-
1
-
-
33847638137
-
Estimates of the cancer incidence and mortality in Europe in 2006
-
Ferlay J., Autier P., Boniol M., Heanue M., Colombet M., and Boyle P. Estimates of the cancer incidence and mortality in Europe in 2006. Ann. Oncol. 18 (2007) 581-592
-
(2007)
Ann. Oncol.
, vol.18
, pp. 581-592
-
-
Ferlay, J.1
Autier, P.2
Boniol, M.3
Heanue, M.4
Colombet, M.5
Boyle, P.6
-
2
-
-
0037459075
-
Cellular motility driven by assembly and disassembly of actin filaments
-
Pollard T.D., and Borisy G.G. Cellular motility driven by assembly and disassembly of actin filaments. Cell 112 (2003) 453-465
-
(2003)
Cell
, vol.112
, pp. 453-465
-
-
Pollard, T.D.1
Borisy, G.G.2
-
3
-
-
0030049170
-
Actin-based cell motility and cell locomotion
-
Mitchison T.J., and Cramer L.P. Actin-based cell motility and cell locomotion. Cell 84 (1996) 371-379
-
(1996)
Cell
, vol.84
, pp. 371-379
-
-
Mitchison, T.J.1
Cramer, L.P.2
-
4
-
-
33749059234
-
Actin-targeting natural products: structures, properties and mechanisms of action
-
Allingham J.S., Klenchin V.A., and Rayment I. Actin-targeting natural products: structures, properties and mechanisms of action. Cell. Mol. Life Sci. 63 (2006) 2119-2134
-
(2006)
Cell. Mol. Life Sci.
, vol.63
, pp. 2119-2134
-
-
Allingham, J.S.1
Klenchin, V.A.2
Rayment, I.3
-
5
-
-
34848927902
-
-
Chhabra E.S., and Higgs H.N. The many faces of act, matching assembly factors with cellular structures. Nat. Cell. Biol. 9 (2007) 1110-1121
-
(2007)
Nat. Cell. Biol.
, vol.9
, pp. 1110-1121
-
-
Chhabra, E.S.1
Higgs, H.N.2
-
6
-
-
0038049137
-
Tumor-cell invasion and migration: diversity and escape mechanisms
-
Friedl P., and Wolf K. Tumor-cell invasion and migration: diversity and escape mechanisms. Nat. Rev. Cancer 3 (2003) 362-374
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 362-374
-
-
Friedl, P.1
Wolf, K.2
-
9
-
-
0037069690
-
Rho GTPases in cell biology
-
Etienne-Manneville S., and Hall A. Rho GTPases in cell biology. Nature 420 (2002) 629-635
-
(2002)
Nature
, vol.420
, pp. 629-635
-
-
Etienne-Manneville, S.1
Hall, A.2
-
10
-
-
0032559362
-
Rho GTPases and the actin cytoskeleton
-
Hall A. Rho GTPases and the actin cytoskeleton. Science 279 (1998) 509-514
-
(1998)
Science
, vol.279
, pp. 509-514
-
-
Hall, A.1
-
11
-
-
50149083752
-
Mammalian Rho GTPases: new insights into their functions from in vivo studies
-
Heasman S.J., and Ridley A.J. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat. Rev. Mol. Cell. Biol. 9 (2008) 690-701
-
(2008)
Nat. Rev. Mol. Cell. Biol.
, vol.9
, pp. 690-701
-
-
Heasman, S.J.1
Ridley, A.J.2
-
12
-
-
1642273617
-
Rho-regulatory proteins in breast cancer cell motility and invasion
-
Lin M., and van Golen K.L. Rho-regulatory proteins in breast cancer cell motility and invasion. Breast Cancer Res. Tr. 84 (2004) 49-60
-
(2004)
Breast Cancer Res. Tr.
, vol.84
, pp. 49-60
-
-
Lin, M.1
van Golen, K.L.2
-
14
-
-
0037048326
-
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters
-
Fritz G., Brachetti C., Bahlmann F., Schmidt M., and Kaina B. Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Br. J. Cancer 87 (2002) 635-644
-
(2002)
Br. J. Cancer
, vol.87
, pp. 635-644
-
-
Fritz, G.1
Brachetti, C.2
Bahlmann, F.3
Schmidt, M.4
Kaina, B.5
-
15
-
-
0032939619
-
Rho GTPases are over-expressed in human tumors
-
Fritz G., Just I., and Kaina B. Rho GTPases are over-expressed in human tumors. Int. J. Cancer 81 (1999) 682-687
-
(1999)
Int. J. Cancer
, vol.81
, pp. 682-687
-
-
Fritz, G.1
Just, I.2
Kaina, B.3
-
16
-
-
52049085776
-
RhoA protein expression in primary breast cancers and matched lymphocytes is associated with progression of the disease
-
Bellizzi A., Mangia A., Chiriatti A., Petroni S., Quaranta M., Schittulli F., Malfettone A., Cardone R.A., Paradiso A., and Reshkin S.J. RhoA protein expression in primary breast cancers and matched lymphocytes is associated with progression of the disease. Int. J. Mol. Med. 22 (2008) 25-31
-
(2008)
Int. J. Mol. Med.
, vol.22
, pp. 25-31
-
-
Bellizzi, A.1
Mangia, A.2
Chiriatti, A.3
Petroni, S.4
Quaranta, M.5
Schittulli, F.6
Malfettone, A.7
Cardone, R.A.8
Paradiso, A.9
Reshkin, S.J.10
-
17
-
-
0035715879
-
Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways
-
Bouzahzah B., Albanese C., Ahmed F., Pixley F., Lisanti M.P., Segall J.D., Condeelis J., Joyce D., Minden A., Der C.J., Chan A., Symons M., and Pestell R.G. Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways. Mol. Med. 7 (2001) 816-830
-
(2001)
Mol. Med.
, vol.7
, pp. 816-830
-
-
Bouzahzah, B.1
Albanese, C.2
Ahmed, F.3
Pixley, F.4
Lisanti, M.P.5
Segall, J.D.6
Condeelis, J.7
Joyce, D.8
Minden, A.9
Der, C.J.10
Chan, A.11
Symons, M.12
Pestell, R.G.13
-
18
-
-
0038024241
-
Rocks: multifunctional kinases in cell behaviour
-
Riento K., and Ridley A.J. Rocks: multifunctional kinases in cell behaviour. Nat. Rev. Mol. Cell Biol. 4 (2003) 446-456
-
(2003)
Nat. Rev. Mol. Cell Biol.
, vol.4
, pp. 446-456
-
-
Riento, K.1
Ridley, A.J.2
-
19
-
-
56149118852
-
Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells
-
Zaoui K., Honoré S., Isnardon D., Braguer D., and Badache A. Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells. J. Cell. Biol. 183 (2008) 401-408
-
(2008)
J. Cell. Biol.
, vol.183
, pp. 401-408
-
-
Zaoui, K.1
Honoré, S.2
Isnardon, D.3
Braguer, D.4
Badache, A.5
-
20
-
-
0036168355
-
Characterization of RhoC expression in benign and malignant breast disease
-
Kleer C.G., van Golen K.L., Zhang Y., Wu Z.F., Rubin M.A., and Merajver S.D. Characterization of RhoC expression in benign and malignant breast disease. Am. J. Pathol. 160 (2002) 579-584
-
(2002)
Am. J. Pathol.
, vol.160
, pp. 579-584
-
-
Kleer, C.G.1
van Golen, K.L.2
Zhang, Y.3
Wu, Z.F.4
Rubin, M.A.5
Merajver, S.D.6
-
21
-
-
24344486013
-
RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis
-
Hakem A., Sanchez-Sweatman O., You-Ten A., Duncan G., Wakeham A., Khokha R., and Mak T.W. RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev. 19 (2005) 1974-1979
-
(2005)
Genes Dev.
, vol.19
, pp. 1974-1979
-
-
Hakem, A.1
Sanchez-Sweatman, O.2
You-Ten, A.3
Duncan, G.4
Wakeham, A.5
Khokha, R.6
Mak, T.W.7
-
22
-
-
35148886434
-
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
-
Ma L., Teruya-Feldstein J., and Weinberg R.A. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449 (2007) 682-689
-
(2007)
Nature
, vol.449
, pp. 682-689
-
-
Ma, L.1
Teruya-Feldstein, J.2
Weinberg, R.A.3
-
23
-
-
0036305635
-
ROCK and Dia have opposing effects on adherens junctions downstream of Rho
-
Sahai E., and Marshall C.J. ROCK and Dia have opposing effects on adherens junctions downstream of Rho. Nat. Cell Biol. 4 (2002) 408-415
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 408-415
-
-
Sahai, E.1
Marshall, C.J.2
-
24
-
-
0035930585
-
Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells
-
O'Connor K.L., and Mercurio A.M. Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells. J. Biol. Chem. 276 (2001) 47895-47900
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47895-47900
-
-
O'Connor, K.L.1
Mercurio, A.M.2
-
25
-
-
34447623358
-
Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells
-
Baugher P.J., Krishnamoorthy L., Price J.E., and Dharmawardhane S.F. Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells. Breast Cancer. Res. 7 (2005) R965-R974
-
(2005)
Breast Cancer. Res.
, vol.7
-
-
Baugher, P.J.1
Krishnamoorthy, L.2
Price, J.E.3
Dharmawardhane, S.F.4
-
26
-
-
54949151864
-
Positive regulation of migration and invasion by vasodilator-stimulated phosphoprotein via Rac1 pathway in human breast cancer cells
-
Han G., Fan B., Zhang Y., Zhou X., Wang Y., Dong H., Wei Y., Sun S., Hu M., Zhang J., and Wei L. Positive regulation of migration and invasion by vasodilator-stimulated phosphoprotein via Rac1 pathway in human breast cancer cells. Oncol. Rep. 20 (2008) 929-939
-
(2008)
Oncol. Rep.
, vol.20
, pp. 929-939
-
-
Han, G.1
Fan, B.2
Zhang, Y.3
Zhou, X.4
Wang, Y.5
Dong, H.6
Wei, Y.7
Sun, S.8
Hu, M.9
Zhang, J.10
Wei, L.11
-
27
-
-
28344456263
-
Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion
-
Chan A.Y., Coniglio S.J., Chuang Y.Y., Michaelson D., Knaus U.G., Philips M.R., and Symons M. Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion. Oncogene 24 (2005) 7821-7829
-
(2005)
Oncogene
, vol.24
, pp. 7821-7829
-
-
Chan, A.Y.1
Coniglio, S.J.2
Chuang, Y.Y.3
Michaelson, D.4
Knaus, U.G.5
Philips, M.R.6
Symons, M.7
-
28
-
-
34249339776
-
Breast tumor kinase (Protein Tyrosine Kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells
-
Ostrander J.H., Daniel A.R., Lofgren K., Kleer C.G., and Lange C.A. Breast tumor kinase (Protein Tyrosine Kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells. Cancer Res. 67 (2007) 4199-4209
-
(2007)
Cancer Res.
, vol.67
, pp. 4199-4209
-
-
Ostrander, J.H.1
Daniel, A.R.2
Lofgren, K.3
Kleer, C.G.4
Lange, C.A.5
-
29
-
-
0034631957
-
Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration
-
Bourguignon L.Y., Zhu H., Shao L., and Chen Y.W. Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration. J. Cell. Biol. 150 (2000) 177-191
-
(2000)
J. Cell. Biol.
, vol.150
, pp. 177-191
-
-
Bourguignon, L.Y.1
Zhu, H.2
Shao, L.3
Chen, Y.W.4
-
30
-
-
33750523839
-
Enhanced intrinsic migration of aggressive breast cancer cells by inhibition of Rac1 GTPase
-
Zuo Y., Shields S.K., and Chakraborty C. Enhanced intrinsic migration of aggressive breast cancer cells by inhibition of Rac1 GTPase. Biochem. Biophys. Res. Commun. 351 (2006) 361-367
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.351
, pp. 361-367
-
-
Zuo, Y.1
Shields, S.K.2
Chakraborty, C.3
-
31
-
-
0037203546
-
Akt: versatile mediator of cell survival and beyond
-
Kim D., and Chung J. Akt: versatile mediator of cell survival and beyond. J. Biochem. Mol. Biol. 35 (2002) 106-115
-
(2002)
J. Biochem. Mol. Biol.
, vol.35
, pp. 106-115
-
-
Kim, D.1
Chung, J.2
-
32
-
-
34250788809
-
AKT/PKB signaling: navigating downstream
-
Manning B.D., and Cantley L.C. AKT/PKB signaling: navigating downstream. Cell 129 (2007) 1261-1274
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
33
-
-
0033560747
-
Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
-
Meili R., Ellsworth C., Lee S., Reddy T.B., Ma H., and Firtel R.A. Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium. EMBO J. 18 (1999) 2092-2105
-
(1999)
EMBO J.
, vol.18
, pp. 2092-2105
-
-
Meili, R.1
Ellsworth, C.2
Lee, S.3
Reddy, T.B.4
Ma, H.5
Firtel, R.A.6
-
34
-
-
42149177825
-
The regulation of cell motility and chemotaxis by phospholipid signalling
-
Kolsch V., Charest P.G., and Firtel R.A. The regulation of cell motility and chemotaxis by phospholipid signalling. J. Cell Sci. 121 (2007) 551-559
-
(2007)
J. Cell Sci.
, vol.121
, pp. 551-559
-
-
Kolsch, V.1
Charest, P.G.2
Firtel, R.A.3
-
35
-
-
24144496081
-
Akt/PKB regulates actin organization and cell motility via Girdin/APE
-
Enomoto A., Murakami H., Asai N., Morone N., Watanabe T., Kawai K., Murakumo Y., Usukura J., Kaibuchi K., and Takahashi M. Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev. Cell 9 (2005) 389-402
-
(2005)
Dev. Cell
, vol.9
, pp. 389-402
-
-
Enomoto, A.1
Murakami, H.2
Asai, N.3
Morone, N.4
Watanabe, T.5
Kawai, K.6
Murakumo, Y.7
Usukura, J.8
Kaibuchi, K.9
Takahashi, M.10
-
36
-
-
40249116837
-
Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin
-
Kitamura T., Asai N., Enomoto A., Maeda K., Kato T., Ishida M., Jiang P., Watanabe T., Usukura J., Kondo T., Costantini F., Murohara T., and Takahashi M. Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin. Nat. Cell Biol. 10 (2008) 329-337
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 329-337
-
-
Kitamura, T.1
Asai, N.2
Enomoto, A.3
Maeda, K.4
Kato, T.5
Ishida, M.6
Jiang, P.7
Watanabe, T.8
Usukura, J.9
Kondo, T.10
Costantini, F.11
Murohara, T.12
Takahashi, M.13
-
37
-
-
40449105942
-
An actin-binding protein Girdin regulates the motility of breast cancer cells
-
Ping J., Enomoto A., Jijiwa M., Kato T., Hasegawa T., Ishida M., Sato T., Asai N., Murakumo Y., and Takahashi M. An actin-binding protein Girdin regulates the motility of breast cancer cells. Cancer Res. 68 (2008) 1310-1318
-
(2008)
Cancer Res.
, vol.68
, pp. 1310-1318
-
-
Ping, J.1
Enomoto, A.2
Jijiwa, M.3
Kato, T.4
Hasegawa, T.5
Ishida, M.6
Sato, T.7
Asai, N.8
Murakumo, Y.9
Takahashi, M.10
-
38
-
-
24044521010
-
A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis
-
Anai M., Shojima N., Katagiri H., Ogihara T., Sakoda H., Onishi Y., Ono H., Fujishiro M., Fukushima Y., Horike N., Viana A., Kikuchi M., Noguchi N., Takahashi S., Takata K., Oka Y., Uchijima Y., Kurihara H., and Asano T. A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis. J. Biol. Chem. 280 (2005) 18525-18535
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 18525-18535
-
-
Anai, M.1
Shojima, N.2
Katagiri, H.3
Ogihara, T.4
Sakoda, H.5
Onishi, Y.6
Ono, H.7
Fujishiro, M.8
Fukushima, Y.9
Horike, N.10
Viana, A.11
Kikuchi, M.12
Noguchi, N.13
Takahashi, S.14
Takata, K.15
Oka, Y.16
Uchijima, Y.17
Kurihara, H.18
Asano, T.19
-
40
-
-
0035034224
-
Transition from in situ to invasive testicular germ cell neoplasia is associated with the loss of p21 and gain of mdm-2 expression
-
Datta M.W., Macri E., Signoretti S., Renshaw A.A., and Loda M. Transition from in situ to invasive testicular germ cell neoplasia is associated with the loss of p21 and gain of mdm-2 expression. Mod. Pathol. 14 (2001) 437-442
-
(2001)
Mod. Pathol.
, vol.14
, pp. 437-442
-
-
Datta, M.W.1
Macri, E.2
Signoretti, S.3
Renshaw, A.A.4
Loda, M.5
-
41
-
-
33749188859
-
MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation
-
Yang J.Y., Zong C.S., Xia W., Wei Y., Ali-Seyed M., Li Z., Broglio K., Berry D.A., and Hung M.C. MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation. Mol. Cell. Biol. 26 (2006) 7269-7282
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 7269-7282
-
-
Yang, J.Y.1
Zong, C.S.2
Xia, W.3
Wei, Y.4
Ali-Seyed, M.5
Li, Z.6
Broglio, K.7
Berry, D.A.8
Hung, M.C.9
-
42
-
-
34248340402
-
eEF1A2 activates Akt and stimulates Akt-dependent actin remodeling, invasion and migration
-
Amiri A., Noei F., Jeganathan S., Kulkarni G., Pinke D.E., and Lee J.M. eEF1A2 activates Akt and stimulates Akt-dependent actin remodeling, invasion and migration. Oncogene 26 (2007) 3027-3040
-
(2007)
Oncogene
, vol.26
, pp. 3027-3040
-
-
Amiri, A.1
Noei, F.2
Jeganathan, S.3
Kulkarni, G.4
Pinke, D.E.5
Lee, J.M.6
-
43
-
-
34249301918
-
Akt1 governs breast cancer progression in vivo
-
Ju X., Katiyar S., Wang C., Liu M., Jiao X., Li S., Zhou J., Turner J., Lisanti M.P., Russell R.G., Mueller S.C., Ojeifo J., Chen W.S., Hay N., and Pestell R.G. Akt1 governs breast cancer progression in vivo. Proc. Natl. Acad. Sci. USA 104 (2007) 7438-7443
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 7438-7443
-
-
Ju, X.1
Katiyar, S.2
Wang, C.3
Liu, M.4
Jiao, X.5
Li, S.6
Zhou, J.7
Turner, J.8
Lisanti, M.P.9
Russell, R.G.10
Mueller, S.C.11
Ojeifo, J.12
Chen, W.S.13
Hay, N.14
Pestell, R.G.15
-
44
-
-
29144488505
-
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition
-
Irie H.Y., Pearline R.V., Grueneberg D., Hsia M., Ravichandran P., Kothari N., Natesan S., and Brugge J.S. Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J. Cell. Biol. 171 (2005) 1023-1034
-
(2005)
J. Cell. Biol.
, vol.171
, pp. 1023-1034
-
-
Irie, H.Y.1
Pearline, R.V.2
Grueneberg, D.3
Hsia, M.4
Ravichandran, P.5
Kothari, N.6
Natesan, S.7
Brugge, J.S.8
-
45
-
-
27944446105
-
Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT
-
Yoeli-Lerner M., Yiu G.K., Rabinovitz I., Erhardt P., Jauliac S., and Toker A. Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol. Cell 20 (2005) 539-550
-
(2005)
Mol. Cell
, vol.20
, pp. 539-550
-
-
Yoeli-Lerner, M.1
Yiu, G.K.2
Rabinovitz, I.3
Erhardt, P.4
Jauliac, S.5
Toker, A.6
-
46
-
-
33645213629
-
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2
-
Liu H., Radisky D.C., Nelson C.M., Zhang H., Fata J.E., Roth R.A., and Bissell M.J. Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc. Natl. Acad. Sci. USA 103 (2006) 4134-4139
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 4134-4139
-
-
Liu, H.1
Radisky, D.C.2
Nelson, C.M.3
Zhang, H.4
Fata, J.E.5
Roth, R.A.6
Bissell, M.J.7
-
47
-
-
0036595629
-
Epithelial-mesenchymal transitions in tumour progression
-
Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer 2 (2002) 442-454
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 442-454
-
-
Thiery, J.P.1
-
48
-
-
24644480749
-
Molecular requirements for epithelial-mesenchymal transition during tumor progression
-
Huber M.A., Kraut N., and Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell. Biol. 17 (2005) 548-558
-
(2005)
Curr. Opin. Cell. Biol.
, vol.17
, pp. 548-558
-
-
Huber, M.A.1
Kraut, N.2
Beug, H.3
-
49
-
-
18544365655
-
Motility enhancement by tumor-derived mutant E-cadherin is sensitive to treatment with epidermal growth factor receptor and phosphatidylinositol 3-kinase inhibitors
-
Fuchs M., Hutzler P., Brunner I., Schlegel J., Mages J., Reuning U., Hapke S., Duyster J., Hirohashi S., Genda T., Sakamoto M., Uberall F., Höfler H., Becker K.F., and Luber B. Motility enhancement by tumor-derived mutant E-cadherin is sensitive to treatment with epidermal growth factor receptor and phosphatidylinositol 3-kinase inhibitors. Exp. Cell. Res. 276 (2002) 129-141
-
(2002)
Exp. Cell. Res.
, vol.276
, pp. 129-141
-
-
Fuchs, M.1
Hutzler, P.2
Brunner, I.3
Schlegel, J.4
Mages, J.5
Reuning, U.6
Hapke, S.7
Duyster, J.8
Hirohashi, S.9
Genda, T.10
Sakamoto, M.11
Uberall, F.12
Höfler, H.13
Becker, K.F.14
Luber, B.15
-
50
-
-
0032502669
-
The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton
-
Hazan R.B., and Norton L. The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton. J. Biol. Chem. 273 (1998) 9078-9084
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 9078-9084
-
-
Hazan, R.B.1
Norton, L.2
-
51
-
-
16844377441
-
Pak1 phosphorylation of Snail, a master regulator of epithelial-to-mesenchyme transition, modulates Snail's subcellular localization and functions
-
Yang Z., Rayala S., Nguyen D., Vadlamudi R.K., Chen S., and Kumar R. Pak1 phosphorylation of Snail, a master regulator of epithelial-to-mesenchyme transition, modulates Snail's subcellular localization and functions. Cancer Res. 65 (2005) 3179-3184
-
(2005)
Cancer Res.
, vol.65
, pp. 3179-3184
-
-
Yang, Z.1
Rayala, S.2
Nguyen, D.3
Vadlamudi, R.K.4
Chen, S.5
Kumar, R.6
-
52
-
-
40349091380
-
Loss of single minded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of Slug and matrix metalloprotease
-
Laffin B., Wellberg E., Kwak H.I., Burghardt R.C., Metz R.P., Gustafson T., Schedin P., and Porter W.W. Loss of single minded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of Slug and matrix metalloprotease. Mol. Cell. Biol. 28 (2008) 1936-1946
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 1936-1946
-
-
Laffin, B.1
Wellberg, E.2
Kwak, H.I.3
Burghardt, R.C.4
Metz, R.P.5
Gustafson, T.6
Schedin, P.7
Porter, W.W.8
-
53
-
-
35148832569
-
Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression
-
Lo H.W., Hsu S.C., Xia W., Cao X., Shih J.Y., Wei Y., Abbruzzese J.L., Hortobagyi G.N., and Hung M.C. Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Res. 67 (2007) 9066-9076
-
(2007)
Cancer Res.
, vol.67
, pp. 9066-9076
-
-
Lo, H.W.1
Hsu, S.C.2
Xia, W.3
Cao, X.4
Shih, J.Y.5
Wei, Y.6
Abbruzzese, J.L.7
Hortobagyi, G.N.8
Hung, M.C.9
-
55
-
-
4344612243
-
NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
-
Huber M.A., Azoitei N., Baumann B., Grünert S., Sommer A., Pehamberger H., Kraut N., Beug H., and Wirth T. NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J. Clin. Invest. 114 (2004) 569-581
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 569-581
-
-
Huber, M.A.1
Azoitei, N.2
Baumann, B.3
Grünert, S.4
Sommer, A.5
Pehamberger, H.6
Kraut, N.7
Beug, H.8
Wirth, T.9
-
56
-
-
5444269904
-
Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition
-
Zhou B.P., Deng J., Xia W., Xu J., Li Y.M., Gunduz M., and Hung M.C. Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol. 6 (2004) 931-940
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 931-940
-
-
Zhou, B.P.1
Deng, J.2
Xia, W.3
Xu, J.4
Li, Y.M.5
Gunduz, M.6
Hung, M.C.7
-
57
-
-
12144266241
-
Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition
-
Bachelder R.E., Yoon S.-O., Franci C., de Herreros A.G., and Mercurio A.M. Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. J. Cell Biol. 168 (2005) 29-33
-
(2005)
J. Cell Biol.
, vol.168
, pp. 29-33
-
-
Bachelder, R.E.1
Yoon, S.-O.2
Franci, C.3
de Herreros, A.G.4
Mercurio, A.M.5
-
59
-
-
33644769212
-
Endocytosis conducts the cell signalling orchestra
-
Polo S., and Di Fiore P.P. Endocytosis conducts the cell signalling orchestra. Cell 124 (2006) 897-900
-
(2006)
Cell
, vol.124
, pp. 897-900
-
-
Polo, S.1
Di Fiore, P.P.2
-
60
-
-
0036341207
-
Signal transduction and endocytosis: close encounters of many kinds
-
Sorkin A., and von Zastrow M. Signal transduction and endocytosis: close encounters of many kinds. Nat. Rev. Mol. Cell. Biol. 2 (2002) 600-614
-
(2002)
Nat. Rev. Mol. Cell. Biol.
, vol.2
, pp. 600-614
-
-
Sorkin, A.1
von Zastrow, M.2
-
61
-
-
44649198353
-
Endocytic transport of integrins during cell migration and invasion
-
Caswell P., and Norman J. Endocytic transport of integrins during cell migration and invasion. Trends Cell. Biol. 18 (2008) 257-263
-
(2008)
Trends Cell. Biol.
, vol.18
, pp. 257-263
-
-
Caswell, P.1
Norman, J.2
-
62
-
-
0036121308
-
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
-
Fujita Y., Krause G., Scheffner M., Zechner D., Leddy H.E., Behrens J., Sommer T., and Birchmeier W. Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat. Cell Biol. 4 (2002) 222-231
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 222-231
-
-
Fujita, Y.1
Krause, G.2
Scheffner, M.3
Zechner, D.4
Leddy, H.E.5
Behrens, J.6
Sommer, T.7
Birchmeier, W.8
-
63
-
-
0034745356
-
Rac recruits high-affinity integrin αvβ3 to lamellipodia in endothelial cell migration
-
Kiosses W.B., Shattil S.J., Pampori N., and Schwartz M.A. Rac recruits high-affinity integrin αvβ3 to lamellipodia in endothelial cell migration. Nat. Cell Biol. 3 (2001) 316-320
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 316-320
-
-
Kiosses, W.B.1
Shattil, S.J.2
Pampori, N.3
Schwartz, M.A.4
-
64
-
-
0037145037
-
Integrins: bidirectional, allosteric signaling machines
-
Hynes R.O. Integrins: bidirectional, allosteric signaling machines. Cell 110 (2002) 673-687
-
(2002)
Cell
, vol.110
, pp. 673-687
-
-
Hynes, R.O.1
-
65
-
-
5044238876
-
Integrin signalling during tumour progression
-
Guo W., and Giancotti F.G. Integrin signalling during tumour progression. Nat. Rev. Mol. Cell. Biol. 5 (2004) 816-826
-
(2004)
Nat. Rev. Mol. Cell. Biol.
, vol.5
, pp. 816-826
-
-
Guo, W.1
Giancotti, F.G.2
-
66
-
-
40849085396
-
Substrate-bound insulin-like growth factor (IGF)-I-IGF binding protein-vitronectin-stimulated breast cell migration is enhanced by coactivation of the phosphatidylinositide 3-Kinase/AKT pathway by αv-integrins and the IGF-I receptor
-
Hollier B.G., Kricker J.A., Van Lonkhuyzen D.R., Leavesley D.I., and Upton Z. Substrate-bound insulin-like growth factor (IGF)-I-IGF binding protein-vitronectin-stimulated breast cell migration is enhanced by coactivation of the phosphatidylinositide 3-Kinase/AKT pathway by αv-integrins and the IGF-I receptor. Endocrinology 149 (2008) 1075-1090
-
(2008)
Endocrinology
, vol.149
, pp. 1075-1090
-
-
Hollier, B.G.1
Kricker, J.A.2
Van Lonkhuyzen, D.R.3
Leavesley, D.I.4
Upton, Z.5
-
67
-
-
0037229714
-
Overexpression of AKT2/protein kinase B beta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells
-
Arboleda M.J., Lyons J.F., Kabbinavar F.F., Bray M.R., Snow B.E., Ayala R., Danino M., Karlan B.Y., and Slamon D.J. Overexpression of AKT2/protein kinase B beta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells. Cancer Res. 63 (2003) 196-206
-
(2003)
Cancer Res.
, vol.63
, pp. 196-206
-
-
Arboleda, M.J.1
Lyons, J.F.2
Kabbinavar, F.F.3
Bray, M.R.4
Snow, B.E.5
Ayala, R.6
Danino, M.7
Karlan, B.Y.8
Slamon, D.J.9
-
68
-
-
27644528406
-
Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration
-
Li J., Ballif B.A., Powelka A.M., Dai J., Gygi S.P., and Hsu V.W. Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration. Dev. Cell 9 (2005) 663-673
-
(2005)
Dev. Cell
, vol.9
, pp. 663-673
-
-
Li, J.1
Ballif, B.A.2
Powelka, A.M.3
Dai, J.4
Gygi, S.P.5
Hsu, V.W.6
-
69
-
-
33645515261
-
Integrin trafficking and the control of cell migration
-
Caswell P.T., and Norman J.C. Integrin trafficking and the control of cell migration. Traffic 7 (2006) 14-21
-
(2006)
Traffic
, vol.7
, pp. 14-21
-
-
Caswell, P.T.1
Norman, J.C.2
-
70
-
-
19644382160
-
A novel hook-related protein family and the characterization of hook-related protein 1
-
Simpson F., Martin S., Evans T.M., Kerr M., James D.E., Parton R.G., Teasdale R.D., and Wicking C. A novel hook-related protein family and the characterization of hook-related protein 1. Traffic 6 (2005) 442-458
-
(2005)
Traffic
, vol.6
, pp. 442-458
-
-
Simpson, F.1
Martin, S.2
Evans, T.M.3
Kerr, M.4
James, D.E.5
Parton, R.G.6
Teasdale, R.D.7
Wicking, C.8
-
71
-
-
20444472383
-
Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-golgi transport vesicles
-
Le-Niculescu H., Niesman I., Fischer T., DeVries L., and Farquhar M.G. Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-golgi transport vesicles. J. Biol. Chem. 280 (2005) 22012-22020
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 22012-22020
-
-
Le-Niculescu, H.1
Niesman, I.2
Fischer, T.3
DeVries, L.4
Farquhar, M.G.5
-
72
-
-
19944366937
-
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion
-
Williams T.M., Medina F., Badano I., Hazan R.B., Hutchinson J., Muller W.J., Chopra N.G., Scherer P.E., Pestell R.G., and Lisantia M.P. Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. J. Biol. Chem. 279 (2004) 51630-51646
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 51630-51646
-
-
Williams, T.M.1
Medina, F.2
Badano, I.3
Hazan, R.B.4
Hutchinson, J.5
Muller, W.J.6
Chopra, N.G.7
Scherer, P.E.8
Pestell, R.G.9
Lisantia, M.P.10
-
73
-
-
30344437854
-
Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness
-
Sotgia F., Williams T.M., Schubert W., Medina F., Minetti C., Pestell R.G., and Lisanti M.P. Caveolin-1 deficiency (-/-) conveys premalignant alterations in mammary epithelia, with abnormal lumen formation, growth factor independence, and cell invasiveness. Am. J. Pathol. 168 (2006) 292-309
-
(2006)
Am. J. Pathol.
, vol.168
, pp. 292-309
-
-
Sotgia, F.1
Williams, T.M.2
Schubert, W.3
Medina, F.4
Minetti, C.5
Pestell, R.G.6
Lisanti, M.P.7
-
74
-
-
0037018405
-
Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells
-
Fiucci G., Ravid D., Reich R., and Liscovitch M. Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells. Oncogene 21 (2002) 2365-2375
-
(2002)
Oncogene
, vol.21
, pp. 2365-2375
-
-
Fiucci, G.1
Ravid, D.2
Reich, R.3
Liscovitch, M.4
-
75
-
-
36448959111
-
Caveolin-1 expression in benign and malignant lesions of the breast
-
Liedtke C., Kersting C., Bürger H., Kiesel L., and Wülfing P. Caveolin-1 expression in benign and malignant lesions of the breast. World J. Surg. Oncol. 5 (2007) 110
-
(2007)
World J. Surg. Oncol.
, vol.5
, pp. 110
-
-
Liedtke, C.1
Kersting, C.2
Bürger, H.3
Kiesel, L.4
Wülfing, P.5
|