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Volumn 10, Issue 2, 2012, Pages 77-83

Importance of fibroblast growth factor receptor in neovascularization and tumor escape from antiangiogenic therapy

Author keywords

Angiogenesis; Cell signaling; Renal cell carcinoma; Vascular endothelial growth factor receptor

Indexed keywords

ANGIOGENESIS INHIBITOR; AXITINIB; BEVACIZUMAB; BRIVANIB; BRIVANIB ALANINATE; CEDIRANIB; DOVITINIB; ENZASTAURIN; EVEROLIMUS; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; INTERFERON; LENVATINIB; LINIFANIB; MASITINIB; MITOGEN ACTIVATED PROTEIN KINASE; NINTEDANIB; ORANTINIB; PAZOPANIB; PROTEIN KINASE C; REGORAFENIB; SORAFENIB; SUNITINIB; TEMSIROLIMUS; TIVOZANIB; VANDETANIB; VASCULOTROPIN; VATALANIB;

EID: 84862088276     PISSN: 15587673     EISSN: 19380682     Source Type: Journal    
DOI: 10.1016/j.clgc.2012.01.010     Document Type: Review
Times cited : (34)

References (79)
  • 1
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • DOI 10.1038/nrd2115, PII NRD2115
    • J. Folkman Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 6 2007 273 286 (Pubitemid 46505878)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.4 , pp. 273-286
    • Folkman, J.1
  • 2
    • 70349385645 scopus 로고    scopus 로고
    • Resistance to targeted therapy in renal-cell carcinoma
    • B.I. Rini, M.B. Atkins Resistance to targeted therapy in renal-cell carcinoma Lancet Oncol 10 2009 992 1000
    • (2009) Lancet Oncol , vol.10 , pp. 992-1000
    • Rini, B.I.1    Atkins, M.B.2
  • 3
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • G. Bergers, D. Hanahan Modes of resistance to anti-angiogenic therapy Nat Rev Cancer 8 2008 592 603
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 4
    • 79955705800 scopus 로고    scopus 로고
    • Resistance of renal cell carcinoma to sorafenib is mediated by potentially reversible gene expression
    • L. Zhang, M. Bhasin, R. Schor-Bardach Resistance of renal cell carcinoma to sorafenib is mediated by potentially reversible gene expression PLoS ONE 6 2011 e19144
    • (2011) PLoS ONE , vol.6 , pp. 19144
    • Zhang, L.1    Bhasin, M.2    Schor-Bardach, R.3
  • 5
    • 40949148520 scopus 로고    scopus 로고
    • Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors
    • DOI 10.1158/1078-0432.CCR-07-4126
    • N.T. Fernando, M. Koch, C. Rothrock Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors Clin Cancer Res 14 2008 1529 1539 (Pubitemid 351413938)
    • (2008) Clinical Cancer Research , vol.14 , Issue.5 , pp. 1529-1539
    • Fernando, N.T.1    Koch, M.2    Rothrock, C.3    Gollogly, L.K.4    D'Amore, P.A.5    Ryeom, S.6    Yoon, S.S.7
  • 6
    • 0022457546 scopus 로고
    • Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor
    • J.A. Abraham, A. Mergia, J.L. Whang Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor Science 233 1986 545 548 (Pubitemid 16019907)
    • (1986) Science , vol.233 , Issue.4763 , pp. 545-548
    • Abraham, J.A.1    Mergia, A.2    Whang, J.L.3
  • 7
    • 0015008620 scopus 로고
    • Isolation of a tumor factor responsible for angiogenesis
    • J. Folkman, E. Merler, C. Abernathy Isolation of a tumor factor responsible for angiogenesis J Exp Med 133 1971 275 288
    • (1971) J Exp Med , vol.133 , pp. 275-288
    • Folkman, J.1    Merler, E.2    Abernathy, C.3
  • 8
    • 0021265097 scopus 로고
    • Heparin binds endothelial cell growth factor, the principal endothelial cell mitogen in bovine brain
    • T. Maciag, T. Mehlman, R. Friesel Heparin binds endothelial cell growth factor, the principal endothelial cell mitogen in bovine brain Science 225 1984 932 935 (Pubitemid 14064174)
    • (1984) Science , vol.225 , Issue.4665 , pp. 932-935
    • Maciag, T.1    Mehlman, T.2    Friesel, R.3    Schreiber, A.B.4
  • 9
    • 4744372082 scopus 로고    scopus 로고
    • Evolution of the Fgf and Fgfr gene families
    • DOI 10.1016/j.tig.2004.08.007, PII S0168952504002410
    • N. Itoh, D.M. Ornitz Evolution of the Fgf and Fgfr gene families Trends Genet 20 2004 563 569 (Pubitemid 39314564)
    • (2004) Trends in Genetics , vol.20 , Issue.11 , pp. 563-569
    • Itoh, N.1    Ornitz, D.M.2
  • 11
    • 75149170979 scopus 로고    scopus 로고
    • Fibroblast growth factor signalling: From development to cancer
    • N. Turner, R. Grose Fibroblast growth factor signalling: from development to cancer Nat Rev Cancer 10 2010 116 129
    • (2010) Nat Rev Cancer , vol.10 , pp. 116-129
    • Turner, N.1    Grose, R.2
  • 12
    • 69249216604 scopus 로고    scopus 로고
    • The role of fibroblast growth factors in tumor growth
    • M. Korc, R.E. Friesel The role of fibroblast growth factors in tumor growth Curr Cancer Drug Targets 9 2009 639 651
    • (2009) Curr Cancer Drug Targets , vol.9 , pp. 639-651
    • Korc, M.1    Friesel, R.E.2
  • 13
    • 0036789313 scopus 로고    scopus 로고
    • The role of fibroblast growth factors in vascular development
    • S. Javerzat, P. Auguste, A. Bikfalvi The role of fibroblast growth factors in vascular development Trends Mol Med 8 2002 483 489
    • (2002) Trends Mol Med , vol.8 , pp. 483-489
    • Javerzat, S.1    Auguste, P.2    Bikfalvi, A.3
  • 15
    • 0034721640 scopus 로고    scopus 로고
    • Maintenance of vascular integrity in the embryo requires signaling through the fibroblast growth factor receptor
    • S.H. Lee, D.J. Schloss, J.L. Swain Maintenance of vascular integrity in the embryo requires signaling through the fibroblast growth factor receptor J Biol Chem 275 2000 33679 33687
    • (2000) J Biol Chem , vol.275 , pp. 33679-33687
    • Lee, S.H.1    Schloss, D.J.2    Swain, J.L.3
  • 16
    • 0035837317 scopus 로고    scopus 로고
    • Paracrine and autocrine effects of fibroblast growth factor-4 in endothelial cells
    • DOI 10.1038/sj.onc.1204368
    • P. Dell'Era, M. Belleri, H. Stabile Paracrine and autocrine effects of fibroblast growth factor-4 in endothelial cells Oncogene 20 2001 2655 2663 (Pubitemid 32525296)
    • (2001) Oncogene , vol.20 , Issue.21 , pp. 2655-2663
    • Dell'Era, P.1    Belleri, M.2    Stabile, H.3    Massardi, M.L.4    Ribatti, D.5    Presta, M.6
  • 17
    • 0030855812 scopus 로고    scopus 로고
    • Antisense targeting of basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth
    • DOI 10.1038/nm0897-887
    • Y. Wang, D. Becker Antisense targeting of basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth Nat Med 3 1997 887 893 (Pubitemid 27353449)
    • (1997) Nature Medicine , vol.3 , Issue.8 , pp. 887-893
    • Wang, Y.1    Becker, D.2
  • 18
    • 34250200790 scopus 로고    scopus 로고
    • Whole genome oligonucleotide-based array comparative genomic hybridization analysis identified fibroblast growth factor 1 as a prognostic marker for advanced-stage serous ovarian adenocarcinomas
    • DOI 10.1200/JCO.2006.09.0795
    • M.J. Birrer, M.E. Johnson, K. Hao Whole genome oligonucleotide-based array comparative genomic hybridization analysis identified fibroblast growth factor 1 as a prognostic marker for advanced-stage serous ovarian adenocarcinomas J Clin Oncol 25 2007 2281 2287 (Pubitemid 46954656)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.16 , pp. 2281-2287
    • Birrer, M.J.1    Johnson, M.E.2    Hao, K.3    Wong, K.-K.4    Park, D.-C.5    Bell, A.6    Welch, W.R.7    Berkowitz, R.S.8    Mok, S.C.9
  • 21
    • 0035875243 scopus 로고    scopus 로고
    • FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines
    • DOI 10.1054/bjoc.2001.1813
    • I. El-Hariry, M. Pignatelli, N.R. Lemoine FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines Br J Cancer 84 2001 1656 1663 (Pubitemid 32612498)
    • (2001) British Journal of Cancer , vol.84 , Issue.12 , pp. 1656-1663
    • Ei-Hariry, I.1    Pignatelli, M.2    Lemoine, N.R.3
  • 23
    • 0025885692 scopus 로고
    • Autocrinological role of basic fibroblast growth factor on tube formation of vascular endothelial cells in vitro
    • Y. Sato, T. Shimada, R. Takaki Autocrinological role of basic fibroblast growth factor on tube formation of vascular endothelial cells in vitro Biochem Biophys Res Commun 180 1991 1098 1102
    • (1991) Biochem Biophys Res Commun , vol.180 , pp. 1098-1102
    • Sato, Y.1    Shimada, T.2    Takaki, R.3
  • 24
    • 1042289788 scopus 로고    scopus 로고
    • Fibroblast growth factor-2-mediated capillary morphogenesis of endothelial cells requires signals via Flt-1/vascular endothelial growth factor receptor-1. Possible involvement of c-Akt
    • DOI 10.1074/jbc.M307569200
    • S. Kanda, Y. Miyata, H. Kanetake Fibroblast growth factor-2-mediated capillary morphogenesis of endothelial cells requires signals via Flt-1/vascular endothelial growth factor receptor-1: possible involvement of c-Akt J Biol Chem 279 2004 4007 4016 (Pubitemid 38198983)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.6 , pp. 4007-4016
    • Kanda, S.1    Miyata, Y.2    Kanetake, H.3
  • 25
    • 33845439397 scopus 로고    scopus 로고
    • The angiogenic switch molecule, secreted FGF-binding protein, an indicator of early stages of pancreatic and colorectal adenocarcinoma
    • E. Tassi, A. Wellstein The angiogenic switch molecule, secreted FGF-binding protein, an indicator of early stages of pancreatic and colorectal adenocarcinoma Semin Oncol 33 2006 S50 S56
    • (2006) Semin Oncol , vol.33
    • Tassi, E.1    Wellstein, A.2
  • 26
    • 5344262507 scopus 로고    scopus 로고
    • Expression pattern of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) system members in bovine corpus luteum endothelial cells during treatment with FGF-2, VEGF or oestradiol
    • DOI 10.1111/j.1439-0531.2004.00517.x
    • C. Gabler, A. Plath-Gabler, G.J. Killian Expression pattern of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) system members in bovine corpus luteum endothelial cells during treatment with FGF-2, VEGF or oestradiol Reprod Domest Anim 39 2004 321 327 (Pubitemid 39348367)
    • (2004) Reproduction in Domestic Animals , vol.39 , Issue.5 , pp. 321-327
    • Gabler, C.1    Plath-Gabler, A.2    Killian, G.J.3    Berisha, B.4    Schams, D.5
  • 28
    • 34147128640 scopus 로고    scopus 로고
    • Fibroblast growth factor-2-induced host stroma reaction during initial tumor growth promotes progression of mouse melanoma via vascular endothelial growth factor A-dependent neovascularization
    • DOI 10.1111/j.1349-7006.2007.00432.x
    • S. Tsunoda, T. Nakamura, H. Sakurai Fibroblast growth factor-2-induced host stroma reaction during initial tumor growth promotes progression of mouse melanoma via vascular endothelial growth factor A-dependent neovascularization Cancer Sci 98 2007 541 548 (Pubitemid 46562745)
    • (2007) Cancer Science , vol.98 , Issue.4 , pp. 541-548
    • Tsunoda, S.1    Nakamura, T.2    Sakurai, H.3    Saiki, I.4
  • 31
    • 0035866394 scopus 로고    scopus 로고
    • Inhibition of fibroblast growth factor/fibroblast growth factor receptor activity in glioma cells impedes tumor growth by both angiogenesis-dependent and -independent mechanisms
    • P. Auguste, D.B. Gürsel, S. Lemière Inhibition of fibroblast growth factor/fibroblast growth factor receptor activity in glioma cells impedes tumor growth by both angiogenesis-dependent and -independent mechanisms Cancer Res 61 2001 1717 1726 (Pubitemid 34292610)
    • (2001) Cancer Research , vol.61 , Issue.4 , pp. 1717-1726
    • Auguste, P.1    Gursel, D.B.2    Lemiere, S.3    Reimers, D.4    Cuevas, P.5    Carceller, F.6    Di Santo, J.P.7    Bikfalvi, A.8
  • 33
    • 0031776704 scopus 로고    scopus 로고
    • Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumourigenesis
    • DOI 10.1002/(SICI)1098-2264(199807)22:3<200::AID-GCC5>3.0.CO;2-#
    • S.C. Clifford, A.H. Prowse, N.A. Affara Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: evidence for a VHL-independent pathway in clear cell renal tumourigenesis Genes Chromosomes Cancer 22 1998 200 209 (Pubitemid 28262196)
    • (1998) Genes Chromosomes and Cancer , vol.22 , Issue.3 , pp. 200-209
    • Clifford, S.C.1    Prowse, A.H.2    Affara, N.A.3    Buys, C.H.C.M.4    Maher, E.R.5
  • 35
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    • R.J. Motzer, T.E. Hutson, P. Tomczak Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma J Clin Oncol 27 2009 3584 3590
    • (2009) J Clin Oncol , vol.27 , pp. 3584-3590
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 36
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
    • C.N. Sternberg, I.D. Davis, J. Mardiak Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial J Clin Oncol 28 2010 1061 1068
    • (2010) J Clin Oncol , vol.28 , pp. 1061-1068
    • Sternberg, C.N.1    Davis, I.D.2    Mardiak, J.3
  • 39
    • 70249097380 scopus 로고    scopus 로고
    • Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial
    • B. Escudier, T. Eisen, W.M. Stadler Sorafenib for treatment of renal cell carcinoma: final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial J Clin Oncol 27 2009 3312 3318
    • (2009) J Clin Oncol , vol.27 , pp. 3312-3318
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 42
    • 77952318310 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: Final results of CALGB 90206
    • B.I. Rini, S. Halabi, J.E. Rosenberg Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206 J Clin Oncol 28 2010 2137 2143
    • (2010) J Clin Oncol , vol.28 , pp. 2137-2143
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3
  • 43
    • 77956395910 scopus 로고    scopus 로고
    • Toxicity of sunitinib plus bevacizumab in renal cell carcinoma
    • Author reply:e286-7
    • B.I. Rini, J.A. Garcia, M.M. Cooney Toxicity of sunitinib plus bevacizumab in renal cell carcinoma J Clin Oncol 28 2010 e284 e285 Author reply:e286-7
    • (2010) J Clin Oncol , vol.28
    • Rini, B.I.1    Garcia, J.A.2    Cooney, M.M.3
  • 44
    • 79959549917 scopus 로고    scopus 로고
    • Temsirolimus and bevacizumab, or sunitinib, or interferon alfa and bevacizumab for patients with advanced renal cell carcinoma (TORAVA): A randomised phase 2 trial
    • S. Négrier, G. Gravis, D. Pérol Temsirolimus and bevacizumab, or sunitinib, or interferon alfa and bevacizumab for patients with advanced renal cell carcinoma (TORAVA): a randomised phase 2 trial Lancet Oncol 12 2011 673 680
    • (2011) Lancet Oncol , vol.12 , pp. 673-680
    • Négrier, S.1    Gravis, G.2    Pérol, D.3
  • 45
    • 77955895649 scopus 로고    scopus 로고
    • Sorafenib in patients with metastatic renal cell carcinoma refractory to either sunitinib or bevacizumab
    • J.A. Garcia, T.E. Hutson, P. Elson Sorafenib in patients with metastatic renal cell carcinoma refractory to either sunitinib or bevacizumab Cancer 116 2010 5383 5390
    • (2010) Cancer , vol.116 , pp. 5383-5390
    • Garcia, J.A.1    Hutson, T.E.2    Elson, P.3
  • 46
    • 70349388719 scopus 로고    scopus 로고
    • Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma
    • B.I. Rini, G. Wilding, G. Hudes Phase II study of axitinib in sorafenib-refractory metastatic renal cell carcinoma J Clin Oncol 27 2009 4462 4468
    • (2009) J Clin Oncol , vol.27 , pp. 4462-4468
    • Rini, B.I.1    Wilding, G.2    Hudes, G.3
  • 47
    • 82755183572 scopus 로고    scopus 로고
    • Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): A randomised phase 3 trial
    • B.I. Rini, B. Escudier, P. Tomczak Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial Lancet 378 2011 1931 1939
    • (2011) Lancet , vol.378 , pp. 1931-1939
    • Rini, B.I.1    Escudier, B.2    Tomczak, P.3
  • 48
    • 49249087039 scopus 로고    scopus 로고
    • Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma
    • B.I. Rini, M.D. Michaelson, J.E. Rosenberg Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma J Clin Oncol 26 2008 3743 3748
    • (2008) J Clin Oncol , vol.26 , pp. 3743-3748
    • Rini, B.I.1    Michaelson, M.D.2    Rosenberg, J.E.3
  • 49
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
    • R.J. Motzer, B. Escudier, S. Oudard Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial Lancet 372 2008 449 456
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 50
    • 74949126146 scopus 로고    scopus 로고
    • Temsirolimus (TEM) in metastatic renal cell carcinoma (mRCC): Safety and efficacy in patients (pts) previously treated with VEGF-targeted therapy
    • abstract 16067 Accessed: February 7, 2012
    • L. Wood, R.M. Bukowski, R. Dreicer Temsirolimus (TEM) in metastatic renal cell carcinoma (mRCC): safety and efficacy in patients (pts) previously treated with VEGF-targeted therapy J Clin Oncol 26 suppl 2008 abstract 16067 www.asco.org Accessed: February 7, 2012
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Wood, L.1    Bukowski, R.M.2    Dreicer, R.3
  • 51
    • 78650383149 scopus 로고    scopus 로고
    • Temsirolimus in VEGF-refractory metastatic renal cell carcinoma
    • M.J. Mackenzie, B.I. Rini, P. Elson Temsirolimus in VEGF-refractory metastatic renal cell carcinoma Ann Oncol 22 2011 145 148
    • (2011) Ann Oncol , vol.22 , pp. 145-148
    • MacKenzie, M.J.1    Rini, B.I.2    Elson, P.3
  • 52
    • 77955470097 scopus 로고    scopus 로고
    • Clinical outcome in metastatic renal cell carcinoma patients after failure of initial vascular endothelial growth factor-targeted therapy
    • M.M. Vickers, T.K. Choueiri, M. Rogers Clinical outcome in metastatic renal cell carcinoma patients after failure of initial vascular endothelial growth factor-targeted therapy Urology 76 2010 430 434
    • (2010) Urology , vol.76 , pp. 430-434
    • Vickers, M.M.1    Choueiri, T.K.2    Rogers, M.3
  • 53
    • 84856199835 scopus 로고    scopus 로고
    • A phase II study of dovitinib (TKI258), an FGFR- and VEGFR-inhibitor, in patients with advanced or metastatic renal cell cancer (mRCC)
    • abstract 4551 Accessed: February 7, 2012
    • E. Angevin, V. Grünwald, A. Ravaud A phase II study of dovitinib (TKI258), an FGFR- and VEGFR-inhibitor, in patients with advanced or metastatic renal cell cancer (mRCC) J Clin Oncol 29 suppl 2011 abstract 4551 www.asco.org Accessed: February 7, 2012
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Angevin, E.1    Grünwald, V.2    Ravaud, A.3
  • 54
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • DOI 10.1016/j.ccr.2005.09.005, PII S1535610805002989
    • O. Casanovas, D.J. Hicklin, G. Bergers Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors Cancer Cell 8 2005 299 309 (Pubitemid 41443415)
    • (2005) Cancer Cell , vol.8 , Issue.4 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 55
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • M. Paez-Ribes, E. Allen, J. Hudock Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis Cancer Cell 15 2009 220 231
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 56
    • 80051690789 scopus 로고    scopus 로고
    • Brivanib, a dual FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF inhibition
    • E. Allen, I.B. Walters, D. Hanahan Brivanib, a dual FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF inhibition Clin Cancer Res 17 2011 5299 5310
    • (2011) Clin Cancer Res , vol.17 , pp. 5299-5310
    • Allen, E.1    Walters, I.B.2    Hanahan, D.3
  • 59
    • 0242456268 scopus 로고    scopus 로고
    • Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival
    • DOI 10.1016/j.ydbio.2003.08.015
    • D.C. Darland, L.J. Massingham, S.R. Smith Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival Dev Biol 264 2003 275 288 (Pubitemid 37393463)
    • (2003) Developmental Biology , vol.264 , Issue.1 , pp. 275-288
    • Darland, D.C.1    Massingham, L.J.2    Smith, S.R.3    Piek, E.4    Saint-Geniez, M.5    D'Amore, P.A.6
  • 60
    • 0030639167 scopus 로고    scopus 로고
    • Control of angiogenesis by the pericyte: Molecular mechanisms and significance
    • K.K. Hirschi, P.A. D'Amore Control of angiogenesis by the pericyte: molecular mechanisms and significance EXS 79 1997 419 428
    • (1997) EXS , vol.79 , pp. 419-428
    • Hirschi, K.K.1    D'Amore, P.A.2
  • 61
    • 58149346173 scopus 로고    scopus 로고
    • The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis
    • W.K. You, D.M. McDonald The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis BMB Rep 41 2008 833 839
    • (2008) BMB Rep , vol.41 , pp. 833-839
    • You, W.K.1    McDonald, D.M.2
  • 62
    • 81255195494 scopus 로고    scopus 로고
    • MET and VEGF: Synergistic targets in castration-resistant prostate cancer
    • D.T. Aftab, D.M. McDonald MET and VEGF: synergistic targets in castration-resistant prostate cancer Clin Transl Oncol 13 2011 703 709
    • (2011) Clin Transl Oncol , vol.13 , pp. 703-709
    • Aftab, D.T.1    McDonald, D.M.2
  • 65
    • 34247516968 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network Accessed:February 7, 2012
    • National Comprehensive Cancer Network NCCN: Clinical Practice guidelines in oncology. Kidney Cancer http://www.nccn.org/professionals/physician-gls/f- guidelines.asp#site Accessed:February 7, 2012
    • NCCN: Clinical Practice Guidelines in Oncology. Kidney Cancer
  • 66
    • 82555173128 scopus 로고    scopus 로고
    • Phase I/II and pharmacodynamic study of dovitinib (TKI258), an inhibitor of fibroblast growth factor receptors and VEGF receptors, in patients with advanced melanoma
    • K.B. Kim, J. Chesney, D. Robinson Phase I/II and pharmacodynamic study of dovitinib (TKI258), an inhibitor of fibroblast growth factor receptors and VEGF receptors, in patients with advanced melanoma Clin Cancer Res 17 2011 7451 7461
    • (2011) Clin Cancer Res , vol.17 , pp. 7451-7461
    • Kim, K.B.1    Chesney, J.2    Robinson, D.3
  • 67
    • 58149175849 scopus 로고    scopus 로고
    • Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma
    • H. Huynh, V.C. Ngo, J. Fargnoli Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma Clin Cancer Res 14 2008 6146 6153
    • (2008) Clin Cancer Res , vol.14 , pp. 6146-6153
    • Huynh, H.1    Ngo, V.C.2    Fargnoli, J.3
  • 68
    • 77951895481 scopus 로고    scopus 로고
    • A phase i open-label dose-escalation study of oral BIBF 1120 combined with standard paclitaxel and carboplatin in patients with advanced gynecological malignancies
    • A. du Bois, J. Huober, P. Stopfer A phase I open-label dose-escalation study of oral BIBF 1120 combined with standard paclitaxel and carboplatin in patients with advanced gynecological malignancies Ann Oncol 21 2010 370 375
    • (2010) Ann Oncol , vol.21 , pp. 370-375
    • Du Bois, A.1    Huober, J.2    Stopfer, P.3
  • 69
    • 70349658639 scopus 로고    scopus 로고
    • Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT
    • P. Dubreuil, S. Letard, M. Ciufolini Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT PLoS ONE 4 2009 e7258
    • (2009) PLoS ONE , vol.4 , pp. 7258
    • Dubreuil, P.1    Letard, S.2    Ciufolini, M.3
  • 70
    • 77956216884 scopus 로고    scopus 로고
    • Tivozanib, a pan-VEGFR tyrosine kinase inhibitor for the potential treatment of solid tumors
    • A. De Luca, N. Normanno Tivozanib, a pan-VEGFR tyrosine kinase inhibitor for the potential treatment of solid tumors IDrugs 13 2010 636 645
    • (2010) IDrugs , vol.13 , pp. 636-645
    • De Luca, A.1    Normanno, N.2
  • 72
    • 20044375036 scopus 로고    scopus 로고
    • The VEGF receptor tyrosine kinase inhibitor, ZD6474, inhibits angiogenesis and affects microvascular architecture within an orthotopically implanted renal cell carcinoma
    • DOI 10.1007/s10456-005-1394-3
    • J. Drevs, M.A. Konerding, T. Wolloscheck The VEGF receptor tyrosine kinase inhibitor, ZD6474, inhibits angiogenesis and affects microvascular architecture within an orthotopically implanted renal cell carcinoma Angiogenesis 7 2004 347 354 (Pubitemid 40767936)
    • (2004) Angiogenesis , vol.7 , Issue.4 , pp. 347-354
    • Drevs, J.1    Konerding, M.A.2    Wolloscheck, T.3    Wedge, S.R.4    Ryan, A.J.5    Ogilvie, D.J.6    Esser, N.7
  • 74
    • 77349095970 scopus 로고    scopus 로고
    • Phase i evaluation of cediranib, a selective VEGFR signalling inhibitor, in combination with gefitinib in patients with advanced tumours
    • H. van Cruijsen, E.E. Voest, C.J. Punt Phase I evaluation of cediranib, a selective VEGFR signalling inhibitor, in combination with gefitinib in patients with advanced tumours Eur J Cancer 46 2010 901 911
    • (2010) Eur J Cancer , vol.46 , pp. 901-911
    • Van Cruijsen, H.1    Voest, E.E.2    Punt, C.J.3
  • 75
    • 78650325328 scopus 로고    scopus 로고
    • Phase i study of BAY 73-4506, an inhibitor of oncogenic and angiogenic kinases, in patients with advanced solid tumors: Final results of a dose-escalation study
    • abstract 2558 Accessed: February 7, 2012
    • A. Frost, M. Buechert, C. Unger Phase I study of BAY 73-4506, an inhibitor of oncogenic and angiogenic kinases, in patients with advanced solid tumors: final results of a dose-escalation study J Clin Oncol 26 suppl 2008 abstract 2558 www.asco.org Accessed: February 7, 2012
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Frost, A.1    Buechert, M.2    Unger, C.3
  • 76
    • 70350464165 scopus 로고    scopus 로고
    • Phase i and biomarker study of ABT-869, a multiple receptor tyrosine kinase inhibitor, in patients with refractory solid malignancies
    • C.I. Wong, T.S. Koh, R. Soo Phase I and biomarker study of ABT-869, a multiple receptor tyrosine kinase inhibitor, in patients with refractory solid malignancies J Clin Oncol 27 2009 4718 4726
    • (2009) J Clin Oncol , vol.27 , pp. 4718-4726
    • Wong, C.I.1    Koh, T.S.2    Soo, R.3
  • 77
    • 24644457216 scopus 로고    scopus 로고
    • TSU-68 (SU6668) inhibits local tumor growth and liver metastasis of human colon cancer xenografts via anti-angiogenesis
    • K. Yorozuya, T. Kubota, M. Watanabe TSU-68 (SU6668) inhibits local tumor growth and liver metastasis of human colon cancer xenografts via anti-angiogenesis Oncol Rep 14 2005 677 682
    • (2005) Oncol Rep , vol.14 , pp. 677-682
    • Yorozuya, K.1    Kubota, T.2    Watanabe, M.3
  • 79
    • 37349105704 scopus 로고    scopus 로고
    • E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition
    • DOI 10.1002/ijc.23131
    • J. Matsui, Y. Yamamoto, Y. Funahashi E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition Int J Cancer 122 2008 664 671 (Pubitemid 350308963)
    • (2008) International Journal of Cancer , vol.122 , Issue.3 , pp. 664-671
    • Matsui, J.1    Yamamoto, Y.2    Funahashi, Y.3    Tsuruoka, A.4    Watanabe, T.5    Wakabayashi, T.6    Uenaka, T.7    Asada, M.8


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