Somatic Cloning and Epigenetic Reprogramming in Mammals

Principles of Regenerative Medicine

Volumn , Issue , 2011, Pages 129-158

  Niemann, Heiner ^a   Kues, Wilfried A ^a   Lucas Hahn, Andrea ^a   Carnwath, Joseph W ^a  

^a FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84865430251     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-381422-7.10007-0     Document Type: Chapter

References (245)

1. Alexander B., Coppola G., Perrault S.D., Peura T.T., Betts D.H., King W.A. Telomere length status of somatic cell sheep clones and their offspring. Mol. Reprod. Dev. 2007, 74:1525-1537.
2. Alexopoulos N.I., Maddox-Hyttel P., Tveden-Nyborg P., d'Cruz N.T., Tecirlioglu T.R., Cooney M.A., et al. Developmental disparity between in vitro-produced and somatic cell nuclear transfer bovine days 14 and 21 embryos: Implications for embryonic loss. Reproduction 2008, 136:433-445.
3. Antequera F. Structure, function and evolution of CpG island promoters. Cell Mol. Life Sci. 2003, 60:1647-1658.
4. Archer G.S., Dindot S., Friend T.H., Walker S., Zaunbrecher G., Lawhorn B., et al. Hierarchical phenotypic and epigenetic variation in cloned swine. Biol. Reprod. 2003, 69:430-436.
5. Aston K.I., Li G.P., Hicks B.A., Sessions B.R., Davis A.P., Rickords L.F., et al. Abnormal levels of transcript abundance of developmentally important genes in various stages of preimplantation bovine somatic cell nuclear transfer embryos. Cell Reprogramming 2010, 12:23-32.
6. Aston K.I., Li G.P., Hicks B.A., Sessions B.R., Davis A.P., Winger Q.A., et al. Global gene expression analysis of bovine somatic cell nuclear transfer blastocysts and cotyledons. Mol. Reprod. Dev. 2009, 76:471-482.
7. Baguisi A., Behboodi E., Melican D.T., Pollock J.S., Destrempes M.M., Cammuso C., et al. Production of goats by somatic cell nuclear transfer. Nat. Biotechnol. 1999, 17:456-461.
8. Bauersachs S., Ulbrich S.E., Zakhartchenko V., Minten M., Reichenbach M., Reichenbach H.D., et al. The endometrium responds differently to cloned versus fertilized embryos. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:5681-5686.
9. Beaujean N., Taylor J., Gardner J., Wilmut I., Meehan R., Young L. Effect of limited DNA methylation reprogramming in the normal sheep embryo on somatic cell nuclear transfer. Biol. Reprod. 2004, 71:185-193.
10. Berg D.K., Li C., Asher G., Wells D.N., Oback B. Red deer cloned from antler stem cells and their differentiated progeny. Biol. Reprod. 2007, 77:384-394.
11. Bestor T.H. Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain. EMBO J. 1992, 11:2611-2617.
12. Bestor T.H., Tycko B. Creation of genomic methylation patterns. Nat. Genet. 1996, 12:363-367.
13. Betthauser J.M., Pfister-Genskow M., Xu H., Golueke P.J., Lacson J.C., Koppang R.W., et al. Nucleoplasmin facilitates reprogramming and in vivo development of bovine nuclear transfer embryos. Mol. Reprod. Dev. 2006, 73:977-986.
14. Betts D.H., Perrault S.D., Petrik J., Lin L., Favetta L.A., Keefer C.L., et al. Telomere length analysis in goat clones and their offspring. Mol. Reprod. Dev. 2005, 72:461-470.
15. Biggers J.D., Summers M.C. Choosing a culture medium: making informed choices. Fertil. Steril. 2008, 90:473-483.
16. Blackburn E.H. The telomere and telomerase: nucleic acid-protein complexes acting in a telomere homeostasis system. A review. Biochemistry (Mosc.) 2001, 62:1196-1201.
17. Blasco M.A., Gasser S.M., Lingner J. Telomeres and telomerase. Genes Dev. 1999, 13:2353-2359.
18. Blelloch R.H., Hochedlinger K., Yamada Y., Brennan C., Kim M., Mintz B., et al. Nuclear cloning of embryonal carcinoma cells. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:13985-13990.
19. Blelloch R., Wang Z., Meissner A., Pollard S., Smith A., Jaenisch R. Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus. Stem Cells 2006, 24:2007-2013.
20. Boiani M., Eckardt S., Scholer H.R., McLaughlin K.J. Oct4 distribution and level in mouse clones: consequences for pluripotency. Genes Dev. 2002, 16:1209-1219.
21. Bortvin A., Eggan K., Skaletsky H., Akutsu H., Berry D.L., Yanagimachi R., et al. Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development 2003, 130:1673-1680.
22. Bourc'his D., Le Bourhis D., Patin D., Niveleau A., Comizzoli P., Renard J.P., et al. Delayed and incomplete reprogramming of chromosome methylation patterns in bovine cloned embryos. Curr. Biol. 2001, 11:1542-1546.
23. Bourc'his D., Xu G.L., Lin C.S., Bollman B., Bestor T.H. Dnmt3L and the establishment of maternal genomic imprints. Science 2001, 294:2536-2539.
24. Brambrink T., Hochedlinger K., Bell G., Jaenisch R. ES cells derived from cloned and fertilized blastocysts are transcriptionally and functionally indistinguishable. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:933-938.
25. Brem G., Kuhholzer B. The recent history of somatic cloning in mammals. Cloning Stem Cells 2002, 4:57-63.
26. Briggs R., King T.J. Transplantation of living nuclei from blastula cells into enucleated frogs' eggs. Proc. Natl. Acad. Sci. U.S.A. 1952, 38:455-463.
27. Bui L.C., Evsikov A.V., Khan D.R., Archilla C., Peynot N., Hénaut A., et al. Retrotransposon expression as a defining event of genome reprogramming in fertilized and cloned bovine embryos. Reprod. 2009, 138:289-299.
28. Burgers W.A., Fuks F., Kouzarides T. DNA methyltransferases get connected to chromatin. Trends Genet. 2002, 18:275-277.
29. Campbell K.H., McWhir J., Ritchie W.A., Wilmut I. Sheep cloned by nuclear transfer from a cultured cell line. Nature 1996, 380:64-66.
30. Carrozza M.J., Utley R.T., Workman J.L., Cote J. The diverse functions of histone acetyltransferase complexes. Trends Genet. 2003, 19:321-329.
31. Cezar G.G., Bartolomei M.S., Forsberg E.J., First N.L., Bishop M.D., Eilertsen K.J. Genome-wide epigenetic alterations in cloned bovine fetuses. Biol. Reprod. 2003, 68:1009-1014.
32. Chae J.I., Yu K., Cho S.K., Kim J.H., Koo D.B., Lee K.K., et al. Aberrant expression of developmentally important signaling molecules in cloned porcine extraembryonic tissues. Proteomics 2008, 8:2724-2734.
33. Chang C.C., Gao S., Sung L.Y., Corry G.N., Ma Y., Nagy Z.P., et al. Rapid elimination of the histone variant macroH2A from somatic cell heterochromatin after nuclear transfer. Cell Reprogramming 2010, 12:43-53.
34. Chavatte-Palmer P., Heyman Y., Richard C., Monget P., LeBourhis D., Kann G., et al. Clinical, hormonal, and hematologic characteristics of bovine calves derived from nuclei from somatic cells. Biol. Reprod. 2002, 66:1596-1603.
35. Chen T., Zhang Y.L., Jiang Y., Liu J.H., Schatten H., Chen D.Y., et al. Interspecies nuclear transfer reveals that demethylation of specific repetitive sequences is determined by recipient ooplasm but not by donor intrinsic property in cloned embryos. Mol. Reprod. Dev. 2006, 73:313-317.
36. Cheong H.T., Takahashi Y., Kanagawa H. Birth of mice after transplantation of early cell-cycle-stage embryonic nuclei into enucleated oocytes. Biol. Reprod. 1993, 48:958-963.
37. Chesne P., Adenot P.G., Viglietta C., Baratte M., Boulanger L., Renard J.P. Cloned rabbits produced by nuclear transfer from adult somatic cells. Nat. Biotechnol. 2002, 20:366-369.
38. Chung Y.G., Ratnam S., Chaillet J.R., Latham K.E. Abnormal regulation of DNA methyltransferase expression in cloned mouse embryos. Biol. Reprod. 2003, 69:146-153.
39. Chung Y., Bishop C.E., Treff N.R., Walker S.J., Sandler V.M., Becker S., et al. Reprogramming of human somatic cells using human and animal oocytes. Cloning and Stem Cells 2009, 11:213-223.
40. Cibelli J.B., Campbell K.H., Seidel G.E., West M.D., Lanza R.P. The health profile of cloned animals. Nat. Biotechnol. 2002, 20:13-14.
41. Cibelli J.B., Kiessling A.A., Cunniff K., Richards C., Lanza R.P., West M.D. Somatic cell nuclear transfer in humans: pronuclear and early embryonic development. J. Regener. Med. 2001, 2:25-31.
42. Cibelli J.B., Stice S.L., Golueke P.J., Kane J.J., Jerry J., Blackwell C., et al. Cloned transgenic calves produced from nonquiescent fetal fibroblasts. Science 1998, 280:1256-1258.
43. Colman A., Kind A. Therapeutic cloning: concepts and practicalities. Trends Biotechnol. 2000, 18:192-196.
44. Constancia M., Hemberger M., Hughes J., Dean W., Ferguson-Smith A., Fundele R., et al. Placental-specific IGF-II is a major modulator of placental and fetal growth. Nature 2002, 417:945-948.
45. Constancia M., Kelsey G., Reik W. Resourceful imprinting. Nature 2004, 432:53-57.
46. Curchoe C., Zhang S., Bin Y., Zhang X., Yang L., Feng D., et al. Promoter-specific expression of the imprinted IGF2 gene in cattle (Bos taurus). Biol. Reprod. 2005, 73:1275-1281.
47. Dai X., Hao J., Zhou Q. A modified culture method significantly improves the development of mouse somatic cell nuclear transfer embryos. Reproduction 2009, 138:301-308.
48. de Lange T. Protection of mammalian telomeres. Oncogene 2002, 21:532-540.
49. Dean W., Santos F., Reik W. Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer. Semin. Cell Dev. Biol. 2003, 14:93-100.
50. Dean W., Santos F., Stojkovic M., Zakhartchenko V., Walter J., Wolf E., et al. Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:13734-13738.
51. Dennis C. Developmental reprogramming: take a cell, any cell... Nature 2003, 426:490-491.
52. Dindot S.V., Farin P.W., Farin C.E., Romano J., Walker S., Long C., et al. Epigenetic and genomic imprinting analysis in nuclear transfer derived Bos gaurus/Bos taurus hybrid fetuses. Biol. Reprod. 2004, 71:470-478.
53. Eggan K., Akutsu H., Hochedlinger K., Rideout W., Yanagimachi R., Jaenisch R. X-Chromosome inactivation in cloned mouse embryos. Science 2000, 290:1578-1581.
54. Eggan K., Baldwin K., Tackett M., Osborne J., Gogos J., Chess A., et al. Mice cloned from olfactory sensory neurons. Nature 2004, 428:44-49.
55. Egli D., Rosains J., Birkhoff G., Eggan K. Developmental reprogramming after chromosome transfer into mitotic mouse zygotes. Nature 2007, 447:679-685.
56. Enright B.P., Kubota C., Yang X., Tian X.C. Epigenetic characteristics and development of embryos cloned from donor cells treated by trichostatin A or 5-aza-2′-deoxycytidine. Biol. Reprod. 2003, 69:896-901.
57. Enright B.P., Sung L.Y., Chang C.C., Yang X., Tian X.C. Methylation and acetylation characteristics of cloned bovine embryos from donor cells treated with 5-aza-2′-deoxycytidine. Biol. Reprod. 2005, 72:944-948.
58. Enright B.P., Taneja M., Schreiber D., Riesen J., Tian X.C., Fortune J.E., et al. Reproductive characteristics of cloned heifers derived from adult somatic cells. Biol. Reprod. 2002, 66:291-296.
59. Esteban M., Xu J., Yang J., Peng M., Qin D., Li W., et al. Generation of induced pluripotent stem cell lines from Tibetan miniature pig. J. Biol. Chem. 2009, 284:17634-17640.
60. Ezashi T., Telugu B., Alexenko A., Sachdev S., Sinha S., Roberts M. Derivation of induced pluripotent stem cells from pig somatic cells. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:10993-10998.
61. Farin P., Piedrahita J.A., Farin C.E. Errors in development of fetuses and placentas from in vitro-produced bovine embryos. Theriogenology 2006, 65:178-191.
62. Fischle W., Wang Y., Allis C.D. Binary switches and modification cassettes in histone biology and beyond. Nature 2003, 425:475-479.
63. Fletcher C.J., Roberts C.T., Hartwich K.M., Walker S.K., McMillen I.C. Somatic cell nuclear transfer in the sheep induces placental defects that likely precede fetal demise. Reproduction 2007, 133:243-255.
64. Fox J.L. Cloned animals deemed safe to eat, but labelling issues loom. Nat. Biotech. 2008, 26:249-250.
65. French A.J., Adams C.A., Anderson L.S., Kitchen J.R., Hughes M.R., Wood S.H. Development of human cloned blastocysts following somatic cell nuclear transfer (SCNT) with adult fibroblasts. Stem Cells 2008, 26:485-493.
66. Galli C., Lagutina I., Crotti G., Colleoni S., Turini P., Ponderato N., et al. Pregnancy: a cloned horse born to its dam twin. Nature 2003, 424:635.
67. Gebert C., Wrenzycki C., Herrmann D., Groger D., Reinhardt R., Hajkova P., et al. The bovine IGF2 gene is differentially methylated in oocyte and sperm DNA. Genomics 2006, 88:222-229.
68. Gebert C., Wrenzycki C., Herrmann D., Gröger D., Thiel J., Reinhardt R., et al. DNA methylation in the IGF2 intrageneric DMR is re-established in a sex-specific manner in bovine blastocysts after somatic cloning. Genomics 2009, 94:63-69.
69. Giraldo A.M., Hylan D.A., Ballard C.B., Purpera M.N., Vaught T.D., Lynn J.W., et al. Effect of epigenetic modifications of donor somatic cells on the subsequent chromatin remodeling of cloned bovine embryos. Biol. Reprod. 2008, 78:832-840.
70. Govoni K.E., Tian X.C., Kazmer G.W., Taneja M., Enright B.P., Rivard A.L., et al. Age-related changes of the somatotropic axis in cloned Holstein calves. Biol. Reprod. 2002, 66:1293-1298.
71. Green A.L., Wells D.N., Oback B. Cattle cloned from increasingly differentiated muscle cells. Biol. Reprod. 2007, 77:395-406.
72. Gurdon J.B., Byrne J.A. The first half-century of nuclear transplantation. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:8048-8052.
73. Hajkova P., Surani M.A. Development. Programming the X chromosome. Science 2004, 303:633-634.
74. Hiendleder S., Mund C., Reichenbach H.D., Wenigerkind H., Brem G., Zakhartchenko V., et al. Tissue-specific elevated genomic cytosine methylation levels are associated with an overgrowth phenotype of bovine fetuses derived by in vitro techniques. Biol. Reprod. 2004, 71:217-223.
75. Hiendleder S., Prelle K., Bruggerhoff K., Reichenbach H.D., Wenigerkind H., Bebbere D., et al. Nuclear-cytoplasmic interactions affect in utero developmental capacity, phenotype, and cellular metabolism of bovine nuclear transfer fetuses. Biol. Reprod. 2004, 70:1196-1205.
76. Hiiragi T., Solter D. Reprogramming is essential in nuclear transfer. Mol. Reprod. Dev. 2005, 70:417-421.
77. Hochedlinger K., Jaenisch R. Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature 2002, 415:1035-1038.
78. Hochedlinger K., Jaenisch R. Nuclear transplantation, embryonic stem cells, and the potential for cell therapy. N. Engl. J. Med. 2003, 349:275-286.
79. Hochedlinger K., Jaenisch R. On the cloning of animals from terminally differentiated cells. Nat. Genet. 2007, 39:136-137.
80. Hochedlinger K., Blelloch R., Brennan C., Yamada Y., Kim M., Chin L., et al. Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev. 2004, 18:1875-1885.
81. Hornen N., Kues W.A., Carnwath J.W., Lucas-Hahn A., Petersen B., Hassel P., et al. Production of viable pigs from fetal somatic stem cells. Cloning and Stem Cells 2007, 9:364-373.
82. Hsieh C.L. In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b. Mol. Cell Biol. 1999, 19:8211-8218.
83. Humpherys D., Eggan K., Akutsu H., Hochedlinger K., Rideout W.M., Biniszkiewicz D., et al. Epigenetic instability in ES cells and cloned mice. Science 2001, 293:95-97.
84. Huynh K.D., Lee J.T. Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos. Nature 2003, 426:857-862.
85. Hwang W.S., Roh S.I., Lee B.C., Kang S.K., Kwon D.K., Kim S., et al. Patient-specific embryonic stem cells derived from human SCNT blastocysts. Science 2005, 308:1777-1783.
86. Hwang W.S., Ryu Y.J., Park J.H., Park E.S., Lee E.G., Koo J.M., et al. Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst. Science 2004, 303:1669-1674.
87. Illmensee K., Hoppe P.C. Nuclear transplantation in Mus musculus: developmental potential of nuclei from preimplantation embryos. Cell 1981, 23:9-18.
88. Inoue K., Wakao H., Ogonuki N., Miki H., Seino K.-I., Nambu-Wakao R., et al. Generation of cloned mice by direct nuclear transfer from natural killer T cells. Curr. Biol. 2005, 15:1114-1118.
89. Jaenisch R., Wilmut I. Developmental biology. Don't clone humans!. Science 2001, 291:2552.
90. Jeon H.Y., Hyun S.H., Lee G.S., Kim H.S., Kim S., Jeong Y.W., et al. The analysis of telomere length and telomerase activity in cloned pigs and cows. Mol. Reprod. Dev. 2005, 71:315-320.
91. Jiang L., Carter D.B., Xu J., Yang X., Prather R.S., Tian X.C. Telomere lengths in cloned transgenic pigs. Biol. Reprod. 2004, 70:1589-1593.
92. Jones P.A. The DNA methylation paradox. Trends Genet. 1999, 15:34-37.
93. Kang Y.K., Koo D.B., Park J.S., Choi Y.H., Chung A.S., Lee K.K., et al. Aberrant methylation of donor genome in cloned bovine embryos. Nat. Genet. 2001, 28:173-177.
94. Kang Y.K., Koo D.B., Park J.S., Choi Y.H., Kim H.N., Chang W.K., et al. Typical demethylation events in cloned pig embryos. Clues on species-specific differences in epigenetic reprogramming of a cloned donor genome. J. Biol. Chem. 2001, 276:39980-39984.
95. Kato Y., Tani T., Tsunoda Y. Cloning of calves from various somatic cell types of male and female adult, newborn and fetal cows. J. Reprod. Fertil. 2000, 120:231-237.
96. Kato Y., Tani T., Sotomaru Y., Kurokawa K., Kato J., Doguchi H., et al. Eight calves cloned from somatic cells of a single adult. Science 1998, 282:2095-2098.
97. Kennedy D. Editorial retraction. Science 2006, 311:335.
98. Kind A., Schnieke A. Animal pharming, two decades on. Transgenic Res. 2008, 17:1025-1033.
99. Knijn H.M., Wrenzycki C., Hendriksen P.J., Vos P.L., Zeinstra E.C., van der Weijden G.C., et al. In vitro and in vivo culture effects on mRNA expression of genes involved in metabolism and apoptosis in bovine embryos. Reprod. Fertil. Dev. 2005, 17:775-784.
100. Koo D.B., Kang Y.K., Choi Y.H., Park J.S., Kim H.N., Oh K.B., et al. Aberrant allocations of inner cell mass and trophectoderm cells in bovine nuclear transfer blastocysts. Biol. Reprod. 2003, 67:487-492.
101. Kubota C., Tian X.C., Yang X. Serial bull cloning by somatic cell nuclear transfer. Nat. Biotechnol. 2004, 22:693-694.
102. Kubota C., Yamakuchi H., Todoroki J., Mizoshita K., Tabara N., Barber M., et al. Six cloned calves produced from adult fibroblast cells after long-term culture. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:990-995.
103. Kues W.A., Niemann H. The contribution of farm animals to human health. Trends Biotechnol. 2004, 22:286-294.
104. Kues W.A., Rath D., Niemann H. Reproductive biotechnology in farm animals goes genomics. CAB Rev. 2008, 3:1-18.
105. Kues W.A., Sudheer S., Herrmann D., Carnwath J.W., Havlicek S., Besenfelder U., et al. Genome-wide expression profiling reveals distinct clusters of transcriptional regulation during bovine preimplantation development in vivo. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:19768-19773.
106. Kumugai S. Safety of animal foods that utilize cloning technology 2002, Report to the Japanese Ministry for Agriculture, Forestry and Fishery (MAFF).
107. Lanza R.P., Chung H.Y., Yoo J.J., Wettstein P.J., Blackwell C., Borson N., et al. Generation of histocompatible tissues using nuclear transplantation. Nat. Biotechnol. 2002, 20:689-696.
108. Lanza R.P., Cibelli J.B., Faber D., Sweeney R.W., Henderson B., Nevala W., et al. Cloned cattle can be healthy and normal. Science 2001, 294:1893-1894.
109. Law J.A., Jacobsen S.E. Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nature Reviews Genetics 2010, 11:204-220.
110. Lee B.C., Kim M.K., Jang G., Oh H.J., Yuda F., Kim H.J., et al. DNA analysis of a putative dog clone. Nature 2005, 436:641.
111. Lee J.B., Park C. Verification that Snuppy is a clone. Nature 2006, 440:E2-E3.
112. Lee R.S.F., Peterson A.J., Donnison M.J., Ravelich S., Ledgard A.M., Li N., et al. Cloned cattle fetuses with the same nuclear genetics are more variable than contemporary half-siblings resulting from artificial insemination and exhibit fetal and placental growth deregulation even in the first trimester. Biol. Reprod. 2004, 70:1-11.
113. Lepikhov K., Zakhartchenko V., Hao R., Yang F., Wrenzycki C., Niemann H., et al. Evidence for conserved DNA and histone H3 methylation reprogramming in mouse, bovine and rabbit zygotes. Epigenetics & Chromatin 2008, doi:10.1186/1756-8935-1-8.
114. Li E. Chromatin modification and epigenetic reprogramming in mammalian development. Nature Reviews Genetics 2002, 3:662-673.
115. Li E., Beard C., Jaenisch R. Role for DNA methylation in genomic imprinting. Nature 1993, 366:362-365.
116. Li J., Mombaerts P. Nuclear transfer-mediated rescue of the nuclear genome of nonviable mouse cells frozen without cryoprotectant. Biol. Reprod. 2008, 79:588-593.
117. Li J., Ishli T., Feinstein P., Mombaerts P. Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons. Nature 2004, 428:393-399.
118. Li S., Li Y., Du W., Zhang L., Yu S., Dai Y., et al. Aberrant gene expression in organs of bovine clones that die within two days after birth. Biol. Reprod. 2005, 72:258-265.
119. Li S., Li Y., Yu S., Du W., Zhang L., Dai Y., et al. Expression of insulin-like growth factors systems in cloned cattle dead within hours after birth. Mol. Reprod. Dev. 2007, 74:397-402.
120. Li W., Wei W., Zhu S., Zhu J., Shi Y., Lin T., et al. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell 2009, 4:16-19.
121. Li Z., Sun X., Chen J., Liu X., Wisely S.M., Zhou Q., et al. Cloned ferrets produced by somatic cell nuclear transfer. Dev. Biol. 2006, 293:439-448.
122. Liao J., Cui C., Chen S., Ren J., Chen J., Gao Y., et al. Generation of induced pluripotent stem cell lines from adult rat cells. Cell Stem Cell 2009, 4:11-15.
123. Lin T., Ambasudhan R., Yuan X., Li W., Hilcove S., Abujarour R., et al. A chemical platform for improved induction of human iPSCs. Nat. Methods 2009, 6:805-808.
124. Liu H., Zhu F., Yong J., Zhang P., Hou P., Li H., et al. Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts. Cell Stem Cell 2008, 4:587-590.
125. Liu J.H., Yin S., Xiong B., Hou Y., Chen D.Y., Sun Q.Y. Aberrant DNA methylation imprints in aborted bovine clones. Mol. Reprod. Dev. 2008, 75:598-607.
126. Lucifero D., Suzuki J., Bordignon V., Martel J., Vigneault C., Therrien J., et al. Bovine SNRPN methylation imprint in oocytes and day 17 in vitro-produced and somatic cell nuclear transfer embryos. Biol. Reprod. 2006, 75:531-538.
127. Lyon M.F. Gene action in the X-chromosome of the mouse (Mus musculus L.). Nature 1961, 190:372-373.
128. Mager J., Bartholomei M.S. Strategies for dissecting epigenetic mechanisms in the mouse. Nature Genetics 2005, 37:1194-1199.
129. Mak W., Nesterova T.B., de Napoles M., Appanah R., Yamanaka S., Otte A.P., et al. Reactivation of the paternal X chromosome in early mouse embryos. Science 2004, 303:666-669.
130. Mann M.R., Chung Y.G., Nolen L.D., Verona R.I., Latham K.E., Bartolomei M.S. Disruption of imprinted gene methylation and expression in cloned preimplantation stage mouse embryos. Biol. Reprod. 2003, 69:902-914.
131. Mansouri-Attia N., Sandra O., Aubert J., Degrelle S., Everts R.E., Giraud-Delville C., et al. Endometrium as an early sensor of in vitro embryo manipulation technologies. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:5687-5692.
132. Martinez-Diaz M.A., Che L., Albornoz M., Seneda M.M., Collis D., Coutinho A.R.S., et al. Pre- and postimplantation development of swine-cloned embryos derived from fibroblasts and bone marrow cells after inhibition of histone deacetylases. Cell Reprogramming 2010, 12:85-94.
133. Mayer W., Niveleau A., Walter J., Fundele R., Haaf T. Demethylation of the zygotic paternal genome. Nature 2000, 403:501-502.
134. McGrath J., Solter D. Nuclear transplantation in mouse embryos. J. Exp. Zool. 1983, 228:355-362.
135. McGrath J., Solter D. Inability of mouse blastomere nuclei transferred to enucleated zygotes to support development in vitro. Science 1984, 226:1317-1319.
136. Meng L., Ely J.J., Stouffer R.L., Wolf D.P. Rhesus monkeys produced by nuclear transfer. Biol. Reprod. 1997, 57:454-459.
137. Miyashita N., Shiga K., Yonai M., Kaneyama K., Kobayashi S., Kojima T., et al. Remarkable differences in telomere lengths among cloned cattle derived from different cell types. Biol. Reprod. 2002, 66:1649-1655.
138. Miyoshi K., Mori H., Mizobe Y., Akasaka E., Ozawa A., Yoshida M., et al. Valproic acid enhances in vitro development and Oct-3/4 expression of miniature pig somatic cell nuclear transfer embryos. Cell Reprogramming 2010, 12:67-74.
139. Miyoshi K., Rzucidlo S.J., Pratt S.L., Stice S.L. Improvements in cloning efficiencies may be possible by increasing uniformity in recipient oocytes and donor cells. Biol. Reprod. 2003, 68:1079-1086.
140. Mizutani E., Ohta H., Kishigami S., Thuan N.V., Hikichi T., Wakayama S., et al. Developmental ability of cloned embryos from neural stem cells. Reproduction 2006, 132:849-857.
141. Moore K., Kramer J.M., Rodriguez-Sallaberry C.J., Yelich J.V., Drost M. Insulin-like growth factor (IGF) family genes are aberrantly expressed in bovine conceptuses produced in vitro or by nuclear transfer. Theriogenology 2007, 68:717-727.
142. Nakayama J., Tahara H., Tahara E., Saito M., Ito K., Nakamura H., et al. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat. Genet. 1998, 18:65-68.
143. Niemann H., Kues W.A. Transgenic farm animals - an update. Reprod. Fert. Dev. 2007, 19:762-770.
144. Niemann H., Wrenzycki C. Alterations of expression of developmentally important genes in preimplantation bovine embryos by in vitro culture conditions: implications for subsequent development. Theriogenology 2000, 53:21-34.
145. Niemann H., Carnwath J.W., Herrmann D., Wieczorek G., Lemme E., Lucas-Hahn A., et al. DNA methylation patterns reflect epigenetic reprogramming in bovine embryos. Cell Reprogramming 2010, 12:33-42.
146. Niemann H., Tian X.C., King W.A., Lee R.S.F. Epigenetic reprogramming in embryonic and foetal development upon somatic cell nuclear transfer cloning. Reproduction 2008, 135:151-163.
147. Niemann H., Wrenzycki C., Lucas-Hahn A., Brambrink T., Kues W.A., Carnwath J.W. Gene expression patterns in bovine in vitro-produced and nuclear transfer-derived embryos and their implications for early development. Cloning and Stem Cells 2002, 4:29-38.
148. Niwa H., Miyazaki J., Smith A.G. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 2000, 24:372-376.
149. Nowak-Imialek M., Wrenzycki C., Herrmann D., Lucas-Hahn A., Lagutina I., Lemme E., et al. Messenger RNA expression patterns of histone-associated genes in bovine preimplantation embryos derived from different origins. Mol. Reprod. Dev. 2008, 75:731-743.
150. Oback B., Wells D.N. Donor cell differentiation, reprogramming, and cloning efficiency: elusive or illusive correlation?. Mol. Reprod. Dev. 2007, 74:646-654.
151. Oestrup O., Petrovica I., Strejcek F., Morovic M., Lucas-Hahn A., Lemme E., et al. Nuclear and nucleolar reprogramming during the first cell cycle in bovine nuclear transfer embryos. Cloning and Stem Cells 2009, 11:367-375.
152. Ogonuki N., Inoue K., Yamamoto Y., Noguchi Y., Tanemura K., Suzuki O., et al. Early death of mice cloned from somatic cells. Nat. Genet. 2002, 30:253-254.
153. Oh H.J., Kim M.K., Jang G., Kim H.J., Hong S.G., Park J.E., et al. Cloning endangered gray wolves (Canis lupus) from somatic cells collected postmortem. Theriogenology 2008, 70:638-647.
154. Oishi M., Gohma H., Hashizume K., Taniguchi Y., Yasue H., Takahashi S., et al. Early embryonic death - associated changes in genome-wide gene expression profiles in the fetal placenta of the cow carrying somatic nuclear-derived cloned embryo. Mol. Reprod. Dev. 2006, 73:404-409.
155. Okamoto I., Otte A.P., Allis C.D., Reinberg D., Heard E. Epigenetic dynamics of imprinted X-inactivation during early mouse development. Science 2004, 303:644-649.
156. Okano M., Bell D.W., Haber D.A., Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999, 99:247-257.
157. Okita K., Ichisaka T., Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature 2007, 448:313-317.
158. Okita K., Nakagawa M., Hyenjong H., Ichisaka T., Yamanaka S. Generation of mouse induced pluripotent stem cells without viral vectors. Science 2008, 322:949-953.
159. Onishi A., Iwamoto M., Akita T., Mikawa S., Takeda K., Awata T., et al. Pig cloning by microinjection of fetal fibroblast nuclei. Science 2000, 289:1188-1190.
160. Oropeza A., Hadeler K.G., Niemann H. Application of ultrasound-guided follicular aspiration (OPU) in prepubertal and adult cattle. J. Reprod. Dev. 2007, 52:S31-S38.
161. Oropeza M., Petersen B., Carnwath J.W., Lucas-Hahn A., Lemme E., Hassel P., et al. Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli. Xenotransplantation 2009, 16:522-534.
162. Oswald J., Engemann S., Lane N., Mayer W., Olek A., Fundele R., et al. Active demethylation of the paternal genome in the mouse zygote. Curr. Biol. 2000, 10:475-478.
163. Pace M.M., Augenstein M.L., Betthauser J.M., Childs L.A., Eilertsen K.J., Enos J.M., et al. Ontogeny of cloned cattle to lactation. Biol. Reprod. 2002, 67:334-339.
164. Panarace M., Agüero J.I., Garrote M., Jauregui G., Segovia A., Cané L., et al. How healthy are clones and their progeny: 5 years of field experience. Theriogenology 2007, 67:142-151.
165. Parker H.G., Kruglyak L., Ostrander E.A. DNA analysis of a putative dog clone. Nature 2006, 440:E1-E2.
166. Perry A.C., Wakayama T. Untimely ends and new beginnings in mouse cloning. Nat. Genet. 2002, 30:243-244.
167. Pesce M., Schöler H.R. Oct-4: gatekeeper in the beginnings of mammalian development. Stem Cells 2001, 19:271-278.
168. Petersen B., Carnwath J.W., Niemann H. The perspectives for porcine-to-human xenografts. Comp. Immunol. Microbiol. Infectious Diseases 2009, 32:91-105.
169. Petersen B., Lucas-Hahn A., Oropeza M., Hornen N., Lemme E., Hassel P., et al. Development and validation of a highly efficient protocol of porcine somatic cloning using preovulatory embryo transfer in peripubertal gilts. Cloning and Stem Cells 2008, 10:355-362.
170. Petersen B., Ramackers W., Tiede A., Lucas-Hahn A., Herrmann D., Barg-Kues B., et al. Pigs transgenic for human thrombomodulin have elevated production of activated protein C. Xenotransplantation 2009, 16:486-495.
171. Polejaeva I.A., Chen S.H., Vaught T.D., Page R.L., Mullins J., Ball S., et al. Cloned pigs produced by nuclear transfer from adult somatic cells. Nature 2000, 407:86-90.
172. Powell A.M., Talbot N.C., Wells K.D., Kerr D.E., Pursel V.G., Wall R.J. Cell donor influences success of producing cattle by somatic cell nuclear transfer. Biol. Reprod. 2004, 71:210-216.
173. Prather R.S., Sims M.M., First N.L. Nuclear transplantation in early pig embryos. Biol. Reprod. 1989, 41:414-418.
174. Reik W., Walter J. Genomic imprinting: parental influence on the genome. Nat. Rev. Genet. 2001, 2:21-32.
175. Reik W., Dean W., Walter J. Epigenetic reprogramming in mammalian development. Science 2001, 293:1089-1093.
176. Renard J.P., Chastant S., Chesne P., Richard C., Marchal J., Cordonnier N., et al. Lymphoid hypoplasia and somatic cloning. Lancet 1999, 353:1489-1491.
177. Rhind S.M., King T.J., Harkness L.M., Bellamy C., Wallace W., DeSousa P., et al. Cloned lambs - lessons from pathology. Nat. Biotechnol. 2003, 21:744-745.
178. Rideout W.M., Hochedlinger K., Kyba M., Daley G.Q., Jaenisch R. Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell 2002, 109:17-27.
179. Ruddock N.T., Wilson K.J., Cooney M.A., Korfiatis N.A., Tecirlioglu R.T., French A.J. Analysis of imprinted messenger RNA expression during bovine preimplantation development. Biol. Reprod. 2004, 70:1131-1135.
180. Rudenko L., Matheson J.C., Sundlof S.F. Animal cloning and the FDA - the risk assessment paradigm under public scrutiny. Nat. Biotech. 2007, 25:39-43.
181. Saito S., Sawai K., Ugai H., Moriyasu S., Minamihashi A., Yamamoto Y., et al. Generation of cloned calves and transgenic chimeric embryos from bovine embryonic stem-like cells. Biochem. Biophys. Res. Comm. 2003, 309:104-113.
182. Santos F., Hendrich B., Reik W., Dean W. Dynamic reprogramming of DNA methylation in the early mouse embryo. Dev. Biol. 2002, 241:172-182.
183. Sawai K., Takahashi M., Moriyasu S., Hirayama H., Minamihashi A., Hashizume T., et al. Changes in the DNA methylation status of bovine embryos from the blastocyst to elongated stage derived from somatic cell nuclear transfer. Cell Reprogramming 2010, 12:15-22.
184. Schaetzlein S., Rudolph K.L. Telomere length regulation during cloning, embryogenesis and ageing. Reprod. Fertil. Dev. 2005, 17:85-96.
185. Schaetzlein S., Lucas-Hahn A., Lemme E., Kues W.A., Dorsch M., Manns M.P., et al. Telomere length is reset during early mammalian embryogenesis. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:8034-8038.
186. Schurmann A., Wells D.N., Oback B. Early zygotes are suitable recipients for bovine somatic nuclear transfer and result in cloned offspring. Reproduction 2006, 132:839-848.
187. Schwarzer M., Carnwath J.W., Lucas-Hahn A., Lemme E., Kues W.A., Wachsmann B., et al. Isolation of bovine cardiomyocytes for reprogramming studies based on nuclear transfer. Cloning and Stem Cells 2006, 8:150-158.
188. Shi D., Lu F., Wei Y., Cui K., Yang S., Wei J., et al. Buffaloes (Bubalus bubalis) cloned by nuclear transfer of somatic cells. Biol. Reprod. 2007, 77:285-291.
189. Shiels P.G., Kind A.J., Campbell K.H., Wilmut I., Waddington D., Colman A., et al. Analysis of telomere lengths in cloned sheep. Nature 1999, 399:316-317.
190. Shin T., Kraemer D., Pryor J., Liu L., Rugila J., Howe L., et al. A cat cloned by nuclear transplantation. Nature 2002, 415:859-860.
191. Simonsson S., Gurdon J. DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei. Nat. Cell Biol. 2004, 6:984-990.
192. Sims M., First N.L. Production of calves by transfer of nuclei from cultured inner cell mass cells. Proc. Natl. Acad. Sci. U.S.A. 1994, 91:6143-6147.
193. Smith S.L., Everts R.E., Tian X.C., Du F., Sung L.Y., Rodriguez-Zas S.L., et al. Global gene expression profiles reveal significant nuclear reprogramming by the blastocyst stage after cloning. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:17582-17587.
194. Stadtfeld M., Nagaya M., Utikal J., Weir G., Hochedlinger K. Induced pluripotent stem cells generated without viral integration. Science 2008, 322:945-949.
195. Stice S.L., Robl J.M. Nuclear reprogramming in nuclear transplant rabbit embryos. Biol. Reprod. 1988, 39:657-664.
196. Sung L.Y., Gao S., Shen H., Yu H., Song Y., Smith S.L., et al. Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer. Nat. Genet. 2006, 38:1323-1328.
197. Suzuki J., Therrien J., Filion F., Lefebvre R., Goff A.K., Smith L.C. In vitro culture and somatic cell nuclear transfer affect imprinting of SNRPN gene in pre- and post-implantation stages of development in cattle. BMC Dev. Biol. 2009, 9. doi:10.1186/1471-213X-9-9.
198. Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
199. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131:1-12.
200. Tamashiro K.L., Wakayama T., Blanchard R.J., Blanchard D.C., Yanagimachi R. Postnatal growth and behavioral development of mice cloned from adult cumulus cells. Biol. Reprod. 2000, 63. 328-234.
201. Telford N.A., Watson A.J., Schultz G.A. Transition from maternal to embryonic control in early mammalian development: a comparison of several species. Mol. Reprod. Dev. 1990, 26:90-100.
202. Theoret C., Dore M., Mulon P.Y., Desrochers A., Viramontes F., Filion F., et al. Short- and longterm skin graft survival in cattle clones with different mitochondrial haplotypes. Theriogenology 2006, 65:1465-1479.
203. Tian X.C., Kubota C., Sakashita K., Izaike Y., Okano R., Tabara N., et al. Meat and milk compositions of bovine clones. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:6261-6266.
204. Wadman M. Dolly: a decade on. Nature 2007, 445:800-801.
205. Wakayama S., Ohta H., Hikichi T., Mizutani E., Iwaki T., Kanagawa O., et al. Production of healthy cloned mice from bodies frozen at -20°C for 16 years. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:17318-17322.
206. Wakayama S., Ohta H., Kishigami S., van Thuan N., Hikichi T., Mizutani E., et al. Establishment of male and female nuclear transfer embryonic stem cell lines from different mouse strains and tissues. Biol. Reprod. 2005, 72:932-936.
207. Wakayama T., Yanagimachi R. Cloning of male mice from adult tail-tip cells. Nat. Genet. 1999, 22:127-128.
208. Wakayama T., Yanagimachi R. Mouse cloning with nucleus donor cells of different age and type. Mol. Reprod. Dev. 2001, 58:376-383.
209. Wakayama T., Perry A.C., Zuccotti M., Johnson K.R., Yanagimachi R. Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei. Nature 1998, 394:369-374.
210. Wakayama T., Rodriguez I., Perry A.C., Yanagimachi R., Mombaerts P. Mice cloned from embryonic stem cells. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:14984-14989.
211. Wakayama T., Shinkai Y., Tamashiro K.L., Niida H., Blanchard D.C., Blanchard R.J., et al. Cloning of mice to six generations. Nature 2000, 407:318-319.
212. Wakayama T., Tabar V., Rodriguez I., Perry A.C., Studer L., Mombaerts P. Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer. Science 2001, 292:740-743.
213. Wang L., Duan E., Sung L.Y., Jeong B.S., Yang X., Tian X.C. Generation and characterization of pluripotent cells from cloned bovine embryos. Biol. Reprod. 2005, 73:149-155.
214. Wani N.A., Wernery U., Hassan F.A.H., Wernery R., Skidmore J.A. Production of the first cloned camel by somatic cell nuclear transfer. Biol. Reprod. 2010, 82:373-379.
215. Wee G., Koo D.B., Song B.S., Kim J.S., Kang M.J., Moon S.J., et al. Inheritable histone H4 acetylation of somatic chromatins in cloned embryos. J. Biol. Chem. 2006, 281:6048-6057.
216. Wee G., Shim J.J., Koo D.B., Chae J.I., Lee K.K., Han Y.M. Epigenetic alteration of the donor cells does not recapitulate the reprogramming of DNA methylation in cloned embryos. Reproduction 2007, 134:781-787.
217. Willadsen S.M. Nuclear transplantation in sheep embryos. Nature 1986, 320:63-65.
218. Wilmut I., Schnieke A.E., McWhir J., Kind A.J., Campbell K.H. Viable offspring derived from fetal and adult mammalian cells. Nature 1997, 385:810-813.
219. Wongsrikeao P., Nagai T., Agung B., Taniguchi M., Kunishi M., Suto S., et al. Improvement of transgenic cloning efficiencies by culturing recipient oocytes and donor cells with antioxidant vitamins in cattle. Mol. Reprod. Dev. 2007, 74:694-702.
220. Woods G.L., White K.L., Vanderwall D.K., Li G.P., Aston K.I., Bunch T.D., et al. A mule cloned from fetal cells by nuclear transfer. Science 2003, 301:1063.
221. Wrenzycki C., Niemann H. Epigenetic reprogramming in early embryonic development: effects of in-vitro production and somatic nuclear transfer. Reprod. Biomed. Online 2003, 7:649-656.
222. Wrenzycki C., Herrmann D., Keskintepe L., Martins A., Sirisathien S., Brackett B., et al. Effects of culture system and protein supplementation on mRNA expression in pre-implantation bovine embryos. Hum. Reprod. 2001, 16:893-901.
223. Wrenzycki C., Herrmann D., Lucas-Hahn A., Gebert C., Korsawe K., Lemme E., et al. Epigenetic reprogramming throughout preimplantation development and consequences for assisted reproductive technologies. Birth Defects Res. C Embryo Today 2005, 75:1-9.
224. Wrenzycki C., Herrmann D., Lucas-Hahn A., Korsawe K., Lemme E., Niemann H. Messenger RNA expression patterns in bovine embryos derived from in vitro procedures and their implications for development. Reprod. Fertil. Dev. 2005, 17:23-35.
225. Wrenzycki C., Lucas-Hahn A., Herrmann D., Lemme E., Korsawe K., Niemann H. In vitro production and nuclear transfer affect dosage compensation of the X-linked gene transcripts G6PD, PGK, and Xist in preimplantation bovine embryos. Biol. Reprod. 2002, 66:127-134.
226. Wrenzycki C., Wells D., Herrmann D., Miller A., Oliver J., Tervit R., et al. Nuclear transfer protocol affects messenger RNA expression patterns in cloned bovine blastocysts. Biol. Reprod. 2001, 65:309-317.
227. Wu Z., Chen J., Ren J., Bao L., Liao J., Cui C., et al. Generation of pig-induced pluripotent stem cells with a drug-inducible system. J. Mol. Cell Biol. 2009, 1:46-54.
228. Wuensch A., Habermann F.A., Kurosaka S., Klose R., Zakhartchenko V., Reichenbach H.D., et al. Quantitative monitoring of pluripotency gene activation after somatic cloning in cattle. Biol. Reprod. 2007, 76:983-991.
229. Xu Y., Zhang J.J., Grifo J.A., Krey L.C. DNA methylation patterns in human tripronucleate zygotes. Mol. Hum. Reprod. 2005, 11:167-171.
230. Xue F., Tian X.C., Du F., Kubota C., Taneja M., Dinnyes A., et al. Aberrant patterns of X chromosome inactivation in bovine clones. Nat. Genet. 2002, 31:216-220.
231. Yamazaki Y., Fujita T.C., Low E.W., Alarcón V.B., Yanagimachi R., Marikawa Y. Gradual DNA demethylation of the Oct4 promoter in cloned mouse embryos. Mol. Reprod. Dev. 2006, 73:180-188.
232. Yang L., Chavatte-Palmer P., Kubota C., O'Neill M., Hoagland T., Renard J.P., et al. Expression of imprinted genes is aberrant in deceased newborn cloned calves and relatively normal in surviving adult clones. Mol. Reprod. Dev. 2005, 71:431-438.
233. Yang X., Li H., Ma Q., Yan J., Zhao J., Li H., et al. Improved efficiency of bovine cloning by autologous somatic cell nuclear transfer. Reprod. 2006, 132:733-739.
234. Yang X., Smith S.L., Tian X.C., Lewin H.A., Renard J.P., Wakayama T. Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning. Nat. Genet. 2007, 39:295-302.
235. Yang X., Tian X.C., Kubota C., Page R., Xu J., Cibelli J., et al. Risk assessment of meat and milk from cloned animals. Nat. Biotech. 2007, 25:77-83.
236. Young L.E., Fernandes K., McEvoy T.G., Butterwith S.C., Gutierrez C.G., Carolan C., et al. Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture. Nat. Genet. 2001, 27:153-154.
237. Yu J., Vodyanik M., Smuga-Otto K., Antosiewicz-Bourget J., Frane J., Tian S., et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007, 318:1917-1920.
238. Yu Y., Mai Q., Chen X., Wang L., Gao L., Zhou C., et al. Assessment of the developmental competence of human somatic cell nuclear transfer embryos by oocyte morphology classification. Hum. Reprod. 2009, 24:649-657.
239. Yusa K., Rad R., Takeda J., Bradley A. Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat. Methods 2009, 6:363-369.
240. Zhang S., Kubota C., Yang L., Zhang Y., Page R., O'Neill M., et al. Genomic imprinting of H19 in naturally reproduced and cloned cattle. Biol. Reprod. 2004, 71:1540-1544.
241. Zhao J., Hao Y., Ross J.W., Spate L.D., Walters E.M., Samuel M.S., et al. Histone deacetylase inhibitors improve in vitro and in vivo developmental competence of somatic cell nuclear transfer porcine embryos. Cell Reprogramming 2010, 12:75-83.
242. Zhao J., Ross J.W., Hao Y., Spate L.D., Walters E.M., Samuel M.S., et al. Significant improvement in cloning efficiency of an inbred miniature pig by histone deacetylase inhibitor treatment after somatic cell nuclear transfer. Biol. Reprod. 2009, 81:525-530.
243. Zhou H., Wu S., Joo J., Zhu S., Han D., Lin T., Trauger S., et al. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 2009, 4:1-4.
244. Zhou Q., Renard J.-P., Friec G., Brochard V., Beaujean N., Cherifi Y., et al. Generation of fertile cloned rats using controlled timing of oocyte activation. Science 2003, 302:1179.
245. Zhu H., Craig J.A., Dyce P.W., Sunnen N., Li J. Embryos derived from porcine skin-derived stem cells exhibit enhanced preimplantation development. Biol. Reprod. 2004, 71:1890-1897.