Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor

Biochemistry

Volumn 42, Issue 3, 2003, Pages 710-717

  Gerlach, Lars Ole ^a,d   Jakobsen, Janus S ^a   Jensen, Kasper P ^b   Rosenkilde, Mette R ^a   Skerlj, Renato T ^c   Ryde, Ulf ^b   Bridger, Gary J ^c   Schwartz, Thue W ^a,d  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b LUND UNIVERSITY   (Sweden)

^c GENZYME CORPORATION   (United States)

^d 7TM Pharma A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; HYDROGEN BONDS; NICKEL; RINGS (COMPONENTS); ZINC;

SYMMETRICAL NONPEPTIDE;

BIOCHEMISTRY;

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); ASPARTIC ACID; CARBOXYLIC ACID; CHEMOKINE RECEPTOR CXCR4; COMPLEMENTARY DNA; COPPER ION; CYCLAM; METAL ION; NICKEL; NITROGEN; OXYGEN; STROMAL CELL DERIVED FACTOR 1; ZINC ION;

ANIMAL CELL; ARTICLE; CELL STRAIN COS7; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HUMAN; HYDROGEN BOND; LIGAND BINDING; METAL BINDING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; QUANTUM CHEMISTRY; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; ASPARTIC ACID; BINDING, COMPETITIVE; CARBOXYLIC ACIDS; CATIONS, DIVALENT; CHEMOKINES, CXC; COPPER; COS CELLS; DNA MUTATIONAL ANALYSIS; HETEROCYCLIC COMPOUNDS; HUMANS; LIGANDS; MACROMOLECULAR SUBSTANCES; METALS, HEAVY; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NICKEL; RECEPTORS, CXCR4; TRANSFECTION; ZINC;

ANIMALIA; RNA VIRUSES;

EID: 0037469138     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0264770     Document Type: Article

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