The coffee constituent chlorogenic acid induces cellular DNA damage and formation of topoisomerase I- and II-DNA complexes in cells

Journal of Agricultural and Food Chemistry

Volumn 60, Issue 30, 2012, Pages 7384-7391

  Burgos Morón, Estefanía ^a   Calderón Montaño, José Manuel ^a   Orta, Manuel Luis ^a   Pastor, Nuria ^a   Pérez Guerrero, Concepción ^a   Austin, Caroline ^b   Mateos, Santiago ^a   López Lázaro, Miguel ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

apoptosis; DNA damage; DNA topoisomerases; hydrogen peroxide; leukemia; lung cancer

Indexed keywords

ANTICANCER PROPERTIES; ANTIOXIDANT PROPERTIES; CANCER CELLS; CARCINOGENIC EFFECTS; CELLULAR DNA DAMAGE; CHLOROGENIC ACIDS; COMET ASSAYS; CYTOTOXIC ACTIVITIES; DNA DAMAGES; LEUKEMIA; LUNG CANCER; LUNG CANCER CELLS; PHARMACOKINETIC PROFILES; POLYPHENOLS; PRE-TREATMENT; THERAPEUTIC POTENTIALS; TOPOISOMERASE I; TOPOISOMERASES;

BIOLOGICAL ORGANS; CELL CULTURE; CELL DEATH; DAMAGE DETECTION; DISEASES; HYDROGEN PEROXIDE;

DNA;

ANTINEOPLASTIC AGENT; ANTIOXIDANT; CHLOROGENIC ACID; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); HYDROGEN PEROXIDE; TOP1 PROTEIN, HUMAN;

ARTICLE; CELL PROLIFERATION; CHEMISTRY; COFFEE; COMET ASSAY; DNA DAMAGE; DRUG EFFECT; FIBROBLAST; HUMAN; K562 CELL LINE; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHLOROGENIC ACID; COFFEE; COMET ASSAY; DNA DAMAGE; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; FIBROBLASTS; HUMANS; HYDROGEN PEROXIDE; K562 CELLS;

EID: 84864745110     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf300999e     Document Type: Article

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