Developmental Biology: Patient-specific embryonic stem cells derived from human SCNT blastocysts

Science

Volumn 308, Issue 5729, 2005, Pages 1777-1783

  Hwang, Woo Suk ^a   Roh, Sung Il ^b   Lee, Byeong Chun ^a   Kang, Sung Keun ^a   Kwon, Dae Kee ^a   Kim, Sue ^a   Kim, Sun Jong ^b   Park, Sun Woo ^a   Kwon, Hee Sun ^a   Lee, Chang Kyu ^a   Lee, Jung Bok ^b   Kim, Jin Mee ^b   Ahn, Curie ^a   Paek, Sun Ha ^a   Chang, Sang Sik ^c   Koo, Jung Jin ^c   Yoon, Hyun Soo ^d   Hwang, Jung Hye ^d   Hwang, Youn Young ^d   Park, Ye Soo ^d   Oh, Sun Kyung ^a   Kim, Hee Sun ^a   Park, Jong Hyuk ^e   Moon, Shin Yong ^a   Schatten, Gerald ^e   more..

^a Seoul National University   (South Korea)

^b Mizmedi Hospital   (South Korea)

^c Hanna Women's Clinic   (South Korea)

^d Hanyang University   (South Korea)

^e UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMEDICAL ENGINEERING; DISEASES; DNA; IMMUNOLOGY; TRANSPLANTATION (SURGICAL);

HUMAN EMBRYONIC STEM CELLS (HESC); NUCLEAR TRANSFER (NT); SOMATIC CELL NUCLEAR TRANSFER (SCNT); STEM CELL TRANSPLANTATION;

CELL CULTURE;

BIOLOGY;

ARTICLE; BLASTOCYST; CELL NUCLEUS TRANSPLANTATION; CONTROLLED STUDY; GENETIC COMPATIBILITY; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; OOCYTE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; SKIN CELL; STEM CELL; STEM CELL TRANSPLANTATION; ADULT; AGAMMAGLOBULINEMIA; CELL DIFFERENTIATION; CELL LINE; CHILD; CLONING; CYTOLOGY; DNA FINGERPRINTING; FEMALE; FIBROBLAST; GENETIC EPIGENESIS; IMMUNOLOGY; INFORMED CONSENT; INSULIN DEPENDENT DIABETES MELLITUS; KARYOTYPING; MALE; OOCYTE DONATION; PRESCHOOL CHILD; PROFESSIONAL STANDARD; RETRACTED ARTICLE; SPINAL CORD INJURY; TRANSPLANTATION;

ANIMALIA;

HLA ANTIGEN;

ADULT; AGAMMAGLOBULINEMIA; BLASTOCYST; CELL DIFFERENTIATION; CELL LINE; CHILD; CHILD, PRESCHOOL; CLONING, ORGANISM; DIABETES MELLITUS, TYPE 1; DNA FINGERPRINTING; EPIGENESIS, GENETIC; ETHICS COMMITTEES, RESEARCH; FEMALE; FIBROBLASTS; HLA ANTIGENS; HUMANS; INFORMED CONSENT; KARYOTYPING; MALE; NUCLEAR TRANSFER TECHNIQUES; OOCYTE DONATION; PLURIPOTENT STEM CELLS; SPINAL CORD INJURIES; STEM CELL TRANSPLANTATION; TISSUE AND ORGAN PROCUREMENT;

EID: 20544451854     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1112286     Document Type: Article

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32. We thank foremost all donors. We also thank K. H. Man, J. H. Choi, J. T. Kang, S. G. Hong, and O. S. Kwon (Seoul National University); M. H. Kim, H. J. Jeong, E. K. Chun, and Y. J. Kim (MizMedi Hospital); and M. K. Koong and I. S. Kang (Samsung Cheil Hospital and Women's Healthcare Center) for assistance on NT-hESC culture; D. H. Chung (Seoul National University Hospital) for teratoma histopathology; J. Y. Kim and M. H. Park (Seoul National University Hospital) for HLA typing; and S. S. Yoo (Harvard Medical School) and the anonymous reviewers for their constructive critiques. All experiments were performed in Korea by Korean scientists, and all results were obtained in Korea using Korean equipment and Korean sponsorship. G.S and J.-H.P are grateful for the private philanthropy of the Magee-Womens Foundation, which supported their advisory roles in the analysis and for the interpretation and preparation for publication of these results obtained in Korea. No U.S. federal or Commonwealth of Pennsylvania funds were used in any aspect of this report. The authors are grateful for a graduate fellowship provided by the Ministry of Education, through BK21 program. This study was supported by grants from the Biodiscovery program of the Korean Ministry of Science and Technology to W.S.H. Until the formal establishment by the Republic of Korea of its National Center for Stem Cell Research, in which the previous NT-hESC line (-1) (6) and these new ones (-2 to -12) will be deposited and available for distribution, requests for cells and/or other materials should be addressed to W.S.H.