Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling

Journal of Biological Chemistry

Volumn 285, Issue 8, 2010, Pages 5392-5404

  Ogihara, Takeshi ^a   Chuang, Jen Chieh ^b   Vestermark, George L ^a   Garmey, James C ^c   Ketchum, Robert J ^d   Huang, Xiaolun ^c   Brayman, Kenneth L ^d   Thorner, Michael O ^c   Repa, Joyce J ^b   Mirmira, Raghavendra G ^a   Evans Molina, Carmella ^a,c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d ROCKY VISTA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFTER-TREATMENT; ANAPLEROTIC PATHWAY; CHOLESTEROL TRANSPORT; CLINICAL USE; DOWNSTREAM TARGET; GENES ENCODING; GLUCOSE HOMEOSTASIS; HORMONE-SENSITIVE LIPASE; HUMAN ISLETS; INSULIN GENE; INSULIN PROMOTERS; INSULIN SECRETION; KEY REGULATORS; LIPOGENESIS; LIVER X RECEPTORS; NUCLEAR PROTEINS; PYRUVATE CARBOXYLASE; PYRUVATES; RODENT MODELS; SIDE EFFECT;

ACIDS; ENZYME ACTIVITY; ENZYMES; FATTY ACIDS; GLUCOSE; INSULIN; LIVER; PHYSIOLOGY;

GENE EXPRESSION;

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; CHOLESTEROL; FATTY ACID; GLUCOSE; GLYCEROLIPID; HORMONE SENSITIVE LIPASE; INSULIN; LIVER X RECEPTOR; LIVER X RECEPTOR AGONIST; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; PYRUVATE DECARBOXYLASE; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; ACYLGLYCEROL; BENZOIC ACID DERIVATIVE; BENZYLAMINE DERIVATIVE; FLUORINATED HYDROCARBON; HOMEODOMAIN PROTEIN; INSULIN PROMOTER FACTOR 1; ORPHAN NUCLEAR RECEPTOR; PYRUVATE CARBOXYLASE; PYRUVIC ACID; SULFONAMIDE; SWEETENING AGENT; TO-901317; TRANSACTIVATOR PROTEIN;

ADOLESCENT; ADULT; ARTICLE; CELL STIMULATION; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID METABOLISM; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INSULIN RELEASE; LIPID METABOLISM; LIPOGENESIS; LIPOLYSIS; MALE; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; CELL NUCLEUS; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; MIDDLE AGED; PANCREAS ISLET; PHYSIOLOGY; PROMOTER REGION; SECRETION;

RODENTIA;

ADOLESCENT; ADULT; BENZOIC ACIDS; BENZYLAMINES; CELL NUCLEUS; FATTY ACIDS, NONESTERIFIED; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE; GLYCERIDES; HOMEODOMAIN PROTEINS; HUMANS; HYDROCARBONS, FLUORINATED; INSULIN; ISLETS OF LANGERHANS; LIPOGENESIS; MALE; MIDDLE AGED; ORPHAN NUCLEAR RECEPTORS; PROMOTER REGIONS, GENETIC; PYRUVATE CARBOXYLASE; PYRUVIC ACID; SULFONAMIDES; SWEETENING AGENTS; TRANS-ACTIVATORS;

EID: 77949316652     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.064659     Document Type: Article

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