-
1
-
-
0036159487
-
A Danish population-based analysis of 105 mantle cell lymphoma patients: Incidences, clinical features, response, survival and prognostic factors
-
Andersen NS, Jensen MK, de Nully Brown P, Geisler CH. A Danish population-based analysis of 105 mantle cell lymphoma patients: incidences, clinical features, response, survival and prognostic factors. Eur J Cancer 2002;38:401-8.
-
(2002)
Eur J Cancer
, vol.38
, pp. 401-408
-
-
Andersen, N.S.1
Jensen, M.K.2
De Nully Brown, P.3
Geisler, C.H.4
-
2
-
-
47149105457
-
Mantle cell lymphoma: Advances in biology and therapy
-
Smith MR. Mantle cell lymphoma: advances in biology and therapy. Curr Opin Hematol 2008;15:415-21.
-
(2008)
Curr Opin Hematol
, vol.15
, pp. 415-421
-
-
Smith, M.R.1
-
3
-
-
34648824397
-
Genetic and molecular pathogenesis of mantle cell lymphoma: Perspectives for new targeted therapeutics
-
Jares P, Colomer D, Campo E. Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics. Nat Rev Cancer 2007;7:750-62.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 750-762
-
-
Jares, P.1
Colomer, D.2
Campo, E.3
-
4
-
-
54049129362
-
Therapy of mantle cell lymphoma: Current standards and future strategies
-
ix
-
Schmidt C, Dreyling M. Therapy of mantle cell lymphoma: current standards and future strategies. Hematol Oncol Clin North Am 2008;22:953-63, ix.
-
(2008)
Hematol Oncol Clin North Am
, vol.22
, pp. 953-963
-
-
Schmidt, C.1
Dreyling, M.2
-
5
-
-
45249090747
-
Mantle cell lymphoma: Identifying novel molecular targets in growth and survival pathways
-
O'Connor OA. Mantle cell lymphoma: identifying novel molecular targets in growth and survival pathways. Hematology (Am Soc Hematol Educ Program) 2007:270-6.
-
(2007)
Hematology (Am Soc Hematol Educ Program)
, pp. 270-276
-
-
O'Connor, O.A.1
-
6
-
-
61849128387
-
Patients with chemotherapy-refractory mantle cell lymphoma experience high response rates and identical progression-free survivals compared with patients with relapsed disease following treatment with single agent bortezomib: Results of a multicentre Phase 2 clinical trial
-
O'Connor OA, Moskowitz C, Portlock C, et al. Patients with chemotherapy-refractory mantle cell lymphoma experience high response rates and identical progression-free survivals compared with patients with relapsed disease following treatment with single agent bortezomib: results of a multicentre Phase 2 clinical trial. Br J Hematol 2009;145:34-9.
-
(2009)
Br J Hematol
, vol.145
, pp. 34-39
-
-
O'Connor, O.A.1
Moskowitz, C.2
Portlock, C.3
-
7
-
-
30144442233
-
The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status
-
Perez-Galan P, Roue G, Villamor N, Montserrat E, Campo E, Colomer D. The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status. Blood 2006;107:257-64.
-
(2006)
Blood
, vol.107
, pp. 257-264
-
-
Perez-Galan, P.1
Roue, G.2
Villamor, N.3
Montserrat, E.4
Campo, E.5
Colomer, D.6
-
8
-
-
53049083867
-
Mechanisms of proteasome inhibitor action and resistance in cancer
-
McConkey DJ, Zhu K. Mechanisms of proteasome inhibitor action and resistance in cancer. Drug Resist Updat 2008;11:164-79.
-
(2008)
Drug Resist Updat
, vol.11
, pp. 164-179
-
-
McConkey, D.J.1
Zhu, K.2
-
9
-
-
29244470510
-
Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells
-
Nawrocki ST, Carew JS, Dunner K, Jr., et al. Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells. Cancer Res 2005;65:11510-9.
-
(2005)
Cancer Res
, vol.65
, pp. 11510-11519
-
-
Nawrocki, S.T.1
Carew, J.S.2
Dunner Jr., K.3
-
10
-
-
67449109154
-
Phase IA/II study of oral panobinostat (LBH589), a novel pan-deacetylase inhibitor (DACi) demonstrating efficacy in patients with advanced hematologic malignancies
-
Abstract 958
-
Ottmann OG, Spencer A, Prince HM, et al. Phase IA/II study of oral panobinostat (LBH589), a novel pan-deacetylase inhibitor (DACi) demonstrating efficacy in patients with advanced hematologic malignancies. Blood 2008;110:Abstract 958.
-
(2008)
Blood
, vol.110
-
-
Ottmann, O.G.1
Spencer, A.2
Prince, H.M.3
-
11
-
-
33845996135
-
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
-
Duvic M, Talpur R, Ni X, et al. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood 2007;109:31-9.
-
(2007)
Blood
, vol.109
, pp. 31-39
-
-
Duvic, M.1
Talpur, R.2
Ni, X.3
-
12
-
-
71849117270
-
Potential efficacy of the oral histone deacetylase inhibitor vorinostat in a phase I trial in follicular and mantle cell lymphoma
-
Watanabe T, Kato H, Kobayashi Y, et al. Potential efficacy of the oral histone deacetylase inhibitor vorinostat in a phase I trial in follicular and mantle cell lymphoma. Cancer Sci 2009;101:196-200.
-
(2009)
Cancer Sci
, vol.101
, pp. 196-200
-
-
Watanabe, T.1
Kato, H.2
Kobayashi, Y.3
-
13
-
-
30344477367
-
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
-
Minucci S, Pelicci PG. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 2006;6:38-51.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 38-51
-
-
Minucci, S.1
Pelicci, P.G.2
-
14
-
-
53449090857
-
Molecular and biologic characterization and drug-sensitivity of pan histone deacetylase inhibitor resistant acute myeloid leukemia cells
-
Fiskus W, Rao R, Fernandez P, et al. Molecular and biologic characterization and drug-sensitivity of pan histone deacetylase inhibitor resistant acute myeloid leukemia cells. Blood 2008;112:2896-905.
-
(2008)
Blood
, vol.112
, pp. 2896-2905
-
-
Fiskus, W.1
Rao, R.2
Fernandez, P.3
-
15
-
-
22844432021
-
Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: A novel basis for antileukemia activity of histone deacetylase inhibitors
-
Bali P, Pranpat M, Bradner J, et al. Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. J Biol Chem 2005;280:26729-34.
-
(2005)
J Biol Chem
, vol.280
, pp. 26729-26734
-
-
Bali, P.1
Pranpat, M.2
Bradner, J.3
-
16
-
-
49649108912
-
Role of acetylation and extracellular location of heat shock protein 90α in tumor cell invasion
-
Yang Y, Rao R, Shen J, et al. Role of acetylation and extracellular location of heat shock protein 90α in tumor cell invasion. Cancer Res 2008;68:4833-42.
-
(2008)
Cancer Res
, vol.68
, pp. 4833-4842
-
-
Yang, Y.1
Rao, R.2
Shen, J.3
-
17
-
-
41149111451
-
The Hsp90 molecular chaperone: An open and shut case for treatment
-
Pearl LH, Prodromou C, Workman P. The Hsp90 molecular chaperone: an open and shut case for treatment. Biochem J 2008;410:439-53.
-
(2008)
Biochem J
, vol.410
, pp. 439-453
-
-
Pearl, L.H.1
Prodromou, C.2
Workman, P.3
-
18
-
-
0346020435
-
The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
-
Kawaguchi Y, Kovacs JJ, McLaurin A, Vance JM, Ito A, Yao TP. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 2003;115:727-38.
-
(2003)
Cell
, vol.115
, pp. 727-738
-
-
Kawaguchi, Y.1
Kovacs, J.J.2
McLaurin, A.3
Vance, J.M.4
Ito, A.5
Yao, T.P.6
-
19
-
-
53549119055
-
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation
-
Park MA, Zhang G, Martin AP, et al. Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. Cancer Biol Ther 2008;7:1648-62.
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 1648-1662
-
-
Park, M.A.1
Zhang, G.2
Martin, A.P.3
-
20
-
-
20844435806
-
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma
-
Hideshima T, Bradner JE, Wong J, et al. Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc Natl Acad Sci U S A 2005;102:8567-72.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 8567-8572
-
-
Hideshima, T.1
Bradner, J.E.2
Wong, J.3
-
21
-
-
34948890040
-
Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells
-
Davenport EL, Moore HE, Dunlop AS, et al. Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells. Blood 2007;110:2641-9.
-
(2007)
Blood
, vol.110
, pp. 2641-2649
-
-
Davenport, E.L.1
Moore, H.E.2
Dunlop, A.S.3
-
22
-
-
33748789479
-
Mediators of endoplasmic reticulum stress-induced apoptosis
-
Szegezdi E, Logue SE, Gorman AM, Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 2006;7:880-5.
-
(2006)
EMBO Rep
, vol.7
, pp. 880-885
-
-
Szegezdi, E.1
Logue, S.E.2
Gorman, A.M.3
Samali, A.4
-
23
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 2007;8:519-29.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
24
-
-
10644233167
-
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
-
Marciniak SJ, Yun CY, Oyadomari S, et al. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev 2004;18:3066-77.
-
(2004)
Genes Dev
, vol.18
, pp. 3066-3077
-
-
Marciniak, S.J.1
Yun, C.Y.2
Oyadomari, S.3
-
25
-
-
36049049392
-
IRE1 signaling affects cell fate during the unfolded protein response
-
Lin JH, Li H, Yasumura D, et al. IRE1 signaling affects cell fate during the unfolded protein response. Science 2007;318:944-9.
-
(2007)
Science
, vol.318
, pp. 944-949
-
-
Lin, J.H.1
Li, H.2
Yasumura, D.3
-
26
-
-
68149169939
-
Co-treatment with heat shock protein 90 inhibitor 17- dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and vorinostat: A highly active combination against human mantle cell lymphoma (MCL) cells
-
Rao R, Lee P, Fiskus W, et al. Co-treatment with heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and vorinostat: a highly active combination against human mantle cell lymphoma (MCL) cells. Cancer Biol Ther 2009;8:1273-80.
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 1273-1280
-
-
Rao, R.1
Lee, P.2
Fiskus, W.3
-
27
-
-
34547137412
-
Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas
-
Lwin T, Hazlehurst LA, Dessureault S, et al. Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas. Blood 2007;110:1631-8.
-
(2007)
Blood
, vol.110
, pp. 1631-1638
-
-
Lwin, T.1
Hazlehurst, L.A.2
Dessureault, S.3
-
28
-
-
0032576605
-
Aggresomes: A cellular response to misfolded proteins
-
Johnston JA, Ward CL, Kopito RR. Aggresomes: a cellular response to misfolded proteins. J Cell Biol 1998;143:1883-98.
-
(1998)
J Cell Biol
, vol.143
, pp. 1883-1898
-
-
Johnston, J.A.1
Ward, C.L.2
Kopito, R.R.3
-
30
-
-
58449084895
-
Divergent effects of PERK and IRE1 signaling on cell viability
-
Lin JH, Li H, Zhang Y, Ron D, Walter P. Divergent effects of PERK and IRE1 signaling on cell viability. PLoS One 2009;4:e4170.
-
(2009)
PLoS One
, vol.4
-
-
Lin, J.H.1
Li, H.2
Zhang, Y.3
Ron, D.4
Walter, P.5
-
31
-
-
0035947778
-
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2α
-
Novoa I, Zeng H, Harding HP, Ron D. Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2α. J Cell Biol 2001;153:1011-22.
-
(2001)
J Cell Biol
, vol.153
, pp. 1011-1022
-
-
Novoa, I.1
Zeng, H.2
Harding, H.P.3
Ron, D.4
-
32
-
-
0037416211
-
Stress-induced gene expression requires programmed recovery from translational repression
-
Novoa I, Zhang Y, Zeng H, Jungreis R, Harding HP, Ron D. Stress-induced gene expression requires programmed recovery from translational repression. EMBO J 2003;22:1180-7.
-
(2003)
EMBO J
, vol.22
, pp. 1180-1187
-
-
Novoa, I.1
Zhang, Y.2
Zeng, H.3
Jungreis, R.4
Harding, H.P.5
Ron, D.6
-
33
-
-
34548416641
-
HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates
-
Boyault C, Zhang Y, Fritah S, et al. HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev 2007;21:2172-81.
-
(2007)
Genes Dev
, vol.21
, pp. 2172-2181
-
-
Boyault, C.1
Zhang, Y.2
Fritah, S.3
-
34
-
-
38349195601
-
HDAC6 a new cellular stress surveillance factor
-
Matthias P, Yoshida M, Khochbin S. HDAC6 a new cellular stress surveillance factor. Cell Cycle 2008;7:7-10.
-
(2008)
Cell Cycle
, vol.7
, pp. 7-10
-
-
Matthias, P.1
Yoshida, M.2
Khochbin, S.3
-
35
-
-
14944371187
-
The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis
-
Zhang K, Wong HN, Song B, Miller CN, Scheuner D, Kaufman RJ. The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis. J Clin Invest 2005;115:268-81.
-
(2005)
J Clin Invest
, vol.115
, pp. 268-281
-
-
Zhang, K.1
Wong, H.N.2
Song, B.3
Miller, C.N.4
Scheuner, D.5
Kaufman, R.J.6
-
36
-
-
0035913294
-
Plasma cell differentiation requires the transcription factor XBP-1
-
Reimold AM, Iwakoshi NN, Manis J, et al. Plasma cell differentiation requires the transcription factor XBP-1. Nature 2001;412:300-7.
-
(2001)
Nature
, vol.412
, pp. 300-307
-
-
Reimold, A.M.1
Iwakoshi, N.N.2
Manis, J.3
-
37
-
-
34047136169
-
The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis
-
Carrasco DR, Sukhdeo K, Protopopova M, et al. The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell 2007;11:349-60.
-
(2007)
Cancer Cell
, vol.11
, pp. 349-360
-
-
Carrasco, D.R.1
Sukhdeo, K.2
Protopopova, M.3
-
38
-
-
74049142026
-
The use of novel agents in the treatment of relapsed and refractory multiple myeloma
-
Laubach JP, Mahindra A, Mitsiades CS, et al. The use of novel agents in the treatment of relapsed and refractory multiple myeloma. Leukemia 2009;23:2222-32.
-
(2009)
Leukemia
, vol.23
, pp. 2222-2232
-
-
Laubach, J.P.1
Mahindra, A.2
Mitsiades, C.S.3
-
39
-
-
64749088834
-
Emerging treatments for multiple myeloma: Beyond immunomodulatory drugs and bortezomib
-
Mitsiades CS, Hideshima T, Chauhan D, et al. Emerging treatments for multiple myeloma: beyond immunomodulatory drugs and bortezomib. Semin Hematol 2009;46:166-75.
-
(2009)
Semin Hematol
, vol.46
, pp. 166-175
-
-
Mitsiades, C.S.1
Hideshima, T.2
Chauhan, D.3
-
40
-
-
33751172982
-
Aggresome induction by proteasome inhibitor bortezomib and α-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells
-
Catley L, Weisberg E, Kiziltepe T, et al. Aggresome induction by proteasome inhibitor bortezomib and α-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells. Blood 2006;108:3441-9.
-
(2006)
Blood
, vol.108
, pp. 3441-3449
-
-
Catley, L.1
Weisberg, E.2
Kiziltepe, T.3
-
41
-
-
53049110009
-
Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA
-
Nawrocki ST, Carew JS, Maclean KH, et al. Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA. Blood 2008;112:2917-26.
-
(2008)
Blood
, vol.112
, pp. 2917-2926
-
-
Nawrocki, S.T.1
Carew, J.S.2
Maclean, K.H.3
-
42
-
-
60549109872
-
ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells
-
Wang Q, Mora-Jensen H, Weniger MA, et al. ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proc Natl Acad Sci U S A 2009;106:2200-5.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 2200-2205
-
-
Wang, Q.1
Mora-Jensen, H.2
Weniger, M.A.3
-
43
-
-
34250758642
-
ER stress triggers apoptosis by activating BH3-only protein Bim
-
Puthalakath H, O'Reilly LA, Gunn P. ER stress triggers apoptosis by activating BH3-only protein Bim. Cell 2007;129:1337-49.
-
(2007)
Cell
, vol.129
, pp. 1337-1349
-
-
Puthalakath, H.1
O'Reilly, L.A.2
Gunn, P.3
-
44
-
-
38949105902
-
Interactions between bortezomib and romidepsin and belinostat in chronic lymphocytic leukemia cells
-
Dai Y, Chen S, Kramer LB, Funk VL, Dent P, Grant S. Interactions between bortezomib and romidepsin and belinostat in chronic lymphocytic leukemia cells. Clin Cancer Res 2009;14:549-58.
-
(2009)
Clin Cancer Res
, vol.14
, pp. 549-558
-
-
Dai, Y.1
Chen, S.2
Kramer, L.B.3
Funk, V.L.4
Dent, P.5
Grant, S.6
-
45
-
-
57349198343
-
Control of cellular GADD34 levels by the 26S proteasome
-
Brush MH, Shenolikar S. Control of cellular GADD34 levels by the 26S proteasome. Mol Cell Biol 2008;28:6989-7000.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 6989-7000
-
-
Brush, M.H.1
Shenolikar, S.2
-
46
-
-
69349097803
-
Phase I study of vorinostat in combination with bortezomib for relapsed and refractory multiple myeloma
-
Badros A, Burger AM, Philip S, et al. Phase I study of vorinostat in combination with bortezomib for relapsed and refractory multiple myeloma. Clin Cancer Res 2009;15:5250-7.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5250-5257
-
-
Badros, A.1
Burger, A.M.2
Philip, S.3
|