Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)

Biochemical Journal

Volumn 406, Issue 3, 2007, Pages 407-414

  Robinson, Mary M ^a   McBryant, Steven J ^a   Tsukamoto, Takashi ^b   Rojas, Camilo ^b   Ferraris, Dana V ^b   Hamilton, Sean K ^b   Hansen, Jeffrey C ^a   Curthoys, Norman P ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b MGI Pharma   (United States)

Author keywords

Bis 2 (5 phenylacetamido 1,2,4 thiadiazol 2 yl)ethyl sulfide (BPTES); Glutamate excitotoxicity; Glutaminase inhibitor

Indexed keywords

BIS-2-(5-PHENYLACETAMIDO-1,2,4-THIADIAZOL-2-YL)ETHYL SULFIDE (BPTES); GLUTAMATE EXCITOTOXICITY; GLUTAMINASE INHIBITORS; PHOSPHATE DEPENDENT OLIGOMERIZATION;

BIOLOGICAL ORGANS; LIVING SYSTEMS STUDIES; NEURONS; OLIGOMERS; TOXICITY;

ENZYMES;

ACETANILIDE; BIS 2 (5 PHENYLACETAMIDO 1,2,4 THIADIAZOL 2 YL)ETHYL SULFIDE; GAMMA GLUTAMYLTRANSFERASE; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; GLUTAMINASE; GLUTAMINE; ISOENZYME; OLIGOMER; PHOSPHATE; SULFIDE; TETRAMER; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; COMPLEX FORMATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG STRUCTURE; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ENZYME KINETICS; EXCITOTOXICITY; GEL FILTRATION CHROMATOGRAPHY; NERVE CELL; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; RAT; SEDIMENTATION; VELOCITY;

ANIMALS; CHROMATOGRAPHY, GEL; ENZYME INHIBITORS; FRACTIONATION, FIELD FLOW; GLUTAMINASE; KIDNEY; KINETICS; RATS; RATS, SPRAGUE-DAWLEY; SULFIDES; THIADIAZOLES; ULTRACENTRIFUGATION;

RATTUS;

EID: 34548789512     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20070039     Document Type: Article

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