Pregnane X receptor mediated-transcription regulation of CYP3A by glycyrrhizin: A possible mechanism for its hepatoprotective property against lithocholic acid-induced injury

Chemico-Biological Interactions

Volumn 200, Issue 1, 2012, Pages 11-20

  Wang, Yu Guang ^a   Zhou, Jian Ming ^a   Ma, Zeng Chun ^a   Li, Hua ^b   Liang, Qian De ^a   Tan, Hong Ling ^a   Xiao, Cheng Rong ^a   Zhang, Bo Li ^c   Gao, Yue ^a  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^b BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^c TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Cytochrome 3A; Glycyrrhizin; Licorice; Pregnane X receptor

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450 3A; CYTOCHROME P450 3A11; CYTOCHROME P450 3A7; GLYCYRRHIZIC ACID; MESSENGER RNA; PREGNANE X RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL STRAIN HEPG2; CHOLESTASIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYP3A4 GENE; DNA BINDING; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GLYCYRRHIZA; HISTOPATHOLOGY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; CHOLESTASIS; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CYTOCHROME P-450 CYP3A; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; ENZYME INDUCTION; GENE EXPRESSION REGULATION; GLYCYRRHIZIC ACID; HEP G2 CELLS; HUMANS; LITHOCHOLIC ACID; LIVER; MALE; MICE; PROMOTER REGIONS, GENETIC; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; TIME FACTORS; TRANSCRIPTION, GENETIC;

GLYCYRRHIZA; MUS;

EID: 84866873375     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.08.023     Document Type: Article

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