Construction of a high affinity zinc binding site in the metabotropic glutamate receptor mGluR1: Noncompetitive antagonism originating from the amino-terminal domain of a family C G-protein-coupled receptor

Journal of Biological Chemistry

Volumn 276, Issue 13, 2001, Pages 10110-10118

  Jensen, Anders A ^a   Sheppard, Paul O ^b   Jensen, Liselotte B ^a   O'Hara, Patrick J ^b   Bräuner Osborne, Hans ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b ZYMOGENETICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BACTERIA; CONFORMATIONS; DIMERIZATION; PROTEINS; ZINC;

AGONIST BINDINGS;

BIOCHEMISTRY;

BINDING PROTEIN; G PROTEIN COUPLED RECEPTOR; HISTIDINE; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1; METAL ION; UNCLASSIFIED DRUG; ZINC; ALANINE; CHLORIDE; GLUTAMIC ACID; INOSITOL PHOSPHATE; ION; LIGAND; LYSINE; METABOTROPIC GLUTAMATE RECEPTOR TYPE 1; ZINC CHLORIDE; ZINC DERIVATIVE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DIMERIZATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; ANIMAL; CELL LINE; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; DOSE RESPONSE; GENETIC TRANSFECTION; HAMSTER; IC 50; KINETICS; METABOLISM; MUTATION; PLASMID; POINT MUTATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; WESTERN BLOTTING;

BACTERIA (MICROORGANISMS);

ALANINE; ANIMALS; BINDING SITES; BLOTTING, WESTERN; CELL LINE; CELL MEMBRANE; CHLORIDES; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; HISTIDINE; HUMANS; IMMUNOBLOTTING; INHIBITORY CONCENTRATION 50; INOSITOL PHOSPHATES; IONS; KINETICS; LIGANDS; LYSINE; MODELS, MOLECULAR; MUTATION; PLASMIDS; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, METABOTROPIC GLUTAMATE; TRANSFECTION; ZINC; ZINC COMPOUNDS;

EID: 0035971068     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M007220200     Document Type: Article

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