., Pasqualini R. GRP78 signaling hub a receptor for targeted tumor therapy. Advances in Genetics 2010, 69:97-114.
-
(2010)
Advances in Genetics
, vol.69
, pp. 97-114
-
-
Sato, M.1
Yao, V.J.2
Arap, W.3
Pasqualini, R.4
-
77
-
-
33846014703
-
An acetylation site in the middle domain of Hsp90 regulates chaperone function
-
Scroggins B.T., Robzyk K., Wang D., Marcu M.G., Tsutsumi S., Beebe K., et al. An acetylation site in the middle domain of Hsp90 regulates chaperone function. Molecular Cell 2007, 25:151-159.
-
(2007)
Molecular Cell
, vol.25
, pp. 151-159
-
-
Scroggins, B.T.1
Robzyk, K.2
Wang, D.3
Marcu, M.G.4
Tsutsumi, S.5
Beebe, K.6
-
78
-
-
33750008686
-
Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements
-
Shiau A.K., Harris S.F., Southworth D.R., Agard D.A. Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements. Cell 2006, 127:329-340.
-
(2006)
Cell
, vol.127
, pp. 329-340
-
-
Shiau, A.K.1
Harris, S.F.2
Southworth, D.R.3
Agard, D.A.4
-
79
-
-
10644265069
-
Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle
-
Siligardi G., Hu B., Panaretou B., Piper P.W., Pearl L.H., Prodromou C. Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle. The Journal of Biological Chemistry 2004, 279:51989-51998.
-
(2004)
The Journal of Biological Chemistry
, vol.279
, pp. 51989-51998
-
-
Siligardi, G.1
Hu, B.2
Panaretou, B.3
Piper, P.W.4
Pearl, L.H.5
Prodromou, C.6
-
80
-
-
0037036458
-
Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37
-
Siligardi G., Panaretou B., Meyer P., Singh S., Woolfson D.N., Piper P.W., et al. Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37. The Journal of Biological Chemistry 2002, 277:20151-20159.
-
(2002)
The Journal of Biological Chemistry
, vol.277
, pp. 20151-20159
-
-
Siligardi, G.1
Panaretou, B.2
Meyer, P.3
Singh, S.4
Woolfson, D.N.5
Piper, P.W.6
-
81
-
-
79954994442
-
Extracellular heat shock protein (Hsp)70 and Hsp90alpha assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasion
-
Sims J.D., McCready J., Jay D.G. Extracellular heat shock protein (Hsp)70 and Hsp90alpha assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasion. PLoS One 2011, 6:e18848.
-
(2011)
PLoS One
, vol.6
-
-
Sims, J.D.1
McCready, J.2
Jay, D.G.3
-
82
-
-
82255161944
-
Road to ruin: Targeting proteins for degradation in the endoplasmic reticulum
-
Smith M.H., Ploegh H.L., Weissman J.S. Road to ruin: Targeting proteins for degradation in the endoplasmic reticulum. Science 2011, 334:1086-1090.
-
(2011)
Science
, vol.334
, pp. 1086-1090
-
-
Smith, M.H.1
Ploegh, H.L.2
Weissman, J.S.3
-
83
-
-
34548785473
-
Non-oncogene addiction and the stress phenotype of cancer cells
-
Solimini N.L., Luo J., Elledge S.J. Non-oncogene addiction and the stress phenotype of cancer cells. Cell 2007, 130:986-988.
-
(2007)
Cell
, vol.130
, pp. 986-988
-
-
Solimini, N.L.1
Luo, J.2
Elledge, S.J.3
-
84
-
-
84856524861
-
Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy
-
Spiegel S., Milstien S., Grant S. Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy. Oncogene 2012, 3:537-551.
-
(2012)
Oncogene
, vol.3
, pp. 537-551
-
-
Spiegel, S.1
Milstien, S.2
Grant, S.3
-
85
-
-
79953308070
-
Substrate binding drives large-scale conformational changes in the Hsp90 molecular chaperone
-
Street T.O., Lavery L.A., Agard D.A. Substrate binding drives large-scale conformational changes in the Hsp90 molecular chaperone. Molecular Cell 2011, 42:96-105.
-
(2011)
Molecular Cell
, vol.42
, pp. 96-105
-
-
Street, T.O.1
Lavery, L.A.2
Agard, D.A.3
-
86
-
-
84855293594
-
Cross-monomer substrate contacts reposition the Hsp90 N-terminal domain and prime the chaperone activity
-
Street T.O., Lavery L.A., Verba K.A., Lee C.T., Mayer M.P., Agard D.A. Cross-monomer substrate contacts reposition the Hsp90 N-terminal domain and prime the chaperone activity. Journal of Molecular Biology 2012, 415:3-15.
-
(2012)
Journal of Molecular Biology
, vol.415
, pp. 3-15
-
-
Street, T.O.1
Lavery, L.A.2
Verba, K.A.3
Lee, C.T.4
Mayer, M.P.5
Agard, D.A.6
-
87
-
-
79952264011
-
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
-
Tabas I., Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nature Cell Biology 2011, 13:184-190.
-
(2011)
Nature Cell Biology
, vol.13
, pp. 184-190
-
-
Tabas, I.1
Ron, D.2
-
89
-
-
77954945333
-
Targeting the dynamic HSP90 complex in cancer
-
Trepel J., Mollapour M., Giaccone G., Neckers L. Targeting the dynamic HSP90 complex in cancer. Nature Reviews. Cancer 2010, 10:537-549.
-
(2010)
Nature Reviews. Cancer
, vol.10
, pp. 537-549
-
-
Trepel, J.1
Mollapour, M.2
Giaccone, G.3
Neckers, L.4
-
90
-
-
84855424390
-
Interplay between histone deacetylases and autophagy-From cancer therapy to neurodegeneration
-
True O., Matthias P. Interplay between histone deacetylases and autophagy-From cancer therapy to neurodegeneration. Immunology & Cell Biology 2012, 90:78-84.
-
(2012)
Immunology & Cell Biology
, vol.90
, pp. 78-84
-
-
True, O.1
Matthias, P.2
-
91
-
-
0034723235
-
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
-
Urano F., Wang X., Bertolotti A., Zhang Y., Chung P., Harding H.P., et al. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000, 287:664-666.
-
(2000)
Science
, vol.287
, pp. 664-666
-
-
Urano, F.1
Wang, X.2
Bertolotti, A.3
Zhang, Y.4
Chung, P.5
Harding, H.P.6
-
93
-
-
79955478704
-
RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation
-
Walsh N., Larkin A., Swan N., Conlon K., Dowling P., McDermott R., et al. RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation. Cancer Letters 2011, 306:180-189.
-
(2011)
Cancer Letters
, vol.306
, pp. 180-189
-
-
Walsh, N.1
Larkin, A.2
Swan, N.3
Conlon, K.4
Dowling, P.5
McDermott, R.6
-
94
-
-
34047097863
-
FK228 inhibits Hsp90 chaperone function in K562 cells via hyperacetylation of Hsp70
-
Wang Y., Wang S.Y., Zhang X.H., Zhao M., Hou C.M., Xu Y.J., et al. FK228 inhibits Hsp90 chaperone function in K562 cells via hyperacetylation of Hsp70. Biochemical and Biophysical Research Communications 2007, 356:998-1003.
-
(2007)
Biochemical and Biophysical Research Communications
, vol.356
, pp. 998-1003
-
-
Wang, Y.1
Wang, S.Y.2
Zhang, X.H.3
Zhao, M.4
Hou, C.M.5
Xu, Y.J.6
-
96
-
-
0036789884
-
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu
-
Xu W., Marcu M., Yuan X., Mimnaugh E., Patterson C., Neckers L. Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu. Proceedings of the National Academy of Sciences of the United States of America 2002, 99:12847-12852.
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, pp. 12847-12852
-
-
Xu, W.1
Marcu, M.2
Yuan, X.3
Mimnaugh, E.4
Patterson, C.5
Neckers, L.6
-
97
-
-
8544283103
-
CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells
-
Yamaguchi H., Wang H.G. CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. Journal of Biological Chemistry 2004, 279:45495-45502.
-
(2004)
Journal of Biological Chemistry
, vol.279
, pp. 45495-45502
-
-
Yamaguchi, H.1
Wang, H.G.2
-
98
-
-
49649108912
-
Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion
-
Yang Y., Rao R., Shen J., Tang Y., Fiskus W., Nechtman J., et al. Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion. Cancer Research 2008, 68:4833-4842.
-
(2008)
Cancer Research
, vol.68
, pp. 4833-4842
-
-
Yang, Y.1
Rao, R.2
Shen, J.3
Tang, Y.4
Fiskus, W.5
Nechtman, J.6
-
99
-
-
0034905085
-
Regulation of transcription factor YY1 by acetylation and deacetylation
-
Yao Y.L., Yang W.M., Seto E. Regulation of transcription factor YY1 by acetylation and deacetylation. Molecular and Cellular Biology 2001, 21:5979-5991.
-
(2001)
Molecular and Cellular Biology
, vol.21
, pp. 5979-5991
-
-
Yao, Y.L.1
Yang, W.M.2
Seto, E.3
-
100
-
-
33644856123
-
Epigenetic therapy of cancer: Past, present and future
-
Yoo C.B., Jones P.A. Epigenetic therapy of cancer: Past, present and future. Nature Reviews. Drug Discovery 2006, 5:37-50.
-
(2006)
Nature Reviews. Drug Discovery
, vol.5
, pp. 37-50
-
-
Yoo, C.B.1
Jones, P.A.2
-
101
-
-
33749579383
-
Endoplasmic reticulum stress triggers autophagy
-
Yorimitsu T., Nair U., Yang Z., Klionsky D.J. Endoplasmic reticulum stress triggers autophagy. The Journal of Biological Chemistry 2006, 281:30299-30304.
-
(2006)
The Journal of Biological Chemistry
, vol.281
, pp. 30299-30304
-
-
Yorimitsu, T.1
Nair, U.2
Yang, Z.3
Klionsky, D.J.4
-
102
-
-
77952061607
-
Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP
-
Zhang Y., Liu R., Ni M., Gill P., Lee A.S. Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP. The Journal of Biological Chemistry 2010, 285:15065-15075.
-
(2010)
The Journal of Biological Chemistry
, vol.285
, pp. 15065-15075
-
-
Zhang, Y.1
Liu, R.2
Ni, M.3
Gill, P.4
Lee, A.S.5
-
103
-
-
6044271613
-
HDAC6 expression is correlated with better survival in breast cancer
-
Zhang Z., Yamashita H., Toyama T., Sugiura H., Omoto Y., Ando Y., et al. HDAC6 expression is correlated with better survival in breast cancer. Clinical Cancer Research 2004, 10:6962-6968.
-
(2004)
Clinical Cancer Research
, vol.10
, pp. 6962-6968
-
-
Zhang, Z.1
Yamashita, H.2
Toyama, T.3
Sugiura, H.4
Omoto, Y.5
Ando, Y.6
-
104
-
-
34447315270
-
HDAC6 modulates cell motility by altering the acetylation level of cortactin
-
Zhang X., Yuan Z., Zhang Y., Yong S., Salas-Burgos A., Koomen J., et al. HDAC6 modulates cell motility by altering the acetylation level of cortactin. Molecular Cell 2007, 27(2):197-213.
-
(2007)
Molecular Cell
, vol.27
, Issue.2
, pp. 197-213
-
-
Zhang, X.1
Yuan, Z.2
Zhang, Y.3
Yong, S.4
Salas-Burgos, A.5
Koomen, J.6
|