Evidence of a Pluripotent Human Embryonic Stem Cell Line Derived from a Cloned Blastocyst

Science

Volumn 303, Issue 5664, 2004, Pages 1669-1674

  Hwang, Woo Suk ^a   Ryu, Young June ^a   Park, Jong Hyuk ^b   Park, Eul Soon ^a   Lee, Eu Gene ^a   Koo, Ja Min ^c   Jeon, Hyun Yong ^a   Lee, Byeong Chun ^a   Kang, Sung Keun ^a   Kim, Sun Jong ^b   Ahn, Curie ^a   Hwang, Jung Hye ^d   Park, Ky Young ^e   Cibelli, Jose B ^f   Moon, Shin Yong ^a  

^a Seoul National University   (South Korea)

^b Mizmedi Hospital   (South Korea)

^c Gachon University College of Medicine   (South Korea)

^d Hanyang University   (South Korea)

^e Sunchon National University   (South Korea)

^f MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMARKERS; CLONING; COMPOSITION; CYTOLOGY; MORPHOLOGY;

CELL SURFACE MARKERS; SOMATIC NUCLEAR DONOR CELLS;

CELLS;

BIOLOGY;

ARTICLE; BLASTOCYST; CELL DIFFERENTIATION; CELL LINE; CLONING; DNA FINGERPRINTING; EMBRYO; EMBRYO CELL; EMBRYO DEVELOPMENT; GENE SILENCING; HUMAN; HUMAN CELL; PARTHENOGENESIS; PRIORITY JOURNAL; SOMATIC CELL GENETICS; STEM CELL;

ANIMALS; BIOLOGICAL MARKERS; BLASTOCYST; CELL DIFFERENTIATION; CELL LINE; CLONING, ORGANISM; CULTURE MEDIA; CULTURE TECHNIQUES; DNA FINGERPRINTING; EMBRYO; FEMALE; GENOMIC IMPRINTING; HUMANS; KARYOTYPING; MALE; MICE; MICE, SCID; NUCLEAR TRANSFER TECHNIQUES; OOCYTE DONATION; OVARIAN FOLLICLE; PARTHENOGENESIS; PLURIPOTENT STEM CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TANDEM REPEAT SEQUENCES; TERATOMA; TESTICULAR NEOPLASMS;

ANIMALIA; MAMMALIA;

EID: 12144286557     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1094515     Document Type: Article

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30. We thank Y. Y. Hwang (Hanyang University) for assistance with oocyte collections; S. I. Rho (MizMedi Hospital), H. S. Yoon (MizMedi Hospital.) and S. K. Oh (Seoul National University) for assistance on hES cells culture; Y. K. Choi (Korea Research Institute of Bioscience and Biotechnology) for assistance on teratoma formation; Tak Ko (Michigan State University) for gene expression analysis of Cyno-1 cells; and A. Trounson (Monash University), B. D. Bavister (University of New Orleans), and D. P. Wolf (Oregon National Primate Research Center) for critical review of the manuscript. J. B. Cibelli made intellectual contributions to the manuscript and the RNA analysis of nonhuman primate cells. All human experiments were performed in Korea by Korean scientists. This study was supported by grants from Advanced Backbone IT Technology Development (grant IMT2000-C1-1) to W.S.H. and the Stem Cell Research Center (grant M102KL0 100-02K 1201-00223) to S.Y.M. The authors are grateful for a graduate fellowship provided by the Ministry of Education through the BK21 program.