Mice lacking Tbk1 activity exhibit immune cell infiltrates in multiple tissues and increased susceptibility to LPS-induced lethality

Journal of Leukocyte Biology

Volumn 88, Issue 6, 2010, Pages 1171-1180

  Marchlik, Erica ^a   Thakker, Paresh ^a   Carlson, Thaddeus ^a   Jiang, Zhaozhao ^c   Ryan, Mark ^a   Marusic, Suzana ^a   Goutagny, Nadege ^c   Kuang, Wen ^a   Askew, G Roger ^a   Roberts, Victoria ^a   Benoit, Stephen ^a   Zhou, Tianhui ^a   Ling, Vincent ^b   Pfeifer, Richard ^a   Stedman, Nancy ^a   Fitzgerald, Katherine A ^c   Lin, Lih Ling ^a   Hall, J Perry ^a  

^a PFIZER INC   (United States)

^b Dragonfly Sciences Inc   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Lipopolysaccharide; TANK binding kinase 1

Indexed keywords

CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL INFILTRATION; CELL POPULATION; EDEMA; EMBRYO; GENE; GRANULOMATOSIS; HYPERKERATOSIS; HYPERPLASIA; IMMUNOCOMPETENT CELL; INFLAMMATION; INFLAMMATORY CELL; INFLAMMATORY INFILTRATE; LETHALITY; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; TBK1 GENE;

ANIMALS; CHEMOKINE CCL2; FEMALE; INTERFERON REGULATORY FACTOR-3; INTERFERON-BETA; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MONOCYTES; PROTEIN-SERINE-THREONINE KINASES;

MUS;

EID: 78649737887     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0210071     Document Type: Article

References (32)

1. O'Neill, L. A. (2008) The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress. Immunol. Rev. 226, 10-18.
2. O'Neill, L. A., Bowie, A. G. (2007) The family of five: TIR-domain-containing adaptors in Toll-like receptor signaling. Nat. Rev. Immunol. 7, 353-364.
3. Chau, T. L., Gioia, R., Gatot, J. S., Patrascu, F., Carpentier, I., Chapelle, J. P., O'Neill, L., Beyaert, R., Piette, J., Chariot, A. (2008) Are the IKKs and IKK-related kinases TBK1 and IKK-ε similarly activated? Trends Biochem. Sci. 33, 171-180.
4. Honda, K., Taniguchi, T. (2006) IRFs: master regulators of signaling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat. Rev. Immunol. 6, 644-658.
5. Hemmi, H., Takeuchi, O., Sato, S., Yamamoto, M., Kaisho, T., Sanjo, H., Kawai, T., Hoshino, K., Takeda, K., Akira, S. (2004) The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J. Exp. Med. 199, 1641-1650.
6. Perry, A. K., Chow, E. K., Goodnough, J. B., Yeh, W. C., Cheng, G. (2004) Differential requirement for TANK-binding kinase-1 in type I interferon responses to Toll-like receptor activation and viral infection. J. Exp. Med. 199, 1651-1658.
7. O'Gorman, S., Dagenais, N. A., Qian, M., Marchuk, Y. (1997) Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells. Proc. Natl. Acad. Sci. USA 94, 14602-14607.
8. Hall, J. P., Davis, R. J. (2002) Inhibition of the p38 pathway upregulates macrophage JNK and ERK activities, and the ERK, JNK, and p38 MAP kinase pathways are reprogrammed during differentiation of the murine myeloid M1 cell line. J. Cell. Biochem. 86, 1-11.
9. Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S. M., Maniatis, T. (2003) IKKε and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4, 491-496.
10. Qin, B. Y., Liu, C., Lam, S. S., Srinath, H., Delston, R., Correia, J. J., Derynck, R., Lin, K. (2003) Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation. Nat. Struct. Biol. 10, 913-921.
11. Zhang, X., Goncalves, R., Mosser, D. M. (2008) The isolation and characterization of murine macrophages. Curr. Protoc. Immunol. Nov., Chapter 14, Unit 14.1.
12. Rothenfusser, S., Goutagny, N., DiPerna, G., Gong, M., Monks, B. G., Schoenemeyer, A., Yamamoto, M., Akira, S., Fitzgerald, K. A. (2005) The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J. Immunol. 175, 5260-5268.
13. Muller-Rover, S., Handjiski, B., van der Veen, C., Eichmuller, S., Foitzik, K., McKay, I. A., Stenn, K. S., Paus, R. (2001) A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J. Invest. Dermatol. 117, 3-15.
14. Kuai, J., Wooters, J., Hall, J. P., Rao, V. R., Nickbarg, E., Li, B., Chatterjee-Kishore, M., Qiu, Y., Lin, L. L. (2004) NAK is recruited to the TNFR1 complex in a TNFα-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-interacting proteins by a proteomic approach. J. Biol. Chem. 279, 53266-53271.
15. McWhirter, S. M., Fitzgerald, K. A., Rosains, J., Rowe, D. C., Golenbock, D. T., Maniatis, T. (2004) IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc. Natl. Acad. Sci. USA 101, 233-238.
16. Fitzgerald, K. A., Rowe, D. C., Barnes, B. J., Caffrey, D. R., Visintin, A., Latz, E., Monks, B., Pitha, P. M., Golenbock, D. T. (2003) LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the Toll adapters TRAM and TRIF. J. Exp. Med. 198, 1043-1055.
17. Thomas, K. E., Galligan, C. L., Newman, R. D., Fish, E. N., Vogel, S. N. (2006) Contribution of interferon-β to the murine macrophage response to the Toll-like receptor 4 agonist, lipopolysaccharide. J. Biol. Chem. 281, 31119-31130.
18. Hoebe, K., Du, X., Georgel, P., Janssen, E., Tabeta, K., Kim, S. O., Goode, J., Lin, P., Mann, N., Mudd, S., Crozat, K., Sovath, S., Han, J., Beutler, B. (2003) Identification of LPS2 as a key transducer of MyD88-independent TIR signaling. Nature 424, 743-748.
19. Karaghiosoff, M., Steinborn, R., Kovarik, P., Kriegshauser, G., Baccarini, M., Donabauer, B., Reichart, U., Kolbe, T., Bogdan, C., Leanderson, T., Levy, D., Decker, T., Muller, M. (2003) Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock. Nat. Immunol. 4, 471-477.
20. Sakaguchi, S., Negishi, H., Asagiri, M., Nakajima, C., Mizutani, T., Takaoka, A., Honda, K., Taniguchi, T. (2003) Essential role of IRF-3 in lipopolysaccharide-induced interferon-β gene expression and endotoxin shock. Biochem. Biophys. Res. Commun. 306, 860-866. (Pubitemid 36776210)
21. Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., Akira, S. (2003) Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway. Science 301, 640-643. (Pubitemid 36927946)
22. Ge, Y., Ezzell, R. M., Clark, B. D., Loiselle, P. M., Amato, S. F., Warren, H. S. (1997) Relationship of tissue and cellular interleukin-1 and lipopolysaccharide after endotoxemia and bacteremia. J. Infect. Dis. 176, 1313-1321.
23. Huston, J. M., Ochani, M., Rosas-Ballina, M., Liao, H., Ochani, K., Pavlov, V. A., Gallowitsch-Puerta, M., Ashok, M., Czura, C. J., Foxwell, B., Tracey, K. J., Ulloa, L. (2006) Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis. J. Exp. Med. 203, 1623-1628.
24. Peters, A. L., Stunz, L. L., Bishop, G. A. (2009) CD40 and autoimmunity: the dark side of a great activator. Semin. Immunol. 21, 293-300.
25. Dawson, J., Miltz, W., Mir, A. K., Wiessner, C. (2003) Targeting monocyte chemoattractant protein-1 signaling in disease. Expert Opin. Ther. Targets 7, 35-48.
26. Gardner, J., Ghorpade, A. (2003) Tissue inhibitor of metalloproteinase (TIMP)-1: the TIMPed balance of matrix metalloproteinases in the central nervous system. J. Neurosci. Res. 74, 801-806.
27. Williams, I. R. (2006) CCR6 and CCL20: partners in intestinal immunity and lymphorganogenesis. Ann. N. Y. Acad. Sci. 1072, 52-61.
28. Nishimura, M., Kuboi, Y., Muramoto, K., Kawano, T., Imai, T. (2009) Chemokines as novel therapeutic targets for inflammatory bowel disease. Ann. N. Y. Acad. Sci. 1173, 350-356.
29. Eleuteri, E., Magno, F., Gnemmi, I., Carbone, M., Colombo, M., La Rocca, G., Anzalone, R., Genta, F. T., Zummo, G., Di Stefano, A., Giannuzzi, P. (2009) Role of oxidative and nitrosative stress biomarkers in chronic heart failure. Front. Biosci. 14, 2230-2237.
30. Nielsen, M. J., Moestrup, S. K. (2009) Receptor targeting of hemoglobin mediated by the haptoglobins: roles beyond heme scavenging. Blood 114, 764-771.
31. Sharma, S., tenOever, B. R., Grandvaux, N., Zhou, G. P., Lin, R., Hiscott, J. (2003) Triggering the interferon antiviral response through an IKKrelated pathway. Science 300, 1148-1151.
32. Beutler, B., Milsark, I. W., Cerami, A. C. (1985) Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science 229, 869-871.