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Volumn 139, Issue 20, 2012, Pages 3752-3763

Multifaceted roles of PTEN and TSC orchestrate growth and differentiation of Drosophila blood progenitors

Author keywords

Drosophila; Lymph gland; Myeloid; PTEN; TOR; TSC

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN; RNA; TARGET OF RAPAMYCIN KINASE; TUBEROUS SCLEROSIS COMPLEX 1; TUBEROUS SCLEROSIS COMPLEX 2; UNCLASSIFIED DRUG;

EID: 84866488064     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.074203     Document Type: Article
Times cited : (43)

References (49)
  • 1
    • 79958207849 scopus 로고    scopus 로고
    • Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells
    • Amcheslavsky, A., Ito, N., Jiang, J. and Ip, Y. T. (2011). Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells. J. Cell Biol. 193, 695-710.
    • (2011) J. Cell Biol , vol.193 , pp. 695-710
    • Amcheslavsky, A.1    Ito, N.2    Jiang, J.3    Ip, Y.T.4
  • 2
    • 34547874440 scopus 로고    scopus 로고
    • Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche
    • Arai, F. and Suda, T. (2007). Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche. Ann. N. Y. Acad. Sci. 1106, 41-53.
    • (2007) Ann. N. Y. Acad. Sci , vol.1106 , pp. 41-53
    • Arai, F.1    Suda, T.2
  • 3
    • 36949034117 scopus 로고    scopus 로고
    • Mechanisms of disease: The PI3K-Akt-PTEN signaling node-an intercept point for the control of angiogenesis in brain tumors
    • Castellino, R. C. and Durden, D. L. (2007). Mechanisms of disease: the PI3K-Akt-PTEN signaling node-an intercept point for the control of angiogenesis in brain tumors. Nat. Clin. Pract. Neuro. 3, 682-693.
    • (2007) Nat. Clin. Pract. Neuro , vol.3 , pp. 682-693
    • Castellino, R.C.1    Durden, D.L.2
  • 4
    • 53349091768 scopus 로고    scopus 로고
    • TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
    • Chen, C., Liu, Y., Liu, R., Ikenoue, T., Guan, K. L., Liu, Y. and Zheng, P. (2008). TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J. Exp. Med. 205, 2397-2408.
    • (2008) J. Exp. Med , vol.205 , pp. 2397-2408
    • Chen, C.1    Liu, Y.2    Liu, R.3    Ikenoue, T.4    Guan, K.L.5    Liu, Y.6    Zheng, P.7
  • 5
    • 0038300342 scopus 로고    scopus 로고
    • Transcriptional regulation of hematopoiesis in Drosophila
    • Evans, C. J. and Banerjee, U. (2000). Transcriptional regulation of hematopoiesis in Drosophila. Blood Cells Mol. Dis. 30, 223-228.
    • (2000) Blood Cells Mol. Dis , vol.30 , pp. 223-228
    • Evans, C.J.1    Banerjee, U.2
  • 6
    • 0242362740 scopus 로고    scopus 로고
    • Thicker than blood: Conserved mechanisms in Drosophila and vertebrate hematopoiesis
    • Evans, C. J., Hartenstein, V. and Banerjee, U. (2003). Thicker than blood: conserved mechanisms in Drosophila and vertebrate hematopoiesis. Dev. Cell 5, 673-690.
    • (2003) Dev. Cell , vol.5 , pp. 673-690
    • Evans, C.J.1    Hartenstein, V.2    Banerjee, U.3
  • 8
    • 0037097863 scopus 로고    scopus 로고
    • Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
    • Fingar, D. C., Salama, S., Tsou, C., Harlow, E. and Blenis, J. (2002). Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 16, 1472-1487.
    • (2002) Genes Dev , vol.16 , pp. 1472-1487
    • Fingar, D.C.1    Salama, S.2    Tsou, C.3    Harlow, E.4    Blenis, J.5
  • 10
    • 0035312747 scopus 로고    scopus 로고
    • Regulation of translation initiation by FRAP/mTOR
    • Gingras, A. C., Raught, B. and Sonenberg, N. (2001). Regulation of translation initiation by FRAP/mTOR. Genes Dev. 15, 807-826.
    • (2001) Genes Dev , vol.15 , pp. 807-826
    • Gingras, A.C.1    Raught, B.2    Sonenberg, N.3
  • 11
    • 85027917410 scopus 로고    scopus 로고
    • Hematopoiesis at the onset of metamorphosis: Terminal differentiation and dissociation of the Drosophila lymph gland
    • Grigorian, M., Mandal, L. and Hartenstein, V. (2011). Hematopoiesis at the onset of metamorphosis: terminal differentiation and dissociation of the Drosophila lymph gland. Dev. Genes Evol. 221, 121-131.
    • (2011) Dev. Genes Evol , vol.221 , pp. 121-131
    • Grigorian, M.1    Mandal, L.2    Hartenstein, V.3
  • 13
    • 27744569843 scopus 로고    scopus 로고
    • mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
    • Holz, M. K., Ballif, B. A., Gygi, S. P. and Blenis, J. (2005). mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 123, 569-580.
    • (2005) Cell , vol.123 , pp. 569-580
    • Holz, M.K.1    Ballif, B.A.2    Gygi, S.P.3    Blenis, J.4
  • 14
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki, K., Li, Y., Zhu, T., Wu, J. and Guan, K. L. (2002). TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4, 648-657.
    • (2002) Nat. Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 15
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • Inoki, K., Li, Y., Xu, T. and Guan, K. L. (2003). Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17, 1829-1834.
    • (2003) Genes Dev , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.L.4
  • 17
    • 0033582748 scopus 로고    scopus 로고
    • gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle
    • Ito, N. and Rubin, G. M. (1999). gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle. Cell 96, 529-539.
    • (1999) Cell , vol.96 , pp. 529-539
    • Ito, N.1    Rubin, G.M.2
  • 18
    • 35548936968 scopus 로고    scopus 로고
    • A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
    • Jang, Y. Y. and Sharkis, S. J. (2007). A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood 110, 3056-3063.
    • (2007) Blood , vol.110 , pp. 3056-3063
    • Jang, Y.Y.1    Sharkis, S.J.2
  • 19
    • 21244501788 scopus 로고    scopus 로고
    • The Drosophila lymph gland as a developmental model of hematopoiesis
    • Jung, S., Evans, C., Uemura, C. and Banerjee, U. (2005). The Drosophila lymph gland as a developmental model of hematopoiesis. Development 132, 2521-2533.
    • (2005) Development , vol.132 , pp. 2521-2533
    • Jung, S.1    Evans, C.2    Uemura, C.3    Banerjee, U.4
  • 21
    • 77954156681 scopus 로고    scopus 로고
    • Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling
    • Kockel, L., Kerr, K. S., Melnick, M., Brückner, K., Hebrok, M. and Perrimon, N. (2010). Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling. PLoS Genet. 6, e1000990.
    • (2010) PLoS Genet , vol.6
    • Kockel, L.1    Kerr, K.S.2    Melnick, M.3    Brückner, K.4    Hebrok, M.5    Perrimon, N.6
  • 22
    • 33947246071 scopus 로고    scopus 로고
    • Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre
    • Krzemien, J., Dubois, L., Makki, R., Meister, M., Vincent, A. and Crozatier, M. (2007). Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre. Nature 446, 325-328.
    • (2007) Nature , vol.446 , pp. 325-328
    • Krzemien, J.1    Dubois, L.2    Makki, R.3    Meister, M.4    Vincent, A.5    Crozatier, M.6
  • 23
    • 77956880939 scopus 로고    scopus 로고
    • Hematopoietic progenitors and hemocyte lineages in the Drosophila lymph gland
    • Krzemien, J., Oyallon, J., Crozatier, M. and Vincent, A. (2010). Hematopoietic progenitors and hemocyte lineages in the Drosophila lymph gland. Dev. Biol. 346, 310-319.
    • (2010) Dev. Biol , vol.346 , pp. 310-319
    • Krzemien, J.1    Oyallon, J.2    Crozatier, M.3    Vincent, A.4
  • 24
    • 77953299671 scopus 로고    scopus 로고
    • Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary
    • LaFever, L., Feoktistov, A., Hsu, H. J. and Drummond-Barbosa, D. (2010). Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary. Development 137, 2117-2126.
    • (2010) Development , vol.137 , pp. 2117-2126
    • Lafever, L.1    Feoktistov, A.2    Hsu, H.J.3    Drummond-Barbosa, D.4
  • 25
    • 0035865050 scopus 로고    scopus 로고
    • Postembryonic hematopoiesis in Drosophila
    • Lanot, R., Zachary, D., Holder, F. and Meister, M. (2001). Postembryonic hematopoiesis in Drosophila. Dev. Biol. 230, 243-257.
    • (2001) Dev. Biol , vol.230 , pp. 243-257
    • Lanot, R.1    Zachary, D.2    Holder, F.3    Meister, M.4
  • 26
    • 0034616310 scopus 로고    scopus 로고
    • Specification of Drosophila hematopoietic lineage by conserved transcription factors
    • Lebestky, T., Chang, T., Hartenstein, V. and Banerjee, U. (2000). Specification of Drosophila hematopoietic lineage by conserved transcription factors. Science 288, 146-149.
    • (2000) Science , vol.288 , pp. 146-149
    • Lebestky, T.1    Chang, T.2    Hartenstein, V.3    Banerjee, U.4
  • 27
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • Ma, X. M. and Blenis, J. (2009). Molecular mechanisms of mTOR-mediated translational control. Nat. Rev. Mol. Cell Biol. 10, 307-318.
    • (2009) Nat. Rev. Mol. Cell Biol , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 28
    • 33947236864 scopus 로고    scopus 로고
    • A Hedgehog-and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors
    • Mandal, L., Martinez-Agosto, J., Evans, C., Hartenstein, V. and Banerjee, U. (2007). A Hedgehog-and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors. Nature 446, 320-324.
    • (2007) Nature , vol.446 , pp. 320-324
    • Mandal, L.1    Martinez-Agosto, J.2    Evans, C.3    Hartenstein, V.4    Banerjee, U.5
  • 31
    • 0344629443 scopus 로고    scopus 로고
    • Signaling from Akt to FRAP/TOR Targets both 4E-BP and S6K in Drosophila melanogaster
    • Miron, M., Lasko, P. and Sonenberg, N. (2003). Signaling from Akt to FRAP/TOR Targets both 4E-BP and S6K in Drosophila melanogaster. Mol. Cell. Biol. 23, 9117-9126.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 9117-9126
    • Miron, M.1    Lasko, P.2    Sonenberg, N.3
  • 32
    • 84455178975 scopus 로고    scopus 로고
    • Interaction between differentiating cell- and niche-derived signals in hematopoietic progenitor maintenance
    • Mondal, B. C., Mukherjee, T., Mandal, L., Evans, C. J., Sinenko, S. A., Martinez-Agosto, J. A. and Banerjee, U. (2011). Interaction between differentiating cell- and niche-derived signals in hematopoietic progenitor maintenance. Cell 147, 1589-1600.
    • (2011) Cell , vol.147 , pp. 1589-1600
    • Mondal, B.C.1    Mukherjee, T.2    Mandal, L.3    Evans, C.J.4    Sinenko, S.A.5    Martinez-Agosto, J.A.6    Banerjee, U.7
  • 33
    • 70349446465 scopus 로고    scopus 로고
    • Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation
    • Owusu-Ansah, E. and Banerjee, U. (2009). Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation. Nature 461, 537-541.
    • (2009) Nature , vol.461 , pp. 537-541
    • Owusu-Ansah, E.1    Banerjee, U.2
  • 34
    • 0036714127 scopus 로고    scopus 로고
    • Akt regulates growth by directly phosphorylating Tsc2
    • Potter, C. J., Pedraza, L. G. and Xu, T. (2002). Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 4, 658-665.
    • (2002) Nat. Cell Biol , vol.4 , pp. 658-665
    • Potter, C.J.1    Pedraza, L.G.2    Xu, T.3
  • 35
    • 79960761944 scopus 로고    scopus 로고
    • An emerging role for TOR signaling in mammalian tissue and stem cell physiology
    • Russell, R. C., Fang, C. and Guan, K. L. (2011). An emerging role for TOR signaling in mammalian tissue and stem cell physiology. Development 138, 3343-3356.
    • (2011) Development , vol.138 , pp. 3343-3356
    • Russell, R.C.1    Fang, C.2    Guan, K.L.3
  • 36
    • 84859429092 scopus 로고    scopus 로고
    • Direct sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophila
    • Shim, J., Mukherjee, T. and Banerjee, U. (2012). Direct sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophila. Nat. Cell Biol. 14, 394-400.
    • (2012) Nat. Cell Biol , vol.14 , pp. 394-400
    • Shim, J.1    Mukherjee, T.2    Banerjee, U.3
  • 37
    • 65549109672 scopus 로고    scopus 로고
    • Dual role of Wingless signaling in stem-like hematopoietic precursor maintenance in Drosophila
    • Sinenko, S. A., Mandal, L., Martinez-Agosto, J. A. and Banerjee, U. (2009). Dual role of Wingless signaling in stem-like hematopoietic precursor maintenance in Drosophila. Dev. Cell 16, 756-763.
    • (2009) Dev. Cell , vol.16 , pp. 756-763
    • Sinenko, S.A.1    Mandal, L.2    Martinez-Agosto, J.A.3    Banerjee, U.4
  • 38
    • 0036499538 scopus 로고    scopus 로고
    • Cellular immune response to parasite infection in the Drosophila lymph gland is developmentally regulated
    • Sorrentino, R., Carton, Y. and Govind, S. (2002). Cellular immune response to parasite infection in the Drosophila lymph gland is developmentally regulated. Dev. Biol. 243, 65-80.
    • (2002) Dev. Biol , vol.243 , pp. 65-80
    • Sorrentino, R.1    Carton, Y.2    Govind, S.3
  • 39
    • 79953044605 scopus 로고    scopus 로고
    • Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila
    • Sousa-Nunes, R., Yee, L. L. and Gould, A. P. (2011). Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. Nature 471, 508-512.
    • (2011) Nature , vol.471 , pp. 508-512
    • Sousa-Nunes, R.1    Yee, L.L.2    Gould, A.P.3
  • 40
    • 0037086001 scopus 로고    scopus 로고
    • Living with lethal PIP3 levels: Viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
    • Stocker, H., Andjelkovic, M., Oldham, S., Laffargue, M., Wymann, M. P., Hemmings, B. A. and Hafen, E. (2002). Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science 295, 2088-2091.
    • (2002) Science , vol.295 , pp. 2088-2091
    • Stocker, H.1    Andjelkovic, M.2    Oldham, S.3    Laffargue, M.4    Wymann, M.P.5    Hemmings, B.A.6    Hafen, E.7
  • 41
    • 0035805180 scopus 로고    scopus 로고
    • The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation
    • Tapon, N., Ito, N., Dickson, B. J., Treisman, J. E. and Hariharan, I. K. (2001). The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105, 345-355.
    • (2001) Cell , vol.105 , pp. 345-355
    • Tapon, N.1    Ito, N.2    Dickson, B.J.3    Treisman, J.E.4    Hariharan, I.K.5
  • 42
    • 0042701991 scopus 로고    scopus 로고
    • Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
    • Tee, A. R., Manning, B. D., Roux, P. P., Cantley, L. C. and Blenis, J. (2003). Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 13, 1259-1268.
    • (2003) Curr. Biol , vol.13 , pp. 1259-1268
    • Tee, A.R.1    Manning, B.D.2    Roux, P.P.3    Cantley, L.C.4    Blenis, J.5
  • 44
    • 66349138676 scopus 로고    scopus 로고
    • Nutrient control of TORC1, a cell-cycle regulator
    • Wang, X. and Proud, C. G. (2009). Nutrient control of TORC1, a cell-cycle regulator. Trends Cell Biol. 19, 260-267.
    • (2009) Trends Cell Biol , vol.19 , pp. 260-267
    • Wang, X.1    Proud, C.G.2
  • 45
    • 67349208962 scopus 로고    scopus 로고
    • Aberrant expression of TSC2 gene in the newly diagnosed acute leukemia
    • Xu, Z., Wang, M., Wang, L., Wang, Y., Zhao, X., Rao, Q. and Wang, J. (2009). Aberrant expression of TSC2 gene in the newly diagnosed acute leukemia. Leuk. Res. 33, 891-897.
    • (2009) Leuk. Res , vol.33 , pp. 891-897
    • Xu, Z.1    Wang, M.2    Wang, L.3    Wang, Y.4    Zhao, X.5    Rao, Q.6    Wang, J.7
  • 46
    • 34547907805 scopus 로고    scopus 로고
    • Expanding mTOR signaling
    • Yang, Q. and Guan, K. L. (2007). Expanding mTOR signaling. Cell Res. 17, 666-681.
    • (2007) Cell Res , vol.17 , pp. 666-681
    • Yang, Q.1    Guan, K.L.2
  • 47
    • 33646376411 scopus 로고    scopus 로고
    • Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    • Yilmaz, O. H., Valdez, R., Theisen, B. K., Guo, W., Ferguson, D. O., Wu, H. and Morrison, S. J. (2006). Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441, 475-482.
    • (2006) Nature , vol.441 , pp. 475-482
    • Yilmaz, O.H.1    Valdez, R.2    Theisen, B.K.3    Guo, W.4    Ferguson, D.O.5    Wu, H.6    Morrison, S.J.7
  • 48
    • 77952423161 scopus 로고    scopus 로고
    • Relevant mouse model for human monocytic leukemia through Cre/lox-controlled myeloid-specific deletion of PTEN
    • Yu, H., Li, Y., Gao, C., Fabien, L., Jia, Y., Lu, J., Silberstein, L. E., Pinkus, G. S., Ye, K., Chai, L. et al. (2010). Relevant mouse model for human monocytic leukemia through Cre/lox-controlled myeloid-specific deletion of PTEN. Leukemia 24, 1077-1080.
    • (2010) Leukemia , vol.24 , pp. 1077-1080
    • Yu, H.1    Li, Y.2    Gao, C.3    Fabien, L.4    Jia, Y.5    Lu, J.6    Silberstein, L.E.7    Pinkus, G.S.8    Ye, K.9    Chai, L.10


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