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Volumn 23, Issue 24, 2003, Pages 9117-9126

Signaling from Akt to FRAP/TOR Targets both 4E-BP and S6K in Drosophila melanogaster

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR; INITIATION FACTOR 4E BINDING PROTEIN; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAPAMYCIN; RNA; S6 KINASE; SERINE; THREONINE; UNCLASSIFIED DRUG;

EID: 0344629443     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.24.9117-9126.2003     Document Type: Article
Times cited : (109)

References (58)
  • 2
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand, A. H., and N. Perrimon. 1993. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118:401-415.
    • (1993) Development , vol.118 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 3
    • 0036484062 scopus 로고    scopus 로고
    • Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions
    • Britton, J. S., W. K. Lockwood, L. Li, S. M. Cohen, and B. A. Edgar. 2002. Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions. Dev. Cell 2:239-249.
    • (2002) Dev. Cell , vol.2 , pp. 239-249
    • Britton, J.S.1    Lockwood, W.K.2    Li, L.3    Cohen, S.M.4    Edgar, B.A.5
  • 4
    • 0031453135 scopus 로고    scopus 로고
    • The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus
    • Brunn, G. J., P. Fadden, T. A. J. Haystead, and J. C. Lawrence, Jr. 1997. The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus. J. Biol. Chem. 272:32547-32550.
    • (1997) J. Biol. Chem. , vol.272 , pp. 32547-32550
    • Brunn, G.J.1    Fadden, P.2    Haystead, T.A.J.3    Lawrence Jr., J.C.4
  • 5
    • 0007588936 scopus 로고    scopus 로고
    • Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway
    • Cho, K. S., J. H. Lee, S. Kim, D. Kim, H. Koh, J. Lee, C. Kim, J. Kim, and J. Chung. 2001. Drosophila phosphoinositide-dependent kinase-1 regulates apoptosis and growth via the phosphoinositide 3-kinase-dependent signaling pathway. Proc. Natl. Acad. Sci. USA 98:6144-6149.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 6144-6149
    • Cho, K.S.1    Lee, J.H.2    Kim, S.3    Kim, D.4    Koh, H.5    Lee, J.6    Kim, C.7    Kim, J.8    Chung, J.9
  • 6
    • 0038482156 scopus 로고    scopus 로고
    • Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor
    • Choi, K. M., L. P. McMahon, and J. C. Lawrence, Jr. 2003. Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor. J. Biol. Chem. 278:19667-19673.
    • (2003) J. Biol. Chem. , vol.278 , pp. 19667-19673
    • Choi, K.M.1    McMahon, L.P.2    Lawrence Jr., J.C.3
  • 8
    • 0033593316 scopus 로고    scopus 로고
    • Size control in animal development
    • Conlon, I., and M. Raff. 1999. Size control in animal development. Cell 96:235-244.
    • (1999) Cell , vol.96 , pp. 235-244
    • Conlon, I.1    Raff, M.2
  • 9
    • 0032973572 scopus 로고    scopus 로고
    • Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation
    • Dufner, A., M. Andjelkovic, B. M. Burgering, B. A. Hemmings, and G. Thomas. 1999. Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation. Mol. Cell. Biol. 19:4525-4534.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 4525-4534
    • Dufner, A.1    Andjelkovic, M.2    Burgering, B.M.3    Hemmings, B.A.4    Thomas, G.5
  • 10
    • 0030934285 scopus 로고    scopus 로고
    • Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes
    • Fadden, P., T. A. Haystead, and J. C. Lawrence, Jr. 1997. Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes. J. Biol. Chem. 272:10240-10247.
    • (1997) J. Biol. Chem. , vol.272 , pp. 10240-10247
    • Fadden, P.1    Haystead, T.A.2    Lawrence Jr., J.C.3
  • 11
    • 0037097863 scopus 로고    scopus 로고
    • Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
    • Fingar, D. C., S. Salama, C. Tsou, E. Harlow, and J. Blenis. 2002. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 16:1472-1487.
    • (2002) Genes Dev. , vol.16 , pp. 1472-1487
    • Fingar, D.C.1    Salama, S.2    Tsou, C.3    Harlow, E.4    Blenis, J.5
  • 12
    • 0034982971 scopus 로고    scopus 로고
    • TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
    • Gao, X., and D. Pan. 2001. TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev. 15:1383-1392.
    • (2001) Genes Dev. , vol.15 , pp. 1383-1392
    • Gao, X.1    Pan, D.2
  • 16
    • 0032520009 scopus 로고    scopus 로고
    • 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway
    • Gingras, A. C., S. G. Kennedy, M. A. O'Leary, N. Sonenberg, and N. Hay. 1998. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev. 12:502-513.
    • (1998) Genes Dev. , vol.12 , pp. 502-513
    • Gingras, A.C.1    Kennedy, S.G.2    O'Leary, M.A.3    Sonenberg, N.4    Hay, N.5
  • 18
    • 0035312747 scopus 로고    scopus 로고
    • Regulation of translation initiation by FRAP/mTOR
    • Gingras, A. C., B. Raught, and N. Sonenberg. 2001. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 15:807-826.
    • (2001) Genes Dev. , vol.15 , pp. 807-826
    • Gingras, A.C.1    Raught, B.2    Sonenberg, N.3
  • 19
    • 0034463918 scopus 로고    scopus 로고
    • A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
    • Haruta, T., T. Uno, J. Kawahara, A. Takano, K. Egawa, P. M. Sharma, J. M. Olefsky, and M. Kobayashi. 2000. A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol. Endocrinol. 14:783-794.
    • (2000) Mol. Endocrinol. , vol.14 , pp. 783-794
    • Haruta, T.1    Uno, T.2    Kawahara, J.3    Takano, A.4    Egawa, K.5    Sharma, P.M.6    Olefsky, J.M.7    Kobayashi, M.8
  • 20
    • 0032533173 scopus 로고    scopus 로고
    • Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor-4E binding protein 1 on the rapamycin-insensitive site (serine-111)
    • Heesom, K. J., M. B. Avison, T. A. Diggle, and R. M. Denton. 1998. Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor-4E binding protein 1 on the rapamycin-insensitive site (serine-111). Biochem. J. 336:39-48.
    • (1998) Biochem. J. , vol.336 , pp. 39-48
    • Heesom, K.J.1    Avison, M.B.2    Diggle, T.A.3    Denton, R.M.4
  • 21
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • Inoki, K., Y. Li, T. Xu, and K. L. Guan. 2003. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17:1829-1834.
    • (2003) Genes Dev. , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.L.4
  • 22
    • 0037191045 scopus 로고    scopus 로고
    • Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent
    • Jaeschke, A., J. Hartkamp, M. Saitoh, W. Roworth, T. Nobukuni, A. Hodges, J. Sampson, G. Thomas, and R. Lamb. 2002. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent. J. Cell Biol. 159:217-224.
    • (2002) J. Cell Biol. , vol.159 , pp. 217-224
    • Jaeschke, A.1    Hartkamp, J.2    Saitoh, M.3    Roworth, W.4    Nobukuni, T.5    Hodges, A.6    Sampson, J.7    Thomas, G.8    Lamb, R.9
  • 23
    • 0036007421 scopus 로고    scopus 로고
    • Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K
    • Kozma, S. C., and G. Thomas. 2002. Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K. Bioessays 24:65-71.
    • (2002) Bioessays , vol.24 , pp. 65-71
    • Kozma, S.C.1    Thomas, G.2
  • 25
    • 0036178103 scopus 로고    scopus 로고
    • Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth
    • Lachance, P. E., M. Miron, B. Raught, N. Sonenberg, and P. Lasko. 2002. Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth. Mol. Cell. Biol. 22:1656-1663.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 1656-1663
    • Lachance, P.E.1    Miron, M.2    Raught, B.3    Sonenberg, N.4    Lasko, P.5
  • 27
    • 0029912854 scopus 로고    scopus 로고
    • Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes
    • Lin, T. A., and J. C. Lawrence, Jr. 1996. Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes. J. Biol. Chem. 271:30199-30204.
    • (1996) J. Biol. Chem. , vol.271 , pp. 30199-30204
    • Lin, T.A.1    Lawrence Jr., J.C.2
  • 28
    • 0041469795 scopus 로고    scopus 로고
    • Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B
    • Lizcano, J. M., S. Alrubaie, A. Kieloch, M. Deak, S. J. Leevers, and D. R. Alessi. 2003. Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B. Biochem. J. 374:297-306.
    • (2003) Biochem. J. , vol.374 , pp. 297-306
    • Lizcano, J.M.1    Alrubaie, S.2    Kieloch, A.3    Deak, M.4    Leevers, S.J.5    Alessi, D.R.6
  • 29
    • 0029166687 scopus 로고
    • The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4γ and the translational repressors 4E-binding proteins
    • Mader, S., H. Lee, A. Pause, and N. Sonenberg. 1995. The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4γ and the translational repressors 4E-binding proteins. Mol. Cell. Biol. 15:4990-4997.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 4990-4997
    • Mader, S.1    Lee, H.2    Pause, A.3    Sonenberg, N.4
  • 30
    • 0033152072 scopus 로고    scopus 로고
    • Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G
    • Marcotrigiano, J., A. C. Gingras, N. Sonenberg, and S. K. Burley. 1999. Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G. Mol. Cell 3:707-716.
    • (1999) Mol. Cell , vol.3 , pp. 707-716
    • Marcotrigiano, J.1    Gingras, A.C.2    Sonenberg, N.3    Burley, S.K.4
  • 31
    • 0037137380 scopus 로고    scopus 로고
    • Growth signaling: TSC takes its place
    • Marygold, S. J., and S. J. Leevers. 2002. Growth signaling: TSC takes its place. Curr. Biol. 12:R785-R787.
    • (2002) Curr. Biol. , vol.12
    • Marygold, S.J.1    Leevers, S.J.2
  • 32
    • 0036712741 scopus 로고    scopus 로고
    • TSC1-TSC2: A complex tale of PKB-mediated S6K regulation
    • McManus, E. J., and D. R. Alessi. 2002. TSC1-TSC2: a complex tale of PKB-mediated S6K regulation. Nat. Cell Biol. 4:E214-E216.
    • (2002) Nat. Cell Biol. , vol.4
    • McManus, E.J.1    Alessi, D.R.2
  • 33
    • 0034976004 scopus 로고    scopus 로고
    • The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila
    • Miron, M., J. Verdu, P. E. Lachance, M. J. Birnbaum, P. F. Lasko, and N. Sonenberg. 2001. The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nat. Cell Biol. 3:596-601.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 596-601
    • Miron, M.1    Verdu, J.2    Lachance, P.E.3    Birnbaum, M.J.4    Lasko, P.F.5    Sonenberg, N.6
  • 34
    • 0037507252 scopus 로고    scopus 로고
    • The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
    • Nojima, H., C. Tokunaga, S. Eguchi, N. Oshiro, S. Hidayat, K. Yoshino, K. Hara, N. Tanaka, J. Avruch, and K. Yonezawa. 2003. The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif. J. Biol. Chem. 278:15461-15464.
    • (2003) J. Biol. Chem. , vol.278 , pp. 15461-15464
    • Nojima, H.1    Tokunaga, C.2    Eguchi, S.3    Oshiro, N.4    Hidayat, S.5    Yoshino, K.6    Hara, K.7    Tanaka, N.8    Avruch, J.9    Yonezawa, K.10
  • 35
    • 0036713481 scopus 로고    scopus 로고
    • The Drosophila insulin/IGF receptor controls growth and size by modulating PtdlnsP(3) levels
    • Oldham, S., H. Stocker, M. Laffargue, F. Wittwer, M. Wymann, and E. Hafen. 2002. The Drosophila insulin/IGF receptor controls growth and size by modulating PtdlnsP(3) levels. Development 129:4103-4109.
    • (2002) Development , vol.129 , pp. 4103-4109
    • Oldham, S.1    Stocker, H.2    Laffargue, M.3    Wittwer, F.4    Wymann, M.5    Hafen, E.6
  • 37
    • 0028034233 scopus 로고
    • Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
    • Pause, A., G. J. Belsham, A.-C. Gingras, O. Donzé, T. A. Lin, J. C. Lawrence, Jr., and N. Sonenberg. 1994. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 371:762-767.
    • (1994) Nature , vol.371 , pp. 762-767
    • Pause, A.1    Belsham, G.J.2    Gingras, A.-C.3    Donzé, O.4    Lin, T.A.5    Lawrence Jr., J.C.6    Sonenberg, N.7
  • 39
    • 0036714127 scopus 로고    scopus 로고
    • Akt regulates growth by directly phosphorylating Tsc2
    • Potter, C. J., L. G. Pedraza, and T. Xu. 2002. Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 4:658-665.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 658-665
    • Potter, C.J.1    Pedraza, L.G.2    Xu, T.3
  • 40
    • 0032577691 scopus 로고    scopus 로고
    • 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family
    • Poulin, F., A.-C. Gingras, H. Olsen, S. Chevalier, and N. Sonenberg. 1998. 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. J. Biol. Chem. 273:14002-14007.
    • (1998) J. Biol. Chem. , vol.273 , pp. 14002-14007
    • Poulin, F.1    Gingras, A.-C.2    Olsen, H.3    Chevalier, S.4    Sonenberg, N.5
  • 41
    • 0037108151 scopus 로고    scopus 로고
    • Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling
    • Radimerski, T., J. Montagne, M. Hemmings-Mieszczak, and G. Thomas. 2002. Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling. Genes Dev. 16:2627-2632.
    • (2002) Genes Dev. , vol.16 , pp. 2627-2632
    • Radimerski, T.1    Montagne, J.2    Hemmings-Mieszczak, M.3    Thomas, G.4
  • 43
    • 0001902617 scopus 로고    scopus 로고
    • Regulation of ribosomal recruitment in eukaryotes
    • N. Sonenberg, J. W. B. Hershey, and M. B. Mathews (ed.). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
    • Raught, B., A. C. Gingras, and N. Sonenberg. 2000. Regulation of ribosomal recruitment in eukaryotes, p. 245-293. In N. Sonenberg, J. W. B. Hershey, and M. B. Mathews (ed.), Translational control of gene expression. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
    • (2000) Translational Control of Gene Expression , pp. 245-293
    • Raught, B.1    Gingras, A.C.2    Sonenberg, N.3
  • 45
    • 0036778129 scopus 로고    scopus 로고
    • Why size matters: Altering cell size
    • Saucedo, L., and B. Edgar. 2002. Why size matters: altering cell size. Curr. Opin. Genet. Dev. 12:565-571.
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 565-571
    • Saucedo, L.1    Edgar, B.2
  • 46
    • 0038643484 scopus 로고    scopus 로고
    • Rheb promotes cell growth as a component of the insulin/TOR signalling network
    • Saucedo, L. J., X. Gao, D. A. Chiarelli, L. Li, D. Pan, and B. A. Edgar. 2003. Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat. Cell Biol. 5:566-571.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 566-571
    • Saucedo, L.J.1    Gao, X.2    Chiarelli, D.A.3    Li, L.4    Pan, D.5    Edgar, B.A.6
  • 47
    • 0037117409 scopus 로고    scopus 로고
    • Identification of a conserved motif required for mTOR signaling
    • Schalm, S. S., and J. Blenis. 2002. Identification of a conserved motif required for mTOR signaling. Curr. Biol. 12:632-639.
    • (2002) Curr. Biol. , vol.12 , pp. 632-639
    • Schalm, S.S.1    Blenis, J.2
  • 48
    • 0037718389 scopus 로고    scopus 로고
    • TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
    • Schalm, S. S., D. C. Fingar, D. M. Sabatini, and J. Blenis. 2003. TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Curr. Biol. 13:797-806.
    • (2003) Curr. Biol. , vol.13 , pp. 797-806
    • Schalm, S.S.1    Fingar, D.C.2    Sabatini, D.M.3    Blenis, J.4
  • 50
    • 0034729749 scopus 로고    scopus 로고
    • Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions
    • Sigrist, S. J., P. R. Thiel, D. F. Reiff, P. E. D. Lachance, P. Lasko, and C. F. Schuster. 2000. Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions. Nature 405:1062-1065.
    • (2000) Nature , vol.405 , pp. 1062-1065
    • Sigrist, S.J.1    Thiel, P.R.2    Reiff, D.F.3    Lachance, P.E.D.4    Lasko, P.5    Schuster, C.F.6
  • 51
    • 0037086001 scopus 로고    scopus 로고
    • Living with lethal PIP3 levels: Viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
    • Stocker, H., M. Andjelkovic, S. Oldham, M. Laffargue, M. P. Wymann, B. A. Hemmings, and E. Hafen. 2002. Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science 295:2088-2091.
    • (2002) Science , vol.295 , pp. 2088-2091
    • Stocker, H.1    Andjelkovic, M.2    Oldham, S.3    Laffargue, M.4    Wymann, M.P.5    Hemmings, B.A.6    Hafen, E.7
  • 53
    • 0036181011 scopus 로고    scopus 로고
    • Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif
    • Tee, A. R., and C. G. Proud. 2002. Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif. Mol. Cell. Biol. 22:1674-1683.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 1674-1683
    • Tee, A.R.1    Proud, C.G.2
  • 55
    • 0037373346 scopus 로고    scopus 로고
    • The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation
    • Wang, X., W. Li, J. L. Parra, A. Beugnet, and C. G. Proud. 2003. The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation. Mol. Cell. Biol. 23:1546-1557.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 1546-1557
    • Wang, X.1    Li, W.2    Parra, J.L.3    Beugnet, A.4    Proud, C.G.5
  • 56
    • 0035881470 scopus 로고    scopus 로고
    • Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase
    • Wang, X., W. Li, M. Williams, N. Terada, D. R. Alessi, and C. G. Proud. 2001. Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J. 20:4370-4379.
    • (2001) EMBO J. , vol.20 , pp. 4370-4379
    • Wang, X.1    Li, W.2    Williams, M.3    Terada, N.4    Alessi, D.R.5    Proud, C.G.6
  • 57
    • 0033994360 scopus 로고    scopus 로고
    • The genetic control of organ growth: Insights from Drosophila
    • Weinkove, D., and S. J. Leevers. 2000. The genetic control of organ growth: insights from Drosophila. Curr. Opin. Genet. Dev. 10:75-80.
    • (2000) Curr. Opin. Genet. Dev. , vol.10 , pp. 75-80
    • Weinkove, D.1    Leevers, S.J.2
  • 58
    • 0038141979 scopus 로고    scopus 로고
    • Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
    • Zhang, Y., X. Gao, L. J. Saucedo, B. Ru, B. A. Edgar, and D. Pan. 2003. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat. Cell Biol. 5:578-581.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 578-581
    • Zhang, Y.1    Gao, X.2    Saucedo, L.J.3    Ru, B.4    Edgar, B.A.5    Pan, D.6


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