Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors

Journal of Medicinal Chemistry

Volumn 55, Issue 18, 2012, Pages 8164-8177

  Thiele, Stefanie ^a   Malmgaard Clausen, Mikkel ^a,e   Engel Andreasen, Jens ^b   Steen, Anne ^a   Rummel, Pia C ^a   Nielsen, Mads C ^b,f   Gloriam, David E ^c   Frimurer, Thomas M ^d   Ulven, Trond ^b   Rosenkilde, Mette M ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d Capital Region   (Denmark)

^e Xellia Pharmaceuticals ApS   (Denmark)

^f ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

1,10 PHENANTHROLINE; 2,2' BIPYRIDINE; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR8; COPPER ION; GLUTAMIC ACID; ZINC ION;

ALLOSTERISM; ARTICLE; BINDING SITE; PROTEIN STRUCTURE;

ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; CHELATING AGENTS; COPPER; COS CELLS; GLUTAMIC ACID; HUMANS; LIGANDS; MODELS, MOLECULAR; ORGANOMETALLIC COMPOUNDS; PROTEIN STRUCTURE, TERTIARY; PYRIDINES; RECEPTORS, CCR; SUBSTRATE SPECIFICITY; ZINC;

EID: 84866848290     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301121j     Document Type: Article

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