메뉴 건너뛰기




Volumn 25, Issue 4, 1999, Pages 324-331

Occurrence of the diffuse amyloid β-protein (Aβ) deposits with numerous Aβ-containing glial cells in the cerebral cortex of patients with Alzheimer's disease

Author keywords

A 40; Astrocytes; Clearance; Degradation; Microglia; Uptake

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 43); AMYLOID BETA-PROTEIN (1-43); AUTACOID; BIOLOGICAL MARKER; PEPTIDE FRAGMENT;

EID: 0033557386     PISSN: 08941491     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1136(19990215)25:4<324::AID-GLIA2>3.0.CO;2-5     Document Type: Article
Times cited : (105)

References (34)
  • 1
    • 0025162755 scopus 로고
    • Brain microglia constitutively express β-2 integrins
    • Akiyama H, McGeer PL. 1990. Brain microglia constitutively express β-2 integrins. J Neuroimmunol 30:81-93.
    • (1990) J Neuroimmunol , vol.30 , pp. 81-93
    • Akiyama, H.1    McGeer, P.L.2
  • 2
    • 0027219569 scopus 로고
    • Expression of intercellular adhesion molecule(ICAM)-1 by a subset of astrocytes in Alzheimer and some other degenerative neurological disorders
    • Akiyama H, Kawamata T, Yamada T, Tooyama I, Ishii T, McGeer PL. 1993a. Expression of intercellular adhesion molecule(ICAM)-1 by a subset of astrocytes in Alzheimer and some other degenerative neurological disorders. Acta Neuropathol 85:628-634.
    • (1993) Acta Neuropathol , vol.85 , pp. 628-634
    • Akiyama, H.1    Kawamata, T.2    Yamada, T.3    Tooyama, I.4    Ishii, T.5    McGeer, P.L.6
  • 3
    • 0027751737 scopus 로고
    • Morphological diversities of CD44 positive astrocytes in the cerebral cortex of normal subjects and patients with Alzheimer's disease
    • Akiyama H, Tooyama I, Kawamata T, Ikeda K, McGeer PL. 1993b. Morphological diversities of CD44 positive astrocytes in the cerebral cortex of normal subjects and patients with Alzheimer's disease. Brain Res 632:249-259.
    • (1993) Brain Res , vol.632 , pp. 249-259
    • Akiyama, H.1    Tooyama, I.2    Kawamata, T.3    Ikeda, K.4    McGeer, P.L.5
  • 4
    • 0028261779 scopus 로고
    • Expression of MRP14, 27E10, alpha-interferon and leucocyte common antigen by reactive microglia in postmortem human brain tissue
    • Akiyama H, Ikeda K, Katoh M, McGeer EG, McGeer PL. 1994. Expression of MRP14, 27E10, alpha-interferon and leucocyte common antigen by reactive microglia in postmortem human brain tissue. J Neuroimmunol 50:195-202.
    • (1994) J Neuroimmunol , vol.50 , pp. 195-202
    • Akiyama, H.1    Ikeda, K.2    Katoh, M.3    McGeer, E.G.4    McGeer, P.L.5
  • 5
    • 0030003487 scopus 로고    scopus 로고
    • Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of β-amyloid protein
    • Akiyama H, Schwab C, Mori H, Kametani F, McGeer PL. 1996a. Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of β-amyloid protein. Neurosci Lett 206:169-172.
    • (1996) Neurosci Lett , vol.206 , pp. 169-172
    • Akiyama, H.1    Schwab, C.2    Mori, H.3    Kametani, F.4    McGeer, P.L.5
  • 6
    • 0030598393 scopus 로고    scopus 로고
    • The amino-terminally truncated forms of amyloid β-protein in brain macrophages in the ischemic lesions of Alzheimer's disease patients
    • Akiyama H, Kondo H, Mori H, Kametani F, Nishimura T, Ikeda K, Kato M, McGeer PL. 1996b. The amino-terminally truncated forms of amyloid β-protein in brain macrophages in the ischemic lesions of Alzheimer's disease patients. Neurosci Lett 219:115-118.
    • (1996) Neurosci Lett , vol.219 , pp. 115-118
    • Akiyama, H.1    Kondo, H.2    Mori, H.3    Kametani, F.4    Nishimura, T.5    Ikeda, K.6    Kato, M.7    McGeer, P.L.8
  • 8
    • 0030038809 scopus 로고    scopus 로고
    • Scavenging of Alzheimer's amyloid β-protein by microglia in culture
    • Ard MD, Cole GM, Wei J, Mehrle AP, Fratkin JD. 1996. Scavenging of Alzheimer's amyloid β-protein by microglia in culture. J Neurosci Res 43:190-202.
    • (1996) J Neurosci Res , vol.43 , pp. 190-202
    • Ard, M.D.1    Cole, G.M.2    Wei, J.3    Mehrle, A.P.4    Fratkin, J.D.5
  • 10
    • 0028891760 scopus 로고
    • The COOH-terminus of the Alzheimer amyloid Aβ peptide: Differences in length influence the process of amyloid deposition in Alzheimer brain and tell us something about relationships among parent
    • Greenberg BD. 1995. The COOH-terminus of the Alzheimer amyloid Aβ peptide: differences in length influence the process of amyloid deposition in Alzheimer brain and tell us something about relationships among parent. Amyloid Int J Exp Clin Invest 2:195-203.
    • (1995) Amyloid Int J Exp Clin Invest , vol.2 , pp. 195-203
    • Greenberg, B.D.1
  • 12
    • 0024436506 scopus 로고
    • Relationship of microglia and astrocytes to amyloid deposits in Alzheimer disease
    • Itagaki S, McGeer PL, Akiyama H, Zhu S, and Selkoe DJ. 1989. Relationship of microglia and astrocytes to amyloid deposits in Alzheimer disease. J Neuroimmunol 224:173-182.
    • (1989) J Neuroimmunol , vol.224 , pp. 173-182
    • Itagaki, S.1    McGeer, P.L.2    Akiyama, H.3    Zhu, S.4    Selkoe, D.J.5
  • 13
    • 0028169925 scopus 로고
    • Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)
    • Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. 1994. Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: evidence that an initially deposited species is Aβ42(43). Neuron 13:45-53.
    • (1994) Neuron , vol.13 , pp. 45-53
    • Iwatsubo, T.1    Odaka, A.2    Suzuki, N.3    Mizusawa, H.4    Nukina, N.5    Ihara, Y.6
  • 14
    • 0029849644 scopus 로고    scopus 로고
    • Full-length amyloid-β(1-42(43)) and amino-terminally modified and truncated amyloid-β42(43) deposit in diffuse plaques
    • Iwatsubo T, Saido T, Mann DMA, Lee VM-Y, Trojanowski JQ. 1996. Full-length amyloid-β(1-42(43)) and amino-terminally modified and truncated amyloid-β42(43) deposit in diffuse plaques. Am J Pathol 149:1823-1830.
    • (1996) Am J Pathol , vol.149 , pp. 1823-1830
    • Iwatsubo, T.1    Saido, T.2    Mann, D.M.A.3    Lee, V.M.-Y.4    Trojanowski, J.Q.5
  • 15
    • 0027258525 scopus 로고
    • The carboxy terminus of the β amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
    • Jarrett JT, Berger EP, Lansbury Jr PT. 1993. The carboxy terminus of the β amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 32:4693-4697.
    • (1993) Biochemistry , vol.32 , pp. 4693-4697
    • Jarrett, J.T.1    Berger, E.P.2    Lansbury P.T., Jr.3
  • 16
    • 0027195933 scopus 로고
    • Seeding "one-dimensional crystallization" of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
    • Jarrett JT, Lansbury Jr. PT. 1993. Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? Cell 73:1055-1058.
    • (1993) Cell , vol.73 , pp. 1055-1058
    • Jarrett, J.T.1    Lansbury P.T., Jr.2
  • 17
    • 0029980902 scopus 로고    scopus 로고
    • Amyloid precursor protein metabolism in primary cell cultures of neurons astrocytes, and microglia
    • LeBlanc AC, Xue R, Gambetti P. 1996. Amyloid precursor protein metabolism in primary cell cultures of neurons astrocytes, and microglia. J Neurochem 66:2300-2310.
    • (1996) J Neurochem , vol.66 , pp. 2300-2310
    • LeBlanc, A.C.1    Xue, R.2    Gambetti, P.3
  • 19
    • 0031044352 scopus 로고    scopus 로고
    • Degradation of Alzheimer's β-amyloid protein by human and rat brain peptidases
    • McDermott JR, Gibson AM. 1997. Degradation of Alzheimer's β-amyloid protein by human and rat brain peptidases. Neurochem Res 22:49-56.
    • (1997) Neurochem Res , vol.22 , pp. 49-56
    • McDermott, J.R.1    Gibson, A.M.2
  • 20
    • 0026794746 scopus 로고
    • Mass spectrometry of purified amyloid β protein in Alzheimer's disease
    • Mori H, Takio K, Ogawara M, Selkoe DJ. 1992. Mass spectrometry of purified amyloid β protein in Alzheimer's disease. J Biol Chem 267:17082-17086.
    • (1992) J Biol Chem , vol.267 , pp. 17082-17086
    • Mori, H.1    Takio, K.2    Ogawara, M.3    Selkoe, D.J.4
  • 21
    • 0028985061 scopus 로고
    • β -Amyloid peptide produced in vitro is degraded bv proteinases released by cultured cells
    • Naidu A, Quon D, Cordell B. 1995. β -Amyloid peptide produced in vitro is degraded bv proteinases released by cultured cells. J Biol Chem 270:1369-1374.
    • (1995) J Biol Chem , vol.270 , pp. 1369-1374
    • Naidu, A.1    Quon, D.2    Cordell, B.3
  • 22
    • 0028106152 scopus 로고
    • Relative abundance of Alzheimer abeta amyloid peptide variants in Alzheimer disease and normal aging
    • Naslund J, Schierhorn A, Hellman U, Lannfelt L, Roses AD. 1994. Relative Abundance of Alzheimer Abeta Amyloid peptide variants in Alzheimer Disease and Normal Aging. Proc Natl Acad Sci USA 91:8378-8382.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 8378-8382
    • Naslund, J.1    Schierhorn, A.2    Hellman, U.3    Lannfelt, L.4    Roses, A.D.5
  • 23
    • 0030248270 scopus 로고    scopus 로고
    • Microglial cells internalize aggregates of the Alzheimer's disease amyloid β-protein via a scavenger receptor
    • Paresce DM, Ghosh RN, Maxfield FR. 1996. Microglial cells internalize aggregates of the Alzheimer's disease amyloid β-protein via a scavenger receptor. Neuron 17:553-565.
    • (1996) Neuron , vol.17 , pp. 553-565
    • Paresce, D.M.1    Ghosh, R.N.2    Maxfield, F.R.3
  • 25
    • 1842367306 scopus 로고    scopus 로고
    • Degradation of amyloid β-protein by metalloprotease secreted by microglia and other neural and non-neural cells
    • Qiu WQ, Ye Z, Kholodenko D, Seubert P, Selkoe DJ. 1997. Degradation of amyloid β-protein by metalloprotease secreted by microglia and other neural and non-neural cells. J Biol Chem 272:6641-6646.
    • (1997) J Biol Chem , vol.272 , pp. 6641-6646
    • Qiu, W.Q.1    Ye, Z.2    Kholodenko, D.3    Seubert, P.4    Selkoe, D.J.5
  • 27
    • 0030582387 scopus 로고    scopus 로고
    • Amino-and carboxyl-terminal heterogeneity of ß-amyloid peptides deposited in human brain
    • Saido TC, Yamao-Harigaya W, Iwatsubo T, Kawashima S. 1996. Amino-and carboxyl-terminal heterogeneity of ß-amyloid peptides deposited in human brain. Neurosci Lett 215:173-176.
    • (1996) Neurosci Lett , vol.215 , pp. 173-176
    • Saido, T.C.1    Yamao-Harigaya, W.2    Iwatsubo, T.3    Kawashima, S.4
  • 28
    • 0029199677 scopus 로고
    • Elevated Aβ levels in Alzheimer's disease brain are associated with selective accumulation of Aβ(42) in parenchymal amyloid plaques and both Aβ(40) and Aβ(42) in cerebrovascular deposits
    • Savage MJ, Kawooya JK, Pinsker LR, Emmons TL, Mistretta S, Siman R, Greenberg BD. 1995. Elevated Aβ levels in Alzheimer's disease brain are associated with selective accumulation of Aβ(42) in parenchymal amyloid plaques and both Aβ(40) and Aβ(42) in cerebrovascular deposits. Amyloid Int J Exp Clin Invest 2:234-240.
    • (1995) Amyloid Int J Exp Clin Invest , vol.2 , pp. 234-240
    • Savage, M.J.1    Kawooya, J.K.2    Pinsker, L.R.3    Emmons, T.L.4    Mistretta, S.5    Siman, R.6    Greenberg, B.D.7
  • 29
    • 0028267440 scopus 로고
    • Normal and abnormal biology of the β-amyloid precursor protein
    • Selkoe DJ. 1994. Normal and abnormal biology of the β-amyloid precursor protein. Annu Rev Neurosci 17:489-517.
    • (1994) Annu Rev Neurosci , vol.17 , pp. 489-517
    • Selkoe, D.J.1
  • 31
    • 0029935765 scopus 로고    scopus 로고
    • Amyloidogenic processing of the human amyloid precursor protein in primary culture of rat hippocampal neurons
    • Simons M, de Strooper B, Multhaup G, Tienari PJ, Dotti CG, Beyreuther K. 1996. Amyloidogenic processing of the human amyloid precursor protein in primary culture of rat hippocampal neurons. J Neurosci 16:899-908.
    • (1996) J Neurosci , vol.16 , pp. 899-908
    • Simons, M.1    De Strooper, B.2    Multhaup, G.3    Tienari, P.J.4    Dotti, C.G.5    Beyreuther, K.6
  • 32
    • 0028922520 scopus 로고
    • Amyloid β-protein 1-42/43 (Aβ1-42/43) in cerebellar diffuse plaques: Enzyme-linked immunosorbent assay and immunocytochemical study
    • Tamaoka A, Sawamura N, Odaka A, Suzuki N, Mizusawa H, Shoji S, Mori H. 1995. Amyloid ß-protein 1-42/43 (Aβ1-42/43) in cerebellar diffuse plaques: enzyme-linked immunosorbent assay and immunocytochemical study. Brain Res 679:151-156.
    • (1995) Brain Res , vol.679 , pp. 151-156
    • Tamaoka, A.1    Sawamura, N.2    Odaka, A.3    Suzuki, N.4    Mizusawa, H.5    Shoji, S.6    Mori, H.7
  • 33
    • 0029167555 scopus 로고
    • Immunohistochemical analysis of COOH-termini of amyloid β protein (Aβ) using end-specific antisera for Aβ40 and Aβ42 in Alzheimer's disease and normal aging
    • Yamaguchi H, Sugihara S, Ishiguro K, Takashima A, Hirai S. 1995. Immunohistochemical analysis of COOH-termini of amyloid β protein (Aβ) using end-specific antisera for Aβ40 and Aβ42 in Alzheimer's disease and normal aging. Amyloid Int J Exp Clin Invest 2:7-16.
    • (1995) Amyloid Int J Exp Clin Invest , vol.2 , pp. 7-16
    • Yamaguchi, H.1    Sugihara, S.2    Ishiguro, K.3    Takashima, A.4    Hirai, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.