메뉴 건너뛰기




Volumn 17, Issue 6 PART B, 2012, Pages 1147-1162

Antiviral resistance and direct-acting antiviral agents for HCV

Author keywords

[No Author keywords available]

Indexed keywords

2' DEOXY 2' FLUORO 2' METHYLCYTIDINE; ABT 333; ANTIINFECTIVE AGENT; ANTIVIRUS AGENT; BI 207127; BILB 1941; BOCEPREVIR; CILUPREVIR; CYCLOSPORIN A; DACLATASVIR; DANOPREVIR; FALDAPREVIR; FILIBUVIR; GSK 625433; INX 189; INX 198; LOMIBUVIR; MERICITABINE; NARLAPREVIR; NESBUVIR; PEGINTERFERON ALPHA; PYROPHOSPHORIC ACID DERIVATIVE; RG 7277; RIBAVIRIN; SETROBUVIR; SOFOSBUVIR; TEGOBUVIR; TELAPREVIR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANIPREVIR; VCH 759; VCH 916;

EID: 84867253952     PISSN: 13596535     EISSN: 20402058     Source Type: Journal    
DOI: 10.3851/IMP2426     Document Type: Review
Times cited : (24)

References (115)
  • 1
    • 0032475822 scopus 로고    scopus 로고
    • Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy
    • Medline doi:10.1126/science.282.5386.103
    • Neumann AU, Lam NP, Dahari H, et al. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. Science 1998; 282: 103-107. Medline doi:10.1126/science.282.5386.103
    • (1998) Science , vol.282 , pp. 103-107
    • Neumann, A.U.1    Lam, N.P.2    Dahari, H.3
  • 2
    • 0033854644 scopus 로고    scopus 로고
    • Hepatitis C kinetics: Mathematical modeling of viral response to therapy
    • Medline doi:10.1055/s-2000-9940
    • Layden TJ, Mika B, Wiley TE. Hepatitis C kinetics: mathematical modeling of viral response to therapy. Semin Liver Dis 2000; 20: 173-183. Medline doi:10.1055/s-2000-9940
    • (2000) Semin Liver Dis , vol.20 , pp. 173-183
    • Layden, T.J.1    Mika, B.2    Wiley, T.E.3
  • 3
    • 80053081987 scopus 로고    scopus 로고
    • Genetic heterogeneity of hepatitis C virus in association with antiviral therapy determined by ultra-deep sequencing
    • Medline doi:10.1371/journal.pone.0024907
    • Nasu A, Marusawa H, Ueda Y, et al. Genetic heterogeneity of hepatitis C virus in association with antiviral therapy determined by ultra-deep sequencing. PLoS ONE 2011; 6: e24907. Medline doi:10.1371/journal.pone.0024907
    • (2011) PLoS ONE , vol.6
    • Nasu, A.1    Marusawa, H.2    Ueda, Y.3
  • 4
    • 51749123143 scopus 로고    scopus 로고
    • Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3.4A protease inhibitors in treatment-naive subjects
    • Medline doi:10.1086/591141
    • Bartels DJ, Zhou Y, Zhang EZ, et al. Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3.4A protease inhibitors in treatment-naive subjects. J Infect Dis 2008; 198: 800-807. Medline doi:10.1086/591141
    • (2008) J Infect Dis , vol.198 , pp. 800-807
    • Bartels, D.J.1    Zhou, Y.2    Zhang, E.Z.3
  • 5
    • 61849168549 scopus 로고    scopus 로고
    • Temporal dynamics of a predominant protease inhibitor-resistance mutation in a treatment-naive, hepatitis C virus-infected individual
    • Medline doi:10.1086/596657
    • Kim AY, Timm J, Nolan BE, et al. Temporal dynamics of a predominant protease inhibitor-resistance mutation in a treatment-naive, hepatitis C virus-infected individual. J Infect Dis 2009; 199: 737-741. Medline doi:10.1086/596657
    • (2009) J Infect Dis , vol.199 , pp. 737-741
    • Kim, A.Y.1    Timm, J.2    Nolan, B.E.3
  • 6
    • 36549028822 scopus 로고    scopus 로고
    • Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient
    • Medline doi:10.1016/j.virol.2007.10.006
    • Cubero M, Esteban JI, Otero T, et al. Naturally occurring NS3-protease-inhibitor resistant mutant A156T in the liver of an untreated chronic hepatitis C patient. Virology 2008; 370: 237-245. Medline doi:10.1016/j.virol.2007.10.006
    • (2008) Virology , vol.370 , pp. 237-245
    • Cubero, M.1    Esteban, J.I.2    Otero, T.3
  • 7
    • 77952709675 scopus 로고    scopus 로고
    • Hepatitis C virus transmission bottlenecks analyzed by deep sequencing
    • Medline doi:10.1128/JVI.02271-09
    • Wang GP, Sherrill-Mix SA, Chang KM, Quince C, Bushman FD. Hepatitis C virus transmission bottlenecks analyzed by deep sequencing. J Virol 2010; 84: 6218-6228. Medline doi:10.1128/JVI.02271-09
    • (2010) J Virol , vol.84 , pp. 6218-6228
    • Wang, G.P.1    Sherrill-Mix, S.A.2    Chang, K.M.3    Quince, C.4    Bushman, F.D.5
  • 8
    • 77957965126 scopus 로고    scopus 로고
    • Tracking the evolution of multiple in vitro hepatitis C virus replicon variants under protease inhibitor selection pressure by 454 deep sequencing
    • Medline doi:10.1128/JVI.01217-10
    • Verbinnen T, Van Marck H, Vandenbroucke I, et al. Tracking the evolution of multiple in vitro hepatitis C virus replicon variants under protease inhibitor selection pressure by 454 deep sequencing. J Virol 2010; 84: 11124-11133. Medline doi:10.1128/JVI.01217-10
    • (2010) J Virol , vol.84 , pp. 11124-11133
    • Verbinnen, T.1    Van Marck, H.2    Vandenbroucke, I.3
  • 9
    • 80053439798 scopus 로고    scopus 로고
    • Sequential bottlenecks drive viral evolution in early acute hepatitis C virus infection
    • Medline doi:10.1371/journal.ppat.1002243
    • Bull RA, Luciani F, McElroy K, et al. Sequential bottlenecks drive viral evolution in early acute hepatitis C virus infection. PLoS Pathog 2011; 7: e1002243. Medline doi:10.1371/journal.ppat.1002243
    • (2011) PLoS Pathog , vol.7
    • Bull, R.A.1    Luciani, F.2    McElroy, K.3
  • 10
    • 58149388300 scopus 로고    scopus 로고
    • Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naive patients
    • Medline doi:10.1002/hep.22549
    • Kuntzen T, Timm J, Berical A, et al. Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naive patients. Hepatology 2008; 48: 1769-1778. Medline doi:10.1002/hep.22549
    • (2008) Hepatology , vol.48 , pp. 1769-1778
    • Kuntzen, T.1    Timm, J.2    Berical, A.3
  • 11
    • 34547236950 scopus 로고    scopus 로고
    • Genetic barriers to resistance and impact on clinical response
    • Medline doi:10.1186/1758-2652-7-3-69
    • Luber AD. Genetic barriers to resistance and impact on clinical response. J Int AIDS Soc 2005; 7: 69. Medline doi:10.1186/1758-2652-7-3-69
    • (2005) J Int AIDS Soc , vol.7 , pp. 69
    • Luber, A.D.1
  • 12
    • 77950848182 scopus 로고    scopus 로고
    • Development of an intergenotypic hepatitis C virus (HCV) cell culture method to assess antiviral susceptibilities and resistance development of HCV NS3 protease genes from HCV genotypes 1 to 6
    • Medline doi:10.1128/JVI.02698-09
    • Imhof I, Simmonds P. Development of an intergenotypic hepatitis C virus (HCV) cell culture method to assess antiviral susceptibilities and resistance development of HCV NS3 protease genes from HCV genotypes 1 to 6. J Virol 2010; 84: 4597-4610. Medline doi:10.1128/JVI.02698-09
    • (2010) J Virol , vol.84 , pp. 4597-4610
    • Imhof, I.1    Simmonds, P.2
  • 13
    • 80052123459 scopus 로고    scopus 로고
    • Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses
    • Medline doi:10.1053/j.gastro.2011.06.004
    • Gottwein JM, Scheel TK, Jensen TB, Ghanem L, Bukh J. Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses. Gastroenterology 2011; 141: 1067-1079. Medline doi:10.1053/j.gastro.2011.06.004
    • (2011) Gastroenterology , vol.141 , pp. 1067-1079
    • Gottwein, J.M.1    Scheel, T.K.2    Jensen, T.B.3    Ghanem, L.4    Bukh, J.5
  • 14
    • 78349268362 scopus 로고    scopus 로고
    • RG7128 alone or in combination with pegylated interferon-alpha2a and ribavirin prevents hepatitis C virus (HCV) replication and selection of resistant variants in HCV-infected patients
    • Medline doi:10.1086/656774
    • Le Pogam S, Seshaadri A, Ewing A, et al. RG7128 alone or in combination with pegylated interferon-alpha2a and ribavirin prevents hepatitis C virus (HCV) replication and selection of resistant variants in HCV-infected patients. J Infect Dis 2010; 202: 1510-1519. Medline doi:10.1086/656774
    • (2010) J Infect Dis , vol.202 , pp. 1510-1519
    • Le Pogam, S.1    Seshaadri, A.2    Ewing, A.3
  • 15
    • 34247594930 scopus 로고    scopus 로고
    • Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir
    • Medline doi:10.1053/j.gastro.2007.02.037
    • Sarrazin C, Kieffer TL, Bartels D, et al. Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir. Gastroenterology 2007; 132: 1767-1777. Medline doi:10.1053/j. gastro.2007.02.037
    • (2007) Gastroenterology , vol.132 , pp. 1767-1777
    • Sarrazin, C.1    Kieffer, T.L.2    Bartels, D.3
  • 16
    • 66149128046 scopus 로고    scopus 로고
    • GT-1a or GT-1b subtype-specific resistance profiles for hepatitis C virus inhibitors telaprevir and HCV-796
    • Medline doi:10.1128/AAC.01598-08
    • McCown MF, Rajyaguru S, Kular S, Cammack N, Najera I. GT-1a or GT-1b subtype-specific resistance profiles for hepatitis C virus inhibitors telaprevir and HCV-796. Antimicrob Agents Chemother 2009; 53: 2129-2132. Medline doi:10.1128/AAC.01598-08
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 2129-2132
    • McCown, M.F.1    Rajyaguru, S.2    Kular, S.3    Cammack, N.4    Najera, I.5
  • 17
    • 34548758435 scopus 로고    scopus 로고
    • Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients
    • Medline doi:10.1002/hep.21781
    • Kieffer TL, Sarrazin C, Miller JS, et al. Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients. Hepatology 2007; 46: 631-639. Medline doi:10.1002/hep.21781
    • (2007) Hepatology , vol.46 , pp. 631-639
    • Kieffer, T.L.1    Sarrazin, C.2    Miller, J.S.3
  • 18
    • 84455173090 scopus 로고    scopus 로고
    • Virologic escape during danoprevir (ITMN-191/RG7227) monotherapy is hepatitis C virus subtype dependent and associated with R155K substitution
    • Medline doi:10.1128/AAC.05636-11
    • Lim SR, Qin X, Susser S, et al . Virologic escape during danoprevir (ITMN-191/RG7227) monotherapy is hepatitis C virus subtype dependent and associated with R155K substitution. Antimicrob Agents Chemother 2012; 56: 271-279. Medline doi:10.1128/AAC.05636-11
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 271-279
    • Lim, S.R.1    Qin, X.2    Susser, S.3
  • 19
    • 67649671594 scopus 로고    scopus 로고
    • Hepatitis C virus compartmentalization and infection recurrence after liver transplantation
    • Medline doi:10.1111/j.1600-6143.2009.02666.x
    • Ramirez S, Perez-Del-Pulgar S, Carrion JA, et al. Hepatitis C virus compartmentalization and infection recurrence after liver transplantation. Am J Transplant 2009; 9: 1591-1601. Medline doi:10.1111/j.1600-6143.2009.02666.x
    • (2009) Am J Transplant , vol.9 , pp. 1591-1601
    • Ramirez, S.1    Perez-Del-Pulgar, S.2    Carrion, J.A.3
  • 20
    • 0029892133 scopus 로고    scopus 로고
    • Detection of hepatitis C virus (HCV) proteins by immunofluorescence and HCV RNA genomic sequences by non-isotopic in situ hybridization in bone marrow and peripheral blood mononuclear cells of chronically HCV-infected patients
    • Medline doi:10.1111/j.1365-2249.1996.tb08296.x
    • Sansonno D, Iacobelli AR, Cornacchiulo V, Iodice G, Dammacco F. Detection of hepatitis C virus (HCV) proteins by immunofluorescence and HCV RNA genomic sequences by non-isotopic in situ hybridization in bone marrow and peripheral blood mononuclear cells of chronically HCV-infected patients. Clin Exp Immunol 1996; 103: 414-421. Medline doi:10.1111/j.1365-2249.1996.tb08296.x
    • (1996) Clin Exp Immunol , vol.103 , pp. 414-421
    • Sansonno, D.1    Iacobelli, A.R.2    Cornacchiulo, V.3    Iodice, G.4    Dammacco, F.5
  • 21
    • 0033985942 scopus 로고    scopus 로고
    • Nucleotide and amino acid complexity of hepatitis C virus quasispecies in serum and liver
    • Medline doi:10.1128/JVI.74.2.805-811.2000
    • Cabot B, Martell M, Esteban JI, et al. Nucleotide and amino acid complexity of hepatitis C virus quasispecies in serum and liver. J Virol 2000; 74: 805-811. Medline doi:10.1128/JVI.74.2.805-811.2000
    • (2000) J Virol , vol.74 , pp. 805-811
    • Cabot, B.1    Martell, M.2    Esteban, J.I.3
  • 22
    • 0033135353 scopus 로고    scopus 로고
    • Comparison of genetic heterogeneity of hepatitis C viral RNA in liver tissue and serum
    • Medline doi:10.1111/j.1572-0241.1999.01085.x
    • Fan X, Solomon H, Poulos JE, Neuschwander-Tetri BA, Di Bisceglie AM. Comparison of genetic heterogeneity of hepatitis C viral RNA in liver tissue and serum. Am J Gastroenterol 1999; 94: 1347-1354. Medline doi:10.1111/j.1572-0241. 1999.01085.x
    • (1999) Am J Gastroenterol , vol.94 , pp. 1347-1354
    • Fan, X.1    Solomon, H.2    Poulos, J.E.3    Neuschwander-Tetri, B.A.4    Di Bisceglie, A.M.5
  • 23
    • 79953905045 scopus 로고    scopus 로고
    • Nonstructural protein 3-4A: The Swiss army knife of hepatitis C virus
    • Medline doi:10.1111/j.1365-2893.2011.01451.x
    • Morikawa K, Lange CM, Gouttenoire J, et al. Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus. J Viral Hepat 2011; 18: 305-315. Medline doi:10.1111/j.1365-2893.2011.01451.x
    • (2011) J Viral Hepat , vol.18 , pp. 305-315
    • Morikawa, K.1    Lange, C.M.2    Gouttenoire, J.3
  • 24
    • 0037687422 scopus 로고    scopus 로고
    • Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease
    • Medline doi:10.1126/science.1082604
    • Foy E, Li K, Wang C, et al. Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science 2003; 300: 1145-1148. Medline doi:10.1126/science.1082604
    • (2003) Science , vol.300 , pp. 1145-1148
    • Foy, E.1    Li, K.2    Wang, C.3
  • 25
    • 0344201903 scopus 로고    scopus 로고
    • An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
    • Medline doi:10.1038/nature02099
    • Lamarre D, Anderson PC, Bailey M, et al. An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus. Nature 2003; 426: 186-189. Medline doi:10.1038/nature02099
    • (2003) Nature , vol.426 , pp. 186-189
    • Lamarre, D.1    Anderson, P.C.2    Bailey, M.3
  • 26
    • 7644232426 scopus 로고    scopus 로고
    • Short-term antiviral efficacy of BILN 2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype 1 patients
    • Medline doi:10.1053/j.gastro.2004.08.002
    • Hinrichsen H, Benhamou Y, Wedemeyer H, et al. Short-term antiviral efficacy of BILN 2061, a hepatitis C virus serine protease inhibitor, in hepatitis C genotype 1 patients. Gastroenterology 2004; 127: 1347-1355. Medline doi:10.1053/j.gastro.2004.08.002
    • (2004) Gastroenterology , vol.127 , pp. 1347-1355
    • Hinrichsen, H.1    Benhamou, Y.2    Wedemeyer, H.3
  • 27
    • 20144387727 scopus 로고    scopus 로고
    • Antiviral efficacy of NS3-serine protease inhibitor BILN-2061 in patients with chronic genotype 2 and 3 hepatitis C
    • Medline doi:10.1002/hep.20612
    • Reiser M, Hinrichsen H, Benhamou Y, et al. Antiviral efficacy of NS3-serine protease inhibitor BILN-2061 in patients with chronic genotype 2 and 3 hepatitis C. Hepatology 2005; 41: 832-835. Medline doi:10.1002/hep.20612
    • (2005) Hepatology , vol.41 , pp. 832-835
    • Reiser, M.1    Hinrichsen, H.2    Benhamou, Y.3
  • 28
    • 2342420348 scopus 로고    scopus 로고
    • In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: Structural analysis indicates different resistance mechanisms
    • Medline doi:10.1074/jbc.M313020200
    • Lin C, Lin K, Luong YP, et al. In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms. J Biol Chem 2004; 279: 17508-17514. Medline doi:10.1074/jbc.M313020200
    • (2004) J Biol Chem , vol.279 , pp. 17508-17514
    • Lin, C.1    Lin, K.2    Luong, Y.P.3
  • 29
    • 77949803029 scopus 로고    scopus 로고
    • Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor
    • Medline doi:10.1021/jm9015526
    • McCauley JA, McIntyre CJ, Rudd MT, et al. Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor. J Med Chem 2010; 53: 2443-2463. Medline doi:10.1021/jm9015526
    • (2010) J Med Chem , vol.53 , pp. 2443-2463
    • McCauley, J.A.1    McIntyre, C.J.2    Rudd, M.T.3
  • 30
    • 78751640008 scopus 로고    scopus 로고
    • Sustained viral response (SVR) rates in genotype 1 treatment-naive patients with chronic hepatitis C (CHC) infection treated with vaniprevir (MK-7009), a NS3/4A protease inhibitor, in combination with pegylated interferon alfa-2a and ribavirin for 28 days
    • Manns MP, Gane EJ, Rodriguez-Torres M, et al. Sustained viral response (SVR) rates in genotype 1 treatment-naive patients with chronic hepatitis C (CHC) infection treated with vaniprevir (MK-7009), a NS3/4A protease inhibitor, in combination with pegylated interferon alfa-2a and ribavirin for 28 days. Hepatology 2010; 52 Suppl 1: S361A.
    • (2010) Hepatology , vol.52 , Issue.SUPPL. 1
    • Manns, M.P.1    Gane, E.J.2    Rodriguez-Torres, M.3
  • 31
    • 80051916510 scopus 로고    scopus 로고
    • Antiviral activity, safety, and pharmacokinetics of danoprevir/ritonavir plus PEG-IFN alpha-2a/RBV in hepatitis C patients
    • Medline doi:10.1016/j.jhep.2011.01.046
    • Gane EJ, Rouzier R, Stedman C, et al. Antiviral activity, safety, and pharmacokinetics of danoprevir/ritonavir plus PEG-IFN alpha-2a/RBV in hepatitis C patients. J Hepatol 2011; 55: 972-979. Medline doi:10.1016/j.jhep.2011.01.046
    • (2011) J Hepatol , vol.55 , pp. 972-979
    • Gane, E.J.1    Rouzier, R.2    Stedman, C.3
  • 32
    • 84455161773 scopus 로고    scopus 로고
    • In vitro resistance profile of the hepatitis C virus NS3 protease inhibitor BI 201335
    • Medline doi:10.1128/AAC.05166-11
    • Lagacé L, White PW, Bousquet C, et al. In vitro resistance profile of the hepatitis C virus NS3 protease inhibitor BI 201335. Antimicrob Agents Chemother 2012; 56: 569-572. Medline doi:10.1128/AAC.05166-11
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 569-572
    • Lagacé, L.1    White, P.W.2    Bousquet, C.3
  • 33
    • 67650529545 scopus 로고    scopus 로고
    • BI 201335, a potent HCV NS3 protease inhibitor, in treatment-naive and experienced chronic HCV genotype-1 infection: Genotypic and phenotypic analysis of the NS3 protease domain
    • doi:10.1016/S0168-8278(09)60956-9
    • Kukolj G, Benhamou Y, Manns MP, et al. BI 201335, a potent HCV NS3 protease inhibitor, in treatment-naive and experienced chronic HCV genotype-1 infection: genotypic and phenotypic analysis of the NS3 protease domain. J Hepatol 2009; 50 Suppl 1: S347. doi:10.1016/S0168-8278(09)60956-9
    • (2009) J Hepatol , vol.50 , Issue.SUPPL. 1
    • Kukolj, G.1    Benhamou, Y.2    Manns, M.P.3
  • 34
    • 84861663637 scopus 로고    scopus 로고
    • In vitro antiviral activity of IDX320, a novel and potent macrocyclic HCV protease inhibitor
    • doi:10.1016/S0168-8278(10)60770-2
    • Lallos LB, McCarville J, Li B, et al. In vitro antiviral activity of IDX320, a novel and potent macrocyclic HCV protease inhibitor. J Hepatol 2010; 52 Suppl 1: S298. doi:10.1016/S0168-8278(10)60770-2
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Lallos, L.B.1    McCarville, J.2    Li, B.3
  • 36
    • 4444299555 scopus 로고    scopus 로고
    • VX-950: The discovery of an inhibitor of the hepatitis C NS3-4A protease and a potential hepatitis C virus therapeutic
    • doi:10.1016/S0270-9139(03)81010-8
    • Perni RB, Chandorkar G, Chaturvedi PR, et al. VX-950: The discovery of an inhibitor of the hepatitis C NS3-4A protease and a potential hepatitis C virus therapeutic. Hepatology 2003; 38 Suppl 1: S624A. doi:10.1016/S0270-9139(03) 81010-8
    • (2003) Hepatology , vol.38 , Issue.SUPPL. 1
    • Perni, R.B.1    Chandorkar, G.2    Chaturvedi, P.R.3
  • 37
    • 33747783479 scopus 로고    scopus 로고
    • Initial results of a 14-day study of the hepatitis C virus inhibitor protease VX-950, in combination with peginterferon-alpha-2a
    • doi:10.1016/S0168-8278(06)80737-3
    • Reesink H, Forestier N, Weegink CJ, et al . Initial results of a 14-day study of the hepatitis C virus inhibitor protease VX-950, in combination with peginterferon-alpha-2a. J Hepatol 2006; 44 Suppl 2: S272. doi:10.1016/S0168- 8278(06)80737-3
    • (2006) J Hepatol , vol.44 , Issue.SUPPL. 2
    • Reesink, H.1    Forestier, N.2    Weegink, C.J.3
  • 38
    • 38749115754 scopus 로고    scopus 로고
    • Characterization of resistance mutations against HCV ketoamide protease inhibitors
    • Medline doi:10.1016/j.antiviral.2007.11.010
    • Tong X, Bogen S, Chase R, et al. Characterization of resistance mutations against HCV ketoamide protease inhibitors. Antiviral Res 2008; 77: 177-185. Medline doi:10.1016/j.antiviral.2007.11.010
    • (2008) Antiviral Res , vol.77 , pp. 177-185
    • Tong, X.1    Bogen, S.2    Chase, R.3
  • 39
    • 73149113353 scopus 로고    scopus 로고
    • Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients
    • Medline doi:10.1002/hep.23192
    • Susser S, Welsch C, Wang Y, et al. Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients. Hepatology 2009; 50: 1709-1718. Medline doi:10.1002/hep.23192
    • (2009) Hepatology , vol.50 , pp. 1709-1718
    • Susser, S.1    Welsch, C.2    Wang, Y.3
  • 40
    • 84855860795 scopus 로고    scopus 로고
    • Mutations selected in the hepatitis C virus NS3 protease domain during sequential treatment with boceprevir with and without pegylated interferon alfa-2b
    • Medline doi:10.1111/j.1365-2893.2011.01449.x
    • Vermehren J, Susser S, Lange CM, et al . Mutations selected in the hepatitis C virus NS3 protease domain during sequential treatment with boceprevir with and without pegylated interferon alfa-2b. J Viral Hepat 2012; 19: 120-127. Medline doi:10.1111/j.1365-2893.2011.01449.x
    • (2012) J Viral Hepat , vol.19 , pp. 120-127
    • Vermehren, J.1    Susser, S.2    Lange, C.M.3
  • 41
    • 78049493632 scopus 로고    scopus 로고
    • Antiviral activity of narlaprevir combined with ritonavir and pegylated interferon in chronic hepatitis C patients
    • Medline doi:10.1002/hep.23899
    • de Bruijne J, Bergmann JF, Reesink HW, et al. Antiviral activity of narlaprevir combined with ritonavir and pegylated interferon in chronic hepatitis C patients. Hepatology 2010; 52: 1590-1599. Medline doi:10.1002/hep.23899
    • (2010) Hepatology , vol.52 , pp. 1590-1599
    • De Bruijne, J.1    Bergmann, J.F.2    Reesink, H.W.3
  • 42
    • 84881338698 scopus 로고    scopus 로고
    • Characterization of HCV resistance from single and multiple dose clinical trials of GS-9256, a novel NS3 protease inhibitor
    • Wong K, Bae A, Qi X, et al. Characterization of HCV resistance from single and multiple dose clinical trials of GS-9256, a novel NS3 protease inhibitor. Hepatology 2010; 52 Suppl 1: S300A.
    • (2010) Hepatology , vol.52 , Issue.SUPPL. 1
    • Wong, K.1    Bae, A.2    Qi, X.3
  • 43
    • 84881353054 scopus 로고    scopus 로고
    • AVL-192 potency against HCV NS3 mutants allows for replicon clearance as monotherapy and in combination studies
    • doi:10.1016/S0168-8278(10)60753-2
    • Hagel M, Niu D, St Martin T, et al. AVL-192 potency against HCV NS3 mutants allows for replicon clearance as monotherapy and in combination studies. J Hepatol 2010; 52 Suppl 1: S292. doi:10.1016/S0168-8278(10)60753-2
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Hagel, M.1    Niu, D.2    St Martin, T.3
  • 44
    • 80051926331 scopus 로고    scopus 로고
    • AVL-181, a potent and selective irreversible HCV protease inhibitor, exploits the binding site microenvironment to form a targeted and highly specific covalent bond with CYS-159
    • doi:10.1016/S0168-8278(10)60766-0
    • Niu D, Hagel M, Qiao L, et al. AVL-181, a potent and selective irreversible HCV protease inhibitor, exploits the binding site microenvironment to form a targeted and highly specific covalent bond with CYS-159. J Hepatol 2010; 52 Suppl 1: S297. doi:10.1016/S0168-8278(10)60766-0
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Niu, D.1    Hagel, M.2    Qiao, L.3
  • 45
    • 34548316984 scopus 로고    scopus 로고
    • The lipid droplet is an important organelle for hepatitis C virus production
    • Medline doi:10.1038/ncb1631
    • Miyanari Y, Atsuzawa K, Usuda N, et al. The lipid droplet is an important organelle for hepatitis C virus production. Nat Cell Biol 2007; 9: 1089-1097. Medline doi:10.1038/ncb1631
    • (2007) Nat Cell Biol , vol.9 , pp. 1089-1097
    • Miyanari, Y.1    Atsuzawa, K.2    Usuda, N.3
  • 46
    • 49149113893 scopus 로고    scopus 로고
    • Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles
    • Medline doi:10.1128/JVI.00826-08
    • Masaki T, Suzuki R, Murakami K, et al. Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles. J Virol 2008; 82: 7964-7976. Medline doi:10.1128/JVI.00826-08
    • (2008) J Virol , vol.82 , pp. 7964-7976
    • Masaki, T.1    Suzuki, R.2    Murakami, K.3
  • 47
    • 42949145532 scopus 로고    scopus 로고
    • Regulation of hepatitis C virion production via phosphorylation of the NS5A protein
    • Medline doi:10.1371/journal.ppat.1000032
    • Tellinghuisen TL, Foss KL, Treadaway J. Regulation of hepatitis C virion production via phosphorylation of the NS5A protein. PLoS Pathog 2008; 4: e1000032. Medline doi:10.1371/journal.ppat.1000032
    • (2008) PLoS Pathog , vol.4
    • Tellinghuisen, T.L.1    Foss, K.L.2    Treadaway, J.3
  • 48
    • 42949130180 scopus 로고    scopus 로고
    • Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly
    • Medline doi:10.1371/journal.ppat.1000035
    • Appel N, Zayas M, Miller S, et al. Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly. PLoS Pathog 2008; 4: e1000035. Medline doi:10.1371/journal.ppat.1000035
    • (2008) PLoS Pathog , vol.4
    • Appel, N.1    Zayas, M.2    Miller, S.3
  • 49
    • 79960390342 scopus 로고    scopus 로고
    • Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052
    • Medline doi:10.1128/JVI.00253-11
    • Fridell RA, Qiu D, Valera L, Wang C, Rose RE, Gao M. Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052. J Virol 2011; 85: 7312-7320. Medline doi:10.1128/JVI. 00253-11
    • (2011) J Virol , vol.85 , pp. 7312-7320
    • Fridell, R.A.1    Qiu, D.2    Valera, L.3    Wang, C.4    Rose, R.E.5    Gao, M.6
  • 50
    • 78149345765 scopus 로고    scopus 로고
    • A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach
    • Medline doi:10.1371/journal.ppat.1001118
    • Yang F, Robotham JM, Grise H, et al. A major determinant of cyclophilin dependence and cyclosporine susceptibility of hepatitis C virus identified by a genetic approach. PLoS Pathog 2010; 6: e1001118. Medline doi:10.1371/journal. ppat.1001118
    • (2010) PLoS Pathog , vol.6
    • Yang, F.1    Robotham, J.M.2    Grise, H.3
  • 51
    • 84881329474 scopus 로고    scopus 로고
    • Updated 15 June Accessed 5 February 2012. Available from
    • Hepatitis C new drug pipeline. (Updated 15 June 2011. Accessed 5 February 2012.) Available from http://hcvdrugs.com/
    • (2011) Hepatitis C New Drug Pipeline
  • 52
    • 77952035218 scopus 로고    scopus 로고
    • Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
    • Medline doi:10.1038/nature08960
    • Gao M, Nettles RE, Belema M, et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature 2010; 465: 96-100. Medline doi:10.1038/nature08960
    • (2010) Nature , vol.465 , pp. 96-100
    • Gao, M.1    Nettles, R.E.2    Belema, M.3
  • 53
    • 84856159009 scopus 로고    scopus 로고
    • Preliminary study of two antiviral agents for hepatitis C genotype 1
    • Medline doi:10.1056/NEJMoa1104430
    • Lok AS, Gardiner DF, Lawitz E, et al. Preliminary study of two antiviral agents for hepatitis C genotype 1. N Engl J Med 2012; 366: 216-224. Medline doi:10.1056/NEJMoa1104430
    • (2012) N Engl J Med , vol.366 , pp. 216-224
    • Lok, A.S.1    Gardiner, D.F.2    Lawitz, E.3
  • 54
    • 0142182744 scopus 로고    scopus 로고
    • Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes
    • Medline doi:10.1053/jhep.2003.50449
    • Watashi K, Hijikata M, Hosaka M, Yamaji M, Shimotohno K. Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes. Hepatology 2003; 38: 1282-1288. Medline doi:10.1053/jhep.2003.50449
    • (2003) Hepatology , vol.38 , pp. 1282-1288
    • Watashi, K.1    Hijikata, M.2    Hosaka, M.3    Yamaji, M.4    Shimotohno, K.5
  • 55
    • 70049096419 scopus 로고    scopus 로고
    • Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics
    • Medline doi:10.1371/journal.ppat.1000546
    • Kaul A, Stauffer S, Berger C, et al . Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. PLoS Pathog 2009; 5: e1000546. Medline doi:10.1371/journal.ppat.1000546
    • (2009) PLoS Pathog , vol.5
    • Kaul, A.1    Stauffer, S.2    Berger, C.3
  • 56
    • 77951224110 scopus 로고    scopus 로고
    • Mechanism of resistance of hepatitis C virus replicons to structurally distinct cyclophilin inhibitors
    • Medline doi:10.1128/AAC.01236-09
    • Puyang X, Poulin DL, Mathy JE, et al. Mechanism of resistance of hepatitis C virus replicons to structurally distinct cyclophilin inhibitors. Antimicrob Agents Chemother 2010; 54: 1981-1987. Medline doi:10.1128/AAC.01236- 09
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 1981-1987
    • Puyang, X.1    Poulin, D.L.2    Mathy, J.E.3
  • 57
    • 0030051777 scopus 로고    scopus 로고
    • Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus
    • Behrens SE, Tomei L, De Francesco R. Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J 1996; 15: 12-22. Medline (Pubitemid 26020384)
    • (1996) EMBO Journal , vol.15 , Issue.1 , pp. 12-22
    • Behrens, S.-E.1    Tomei, L.2    De Francesco, R.3
  • 58
    • 0037192863 scopus 로고    scopus 로고
    • Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity
    • Medline doi:10.1074/jbc.M111392200
    • Shirota Y, Luo H, Qin W, et al . Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity. J Biol Chem 2002; 277: 11149-11155. Medline doi:10.1074/jbc.M111392200
    • (2002) J Biol Chem , vol.277 , pp. 11149-11155
    • Shirota, Y.1    Luo, H.2    Qin, W.3
  • 59
    • 0032876683 scopus 로고    scopus 로고
    • Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site
    • Medline doi:10.1038/13305
    • Lesburg CA, Cable MB, Ferrari E, Hong Z, Mannarino AF, Weber PC. Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site. Nat Struct Biol 1999; 6: 937-943. Medline doi:10.1038/13305
    • (1999) Nat Struct Biol , vol.6 , pp. 937-943
    • Lesburg, C.A.1    Cable, M.B.2    Ferrari, E.3    Hong, Z.4    Mannarino, A.F.5    Weber, P.C.6
  • 60
    • 0033539482 scopus 로고    scopus 로고
    • Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
    • Medline doi:10.1073/pnas.96.23.13034
    • Bressanelli S, Tomei L, Roussel A, et al. Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Proc Natl Acad Sci U S A 1999; 96: 13034-13039. Medline doi:10.1073/pnas.96.23.13034
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 13034-13039
    • Bressanelli, S.1    Tomei, L.2    Roussel, A.3
  • 61
    • 0033571463 scopus 로고    scopus 로고
    • Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
    • Medline doi:10.1016/S0969-2126(00)80031-3
    • Ago H, Adachi T, Yoshida A, et al. Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Structure 1999; 7: 1417-1426. Medline doi:10.1016/S0969-2126(00)80031-3
    • (1999) Structure , vol.7 , pp. 1417-1426
    • Ago, H.1    Adachi, T.2    Yoshida, A.3
  • 62
    • 23744436747 scopus 로고    scopus 로고
    • Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors
    • Medline doi:10.1074/jbc.M413410200
    • Biswal BK, Cherney MM, Wang M, et al. Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J Biol Chem 2005; 280: 18202-18210. Medline doi:10.1074/jbc.M413410200
    • (2005) J Biol Chem , vol.280 , pp. 18202-18210
    • Biswal, B.K.1    Cherney, M.M.2    Wang, M.3
  • 63
    • 42949167169 scopus 로고    scopus 로고
    • The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleoside polymerase or protease inhibitors
    • Medline doi:10.1128/AAC.01317-07
    • McCown MF, Rajyaguru S, Le Pogam S, et al. The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleoside polymerase or protease inhibitors. Antimicrob Agents Chemother 2008; 52: 1604-1612. Medline doi:10.1128/AAC.01317-07
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1604-1612
    • McCown, M.F.1    Rajyaguru, S.2    Le Pogam, S.3
  • 64
    • 57049112290 scopus 로고    scopus 로고
    • Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479
    • Medline doi:10.1128/AAC.00444-08
    • Ali S, Leveque V, Le Pogam S, et al. Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479. Antimicrob Agents Chemother 2008; 52: 4356-4369. Medline doi:10.1128/AAC.00444-08
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 4356-4369
    • Ali, S.1    Leveque, V.2    Le Pogam, S.3
  • 65
    • 33646457538 scopus 로고    scopus 로고
    • Inhibition of hepatitis C replicon RNA synthesis by beta-D-2′- deoxy-2′-fluoro-2′-C-methylcytidine: A specific inhibitor of hepatitis C virus replication
    • Medline
    • Stuyver LJ, McBrayer TR, Tharnish PM, et al. Inhibition of hepatitis C replicon RNA synthesis by beta-D-2′-deoxy-2′-fluoro-2′-C- methylcytidine: a specific inhibitor of hepatitis C virus replication. Antivir Chem Chemother 2006; 17: 79-87. Medline
    • (2006) Antivir Chem Chemother , vol.17 , pp. 79-87
    • Stuyver, L.J.1    McBrayer, T.R.2    Tharnish, P.M.3
  • 66
    • 79960453114 scopus 로고    scopus 로고
    • First SVR data with the nucleoside analogue polymerase inhibitor mericitabine (RG7128) combined with peginterferon/ribavirin in treatment-naive HCV G1/4 patients: Interim analysis from the JUMP-C trial
    • doi:10.1016/S0168-8278(11)61361-5
    • Pockros PJ, Jensen DM, Tsai N, et al. First SVR data with the nucleoside analogue polymerase inhibitor mericitabine (RG7128) combined with peginterferon/ribavirin in treatment-naive HCV G1/4 patients: interim analysis from the JUMP-C trial. J Hepatol 2011; 54 Suppl 1: S538. doi:10.1016/S0168- 8278(11)61361-5
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Pockros, P.J.1    Jensen, D.M.2    Tsai, N.3
  • 67
    • 33744910421 scopus 로고    scopus 로고
    • In vitro selected Con1 subgenomic replicons resistant to 2′-C-methyl-cytidine or to R1479 show lack of cross resistance
    • Medline doi:10.1016/j.virol.2006.03.045
    • Le Pogam S, Jiang WR, Leveque V, et al. In vitro selected Con1 subgenomic replicons resistant to 2′-C-methyl-cytidine or to R1479 show lack of cross resistance. Virology 2006; 351: 349-359. Medline doi:10.1016/j.virol.2006. 03.045
    • (2006) Virology , vol.351 , pp. 349-359
    • Le Pogam, S.1    Jiang, W.R.2    Leveque, V.3
  • 68
    • 83055197050 scopus 로고    scopus 로고
    • Balapiravir plus peginterferon alfa-2a (40KD)/ribavirin in a randomized trial of hepatitis C genotype 1 patients
    • Medline
    • Nelson DR, Zeuzem S, Andreone P, et al. Balapiravir plus peginterferon alfa-2a (40KD)/ribavirin in a randomized trial of hepatitis C genotype 1 patients. Ann Hepatol 2012; 11: 15-31. Medline
    • (2012) Ann Hepatol , vol.11 , pp. 15-31
    • Nelson, D.R.1    Zeuzem, S.2    Andreone, P.3
  • 69
    • 77954646871 scopus 로고    scopus 로고
    • PSI-7851, a pronucleotide of beta-D-2′-deoxy-2′-fluoro- 2′-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication
    • Medline doi:10.1128/AAC.00399-10
    • Lam AM, Murakami E, Espiritu C, et al. PSI-7851, a pronucleotide of beta-D-2′-deoxy-2′-fluoro-2′-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob Agents Chemother 2010; 54: 3187-3196. Medline doi:10.1128/AAC.00399- 10
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 3187-3196
    • Lam, A.M.1    Murakami, E.2    Espiritu, C.3
  • 70
    • 78049375232 scopus 로고    scopus 로고
    • Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977
    • Medline doi:10.1074/jbc.M110.161802
    • Murakami E, Tolstykh T, Bao H, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem 2010; 285: 34337-34347. Medline doi:10.1074/jbc.M110.161802
    • (2010) J Biol Chem , vol.285 , pp. 34337-34347
    • Murakami, E.1    Tolstykh, T.2    Bao, H.3
  • 71
    • 77957913871 scopus 로고    scopus 로고
    • Discovery of a beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta- C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus
    • Medline doi:10.1021/jm100863x
    • Sofia MJ, Bao D, Chang W, et al. Discovery of a beta-d-2′-deoxy- 2′-alpha-fluoro-2′-beta-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. J Med Chem 2010; 53: 7202-7218. Medline doi:10.1021/jm100863x
    • (2010) J Med Chem , vol.53 , pp. 7202-7218
    • Sofia, M.J.1    Bao, D.2    Chang, W.3
  • 72
    • 79960471175 scopus 로고    scopus 로고
    • Once daily dual-nucleotide combination of PSI-938 and PSI-7977 provides 94% HCV RNA
    • doi:10.1016/S0168-8278(11)61372-X
    • Lawitz E, Rodriguez-Torres M, Denning J, et al. Once daily dual-nucleotide combination of PSI-938 and PSI-7977 provides 94% HCV RNA
    • (2011) J Hepatol , vol.54 , Issue.SUPPL. 1
    • Lawitz, E.1    Rodriguez-Torres, M.2    Denning, J.3
  • 73
    • 84855248040 scopus 로고    scopus 로고
    • Once daily PSI-7977 plus RBV: Pegylated interferon-alfa not required for complete rapid viral response in treatment-naive patients with HCV GT2 or GT3
    • Gane EJ, Stedman CA, Hyland RH, et al. Once daily PSI-7977 plus RBV: pegylated interferon-alfa not required for complete rapid viral response in treatment-naive patients with HCV GT2 or GT3. Hepatology 2011; 54 Suppl 1: S377A.
    • (2011) Hepatology , vol.54 , Issue.SUPPL. 1
    • Gane, E.J.1    Stedman, C.A.2    Hyland, R.H.3
  • 74
    • 84881322795 scopus 로고    scopus 로고
    • 100% rapid virologic response for PSI-7977 + ribavirin in genotype 1 null responders (ELECTRON): Early viral decline similar to that observed in genotype 1 and genotype 2/3 treatment-naive patients
    • Abstract 54LB
    • Gane E, Stedman C, Anderson J, et al. 100% rapid virologic response for PSI-7977 + ribavirin in genotype 1 null responders (ELECTRON): early viral decline similar to that observed in genotype 1 and genotype 2/3 treatment-naive patients. 19th Conference on Retroviruses and Opportunistic Infections. 5-8 March 2012, Seattle, WA, USA. Abstract 54LB.
    • 19th Conference on Retroviruses and Opportunistic Infections. 5-8 March 2012, Seattle, WA, USA
    • Gane, E.1    Stedman, C.2    Anderson, J.3
  • 75
    • 84860469344 scopus 로고    scopus 로고
    • Characterization of in vitro selected hepatitis C virus replicon mutants resistant to the phosphoramidate analog of 2′-c-methylguanosine, INX-189
    • Kolykhalov A, Liu Y, Bleiman B, Patti J, McGuigan C, Vernachio J. Characterization of in vitro selected hepatitis C virus replicon mutants resistant to the phosphoramidate analog of 2′-c-methylguanosine, INX-189. Hepatology 2010; 52 Suppl 4: S303A.
    • (2010) Hepatology , vol.52 , Issue.SUPPL. 4
    • Kolykhalov, A.1    Liu, Y.2    Bleiman, B.3    Patti, J.4    McGuigan, C.5    Vernachio, J.6
  • 76
    • 78650674078 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of IDX184, a liver-targeted nucleotide polymerase inhibitor of hepatitis C virus, in healthy subjects
    • Medline doi:10.1128/AAC.01101-10
    • Zhou XJ, Pietropaolo K, Chen J, Khan S, Sullivan-Bolyai J, Mayers D. Safety and pharmacokinetics of IDX184, a liver-targeted nucleotide polymerase inhibitor of hepatitis C virus, in healthy subjects. Antimicrob Agents Chemother 2011; 55: 76-81. Medline doi:10.1128/AAC.01101-10
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 76-81
    • Zhou, X.J.1    Pietropaolo, K.2    Chen, J.3    Khan, S.4    Sullivan-Bolyai, J.5    Mayers, D.6
  • 77
    • 28244461263 scopus 로고    scopus 로고
    • Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase
    • Medline doi:10.1074/jbc.M506407200
    • Kukolj G, McGibbon GA, McKercher G, et al . Binding site characterization and resistance to a class of non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase. J Biol Chem 2005; 280: 39260-39267. Medline doi:10.1074/jbc.M506407200
    • (2005) J Biol Chem , vol.280 , pp. 39260-39267
    • Kukolj, G.1    McGibbon, G.A.2    McKercher, G.3
  • 78
    • 61849172935 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and antiviral effect of BILB 1941, a novel hepatitis C virus RNA polymerase inhibitor, after 5 days oral treatment
    • Medline
    • Erhardt A, Deterding K, Benhamou Y, et al. Safety, pharmacokinetics and antiviral effect of BILB 1941, a novel hepatitis C virus RNA polymerase inhibitor, after 5 days oral treatment. Antivir Ther 2009; 14: 23-32. Medline
    • (2009) Antivir Ther , vol.14 , pp. 23-32
    • Erhardt, A.1    Deterding, K.2    Benhamou, Y.3
  • 79
    • 0038322074 scopus 로고    scopus 로고
    • Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition
    • Medline doi:10.1074/jbc.M209397200
    • Wang M, Ng KK, Cherney MM, et al. Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition. J Biol Chem 2003; 278: 9489-9495. Medline doi:10.1074/jbc. M209397200
    • (2003) J Biol Chem , vol.278 , pp. 9489-9495
    • Wang, M.1    Ng, K.K.2    Cherney, M.M.3
  • 80
    • 67349148535 scopus 로고    scopus 로고
    • Evaluation of VCH-759 monotherapy in hepatitis C infection
    • Medline doi:10.1016/j.jhep.2009.03.015
    • Cooper C, Lawitz EJ, Ghali P, et al. Evaluation of VCH-759 monotherapy in hepatitis C infection. J Hepatol 2009; 51: 39-46. Medline doi:10.1016/j.jhep. 2009.03.015
    • (2009) J Hepatol , vol.51 , pp. 39-46
    • Cooper, C.1    Lawitz, E.J.2    Ghali, P.3
  • 81
    • 55749098373 scopus 로고    scopus 로고
    • Genotypic analysis of HCV NS5B variants selected from patients treated with VCH-759
    • doi:10.1016/S0168-8278(08)60846-6
    • Nicolas O, Boivin I, St-Denis C, Bedard J. Genotypic analysis of HCV NS5B variants selected from patients treated with VCH-759. J Hepatol 2008; 48 Suppl 2: S317. doi:10.1016/S0168-8278(08)60846-6
    • (2008) J Hepatol , vol.48 , Issue.SUPPL. 2
    • Nicolas, O.1    Boivin, I.2    St-Denis, C.3    Bedard, J.4
  • 82
    • 64349088294 scopus 로고    scopus 로고
    • Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3- ((5,7-dimethyl- [[[[[1,2,4]]]]] triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy- 5,6-dihydropyran-2-on e (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor
    • Medline doi:10.1021/jm8014537
    • Li H, Tatlock J, Linton A, et al. Discovery of (R)-6-cyclopentyl-6-(2-(2, 6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl- [[[[[1,2,4]]]]] triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-on e (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor. J Med Chem 2009; 52: 1255-1258. Medline doi:10.1021/jm8014537
    • (2009) J Med Chem , vol.52 , pp. 1255-1258
    • Li, H.1    Tatlock, J.2    Linton, A.3
  • 83
    • 67049145581 scopus 로고    scopus 로고
    • Preclinical characterization of PF-00868554, a potent nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase
    • Medline doi:10.1128/AAC.01599-08
    • Shi ST, Herlihy KJ, Graham JP, et al. Preclinical characterization of PF-00868554, a potent nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase. Antimicrob Agents Chemother 2009; 53: 2544-2552. Medline doi:10.1128/AAC.01599-08
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 2544-2552
    • Shi, S.T.1    Herlihy, K.J.2    Graham, J.P.3
  • 84
    • 0038467627 scopus 로고    scopus 로고
    • Crystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme
    • Medline doi:10.1128/JVI.77.13.7575-7581.2003
    • Love RA, Parge HE, Yu X, et al. Crystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme. J Virol 2003; 77: 7575-7581. Medline doi:10.1128/JVI.77.13. 7575-7581.2003
    • (2003) J Virol , vol.77 , pp. 7575-7581
    • Love, R.A.1    Parge, H.E.2    Yu, X.3
  • 85
    • 84857186976 scopus 로고    scopus 로고
    • Characterization of resistance to the non-nucleoside NS5B inhibitor filibuvir in hepatitis C infected patients
    • Medline doi:10.1128/AAC.05611-11
    • Troke PJ, Lewis M, Simpson P, et al. Characterization of resistance to the non-nucleoside NS5B inhibitor filibuvir in hepatitis C infected patients. Antimicrob Agents Chemother 2012; 56: 1331-1341. Medline doi:10.1128/AAC.05611- 11
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 1331-1341
    • Troke, P.J.1    Lewis, M.2    Simpson, P.3
  • 86
    • 84862920391 scopus 로고    scopus 로고
    • Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir
    • Medline doi:10.1128/AAC.05438-11
    • Yi G, Deval J, Fan B, et al. Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir. Antimicrob Agents Chemother 2012; 56: 830-837. Medline doi:10.1128/AAC.05438-11
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 830-837
    • Yi, G.1    Deval, J.2    Fan, B.3
  • 87
    • 77954745283 scopus 로고    scopus 로고
    • Safety and antiviral activity of the HCV non-nucleoside polymerase inhibitor VX-222 in treatment naive genotype 1 HCV-infected patients
    • doi:10.1016/S0168-8278(10)60033-5
    • Rodriguez-Torres M, Lawitz E, Conway B, et al . Safety and antiviral activity of the HCV non-nucleoside polymerase inhibitor VX-222 in treatment naive genotype 1 HCV-infected patients. J Hepatol 2010; 52 Suppl 1: S14. doi:10.1016/S0168-8278(10)60033-5
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Rodriguez-Torres, M.1    Lawitz, E.2    Conway, B.3
  • 88
    • 9144259740 scopus 로고    scopus 로고
    • Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides
    • Medline doi:10.1128/JVI.78.2.938-946.2004
    • Tomei L, Altamura S, Bartholomew L, et al. Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides. J Virol 2004; 78: 938-946. Medline doi:10.1128/JVI.78.2.938-946.2004
    • (2004) J Virol , vol.78 , pp. 938-946
    • Tomei, L.1    Altamura, S.2    Bartholomew, L.3
  • 89
    • 75149195123 scopus 로고    scopus 로고
    • In vitro studies demonstrate that combinations of antiviral agents that include HCV polymerase inhibitor ANA598 have the potential to overcome viral resistance
    • Thompson PA, Patel R, Showalter RE, Li C, Appleman JR, Steffy K. In vitro studies demonstrate that combinations of antiviral agents that include HCV polymerase inhibitor ANA598 have the potential to overcome viral resistance. Hepatology 2008; 48 Suppl 1: S1164A
    • (2008) Hepatology , vol.48 , Issue.SUPPL. 1
    • Thompson, P.A.1    Patel, R.2    Showalter, R.E.3    Li, C.4    Appleman, J.R.5    Steffy, K.6
  • 90
    • 79952148090 scopus 로고    scopus 로고
    • Safety and antiviral activity of ANA598 in combination with pegylated interferon α2A plus ribavirin in treatment-naive genotype-1 chronic HCV patients
    • doi:10.1016/S0168-8278(10)61200-7
    • Lawitz E, Rodriguez-Torres M, Rustgi VK, et al. Safety and antiviral activity of ANA598 in combination with pegylated interferon α2A plus ribavirin in treatment-naive genotype-1 chronic HCV patients. J Hepatol 2010; 52 Suppl 1: S467. doi:10.1016/S0168-8278(10)61200-7
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Lawitz, E.1    Rodriguez-Torres, M.2    Rustgi, V.K.3
  • 91
    • 67650514054 scopus 로고    scopus 로고
    • Antiviral activity of ANA598, a potent non-nucleoside polymerase inhibitor, in chronic hepatitis C patients
    • doi:10.1016/S0168-8278(09)61057-6
    • Lawitz EJ, Rodriguez-Torres M, DeMicco M, et al. Antiviral activity of ANA598, a potent non-nucleoside polymerase inhibitor, in chronic hepatitis C patients. J Hepatol 2009; 50 Suppl 1: S384. doi:10.1016/S0168-8278(09)61057-6
    • (2009) J Hepatol , vol.50 , Issue.SUPPL. 1
    • Lawitz, E.J.1    Rodriguez-Torres, M.2    DeMicco, M.3
  • 92
    • 34547634733 scopus 로고    scopus 로고
    • GSK625433; a novel and highly potent inhibitor of the HCV NS5B polymerase
    • doi:10.1016/S0168-8278(07)62192-8
    • Gray F, Amphlett H, Bright L, et al. GSK625433; a novel and highly potent inhibitor of the HCV NS5B polymerase. J Hepatol 2007; 46 Suppl 1: S225. doi:10.1016/S0168-8278(07)62192-8
    • (2007) J Hepatol , vol.46 , Issue.SUPPL. 1
    • Gray, F.1    Amphlett, H.2    Bright, L.3
  • 93
    • 67650156483 scopus 로고    scopus 로고
    • Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus
    • Medline doi:10.1074/jbc.M808889200
    • Hang JQ, Yang Y, Harris SF, et al. Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus. J Biol Chem 2009; 284: 15517-15529. Medline doi:10.1074/jbc.M808889200
    • (2009) J Biol Chem , vol.284 , pp. 15517-15529
    • Hang, J.Q.1    Yang, Y.2    Harris, S.F.3
  • 94
    • 75149130302 scopus 로고    scopus 로고
    • Characterization of resistance mutations selected in vitro by the non-nucleoside HCV polymerase inhibitors ABT-333 and ABT-072
    • doi:10.1016/S0168-8278(09)60955-7
    • Koev G, Mondal R, Beyer J, et al. Characterization of resistance mutations selected in vitro by the non-nucleoside HCV polymerase inhibitors ABT-333 and ABT-072. J Hepatol 2009; 50 Suppl 1: S346. doi:10.1016/S0168- 8278(09)60955-7
    • (2009) J Hepatol , vol.50 , Issue.SUPPL. 1
    • Koev, G.1    Mondal, R.2    Beyer, J.3
  • 95
    • 50949134232 scopus 로고    scopus 로고
    • Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796
    • Medline doi:10.1128/AAC.00238-08
    • Howe AY, Cheng H, Johann S, et al. Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796. Antimicrob Agents Chemother 2008; 52: 3327-3338. Medline doi:10.1128/AAC.00238-08
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 3327-3338
    • Howe, A.Y.1    Cheng, H.2    Johann, S.3
  • 96
    • 79952139742 scopus 로고    scopus 로고
    • Resistance profile of ABT-333 and relationship to viral load decrease in patients treated in combination with PEG-interferon and ribavirin for 28 days
    • doi:10.1016/S0168-8278(10)60764-7
    • Middleton T, He Y, Beyer J, et al. Resistance profile of ABT-333 and relationship to viral load decrease in patients treated in combination with PEG-interferon and ribavirin for 28 days. J Hepatol 2010; 52 Suppl 1: S296-S297. doi:10.1016/S0168-8278(10)60764-7
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Middleton, T.1    He, Y.2    Beyer, J.3
  • 97
    • 56849119315 scopus 로고    scopus 로고
    • Mechanistic characterization of GS-9190, a novel non-nucleoside inhibitor of HCV NS5B polymerase with potent antiviral activity and a unique mechanism of action
    • Shih IH, Vliegen I, Peng B, et al. Mechanistic characterization of GS-9190, a novel non-nucleoside inhibitor of HCV NS5B polymerase with potent antiviral activity and a unique mechanism of action. Hepatology 2007; 46 Suppl 1: S859A.
    • (2007) Hepatology , vol.46 , Issue.SUPPL. 1
    • Shih, I.H.1    Vliegen, I.2    Peng, B.3
  • 98
    • 80051820156 scopus 로고    scopus 로고
    • Mechanistic characterization of GS-9190 (tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase
    • Medline doi:10.1128/AAC.00307-11
    • Shih IH, Vliegen I, Peng B, et al . Mechanistic characterization of GS-9190 (tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase. Antimicrob Agents Chemother 2011; 55: 4196-4203. Medline doi:10.1128/AAC.00307-11
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 4196-4203
    • Shih, I.H.1    Vliegen, I.2    Peng, B.3
  • 99
    • 41749085866 scopus 로고    scopus 로고
    • Antiviral pharmacokinetic and safety data for GS-9190, a non-nucleoside HCV NS5B polymerase inhibitor, in a Phase-1 trial in HCV genotype 1 infected subjects
    • Bavisotto L, Wang CC, Jacobson IM, et al. Antiviral pharmacokinetic and safety data for GS-9190, a non-nucleoside HCV NS5B polymerase inhibitor, in a Phase-1 trial in HCV genotype 1 infected subjects. Hepatology 2007; 46 Suppl 1: S255A.
    • (2007) Hepatology , vol.46 , Issue.SUPPL. 1
    • Bavisotto, L.1    Wang, C.C.2    Jacobson, I.M.3
  • 100
    • 84857415002 scopus 로고    scopus 로고
    • The protease inhibitor, GS-9256, and non-nucleoside polymerase inhibitor tegobuvir alone, with ribavirin, or pegylated interferon plus ribavirin in hepatitis C
    • Medline doi:10.1002/hep.24744
    • Zeuzem S, Buggisch P, Agarwal K, et al. The protease inhibitor, GS-9256, and non-nucleoside polymerase inhibitor tegobuvir alone, with ribavirin, or pegylated interferon plus ribavirin in hepatitis C. Hepatology 2012; 55: 749-758. Medline doi:10.1002/hep.24744
    • (2012) Hepatology , vol.55 , pp. 749-758
    • Zeuzem, S.1    Buggisch, P.2    Agarwal, K.3
  • 101
    • 0347361643 scopus 로고    scopus 로고
    • Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase
    • Medline doi:10.1021/jm0342109
    • Summa V, Petrocchi A, Pace P, et al. Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase. J Med Chem 2004; 47: 14-17. Medline doi:10.1021/jm0342109
    • (2004) J Med Chem , vol.47 , pp. 14-17
    • Summa, V.1    Petrocchi, A.2    Pace, P.3
  • 102
    • 33644861780 scopus 로고    scopus 로고
    • 2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: Discovery, SAR, modeling, and mutagenesis
    • Medline doi:10.1021/jm051064t
    • Koch U, Attenni B, Malancona S, et al. 2-(2-Thienyl)-5,6-dihydroxy-4- carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis. J Med Chem 2006; 49: 1693-1705. Medline doi:10.1021/jm051064t
    • (2006) J Med Chem , vol.49 , pp. 1693-1705
    • Koch, U.1    Attenni, B.2    Malancona, S.3
  • 103
    • 77149122375 scopus 로고    scopus 로고
    • Mechanism of hepatitis C virus RNA polymerase inhibition with dihydroxypyrimidines
    • Medline doi:10.1128/AAC.01216-09
    • Powdrill MH, Deval J, Narjes F, De Francesco R, Gotte M. Mechanism of hepatitis C virus RNA polymerase inhibition with dihydroxypyrimidines. Antimicrob Agents Chemother 2010; 54: 977-983. Medline doi:10.1128/AAC.01216-09
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 977-983
    • Powdrill, M.H.1    Deval, J.2    Narjes, F.3    De Francesco, R.4    Gotte, M.5
  • 104
    • 23744446809 scopus 로고    scopus 로고
    • HCV antiviral resistance: The impact of in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase
    • Tomei L, Altamura S, Paonessa G, De Francesco R, Migliaccio G. HCV antiviral resistance: the impact of in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase. Antivir Chem Chemother 2005; 16: 225-245. Medline (Pubitemid 41139709)
    • (2005) Antiviral Chemistry and Chemotherapy , vol.16 , Issue.4 , pp. 225-245
    • Tomei, L.1    Altamura, S.2    Paonessa, G.3    De Francesco, R.4    Migliaccio, G.5
  • 105
    • 84881335474 scopus 로고    scopus 로고
    • Enhanced in vitro antiviral activity and suppression of resistance by combining GS-9256, a novel protease inhibitor, with GS-9190, a non-nucleoside NS5B inhibitor
    • Mo H, Ku K, Yang H, et al. Enhanced in vitro antiviral activity and suppression of resistance by combining GS-9256, a novel protease inhibitor, with GS-9190, a non-nucleoside NS5B inhibitor. Hepatology 2010; 52 Suppl 1: S300A.
    • (2010) Hepatology , vol.52 , Issue.SUPPL. 1
    • Mo, H.1    Ku, K.2    Yang, H.3
  • 106
    • 78049527728 scopus 로고    scopus 로고
    • Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): A randomised, double-blind, placebo-controlled, dose-escalation trial
    • Medline doi:10.1016/S0140-6736(10)61384-0
    • Gane EJ, Roberts SK, Stedman CA, et al. Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet 2010; 376: 1467-1475. Medline doi:10.1016/S0140-6736(10)61384-0
    • (2010) Lancet , vol.376 , pp. 1467-1475
    • Gane, E.J.1    Roberts, S.K.2    Stedman, C.A.3
  • 107
    • 84866119318 scopus 로고    scopus 로고
    • Interferon-free treatment with a combination of mericitabine and danoprevir/r with or without ribavirin in treatment-naive HCV genotype 1-infected patients
    • doi:10.1016/S0168-8278 (12)61423-8
    • Gane E, Pockros PJ, Zeuzem S, et al. Interferon-free treatment with a combination of mericitabine and danoprevir/r with or without ribavirin in treatment-naive HCV genotype 1-infected patients. J Hepatol 2012; 56 Suppl 2: S555. doi:10.1016/S0168-8278 (12)61423-8
    • (2012) J Hepatol , vol.56 , Issue.SUPPL. 2
    • Gane, E.1    Pockros, P.J.2    Zeuzem, S.3
  • 108
    • 81855228070 scopus 로고    scopus 로고
    • Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection
    • Medline doi:10.1053/j.gastro.2011.08.051
    • Zeuzem S, Asselah T, Angus P, et al. Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection. Gastroenterology 2011; 141: 2047-2055. Medline doi:10.1053/j.gastro.2011.08.051
    • (2011) Gastroenterology , vol.141 , pp. 2047-2055
    • Zeuzem, S.1    Asselah, T.2    Angus, P.3
  • 109
    • 78751624731 scopus 로고    scopus 로고
    • 4 week therapy with the non-nucleosidic polymerase inhibitor BI207127 in combination with peginterferon-alfa2a and ribavirin in treatment naive and treatment experienced chronic HCV gt1 patients
    • doi:10.1016/S0168-8278(10)61198-1
    • Larrey D, Lohse A, de Ledinghen V, et al . 4 week therapy with the non-nucleosidic polymerase inhibitor BI207127 in combination with peginterferon-alfa2a and ribavirin in treatment naive and treatment experienced chronic HCV gt1 patients. J Hepatol 2010; 52 Suppl 1: S466. doi:10.1016/S0168- 8278(10)61198-1
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • Larrey, D.1    Lohse, A.2    De Ledinghen, V.3
  • 110
    • 78650968050 scopus 로고    scopus 로고
    • Identification and preclinical profile of the novel HCV NS3 protease inhibitor BMS-650032
    • doi:10.1016/S0168-8278(10)60763-5
    • McPhee F. Identification and preclinical profile of the novel HCV NS3 protease inhibitor BMS-650032. J Hepatol 2010; 52 Suppl 1: S296 doi:10.1016/S0168-8278(10)60763-5
    • (2010) J Hepatol , vol.52 , Issue.SUPPL. 1
    • McPhee, F.1
  • 111
    • 84857395452 scopus 로고    scopus 로고
    • Dual therapy with the nonstructural protein 5A inhibitor, BMS-790052, and the nonstructural protein 3 protease inhibitor, BMS-650032, in hepatitis C virus genotype 1b-infected null responders
    • Medline doi:10.1002/hep.24724
    • Chayama K, Takahashi S, Toyota J, et al. Dual therapy with the nonstructural protein 5A inhibitor, BMS-790052, and the nonstructural protein 3 protease inhibitor, BMS-650032, in hepatitis C virus genotype 1b-infected null responders. Hepatology 2012; 55: 742-748. Medline doi:10.1002/hep.24724
    • (2012) Hepatology , vol.55 , pp. 742-748
    • Chayama, K.1    Takahashi, S.2    Toyota, J.3
  • 112
    • 84864379265 scopus 로고    scopus 로고
    • A 12-week interferon free regimen of ABT-450/r + ABT-333 + ribavirin achieved SVR12 in more than 90% of treatment-naive HCV genotype-1-infected subjects and 47% of previous non-responders
    • doi:10.1016/S0168-8278(12)61410-X
    • Poordad F, Lawitz E, Kowdley K, et al. A 12-week interferon free regimen of ABT-450/r + ABT-333 + ribavirin achieved SVR12 in more than 90% of treatment-naive HCV genotype-1-infected subjects and 47% of previous non-responders. J Hepatol 2012; 56 Suppl 2: S549. doi:10.1016/S0168-8278(12) 61410-X
    • (2012) J Hepatol , vol.56 , Issue.SUPPL. 2
    • Poordad, F.1    Lawitz, E.2    Kowdley, K.3
  • 113
    • 77954699449 scopus 로고    scopus 로고
    • Controlling and ultimately ending the HIV/AIDS pandemic: A feasible goal
    • Medline doi:10.1001/jama.2010.957
    • Folkers GK, Fauci AS. Controlling and ultimately ending the HIV/AIDS pandemic: a feasible goal. JAMA 2010; 304: 350-351. Medline doi:10.1001/jama. 2010.957
    • (2010) JAMA , vol.304 , pp. 350-351
    • Folkers, G.K.1    Fauci, A.S.2
  • 114
    • 47649115323 scopus 로고    scopus 로고
    • Life expectancy of individuals on combination antiretroviral therapy in high-income countries: A collaborative analysis of 14 cohort studies
    • Antiretroviral Therapy Cohort Collaboration. Medline doi:10.1016/S0140- 6736(08)61113-7
    • Antiretroviral Therapy Cohort Collaboration. Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet 2008; 372: 293-299. Medline doi:10.1016/S0140-6736(08)61113-7
    • (2008) Lancet , vol.372 , pp. 293-299
  • 115
    • 84855246805 scopus 로고    scopus 로고
    • Future treatment of chronic hepatitis C with direct acting antivirals: Is resistance important?
    • Medline doi:10.1111/j.1478-3231.2011.02716.x
    • Halfon P, Sarrazin C. Future treatment of chronic hepatitis C with direct acting antivirals: is resistance important? Liver Int 2012; 32: 79-87. Medline doi:10.1111/j.1478-3231.2011.02716.x
    • (2012) Liver Int , vol.32 , pp. 79-87
    • Halfon, P.1    Sarrazin, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.