Inhibition of hepatitis C replicon RNA synthesis by β-D-2′- deoxy-2′-fluoro-2′-C-methylcytidine: A specific inhibitor of hepatitis C virus replication

Antiviral Chemistry and Chemotherapy

Volumn 17, Issue 2, 2006, Pages 79-87

  Stuyver, Lieven J ^a,d   McBrayer, Tamara R ^a,b   Tharnish, Phillip M ^a,b   Clark, Jeremy ^a,e   Hollecker, Laurent ^a,f   Lostia, Stefania ^a,f   Nachman, Tammy ^a,f   Grier, Jason ^b   Bennett, Matthew A ^b   Xie, Meng Yu ^b   Schinazi, Raymond F ^b   Morrey, John D ^c   Julander, Justin L ^c   Furman, Phillip A ^a   Otto, Michael J ^a  

^a PHARMASSET INC   (United States)

^b ATLANTA VA MEDICAL CENTER   (United States)

^c UTAH STATE UNIVERSITY   (United States)

^d Virco BVBA   (Belgium)

^e SOUTHERN RESEARCH INSTITUTE   (United States)

^f Southern Research Institute ^*

Author keywords

Antiviral activity; HCV; PSI 6130

Indexed keywords

2' C METHYLADENOSINE; 2' C METHYLCYTIDINE; 2' F CYTIDINE; ADENOSINE; ALPHA2A INTERFERON; ANTIVIRUS AGENT; BETA DEXTRO 2' DEOXY 2' FLUORO C METHYLCYTIDINE; CYTIDINE; CYTIDINE DERIVATIVE; DEOXYADENOSINE; DEOXYCYTIDINE; DEOXYGUANOSINE; DEOXYURIDINE; GUANOSINE; PSI 6130; RECOMBINANT ALPHA2A INTERFERON; RIBAVIRIN; THYMIDINE; UNCLASSIFIED DRUG; URIDINE;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; BOVINE DIARRHEA VIRUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DENGUE VIRUS; DOSE RESPONSE; DRUG ANTAGONISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG SENSITIVITY; FEMALE; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; MITOCHONDRIAL TOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPLICON; RNA SYNTHESIS; VIRUS MUTATION; VIRUS REPLICATION; WEST NILE FLAVIVIRUS; YELLOW FEVER FLAVIVIRUS;

EID: 33646457538     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632020601700203     Document Type: Article

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