Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease

Journal of Neuroscience

Volumn 25, Issue 21, 2005, Pages 5217-5224

  Jankowsky, Joanna L ^a,c   Melnikova, Tatiana ^a   Fadale, Daniel J ^b   Xu, Guilian M ^a   Slunt, Hilda H ^a   Gonzales, Victoria ^a   Younkin, Linda H ^b   Younkin, Steven G ^b   Borchelt, David R ^a,d   Savonenko, Alena V ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

^c CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

A ; Alzheimer's disease; Amyloid precursor protein; Cognitive behavior; Environmental enrichment; Transgenic mouse

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN;

ACADEMIC ACHIEVEMENT; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL HOUSING; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; ENVIRONMENTAL IMPACT ASSESSMENT; EPIDEMIOLOGICAL DATA; FEMALE; GENE OVEREXPRESSION; GENOTYPE; HIGH RISK POPULATION; HIPPOCAMPUS; IN VIVO STUDY; LEARNING DISORDER; MAZE TEST; MEMORY DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; TASK PERFORMANCE; TRANSGENIC MOUSE;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; ENVIRONMENT; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; MAZE LEARNING; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PRESENILIN-1; TIME FACTORS;

EID: 21144456098     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5080-04.2005     Document Type: Article

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