메뉴 건너뛰기




Volumn 55, Issue 8, 1998, Pages 1139-1149

Cytokines and their roles in pancreatic islet β-cell destruction and insulin-dependent diabetes mellitus

Author keywords

Autoimmunity; Cytokines; Free radicals; Insulin dependent diabetes mellitus; Islet cell; Nitric oxide

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; LYMPHOTOXIN;

EID: 0032523104     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00492-9     Document Type: Article
Times cited : (433)

References (116)
  • 1
    • 0028026652 scopus 로고
    • Insulin-dependent diabetes mellitus as an autoimmune disease
    • J.F. Bach Insulin-dependent diabetes mellitus as an autoimmune disease Endocr Rev 15 1994 516 542
    • (1994) Endocr Rev , vol.15 , pp. 516-542
    • Bach, J.F.1
  • 2
    • 0027448965 scopus 로고
    • Influence of microbial agents on the development and prevention of autoimmune diabetes
    • B. Singh A. Rabinovitch Influence of microbial agents on the development and prevention of autoimmune diabetes Autoimmunity 15 1993 209 213
    • (1993) Autoimmunity , vol.15 , pp. 209-213
    • Singh, B.1    Rabinovitch, A.2
  • 3
    • 0028354067 scopus 로고
    • Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation?
    • A. Rabinovitch Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation? Diabetes 43 1994 613 621
    • (1994) Diabetes , vol.43 , pp. 613-621
    • Rabinovitch, A.1
  • 4
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • T.R. Mosmann R.L Coffman TH1 and TH2 cells Different patterns of lymphokine secretion lead to different functional properties Annu Rev Immunol 7 1989 145 173
    • (1989) Annu Rev Immunol , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L2
  • 5
    • 0027156737 scopus 로고
    • Cytokine regulation of T-cell function: Potential for therapeutic intervention
    • F. Powrie R.L Coffman Cytokine regulation of T-cell function Potential for therapeutic intervention Immunol Today 14 1993 270 274
    • (1993) Immunol Today , vol.14 , pp. 270-274
    • Powrie, F.1    Coffman, R.L2
  • 6
    • 0026469344 scopus 로고
    • TH1 and TH2 subsets: Regulation of differentiation and role in protection and immunopathology
    • S. Romagnani TH1 and TH2 subsets Regulation of differentiation and role in protection and immunopathology Int Arch Allergy Immunol 98 1992 279 285
    • (1992) Int Arch Allergy Immunol , vol.98 , pp. 279-285
    • Romagnani, S.1
  • 8
    • 0000836601 scopus 로고
    • Roles of cytokines in IDDM pathogenesis and islet β-cell destruction
    • A. Rabinovitch Roles of cytokines in IDDM pathogenesis and islet β-cell destruction Diabetes Rev 1 1993 215 240
    • (1993) Diabetes Rev , vol.1 , pp. 215-240
    • Rabinovitch, A.1
  • 9
    • 0013492650 scopus 로고
    • Pancreatic β cells possess defense mechanisms against cell-specific toxicity
    • D. Pipeleers M. Van de Winkel Pancreatic β cells possess defense mechanisms against cell-specific toxicity Proc Natl Acad Sci USA 83 1986 5267 5271
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 5267-5271
    • Pipeleers, D.1    Van de Winkel, M.2
  • 10
    • 0027393063 scopus 로고
    • In’t Veld PA and Pipeleers DG, Interaction of interleukin-1 with islet β-cells. Distinction between indirect, aspecific cytotoxicity and direct, specific functional suppression
    • Z. Ling In’t Veld PA and Pipeleers DG, Interaction of interleukin-1 with islet β-cells. Distinction between indirect, aspecific cytotoxicity and direct, specific functional suppression Diabetes 42 1993 56 65
    • (1993) Diabetes , vol.42 , pp. 56-65
    • Ling, Z.1
  • 11
    • 0024431241 scopus 로고
    • The specificity of rejection and the absence of susceptibility of pancreatic islet β-cells to nonspecific immune destruction in mixed strain islets grafted beneath the renal capsule in the rat
    • R. Sutton D.W.R. Gray P. McShane M.J Dallman P.J Morris The specificity of rejection and the absence of susceptibility of pancreatic islet β-cells to nonspecific immune destruction in mixed strain islets grafted beneath the renal capsule in the rat J Exp Med 170 1989 751 762
    • (1989) J Exp Med , vol.170 , pp. 751-762
    • Sutton, R.1    Gray, D.W.R.2    McShane, P.3    Dallman, M.J4    Morris, P.J5
  • 12
    • 0028231199 scopus 로고
    • Characterization of mixed syngeneic-allogeneic and syngeneic-xenogeneic islet-graft rejections in mice: Evidence of functional impairment of the remaining syngeneic islets in xenograft rejections
    • O. Korsgren L. Jansson Characterization of mixed syngeneic-allogeneic and syngeneic-xenogeneic islet-graft rejections in mice Evidence of functional impairment of the remaining syngeneic islets in xenograft rejections J Clin Invest 93 1994 1113 1119
    • (1994) J Clin Invest , vol.93 , pp. 1113-1119
    • Korsgren, O.1    Jansson, L.2
  • 13
    • 0028989087 scopus 로고
    • IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice
    • A. Rabinovitch W.L Suarez-Pinzon O. Sorensen R.C Bleackley R.F. Power IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice J Immunol 154 1994 4874 4882
    • (1994) J Immunol , vol.154 , pp. 4874-4882
    • Rabinovitch, A.1    Suarez-Pinzon, W.L2    Sorensen, O.3    Bleackley, R.C4    Power, R.F.5
  • 14
    • 0028861576 scopus 로고
    • Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-γ transcription
    • A. Muir A. Peck M. Clare-Salzler Y.-H Song J. Cornelius R. Luchetta J. Krischer N. Maclaren Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-γ transcription J Clin Invest 95 1995 628 634
    • (1995) J Clin Invest , vol.95 , pp. 628-634
    • Muir, A.1    Peck, A.2    Clare-Salzler, M.3    Song, Y.-H4    Cornelius, J.5    Luchetta, R.6    Krischer, J.7    Maclaren, N.8
  • 16
    • 0025981388 scopus 로고
    • Essential role for interferon-γ and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice
    • I.L Campbell T.W.H Kay L. Oxbrow L.C Harrison Essential role for interferon-γ and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice J Clin Invest 87 1991 739 742
    • (1991) J Clin Invest , vol.87 , pp. 739-742
    • Campbell, I.L1    Kay, T.W.H2    Oxbrow, L.3    Harrison, L.C4
  • 19
    • 0025951776 scopus 로고
    • Insulitis in type I (insulin-dependent) diabetes mellitus in man: Macrophages, lymphocytes, and interferon-γ containing cells
    • A.K Foulis M. McGill M.A Farquharson Insulitis in type I (insulin-dependent) diabetes mellitus in man Macrophages, lymphocytes, and interferon-γ containing cells J Pathol 164 1991 97 103
    • (1991) J Pathol , vol.164 , pp. 97-103
    • Foulis, A.K1    McGill, M.2    Farquharson, M.A3
  • 20
    • 0023520177 scopus 로고
    • Immunoreactive α-interferon in insulin-secreting β-cells in type I diabetes mellitus
    • A.K Foulis M.A Farquharson A. Meager Immunoreactive α-interferon in insulin-secreting β-cells in type I diabetes mellitus Lancet 2 1987 1423 1427
    • (1987) Lancet , vol.2 , pp. 1423-1427
    • Foulis, A.K1    Farquharson, M.A2    Meager, A.3
  • 22
    • 0028501432 scopus 로고
    • Islet expression of interferon-α precedes diabetes in both the BB rat and streptozotocin-treated mice
    • X. Huang B. Hultgren N. Dybdal T.A Stewart Islet expression of interferon-α precedes diabetes in both the BB rat and streptozotocin-treated mice Immunity 1 1994 469 478
    • (1994) Immunity , vol.1 , pp. 469-478
    • Huang, X.1    Hultgren, B.2    Dybdal, N.3    Stewart, T.A4
  • 24
    • 0028209739 scopus 로고
    • Consequences of in situ production of IL-2 for islet cell death
    • J. Allison L. Oxbrow J.F.A.P. Miller Consequences of in situ production of IL-2 for islet cell death Int Immunol 6 1994 541 549
    • (1994) Int Immunol , vol.6 , pp. 541-549
    • Allison, J.1    Oxbrow, L.2    Miller, J.F.A.P.3
  • 25
    • 0028346888 scopus 로고
    • Production of interleukin 10 by islet cells accelerates immune-mediated destruction of β cells in nonobese diabetic mice
    • L. Wogensen M.-S Lee N. Sarvetnick Production of interleukin 10 by islet cells accelerates immune-mediated destruction of β cells in nonobese diabetic mice J Exp Med 179 1994 1379 1384
    • (1994) J Exp Med , vol.179 , pp. 1379-1384
    • Wogensen, L.1    Lee, M.-S2    Sarvetnick, N.3
  • 27
    • 0028365499 scopus 로고
    • Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor α leads to autoimmunity in transgenic mice
    • S. Guerder D.E Picarella P.S. Linsley R.A Flavell Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor α leads to autoimmunity in transgenic mice Proc Natl Acad Sci USA 91 1994 5138 5142
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5138-5142
    • Guerder, S.1    Picarella, D.E2    Linsley, P.S.3    Flavell, R.A4
  • 28
    • 0026443846 scopus 로고
    • Insulitis in transgenic mice expressing tumor necrosis factor β (lymphotoxin) in the pancreas
    • D.E Picarella A. Kratz C.-B Li N.H Ruddle R.A Flavell Insulitis in transgenic mice expressing tumor necrosis factor β (lymphotoxin) in the pancreas Proc Natl Acad Sci USA 89 1992 10036 10040
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10036-10040
    • Picarella, D.E1    Kratz, A.2    Li, C.-B3    Ruddle, N.H4    Flavell, R.A5
  • 30
    • 0025020303 scopus 로고
    • Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): Similarities between TNFα and interleukin-1
    • C.O Jacob S. Asiso S.A Michie H.O McDevitt H. Acha-Orbea Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF) Similarities between TNFα and interleukin-1 Proc Natl Acad Sci USA 87 1990 968 972
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 968-972
    • Jacob, C.O1    Asiso, S.2    Michie, S.A3    McDevitt, H.O4    Acha-Orbea, H.5
  • 31
    • 0024795364 scopus 로고
    • Immunostimulation circumvents diabetes in NOD/Lt mice
    • D.V Serreze K. Hamaguchi D.H Leiter Immunostimulation circumvents diabetes in NOD/Lt mice J Autoimmun 2 1989 759 776
    • (1989) J Autoimmun , vol.2 , pp. 759-776
    • Serreze, D.V1    Hamaguchi, K.2    Leiter, D.H3
  • 32
    • 0025014570 scopus 로고
    • Interleukin-2-dependent control of disease development in spontaneously diabetic BB rats
    • J. Zielasek V. Burkart P. Naylor A. Goldstein U. Kiesel H. Kolb Interleukin-2-dependent control of disease development in spontaneously diabetic BB rats Immunology 69 1990 209 214
    • (1990) Immunology , vol.69 , pp. 209-214
    • Zielasek, J.1    Burkart, V.2    Naylor, P.3    Goldstein, A.4    Kiesel, U.5    Kolb, H.6
  • 34
    • 0028222756 scopus 로고
    • Recombinant human IL-10 (rHU IL-10) prevents the onset of diabetes in the nonobese diabetic (NOD) mouse
    • K.J Pennline E. Roque-Gaffney M. Monahan Recombinant human IL-10 (rHU IL-10) prevents the onset of diabetes in the nonobese diabetic (NOD) mouse Clin Immunol Immunopathol 71 1994 169 175
    • (1994) Clin Immunol Immunopathol , vol.71 , pp. 169-175
    • Pennline, K.J1    Roque-Gaffney, E.2    Monahan, M.3
  • 39
    • 0023879559 scopus 로고
    • Defective activation of T suppressor cell function in nonobese diabetic mice: Potential relation to cytokine deficiencies
    • D.V Serreze E.H Leiter Defective activation of T suppressor cell function in nonobese diabetic mice Potential relation to cytokine deficiencies J Immunol 140 1988 3801 3807
    • (1988) J Immunol , vol.140 , pp. 3801-3807
    • Serreze, D.V1    Leiter, E.H2
  • 40
    • 0026758579 scopus 로고
    • Tumor necrosis factor production is deficient in diabetes-prone BB rats and can be corrected by complete Freund’s adjuvant: A possible immunoregulatory role of tumor necrosis factor in the prevention of diabetes
    • P.H Lapchak L.J Guilbert A. Rabinovitch Tumor necrosis factor production is deficient in diabetes-prone BB rats and can be corrected by complete Freund’s adjuvant A possible immunoregulatory role of tumor necrosis factor in the prevention of diabetes Clin Immunol Immunopathol 65 1992 129 134
    • (1992) Clin Immunol Immunopathol , vol.65 , pp. 129-134
    • Lapchak, P.H1    Guilbert, L.J2    Rabinovitch, A.3
  • 41
    • 0027921994 scopus 로고
    • Neuroendocrine–immune interactions
    • S. Reichlin Neuroendocrine–immune interactions N Engl J Med 329 1993 1246 1253
    • (1993) N Engl J Med , vol.329 , pp. 1246-1253
    • Reichlin, S.1
  • 43
    • 0023930164 scopus 로고
    • Anti-interleukin 2 receptor antibody suppresses murine diabetic insulitis and lupus nephritis
    • V.E Kelley G.N Gaulton M. Hattori H. Ikegami G. Eisenbarth T.B Strom Anti-interleukin 2 receptor antibody suppresses murine diabetic insulitis and lupus nephritis J Immunol 140 1988 59 61
    • (1988) J Immunol , vol.140 , pp. 59-61
    • Kelley, V.E1    Gaulton, G.N2    Hattori, M.3    Ikegami, H.4    Eisenbarth, G.5    Strom, T.B6
  • 44
    • 0026599957 scopus 로고
    • Interleukin-2 receptor targeted fusion toxin (DAB480-IL-2) treatment blocks diabetogenic autoimmunity in non-obese diabetic mice
    • A. Pacheco-Silva M.G Bastos R.A Muggia O. Pankewycz J. Nichols J.R. Murphy T.B Strom Interleukin-2 receptor targeted fusion toxin (DAB480-IL-2) treatment blocks diabetogenic autoimmunity in non-obese diabetic mice Eur J Immunol 22 1992 697 702
    • (1992) Eur J Immunol , vol.22 , pp. 697-702
    • Pacheco-Silva, A.1    Bastos, M.G2    Muggia, R.A3    Pankewycz, O.4    Nichols, J.5    Murphy, J.R.6    Strom, T.B7
  • 48
    • 0027509812 scopus 로고
    • Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential
    • + T cell subset that inhibits this autoimmune potential J Exp Med 177 1993 627 636
    • (1993) J Exp Med , vol.177 , pp. 627-636
    • Fowell, D.1    Mason, D.2
  • 50
    • 0029030964 scopus 로고
    • T helper cell subsets in insulin-dependent diabetes
    • J.D Katz C. Benoist D. Mathis T helper cell subsets in insulin-dependent diabetes Science 268 1995 1185 1188
    • (1995) Science , vol.268 , pp. 1185-1188
    • Katz, J.D1    Benoist, C.2    Mathis, D.3
  • 52
    • 0028201726 scopus 로고
    • Acquisition of lymphokine-producing phenotype by CD4+ T cells
    • + T cells Annu Rev Immunol 12 1994 635 673
    • (1994) Annu Rev Immunol , vol.12 , pp. 635-673
    • Seder, R.A1    Paul, W.E2
  • 55
    • 0027177008 scopus 로고
    • IL-12: Initiation cytokine for cell-mediated immunity
    • P. Scott IL-12 Initiation cytokine for cell-mediated immunity Science 260 1993 496 497
    • (1993) Science , vol.260 , pp. 496-497
    • Scott, P.1
  • 56
    • 0026648380 scopus 로고
    • Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell-receptor transgenic system
    • C.-S Hsieh A.B Heimberger J.S. Gold A. O’Garra K.M. Murphy Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell-receptor transgenic system Proc Natl Acad Sci USA 89 1992 6065 6069
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6065-6069
    • Hsieh, C.-S1    Heimberger, A.B2    Gold, J.S.3    O’Garra, A.4    Murphy, K.M.5
  • 57
    • 0026712313 scopus 로고
    • The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice
    • + T cells from T cell receptor transgenic mice J Exp Med 176 1992 1091 1098
    • (1992) J Exp Med , vol.176 , pp. 1091-1098
    • Seder, R.A1    Paul, W.E2    Davis, M.M.3    Fazekas de St. Groth, B.4
  • 58
    • 0028926524 scopus 로고
    • Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice
    • S. Trembleau G. Penna E. Bosi A. Mortara M.K Gately L. Adorini Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice J Exp Med 181 1995 817 821
    • (1995) J Exp Med , vol.181 , pp. 817-821
    • Trembleau, S.1    Penna, G.2    Bosi, E.3    Mortara, A.4    Gately, M.K5    Adorini, L.6
  • 60
    • 0028970060 scopus 로고
    • Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • G. Trinchieri Interleukin-12 A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity Annu Rev Immunol 13 1995 251 276
    • (1995) Annu Rev Immunol , vol.13 , pp. 251-276
    • Trinchieri, G.1
  • 61
    • 0029948898 scopus 로고    scopus 로고
    • Genetic absence of γ-interferon delays but does not prevent diabetes in NOD mice
    • B. Hultgren X. Huang N. Dybdal T.A Stewart Genetic absence of γ-interferon delays but does not prevent diabetes in NOD mice Diabetes 45 1996 812 817
    • (1996) Diabetes , vol.45 , pp. 812-817
    • Hultgren, B.1    Huang, X.2    Dybdal, N.3    Stewart, T.A4
  • 62
    • 0029989197 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice: Identification of iNOS expressing cells and relationships to cytokines expressed in the islets
    • A. Rabinovitch W.L Suarez-Pinzon O. Sorensen R.C Bleackley Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice Identification of iNOS expressing cells and relationships to cytokines expressed in the islets Endocrinology 137 1996 2093 2099
    • (1996) Endocrinology , vol.137 , pp. 2093-2099
    • Rabinovitch, A.1    Suarez-Pinzon, W.L2    Sorensen, O.3    Bleackley, R.C4
  • 63
    • 0025753951 scopus 로고
    • Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation
    • K.-D Kroncke V. Kolb-Bachofen B. Berschick V. Burkart H. Kolb Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation Biochem Biophys Res Commun 175 1991 752 758
    • (1991) Biochem Biophys Res Commun , vol.175 , pp. 752-758
    • Kroncke, K.-D1    Kolb-Bachofen, V.2    Berschick, B.3    Burkart, V.4    Kolb, H.5
  • 64
    • 0028900805 scopus 로고
    • Intraislet release of interleukin 1 inhibits β cell function by inducing β cell expression of inducible nitric oxide synthase
    • J.A Corbett M.L McDaniel Intraislet release of interleukin 1 inhibits β cell function by inducing β cell expression of inducible nitric oxide synthase J Exp Med 181 1995 559 568
    • (1995) J Exp Med , vol.181 , pp. 559-568
    • Corbett, J.A1    McDaniel, M.L2
  • 65
    • 0026683354 scopus 로고
    • Does nitric oxide mediate autoimmune destruction of β-cells?
    • J.A Corbett M.L McDaniel Does nitric oxide mediate autoimmune destruction of β-cells? Diabetes 41 1992 897 903
    • (1992) Diabetes , vol.41 , pp. 897-903
    • Corbett, J.A1    McDaniel, M.L2
  • 67
    • 0022448701 scopus 로고
    • Effect of vitamin E deficiency and selenium deficiency on insulin secretory reserve and free radical scavenging systems in islets: Decrease of islet manganosuperoxide dismutase
    • K. Asayama N.W. Kooy I.M. Burr Effect of vitamin E deficiency and selenium deficiency on insulin secretory reserve and free radical scavenging systems in islets Decrease of islet manganosuperoxide dismutase J Lab Clin Med 107 1986 459 464
    • (1986) J Lab Clin Med , vol.107 , pp. 459-464
    • Asayama, K.1    Kooy, N.W.2    Burr, I.M.3
  • 68
    • 0029984682 scopus 로고    scopus 로고
    • Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
    • S. Lenzen J. Drinkgern M. Tiedge Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues Free Radic Biol Med 20 1996 463 466
    • (1996) Free Radic Biol Med , vol.20 , pp. 463-466
    • Lenzen, S.1    Drinkgern, J.2    Tiedge, M.3
  • 69
    • 0023775296 scopus 로고
    • Superoxide dismutase activity in the BB rat: A dynamic time–course study
    • F. Pisanti S. Frascatore G. Papacio Superoxide dismutase activity in the BB rat A dynamic time–course study Life Sci 43 1988 1625 1632
    • (1988) Life Sci , vol.43 , pp. 1625-1632
    • Pisanti, F.1    Frascatore, S.2    Papacio, G.3
  • 70
    • 0029042224 scopus 로고
    • Superoxide dismutase in the nonobese diabetic (NOD) mouse: A dynamic time–course study
    • G. Papaccio S. Franscatore F. Pisanti M. Latronico T. Linn Superoxide dismutase in the nonobese diabetic (NOD) mouse A dynamic time–course study Life Sci 56 1995 2223 2228
    • (1995) Life Sci , vol.56 , pp. 2223-2228
    • Papaccio, G.1    Franscatore, S.2    Pisanti, F.3    Latronico, M.4    Linn, T.5
  • 71
    • 0027468539 scopus 로고
    • Anti-oxidant enzyme activities in IDD prone and IDD resistant mice: A comparative study
    • I.G Cornelius B.G Luttge A.B Peck Anti-oxidant enzyme activities in IDD prone and IDD resistant mice A comparative study Free Radic Biol Med 14 1993 409 420
    • (1993) Free Radic Biol Med , vol.14 , pp. 409-420
    • Cornelius, I.G1    Luttge, B.G2    Peck, A.B3
  • 72
    • 0023001495 scopus 로고
    • Combined treatment with nicotinamide and desferrioxamine prevents islet allograft destruction in NOD mice
    • I.N Nomikos S.J Prowse P. Carotenuto K.J Lafferty Combined treatment with nicotinamide and desferrioxamine prevents islet allograft destruction in NOD mice Diabetes 35 1986 1302 1304
    • (1986) Diabetes , vol.35 , pp. 1302-1304
    • Nomikos, I.N1    Prowse, S.J2    Carotenuto, P.3    Lafferty, K.J4
  • 74
    • 0022620852 scopus 로고
    • Effect of dietary vitamin E in the vitamin E status in the BB rat during development and after the onset of diabetes
    • W.A Behrens F.W. Scott R. Madere K. Trick K. Hanna Effect of dietary vitamin E in the vitamin E status in the BB rat during development and after the onset of diabetes Ann Nutr Metab 30 1986 157 165
    • (1986) Ann Nutr Metab , vol.30 , pp. 157-165
    • Behrens, W.A1    Scott, F.W.2    Madere, R.3    Trick, K.4    Hanna, K.5
  • 75
    • 0026780794 scopus 로고
    • Vitamin E supplementation reduces the incidence of diabetes but not insulitis in NOD mice
    • A.R. Hayward M. Shriber R. Sokol Vitamin E supplementation reduces the incidence of diabetes but not insulitis in NOD mice J Lab Clin Med 119 1992 503 507
    • (1992) J Lab Clin Med , vol.119 , pp. 503-507
    • Hayward, A.R.1    Shriber, M.2    Sokol, R.3
  • 77
    • 0026439698 scopus 로고
    • Combination therapy with an antioxidant and a corticosteroid prevents autoimmune diabetes in NOD mice
    • A. Rabinovitch W.L Suarez R.F. Power Combination therapy with an antioxidant and a corticosteroid prevents autoimmune diabetes in NOD mice Life Sci 51 1992 1937 1943
    • (1992) Life Sci , vol.51 , pp. 1937-1943
    • Rabinovitch, A.1    Suarez, W.L2    Power, R.F.3
  • 78
    • 0027413011 scopus 로고
    • Lazaroid antioxidant reduces incidence of diabetes and insulitis in nonobese diabetic mice
    • A. Rabinovitch W.L Suarez R.F. Power Lazaroid antioxidant reduces incidence of diabetes and insulitis in nonobese diabetic mice J Lab Clin Med 121 1993 603 607
    • (1993) J Lab Clin Med , vol.121 , pp. 603-607
    • Rabinovitch, A.1    Suarez, W.L2    Power, R.F.3
  • 80
    • 0024463482 scopus 로고
    • Oxygen free radical scavengers protect rat islet cells from damage by cytokines
    • W. Sumoski H. Baquerizo A. Rabinovitch Oxygen free radical scavengers protect rat islet cells from damage by cytokines Diabetologia 32 1989 792 796
    • (1989) Diabetologia , vol.32 , pp. 792-796
    • Sumoski, W.1    Baquerizo, H.2    Rabinovitch, A.3
  • 81
    • 0026510118 scopus 로고
    • Cytotoxic effects of cytokines on rat islets: Evidence for involvement of free radicals and lipid peroxidation
    • A. Rabinovitch W.L Suarez P.D Thomas K. Strynadka I. Simpson Cytotoxic effects of cytokines on rat islets Evidence for involvement of free radicals and lipid peroxidation Diabetologia 35 1992 409 413
    • (1992) Diabetologia , vol.35 , pp. 409-413
    • Rabinovitch, A.1    Suarez, W.L2    Thomas, P.D3    Strynadka, K.4    Simpson, I.5
  • 82
    • 0029795599 scopus 로고    scopus 로고
    • Human pancreatic islet β-cell destruction by cytokines involves oxygen free radicals and aldehyde production
    • A. Rabinovitch W.L Suarez-Pinzon K. Strynadka J.R.T Lakey R.V Rajotte Human pancreatic islet β-cell destruction by cytokines involves oxygen free radicals and aldehyde production J Clin Endocrinol Metab 81 1996 3197 3202
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3197-3202
    • Rabinovitch, A.1    Suarez-Pinzon, W.L2    Strynadka, K.3    Lakey, J.R.T4    Rajotte, R.V5
  • 83
    • 0024539819 scopus 로고
    • Studies on the mechanisms causing inhibition of insulin secretion in rat pancreatic islets exposed to human interleukin-1β indicate a perturbation in the mitochondrial function
    • S. Sandler K. Bendtzen L.A Hakan-Borg D.L Eizirik E. Strandell N. Welsh Studies on the mechanisms causing inhibition of insulin secretion in rat pancreatic islets exposed to human interleukin-1β indicate a perturbation in the mitochondrial function Endocrinology 124 1989 1492 1501
    • (1989) Endocrinology , vol.124 , pp. 1492-1501
    • Sandler, S.1    Bendtzen, K.2    Hakan-Borg, L.A3    Eizirik, D.L4    Strandell, E.5    Welsh, N.6
  • 85
    • 0022496161 scopus 로고
    • Secretion of toxic oxygen products by macrophages: Regulatory cytokines and their effects on the oxidase
    • C. Nathan S. Tsunawaki Secretion of toxic oxygen products by macrophages Regulatory cytokines and their effects on the oxidase Ciba Found Symp 118 1986 211 230
    • (1986) Ciba Found Symp , vol.118 , pp. 211-230
    • Nathan, C.1    Tsunawaki, S.2
  • 86
    • 0026687205 scopus 로고
    • Regulation by cytokines of extracellular superoxide dismutase and other superoxide dismutase isoenzymes in fibroblasts
    • S.L Marklund Regulation by cytokines of extracellular superoxide dismutase and other superoxide dismutase isoenzymes in fibroblasts J Biol Chem 267 1992 6696 6701
    • (1992) J Biol Chem , vol.267 , pp. 6696-6701
    • Marklund, S.L1
  • 87
    • 0030444560 scopus 로고    scopus 로고
    • Destruction of rat pancreatic islet β-cells by cytokines involves the production of cytotoxic aldehydes
    • W.L Suarez-Pinzon K. Strynadka A. Rabinovitch Destruction of rat pancreatic islet β-cells by cytokines involves the production of cytotoxic aldehydes Endocrinology 137 1996 5290 5296
    • (1996) Endocrinology , vol.137 , pp. 5290-5296
    • Suarez-Pinzon, W.L1    Strynadka, K.2    Rabinovitch, A.3
  • 88
    • 0025883342 scopus 로고
    • Nitric oxide: Physiology, pathophysiology, and pharmacology
    • S. Moncada R.M.J Palmer E.A Higgs Nitric oxide Physiology, pathophysiology, and pharmacology Pharmacol Rev 43 1991 109 142
    • (1991) Pharmacol Rev , vol.43 , pp. 109-142
    • Moncada, S.1    Palmer, R.M.J2    Higgs, E.A3
  • 89
    • 0025685395 scopus 로고
    • Inhibition of insulin secretion by interleukin-1β and tumour necrosis factor-α via an l-arginine-dependent nitric oxide generating mechanism
    • C. Southern D. Schulster I.C Green Inhibition of insulin secretion by interleukin-1β and tumour necrosis factor-α via an l -arginine-dependent nitric oxide generating mechanism FEBS Lett 276 1990 42 44
    • (1990) FEBS Lett , vol.276 , pp. 42-44
    • Southern, C.1    Schulster, D.2    Green, I.C3
  • 90
    • 0025721872 scopus 로고
    • l-Arginine stimulates cyclic guanosine 3′,5′-monophosphate formation in rat islets of Langerhans and RINm5F insulinoma cells: Evidence for l-arginine:nitric oxide synthase
    • S.G Laychock M.E Modica C.T Cavanaugh l -Arginine stimulates cyclic guanosine 3′,5′-monophosphate formation in rat islets of Langerhans and RINm5F insulinoma cells Evidence for l -arginine:nitric oxide synthase Endocrinology 129 1991 3043 3052
    • (1991) Endocrinology , vol.129 , pp. 3043-3052
    • Laychock, S.G1    Modica, M.E2    Cavanaugh, C.T3
  • 91
    • 0025720502 scopus 로고
    • Interleukin-1β-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans
    • J.A Corbett J.R. Lancaster Jr M.A Sweetland M.L McDaniel Interleukin-1β-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans J Biol Chem 266 1991 21351 21354
    • (1991) J Biol Chem , vol.266 , pp. 21351-21354
    • Corbett, J.A1    Lancaster, J.R.2    Sweetland, M.A3    McDaniel, M.L4
  • 92
    • 0027054055 scopus 로고
    • Interleukin 1β induces the formation of nitric oxide by β-cells purified from rodent islets of Langerhans. Evidence for the β-cell as a source and site of action of nitric oxide
    • J.A Corbett J.L Wang M.A Sweetland J.R. Lancaster Jr M.L McDaniel Interleukin 1β induces the formation of nitric oxide by β-cells purified from rodent islets of Langerhans. Evidence for the β-cell as a source and site of action of nitric oxide J Clin Invest 90 1992 2384 2391
    • (1992) J Clin Invest , vol.90 , pp. 2384-2391
    • Corbett, J.A1    Wang, J.L2    Sweetland, M.A3    Lancaster, J.R.4    McDaniel, M.L5
  • 93
    • 0028258386 scopus 로고
    • Mechanisms of cytokine-induced destruction of rat insulinoma cells: The role of nitric oxide
    • W.L Suarez-Pinzon K. Strynadka R. Schulz A. Rabinovitch Mechanisms of cytokine-induced destruction of rat insulinoma cells The role of nitric oxide Endocrinology 134 1994 1006 1010
    • (1994) Endocrinology , vol.134 , pp. 1006-1010
    • Suarez-Pinzon, W.L1    Strynadka, K.2    Schulz, R.3    Rabinovitch, A.4
  • 96
    • 0025189864 scopus 로고
    • Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
    • J. Beckman T. Beckman J. Chen P. Marshall B. Freeman Apparent hydroxyl radical production by peroxynitrite Implications for endothelial injury from nitric oxide and superoxide Proc Natl Acad Sci USA 87 1990 1620 1624
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1620-1624
    • Beckman, J.1    Beckman, T.2    Chen, J.3    Marshall, P.4    Freeman, B.5
  • 97
    • 0029037495 scopus 로고
    • The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide
    • W.A Pryor G.L Squadrito The chemistry of peroxynitrite A product from the reaction of nitric oxide with superoxide Am J Physiol 268 1995 L699 L722
    • (1995) Am J Physiol , vol.268 , pp. L699-L722
    • Pryor, W.A1    Squadrito, G.L2
  • 98
    • 0027930057 scopus 로고
    • Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients
    • H. Kaur B. Halliwell Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients FEBS Lett 350 1994 9 12
    • (1994) FEBS Lett , vol.350 , pp. 9-12
    • Kaur, H.1    Halliwell, B.2
  • 99
    • 0029073807 scopus 로고
    • The role of peroxynitrite in nitric oxide-mediated toxicity
    • J.P Crow J.S. Beckman The role of peroxynitrite in nitric oxide-mediated toxicity Curr Top Microbiol Immunol 196 1995 57 73
    • (1995) Curr Top Microbiol Immunol , vol.196 , pp. 57-73
    • Crow, J.P1    Beckman, J.S.2
  • 100
    • 0030203367 scopus 로고    scopus 로고
    • The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury
    • C. Szabó The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury Shock 6 1996 79 88
    • (1996) Shock , vol.6 , pp. 79-88
    • Szabó, C.1
  • 101
    • 0030573997 scopus 로고    scopus 로고
    • Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death
    • C.A Delaney B. Tyrberg L. Bouwens H. Vaghef B. Hellman D.L Eizirik Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death FEBS Lett 394 1996 300 306
    • (1996) FEBS Lett , vol.394 , pp. 300-306
    • Delaney, C.A1    Tyrberg, B.2    Bouwens, L.3    Vaghef, H.4    Hellman, B.5    Eizirik, D.L6
  • 102
    • 0030987135 scopus 로고    scopus 로고
    • Development of autoimmune diabetes in NOD mice is associated with the formation of peroxynitrite in pancreatic islet β-cells
    • W.L Suarez-Pinzon C. Szabó A. Rabinovitch Development of autoimmune diabetes in NOD mice is associated with the formation of peroxynitrite in pancreatic islet β-cells Diabetes 46 1997 907 911
    • (1997) Diabetes , vol.46 , pp. 907-911
    • Suarez-Pinzon, W.L1    Szabó, C.2    Rabinovitch, A.3
  • 103
    • 0027908754 scopus 로고
    • Spotlight on a neuronal enzyme
    • M. Solimena P. De Camilli Spotlight on a neuronal enzyme Nature 366 1993 15 17
    • (1993) Nature , vol.366 , pp. 15-17
    • Solimena, M.1    De Camilli, P.2
  • 105
    • 0027908753 scopus 로고
    • Immune response to glutamic acid decarboxylase correlates with insulitis in nonobese diabetic mice
    • R. Tisch X.-D Yang S.M. Singer R.S. Liblau L. Fugger H.O McDevitt Immune response to glutamic acid decarboxylase correlates with insulitis in nonobese diabetic mice Nature 366 1993 72 75
    • (1993) Nature , vol.366 , pp. 72-75
    • Tisch, R.1    Yang, X.-D2    Singer, S.M.3    Liblau, R.S.4    Fugger, L.5    McDevitt, H.O6
  • 106
    • 0027176158 scopus 로고
    • Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes
    • L.C Harrison M.C Honeyman H.J DeAizpurua R.S. Schmidli P.G Colman B.D Tait D.S. Cram Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes Lancet 341 1993 1365 1369
    • (1993) Lancet , vol.341 , pp. 1365-1369
    • Harrison, L.C1    Honeyman, M.C2    DeAizpurua, H.J3    Schmidli, R.S.4    Colman, P.G5    Tait, B.D6    Cram, D.S.7
  • 107
    • 0028035382 scopus 로고
    • Quantitation of glutamic acid decarboxylase autoantibody levels in prospectively evaluated relatives of patients with type I diabetes
    • L. Yu R. Gianani G.S. Eisenbarth Quantitation of glutamic acid decarboxylase autoantibody levels in prospectively evaluated relatives of patients with type I diabetes Diabetes 43 1994 1229 1233
    • (1994) Diabetes , vol.43 , pp. 1229-1233
    • Yu, L.1    Gianani, R.2    Eisenbarth, G.S.3
  • 108
    • 0028798856 scopus 로고
    • Insulin prophylaxis in insulin-dependent diabetes mellitus: Immunological rationale and therapeutic use
    • V. Ramiya A. Muir N. Maclaren Insulin prophylaxis in insulin-dependent diabetes mellitus Immunological rationale and therapeutic use Clin Immunother 3 1995 177 183
    • (1995) Clin Immunother , vol.3 , pp. 177-183
    • Ramiya, V.1    Muir, A.2    Maclaren, N.3
  • 110
    • 0030026955 scopus 로고    scopus 로고
    • Imogen 38: A novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient
    • S.D Arden B.O Roep P.I Neophytou E.F. Usac G. Duinkerken R.R.P de Vries J.C Hutton Imogen 38 A novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient J Clin Invest 97 1996 551 561
    • (1996) J Clin Invest , vol.97 , pp. 551-561
    • Arden, S.D1    Roep, B.O2    Neophytou, P.I3    Usac, E.F.4    Duinkerken, G.5    de Vries, R.R.P6    Hutton, J.C7
  • 111
    • 0030892035 scopus 로고    scopus 로고
    • Prevention of Type 1 diabetes and recurrent β-cell destruction of transplanted islets
    • R.H Slover G.S. Eisenbarth Prevention of Type 1 diabetes and recurrent β-cell destruction of transplanted islets Endocr Rev 18 1997 241 258
    • (1997) Endocr Rev , vol.18 , pp. 241-258
    • Slover, R.H1    Eisenbarth, G.S.2
  • 112
    • 0028900297 scopus 로고
    • Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse
    • D.J Lenschow S.C Ho H. Sattar L. Rhee G. Gray N. Nabavi K.C Herold J.A Bluestone Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse J Exp Med 181 1995 1145 1155
    • (1995) J Exp Med , vol.181 , pp. 1145-1155
    • Lenschow, D.J1    Ho, S.C2    Sattar, H.3    Rhee, L.4    Gray, G.5    Nabavi, N.6    Herold, K.C7    Bluestone, J.A8
  • 113
    • 0031131886 scopus 로고    scopus 로고
    • A noncytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice
    • X.X Zheng A.W. Steele W.W. Hancock A.C Stevens P.W. Nickerson P. Roy-Chaudhury Y. Tian T.B Strom A noncytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice J Immunol 158 1997 4507 4513
    • (1997) J Immunol , vol.158 , pp. 4507-4513
    • Zheng, X.X1    Steele, A.W.2    Hancock, W.W.3    Stevens, A.C4    Nickerson, P.W.5    Roy-Chaudhury, P.6    Tian, Y.7    Strom, T.B8
  • 115
    • 0030040255 scopus 로고    scopus 로고
    • Selective pharmacological inhibition of distinct nitric oxide synthase isoforms
    • G.J Southan C. Szabó Selective pharmacological inhibition of distinct nitric oxide synthase isoforms Biochem Pharmacol 51 1996 383 394
    • (1996) Biochem Pharmacol , vol.51 , pp. 383-394
    • Southan, G.J1    Szabó, C.2
  • 116
    • 0029899544 scopus 로고    scopus 로고
    • Pharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform
    • C. Szabó R. Bryk B. Zingarelli G.J Southan T.C Gahman V. Bhat A.L Salzman D.J Wolff Pharmacological characterization of guanidinoethyldisulphide (GED), a novel inhibitor of nitric oxide synthase with selectivity towards the inducible isoform Br J Pharmacol 118 1996 1659 1668
    • (1996) Br J Pharmacol , vol.118 , pp. 1659-1668
    • Szabó, C.1    Bryk, R.2    Zingarelli, B.3    Southan, G.J4    Gahman, T.C5    Bhat, V.6    Salzman, A.L7    Wolff, D.J8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.