-
1
-
-
0000912662
-
Vascularization of the Brown-Pearce rabbit epithelioma transplant as seen in the transparent ear chamber
-
Ide AG, Baker NH, Warren SL. Vascularization of the Brown-Pearce rabbit epithelioma transplant as seen in the transparent ear chamber. Am J Roentgenol 1939;42:891-9.
-
(1939)
Am J Roentgenol
, vol.42
, pp. 891-899
-
-
Ide, A.G.1
Baker, N.H.2
Warren, S.L.3
-
2
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182-6.
-
(1971)
N Engl J Med
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
3
-
-
0024818355
-
Vascular endothelial growth factor is a secreted angiogenic mitogen
-
Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Sciences (New York) 1989;246:1306-9. (Pubitemid 20066716)
-
(1989)
Science
, vol.246
, Issue.4935
, pp. 1306-1309
-
-
Leung, D.W.1
Cachianes, G.2
Kuang, W.-J.3
Goeddel, D.V.4
Ferrara, N.5
-
4
-
-
0025194878
-
2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor
-
Senger DR, Connolly DT, Van de Water L, Feder J, Dvorak HF. Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor. Cancer Res 1990;50:1774-8. (Pubitemid 20098819)
-
(1990)
Cancer Research
, vol.50
, Issue.6
, pp. 1774-1778
-
-
Senger, D.R.1
Connolly, D.T.2
Van De Water, L.3
Feder, J.4
Dvorak, H.F.5
-
5
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-42.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
6
-
-
37349124748
-
Bevacizumab: Optimal dose, schedule, and duration of therapy
-
Gandara DR, Sangha R, Davies AM. Bevacizumab: optimal dose, schedule, and duration of therapy. Clin Lung Cancer 2007;8:522-3. (Pubitemid 350292219)
-
(2007)
Clinical Lung Cancer
, vol.8
, Issue.9
, pp. 522-523
-
-
Gandara, D.R.1
Sangha, R.2
Davies, A.M.3
-
7
-
-
33845961014
-
Bevacizumab: An angiogenesis inhibitor for the treatment of solid malignancies
-
Shih T, Lindley C. Bevacizumab: an angiogenesis inhibitor for the treatment of solid malignancies. Clin Ther 2006;28:1779-802.
-
(2006)
Clin Ther
, vol.28
, pp. 1779-1802
-
-
Shih, T.1
Lindley, C.2
-
8
-
-
33748446259
-
Lack of benefit of maintenance paclitaxel in first-line chemotherapy in metastatic breast cancer
-
Gennari A, Amadori D, De Lena M, et al. Lack of benefit of maintenance paclitaxel in first-line chemotherapy in metastatic breast cancer. J Clin Oncol 2006;24:3912-8.
-
(2006)
J Clin Oncol
, vol.24
, pp. 3912-3918
-
-
Gennari, A.1
Amadori, D.2
De Lena, M.3
-
9
-
-
0036499649
-
Phase III trial comparing a defined duration of therapy versus continuous therapy followed by second-line therapy in advanced-stage IIIB/IV non-small-cell lung cancer
-
Socinski MA, Schell MJ, Peterman A, et al. Phase III trial comparing a defined duration of therapy versus continuous therapy followed by second-line therapy in advanced-stage IIIB/IV non-small-cell lung cancer. J Clin Oncol 2002;20:1335-43.
-
(2002)
J Clin Oncol
, vol.20
, pp. 1335-1343
-
-
Socinski, M.A.1
Schell, M.J.2
Peterman, A.3
-
10
-
-
42949149159
-
Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
-
Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol 2008;26:2013-9.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2013-2019
-
-
Saltz, L.B.1
Clarke, S.2
Diaz-Rubio, E.3
-
11
-
-
33846149645
-
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
-
Batchelor TT, Sorensen AG, di Tomaso E, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 2007;11:83-95.
-
(2007)
Cancer Cell
, vol.11
, pp. 83-95
-
-
Batchelor, T.T.1
Sorensen, A.G.2
Di Tomaso, E.3
-
12
-
-
50849089255
-
Reversible tumor growth acceleration following bevacizumab interruption in metastatic colorectal cancer patients scheduled for surgery
-
Cacheux W, Boisserie T, Staudacher L, et al. Reversible tumor growth acceleration following bevacizumab interruption in metastatic colorectal cancer patients scheduled for surgery. Ann Oncol 2008;19:1659-61.
-
(2008)
Ann Oncol
, vol.19
, pp. 1659-1661
-
-
Cacheux, W.1
Boisserie, T.2
Staudacher, L.3
-
13
-
-
55049137067
-
Tumor growth rates derived from data for patients in a clinical trial correlate strongly with patient survival: A novel strategy for evaluation of clinical trial data
-
Stein WD, Figg WD, Dahut W, et al. Tumor growth rates derived from data for patients in a clinical trial correlate strongly with patient survival: a novel strategy for evaluation of clinical trial data. Oncologist 2008;13:1046-54.
-
(2008)
Oncologist
, vol.13
, pp. 1046-1054
-
-
Stein, W.D.1
Figg, W.D.2
Dahut, W.3
-
14
-
-
55049109179
-
Bevacizumab reduces the growth rate constants of renal carcinomas: A novel algorithm suggests early discontinuation of bevacizumab resulted in a lack of survival advantage
-
Stein WD, Yang J, Bates SE, Fojo T. Bevacizumab reduces the growth rate constants of renal carcinomas: a novel algorithm suggests early discontinuation of bevacizumab resulted in a lack of survival advantage. Oncologist 2008;13:1055-62.
-
(2008)
Oncologist
, vol.13
, pp. 1055-1062
-
-
Stein, W.D.1
Yang, J.2
Bates, S.E.3
Fojo, T.4
-
15
-
-
62649101158
-
Cancer: The nuances of therapy
-
Ellis LM, Reardon DA. Cancer: the nuances of therapy. Nature 2009; 458:290-2.
-
(2009)
Nature
, vol.458
, pp. 290-292
-
-
Ellis, L.M.1
Reardon, D.A.2
-
16
-
-
57649135172
-
A role for VEGF as a negative regulator of pericyte function and vessel maturation
-
Greenberg JI, Shields DJ, Barillas SG, et al. A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature 2008;456:809-13.
-
(2008)
Nature
, vol.456
, pp. 809-813
-
-
Greenberg, J.I.1
Shields, D.J.2
Barillas, S.G.3
-
17
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Paez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009;15:220-31.
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Paez-Ribes, M.1
Allen, E.2
Hudock, J.3
-
18
-
-
57649112725
-
Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
-
Stockmann C, Doedens A, Weidemann A, et al. Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature 2008;456:814-8.
-
(2008)
Nature
, vol.456
, pp. 814-818
-
-
Stockmann, C.1
Doedens, A.2
Weidemann, A.3
-
19
-
-
33749441325
-
Rapid vascular regrowth in tumors after reversal of VEGF inhibition
-
Mancuso MR, Davis R, Norberg SM, et al. Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest 2006;116:2610-21.
-
(2006)
J Clin Invest
, vol.116
, pp. 2610-2621
-
-
Mancuso, M.R.1
Davis, R.2
Norberg, S.M.3
-
20
-
-
33644863498
-
Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF
-
Liang WC, Wu X, Peale FV, et al. Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF. J Biol Chem 2006;281:951-61.
-
(2006)
J Biol Chem
, vol.281
, pp. 951-961
-
-
Liang, W.C.1
Wu, X.2
Peale, F.V.3
-
21
-
-
0032931234
-
VEGF is required for growth and survival in neonatal mice
-
Gerber HP, Hillan KJ, Ryan AM, et al. VEGF is required for growth and survival in neonatal mice. Development 1999;126:1149-59.
-
(1999)
Development
, vol.126
, pp. 1149-1159
-
-
Gerber, H.P.1
Hillan, K.J.2
Ryan, A.M.3
-
22
-
-
4043083699
-
Human endocrine gland-derived vascular endothelial growth factor: Expression early in development and in Leydig cell tumors suggests roles in normal and pathological testis angiogenesis
-
DOI 10.1210/jc.2003-032024
-
Samson M, Peale F, Frantz G, Rioux-Leclercq N, Rajpert-De Meyts E, Ferrara N. Human endocrine gland-derived vascular endothelial growth factor: expression early in development and in Leydig cell tumors suggests roles in normal and pathological testis angiogenesis. J Clin Endocrinol Metab 2004;89:4078-88. (Pubitemid 39071516)
-
(2004)
Journal of Clinical Endocrinology and Metabolism
, vol.89
, Issue.8
, pp. 4078-4088
-
-
Samson, M.1
Peale Jr., F.V.2
Frantz, G.3
Rioux-Leclercq, N.4
Rajpert-De Meyts, E.5
Ferrara, N.6
-
23
-
-
57749173152
-
VEGF inhibition: Insights from preclinical and clinical studies
-
Crawford Y, Ferrara N. VEGF inhibition: insights from preclinical and clinical studies. Cell Tissue Res 2009;335:261-9.
-
(2009)
Cell Tissue Res
, vol.335
, pp. 261-269
-
-
Crawford, Y.1
Ferrara, N.2
-
24
-
-
0033018871
-
Efficacy and concentration-response of murine anti-VEGF monoclonal antibody in tumor-bearing mice and extrapolation to humans
-
Mordenti J, Thomsen K, Licko V, Chen H, Meng YG, Ferrara N. Efficacy and concentration-response of murine anti-VEGF monoclonal antibody in tumor-bearing mice and extrapolation to humans. Toxicol Pathol 1999;27:14-21. (Pubitemid 29075738)
-
(1999)
Toxicologic Pathology
, vol.27
, Issue.1
, pp. 14-21
-
-
Mordenti, J.1
Thomsen, K.2
Licko, V.3
Chen, H.4
Meng, Y.G.5
Ferrara, N.6
-
25
-
-
49749124673
-
Clinical pharmacokinetics of bevacizumab in patients with solid tumors
-
Lu J, Bruno R, Eppler S, Novotny W, Lum B, Gaudreault J. Clinical pharmacokinetics of bevacizumab in patients with solid tumors. Cancer Chemother Pharmacol 2008;62:779-86.
-
(2008)
Cancer Chemother Pharmacol
, vol.62
, pp. 779-786
-
-
Lu, J.1
Bruno, R.2
Eppler, S.3
Novotny, W.4
Lum, B.5
Gaudreault, J.6
-
26
-
-
0000391746
-
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
-
Bergers G, Brekken R, McMahon G, et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2000;2:737-44.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 737-744
-
-
Bergers, G.1
Brekken, R.2
McMahon, G.3
-
27
-
-
77549088772
-
Pathways mediating VEGF-independent tumor angiogenesis
-
Ferara N. Pathways mediating VEGF-independent tumor angiogenesis. Cytokine Growth Factor Rev 2010;21:21-6.
-
(2010)
Cytokine Growth Factor Rev
, vol.21
, pp. 21-26
-
-
Ferara, N.1
-
28
-
-
40649104348
-
Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression
-
Shojaei F, Singh M, Thompson JD, Ferrara N. Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression. Proc Natl Acad Sci U S A 2008;105:2640-5.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 2640-2645
-
-
Shojaei, F.1
Singh, M.2
Thompson, J.D.3
Ferrara, N.4
-
29
-
-
36849013036
-
Bv8 regulates myeloid-cell-dependent tumour angiogenesis
-
Shojaei F, Wu X, Zhong C, et al. Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature 2007;450:825-31.
-
(2007)
Nature
, vol.450
, pp. 825-831
-
-
Shojaei, F.1
Wu, X.2
Zhong, C.3
-
30
-
-
33746860827
-
Angiogenesis in colorectal cancer: Prognostic and therapeutic implications
-
Giatromanolaki A, Sivridis E, Koukourakis MI. Angiogenesis in colorectal cancer: prognostic and therapeutic implications. Am J Clin Oncol 2006;29:408-17.
-
(2006)
Am J Clin Oncol
, vol.29
, pp. 408-417
-
-
Giatromanolaki, A.1
Sivridis, E.2
Koukourakis, M.I.3
-
31
-
-
33744962527
-
Clinical implications of angiogenesis in cancers
-
Pang RW, Poon RT. Clinical implications of angiogenesis in cancers. Vasc Health Risk Manag 2006;2:97-108.
-
(2006)
Vasc Health Risk Manag
, vol.2
, pp. 97-108
-
-
Pang, R.W.1
Poon, R.T.2
-
32
-
-
67650380136
-
Biomarkers of response and resistance to antiangiogenic therapy
-
Jain RK, Duda DG, Willett CG, et al. Biomarkers of response and resistance to antiangiogenic therapy. Nat Rev Clin Oncol 2009;6: 327-38.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 327-338
-
-
Jain, R.K.1
Duda, D.G.2
Willett, C.G.3
-
33
-
-
34248386965
-
Challenges for patient selection with VEGF inhibitors
-
Longo R, Gasparini G. Challenges for patient selection with VEGF inhibitors. Cancer Chemother Pharmacol 2007;60:151-70.
-
(2007)
Cancer Chemother Pharmacol
, vol.60
, pp. 151-170
-
-
Longo, R.1
Gasparini, G.2
-
34
-
-
40749125285
-
Sustained VEGF blockade results in microenvironmental sequestration of VEGF by tumors and persistent VEGF receptor-2 activation
-
Kadenhe-Chiweshe A, Papa J, McCrudden KW, et al. Sustained VEGF blockade results in microenvironmental sequestration of VEGF by tumors and persistent VEGF receptor-2 activation. Mol Cancer Res 2008;6:1-9.
-
(2008)
Mol Cancer Res
, vol.6
, pp. 1-9
-
-
Kadenhe-Chiweshe, A.1
Papa, J.2
McCrudden, K.W.3
-
36
-
-
64249114690
-
The use of GEM models for experimental cancer therapeutics
-
Gopinathan A, Tuveson DA. The use of GEM models for experimental cancer therapeutics. Dis Model Mech 2008;1:83-6.
-
(2008)
Dis Model Mech
, vol.1
, pp. 83-86
-
-
Gopinathan, A.1
Tuveson, D.A.2
-
37
-
-
0033617532
-
Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
-
New York
-
Bergers G, Javaherian K, Lo KM, Folkman J, Hanahan D. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Sciences (New York) 1999;284:808-12.
-
(1999)
Sciences
, vol.284
, pp. 808-812
-
-
Bergers, G.1
Javaherian, K.2
Lo, K.M.3
Folkman, J.4
Hanahan, D.5
-
38
-
-
33646586669
-
Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor
-
Albert DH, Tapang P, Magoc TJ, et al. Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol Cancer Ther 2006;5:995-1006.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 995-1006
-
-
Albert, D.H.1
Tapang, P.2
Magoc, T.J.3
-
39
-
-
57849106330
-
PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
-
Crawford Y, Kasman I, Yu L, et al. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell 2009;15:21-34.
-
(2009)
Cancer Cell
, vol.15
, pp. 21-34
-
-
Crawford, Y.1
Kasman, I.2
Yu, L.3
-
40
-
-
52649150833
-
Targeting angiogenesis driven by vascular endothelial growth factors using antibody-based therapies
-
Grothey A, Ellis L. Targeting angiogenesis driven by vascular endothelial growth factors using antibody-based therapies. Cancer J 2008;14:170-7.
-
(2008)
Cancer J
, vol.14
, pp. 170-177
-
-
Grothey, A.1
Ellis, L.2
-
41
-
-
21244450758
-
Association of k-ras, b-raf, and p53 status with the treatment effect of bevacizumab
-
Ince WL, Jubb A, Holden SN, et al. Association of k-ras, b-raf, and p53 status with the treatment effect of bevacizumab. J Natl Cancer Inst 2005;97:981-9.
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 981-989
-
-
Ince, W.L.1
Jubb, A.2
Holden, S.N.3
-
42
-
-
70350721785
-
Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor
-
O'Connor J, Carano R, Clamp A, et al. Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor. Clin Cancer Res 2009;15:6674-82.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6674-6682
-
-
O'Connor, J.1
Carano, R.2
Clamp, A.3
-
43
-
-
59449084872
-
Maintenance treatment with bevacizumab prolongs survival in an in vivo ovarian cancer model
-
Mabuchi S, Terai Y, Morishige K, et al. Maintenance treatment with bevacizumab prolongs survival in an in vivo ovarian cancer model. Clin Cancer Res 2008;14:7781-9.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7781-7789
-
-
Mabuchi, S.1
Terai, Y.2
Morishige, K.3
-
44
-
-
0034894341
-
Combination antiangiogenic therapy: Increased efficacy in a murine model of Wilms tumor
-
Soffer SZ, Moore JT, Kim E, et al. Combination antiangiogenic therapy: increased efficacy in a murine model of Wilms tumor. J Pediatr Surg 2001;36:1177-81.
-
(2001)
J Pediatr Surg
, vol.36
, pp. 1177-1181
-
-
Soffer, S.Z.1
Moore, J.T.2
Kim, E.3
-
45
-
-
58149521889
-
In vivo activity of novel capecitabine regimens alone and with bevacizumab and oxaliplatin in colorectal cancer xenograft models
-
Kolinsky K, Shen BQ, Zhang YE, et al. In vivo activity of novel capecitabine regimens alone and with bevacizumab and oxaliplatin in colorectal cancer xenograft models. Mol Cancer Ther 2009;8:75-82.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 75-82
-
-
Kolinsky, K.1
Shen, B.Q.2
Zhang, Y.E.3
-
46
-
-
57349110570
-
Combining bevacizumab with temozolomide increases the antitumor efficacy of temozolomide in a human glioblastoma orthotopic xenograft model
-
Mathieu V, De Nève N, Le Mercier M, et al. Combining bevacizumab with temozolomide increases the antitumor efficacy of temozolomide in a human glioblastoma orthotopic xenograft model. NEO 2008;10: 1383-92.
-
(2008)
NEO
, vol.10
, pp. 1383-1392
-
-
Mathieu, V.1
De Nève, N.2
Le Mercier, M.3
-
47
-
-
60649116477
-
Silencing or fueling metastasis with VEGF inhibitors: Antiangiogenesis revisited
-
Loges S, Mazzone M, Hohensinner P, Carmeliet P. Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisited. Cancer Cell 2009;15:167-70.
-
(2009)
Cancer Cell
, vol.15
, pp. 167-170
-
-
Loges, S.1
Mazzone, M.2
Hohensinner, P.3
Carmeliet, P.4
-
48
-
-
60649087564
-
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
-
Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel R. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 2009;15:232-9.
-
(2009)
Cancer Cell
, vol.15
, pp. 232-239
-
-
Ebos, J.M.1
Lee, C.R.2
Cruz-Munoz, W.3
Bjarnason, G.A.4
Christensen, J.G.5
Kerbel, R.6
|