AG490 promotes HIF-1α accumulation by inhibiting its hydroxylation

Current Medicinal Chemistry

Volumn 19, Issue 23, 2012, Pages 4014-4023

  Fernandez Sanchez R ^a   Berzal, S ^a   Sánchez Niño, María Dolores ^a   Neria, F ^a   Goncalves S ^b   Calabia, O ^a   Tejedor, A ^c   Calzada, M J ^d,e   Caramelo, C ^a   Deudero, J J P ^a   Ortiz, A ^a,e  

^a 28400 Madrid   (Spain)

^b HOSPITAL DE SANTA MARIA   (Portugal)

^c HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^d HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^e UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Acute kidney injury; Endothelium; HIF 1 ; Hypoxia; JAK2; Kidney cancer; Tubular cell; Tyrphostin; Vascular smooth muscle; VEGF; VHL

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ERBSTATIN; GENISTEIN; GUANYLATE CYCLASE; GUANYLATE CYCLASE INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEASOME; TYRPHOSTIN; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CELL CULTURE; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HALF LIFE TIME; HUMAN; HUMAN CELL; HYDROXYLATION; KIDNEY CARCINOMA; KIDNEY CELL; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; CATTLE; CELLS, CULTURED; ENDOTHELIAL CELLS; GUANYLATE CYCLASE; HUMANS; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; JANUS KINASE 2; PROTEASOME ENDOPEPTIDASE COMPLEX; RECEPTOR, EPIDERMAL GROWTH FACTOR; SWINE; TRANSCRIPTION, GENETIC; TYRPHOSTINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 84865736145     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712802002554     Document Type: Article

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