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Volumn 28, Issue 8, 2007, Pages 1703-1709

Dietary flavonoids induce MLL translocations in primary human CD34+ cells

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; ETOPOSIDE; FLAVONOID; GENISTEIN; HYDROQUINONE; KAEMPFEROL; MIXED LINEAGE LEUKEMIA PROTEIN; QUERCETIN;

EID: 34548099120     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgm102     Document Type: Article
Times cited : (79)

References (56)
  • 1
    • 0032515971 scopus 로고    scopus 로고
    • Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia
    • Ford,A.M. et al. (1998) Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia. Proc. Natl Acad. Sci. USA, 95 4584-4588.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 4584-4588
    • Ford, A.M.1
  • 2
    • 0027276927 scopus 로고
    • In utero rearrangements in the trithorax-related oncogene in infant leukaemias
    • Ford,A.M. et al. (1993) In utero rearrangements in the trithorax-related oncogene in infant leukaemias. Nature, 363 358-360.
    • (1993) Nature , vol.363 , pp. 358-360
    • Ford, A.M.1
  • 3
    • 0030954681 scopus 로고    scopus 로고
    • Defects in yolk sac hematopoiesis in Mll-null embryos
    • Hess,J.L. et al. (1997) Defects in yolk sac hematopoiesis in Mll-null embryos. Blood, 90, 1799-1806.
    • (1997) Blood , vol.90 , pp. 1799-1806
    • Hess, J.L.1
  • 4
    • 0032411481 scopus 로고    scopus 로고
    • The critical role of chromosome translocations in human leukemias
    • Rowley,J.D. (1998) The critical role of chromosome translocations in human leukemias. Annu. Rev. Genet., 32, 495-519.
    • (1998) Annu. Rev. Genet , vol.32 , pp. 495-519
    • Rowley, J.D.1
  • 5
    • 0028650364 scopus 로고
    • Epidemiology of childhood leukemia, with a focus on infants
    • Ross,J.A. et al. (1994) Epidemiology of childhood leukemia, with a focus on infants. Epidemiol. Rev., 16, 243-272.
    • (1994) Epidemiol. Rev , vol.16 , pp. 243-272
    • Ross, J.A.1
  • 6
    • 0028847335 scopus 로고
    • Molecular genetics of 11q23 chromosome translocations
    • Canaani,E. et al. (1995) Molecular genetics of 11q23 chromosome translocations. Adv. Cancer Res., 66, 213-234.
    • (1995) Adv. Cancer Res , vol.66 , pp. 213-234
    • Canaani, E.1
  • 7
    • 0026079804 scopus 로고
    • Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia
    • Pui,C.H. et al. (1991) Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia. N. Engl. J. Med., 325, 1682-1687.
    • (1991) N. Engl. J. Med , vol.325 , pp. 1682-1687
    • Pui, C.H.1
  • 8
    • 0027449111 scopus 로고
    • Epipodophyllotoxins and secondary leukaemia
    • Kumar,L. (1993) Epipodophyllotoxins and secondary leukaemia. Lancet 342, 819-820.
    • (1993) Lancet , vol.342 , pp. 819-820
    • Kumar, L.1
  • 9
    • 0028775357 scopus 로고
    • Infant leukemia, topoisomerase II inhibitors, and the MLL gene
    • Ross,J.A. et al. (1994) Infant leukemia, topoisomerase II inhibitors, and the MLL gene. J. Natl Cancer Inst., 86, 1678-1680.
    • (1994) J. Natl Cancer Inst , vol.86 , pp. 1678-1680
    • Ross, J.A.1
  • 10
    • 0032246492 scopus 로고    scopus 로고
    • Maternal diet and infant leukemia: A role for DNA topoisomerase II inhibitors?
    • Ross,J.A. (1998) Maternal diet and infant leukemia: A role for DNA topoisomerase II inhibitors? Int. J. Cancer, 11, 26-28.
    • (1998) Int. J. Cancer , vol.11 , pp. 26-28
    • Ross, J.A.1
  • 11
    • 0033628701 scopus 로고    scopus 로고
    • Topoisomerase II as a target for anticancer drugs: When enzymes stop being nice
    • Fortune,J.M. et al. (2000) Topoisomerase II as a target for anticancer drugs: When enzymes stop being nice. Prog. Nucleic Acid Res. Mol. Biol., 64, 221-253.
    • (2000) Prog. Nucleic Acid Res. Mol. Biol , vol.64 , pp. 221-253
    • Fortune, J.M.1
  • 12
    • 0030045003 scopus 로고    scopus 로고
    • Structure and mechanism of DNA topoisomerase II
    • Berger,J.M. et al. (1996) Structure and mechanism of DNA topoisomerase II. Nature, 379, 225-232.
    • (1996) Nature , vol.379 , pp. 225-232
    • Berger, J.M.1
  • 13
    • 0028954122 scopus 로고
    • Efficient induction of chromosome-type aberrations by topoisomerase II inhibitors closely associated with stabilization of the cleavable complex in cultured fibroblastic cells
    • Suzuki,H. et al. (1995) Efficient induction of chromosome-type aberrations by topoisomerase II inhibitors closely associated with stabilization of the cleavable complex in cultured fibroblastic cells. Mutat. Res., 328, 151-161.
    • (1995) Mutat. Res , vol.328 , pp. 151-161
    • Suzuki, H.1
  • 14
    • 1342289580 scopus 로고    scopus 로고
    • Etoposide induces chimeric Mll gene fusions
    • Blanco,J.G. et al. (2004) Etoposide induces chimeric Mll gene fusions. FASEB J., 18, 173-175.
    • (2004) FASEB J , vol.18 , pp. 173-175
    • Blanco, J.G.1
  • 15
    • 14944354802 scopus 로고    scopus 로고
    • Therapy-related acute myeloid leukemia-like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansion
    • Libura,J. et al. (2005) Therapy-related acute myeloid leukemia-like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansion. Blood, 105, 2124-2131.
    • (2005) Blood , vol.105 , pp. 2124-2131
    • Libura, J.1
  • 16
    • 33645319963 scopus 로고    scopus 로고
    • MLL rearrangements are induced by low doses of etoposide in human fetal hematopoietic stem cells
    • Moneypenny,C.G. et al. (2006) MLL rearrangements are induced by low doses of etoposide in human fetal hematopoietic stem cells. Carcinogenesis, 27, 874-881.
    • (2006) Carcinogenesis , vol.27 , pp. 874-881
    • Moneypenny, C.G.1
  • 17
    • 0035866811 scopus 로고    scopus 로고
    • Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion
    • Alexander,F.E. et al. (2001) Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion. Cancer Res., 61 2542-2546.
    • (2001) Cancer Res , vol.61 , pp. 2542-2546
    • Alexander, F.E.1
  • 18
    • 0025189757 scopus 로고
    • Induction of mammalian topoisomerase II dependent DNA cleavage by nonintercalative flavonoids, genistein and orobol
    • Yamashita,Y. et al. (1990) Induction of mammalian topoisomerase II dependent DNA cleavage by nonintercalative flavonoids, genistein and orobol. Biochem. Pharmacol., 39, 737-744.
    • (1990) Biochem. Pharmacol , vol.39 , pp. 737-744
    • Yamashita, Y.1
  • 19
    • 0026574138 scopus 로고
    • Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives
    • Austin,C.A. et al. (1992) Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives. Biochem. J., 282, 83-89.
    • (1992) Biochem. J , vol.282 , pp. 83-89
    • Austin, C.A.1
  • 20
    • 0028948804 scopus 로고
    • Flavonoids as DNA topoisomerase antagonists and poisons: Structure-activity relationships
    • Constantinou,A. et al. (1995) Flavonoids as DNA topoisomerase antagonists and poisons: Structure-activity relationships. J. Nat. Prod., 58, 217-225.
    • (1995) J. Nat. Prod , vol.58 , pp. 217-225
    • Constantinou, A.1
  • 21
    • 0034712748 scopus 로고    scopus 로고
    • Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia
    • Strick,R. et al. (2000) Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia. Proc. Natl Acad. Sci. USA, 97, 4790-4795.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 4790-4795
    • Strick, R.1
  • 22
    • 20144389914 scopus 로고    scopus 로고
    • Maternal diet and infant leukemia: The DNA topoisomerase II inhibitor hypothesis: A report from the children's oncology group
    • Spector,L.G. et al. (2005) Maternal diet and infant leukemia: The DNA topoisomerase II inhibitor hypothesis: A report from the children's oncology group. Cancer Epidemiol. Biomarkers Prev., 14, 651-655.
    • (2005) Cancer Epidemiol. Biomarkers Prev , vol.14 , pp. 651-655
    • Spector, L.G.1
  • 23
    • 0029910797 scopus 로고    scopus 로고
    • Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): A report from the Children's Cancer Group
    • Ross,J.A. et al. (1996) Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): A report from the Children's Cancer Group. Cancer Causes Control, 7, 581-590.
    • (1996) Cancer Causes Control , vol.7 , pp. 581-590
    • Ross, J.A.1
  • 24
    • 13944274492 scopus 로고    scopus 로고
    • Leukemic stem cells in childhood high-risk ALL/t(9;22) and t(4;11) are present in primitive lymphoid-restricted CD34+CD19- cells
    • Hotfilder,M. et al. (2005) Leukemic stem cells in childhood high-risk ALL/t(9;22) and t(4;11) are present in primitive lymphoid-restricted CD34+CD19- cells. Cancer Res., 65, 1442-1449.
    • (2005) Cancer Res , vol.65 , pp. 1442-1449
    • Hotfilder, M.1
  • 25
    • 0037269184 scopus 로고    scopus 로고
    • Acute myeloid leukemia with MLL rearrangements: Clinicobiological features, prognostic impact and value of flow cytometry in the detection of residual leukemic cells
    • Munoz,L. et al. (2003) Acute myeloid leukemia with MLL rearrangements: Clinicobiological features, prognostic impact and value of flow cytometry in the detection of residual leukemic cells. Leukemia, 17, 76-82.
    • (2003) Leukemia , vol.17 , pp. 76-82
    • Munoz, L.1
  • 26
    • 0026585352 scopus 로고
    • DNA damage by drugs and radiation: What is important and how is it measured?
    • Whitaker,S.J. (1992) DNA damage by drugs and radiation: What is important and how is it measured? Eur. J. Cancer, 28, 273-276.
    • (1992) Eur. J. Cancer , vol.28 , pp. 273-276
    • Whitaker, S.J.1
  • 27
    • 0032006405 scopus 로고    scopus 로고
    • Benzene metabolites induce the loss and long arm deletion of chromosomes 5 and 7 in human lymphocytes
    • Zhang,L. et al. (1998) Benzene metabolites induce the loss and long arm deletion of chromosomes 5 and 7 in human lymphocytes. Leuk. Res., 22, 105-113.
    • (1998) Leuk. Res , vol.22 , pp. 105-113
    • Zhang, L.1
  • 28
    • 0032748133 scopus 로고    scopus 로고
    • The benzene metabolites hydroquinone and catechol act in synergy to induce dose-dependent hypoploidy and -5q31 in a human cell line
    • Stillman,W.S. et al. (1999) The benzene metabolites hydroquinone and catechol act in synergy to induce dose-dependent hypoploidy and -5q31 in a human cell line. Leuk Lymphoma, 35, 269-281.
    • (1999) Leuk Lymphoma , vol.35 , pp. 269-281
    • Stillman, W.S.1
  • 29
    • 0033982687 scopus 로고    scopus 로고
    • The benzene metabolite, hydroquinone, selectively induces 5q31- and -7 in human CD34+CD19- bone marrow cells
    • Stillman,W.S. et al. (2000) The benzene metabolite, hydroquinone, selectively induces 5q31- and -7 in human CD34+CD19- bone marrow cells. Exp. Hematol., 28, 169-176.
    • (2000) Exp. Hematol , vol.28 , pp. 169-176
    • Stillman, W.S.1
  • 30
    • 0030823976 scopus 로고    scopus 로고
    • The benzene metabolite, hydroquinone, induces dose-dependent hypoploidy in a human cell line
    • Stillman,W.S. et al. (1997) The benzene metabolite, hydroquinone, induces dose-dependent hypoploidy in a human cell line. Leukemia, 11, 1540-1545.
    • (1997) Leukemia , vol.11 , pp. 1540-1545
    • Stillman, W.S.1
  • 31
    • 0033852276 scopus 로고    scopus 로고
    • Hydroquinone a benzene metabolite, increases the level of aneusomy of chromosomes 7 and 8 in human CD34-positive blood progenitor cells
    • Smith,M.T. et al. (2000) Hydroquinone a benzene metabolite, increases the level of aneusomy of chromosomes 7 and 8 in human CD34-positive blood progenitor cells. Carcinogenesis, 21, 1485-1490.
    • (2000) Carcinogenesis , vol.21 , pp. 1485-1490
    • Smith, M.T.1
  • 32
    • 0033584461 scopus 로고    scopus 로고
    • A DNA damage repair mechanism is involved in the origin of chromosomal translocations t(4;11) in primary leukemic cells
    • Gillert,E. et al. (1999) A DNA damage repair mechanism is involved in the origin of chromosomal translocations t(4;11) in primary leukemic cells. Oncogene, 18, 4663-4671.
    • (1999) Oncogene , vol.18 , pp. 4663-4671
    • Gillert, E.1
  • 33
    • 0030041634 scopus 로고    scopus 로고
    • Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment related acute myeloid leukemia: Correlation with scaffold attachment regions and topoisomerase II consensus binding sites
    • Broeker,P.L. et al. (1996) Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment related acute myeloid leukemia: Correlation with scaffold attachment regions and topoisomerase II consensus binding sites. Blood, 87, 1912-1922.
    • (1996) Blood , vol.87 , pp. 1912-1922
    • Broeker, P.L.1
  • 34
    • 0034621854 scopus 로고    scopus 로고
    • Frequent chromosomal translocations induced by DNA double-strand breaks
    • Richardson,C. et al. (2000) Frequent chromosomal translocations induced by DNA double-strand breaks. Nature, 405, 697-700.
    • (2000) Nature , vol.405 , pp. 697-700
    • Richardson, C.1
  • 35
    • 0027465862 scopus 로고
    • A positive role for histone acetylation in transcription factor access to nucleosomal DNA
    • Lee,D.Y. et al. (1993) A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell, 72, 73-84.
    • (1993) Cell , vol.72 , pp. 73-84
    • Lee, D.Y.1
  • 36
    • 2442648882 scopus 로고    scopus 로고
    • Mutational analysis of the tyrosine phosphatome in colorectal cancers
    • Wang,Z. et al. (2004) Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science, 304, 1164-1166.
    • (2004) Science , vol.304 , pp. 1164-1166
    • Wang, Z.1
  • 37
    • 0030138905 scopus 로고    scopus 로고
    • Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island
    • Gu,Y. et al. (1996) Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island. Nat. Genet., 13, 109-113.
    • (1996) Nat. Genet , vol.13 , pp. 109-113
    • Gu, Y.1
  • 38
    • 0030137717 scopus 로고    scopus 로고
    • Identification of the gene FMR2, associated with FRAXE mental retardation
    • Gecz,J. et al. (1996) Identification of the gene FMR2, associated with FRAXE mental retardation. Nat. Genet., 13, 105-108.
    • (1996) Nat. Genet , vol.13 , pp. 105-108
    • Gecz, J.1
  • 39
    • 0027171040 scopus 로고
    • Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product
    • Domer,P.H. et al. (1993) Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product. Proc. Natl Acad. Sci. USA, 90, 7884-7888.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 7884-7888
    • Domer, P.H.1
  • 40
    • 0036022076 scopus 로고    scopus 로고
    • LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia
    • von Bergh,A.R. et al. (2002) LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia. Genes Chromosomes Cancer, 35, 92-96.
    • (2002) Genes Chromosomes Cancer , vol.35 , pp. 92-96
    • von Bergh, A.R.1
  • 41
    • 0033429143 scopus 로고    scopus 로고
    • AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)
    • Taki,T. et al. (1999) AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23). Proc. Natl Acad. Sci. USA, 96, 14535-14540.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 14535-14540
    • Taki, T.1
  • 42
    • 16844372086 scopus 로고    scopus 로고
    • The antifolate activity of tea catechins
    • Navarro-Peran,E. et al. (2005) The antifolate activity of tea catechins. Cancer Res., 65, 2059-2064.
    • (2005) Cancer Res , vol.65 , pp. 2059-2064
    • Navarro-Peran, E.1
  • 43
    • 0035830288 scopus 로고    scopus 로고
    • Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: A case-control study
    • Thompson,J.R. et al. (2001) Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: A case-control study. Lancet, 358, 1935-1940.
    • (2001) Lancet , vol.358 , pp. 1935-1940
    • Thompson, J.R.1
  • 44
    • 0035957379 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia
    • Wiemels,J.L. et al. (2001) Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc. Natl Acad. Sci. USA, 98, 4004-4009.
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 4004-4009
    • Wiemels, J.L.1
  • 45
    • 15244361942 scopus 로고    scopus 로고
    • Chromosomal translocation mechanisms at intronic alu elements in mammalian cells
    • Elliott,B. et al. (2005) Chromosomal translocation mechanisms at intronic alu elements in mammalian cells. Mol. Cell, 17, 885-894.
    • (2005) Mol. Cell , vol.17 , pp. 885-894
    • Elliott, B.1
  • 46
    • 0036778597 scopus 로고    scopus 로고
    • The role of Alu repeat clusters as mediators of recurrent chromosomal aberrations in minors
    • Kolomietz,E. et al. (2002) The role of Alu repeat clusters as mediators of recurrent chromosomal aberrations in minors. Genes Chromosomes Cancer, 35, 97-112.
    • (2002) Genes Chromosomes Cancer , vol.35 , pp. 97-112
    • Kolomietz, E.1
  • 47
    • 0027998890 scopus 로고
    • ALL-1 tandem duplication in acute myeloid leukemia with a normal karyotype involves homologous recombination between Alu elements
    • Schichman,S.A. et al. (1994) ALL-1 tandem duplication in acute myeloid leukemia with a normal karyotype involves homologous recombination between Alu elements. Cancer Res., 54, 4277-4280.
    • (1994) Cancer Res , vol.54 , pp. 4277-4280
    • Schichman, S.A.1
  • 48
    • 31044441712 scopus 로고    scopus 로고
    • Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations
    • Nakada,S. et al. (2006) Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations. J. Clin. Invest., 116, 80-89.
    • (2006) J. Clin. Invest , vol.116 , pp. 80-89
    • Nakada, S.1
  • 49
    • 0035360796 scopus 로고    scopus 로고
    • Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair system
    • Betti,C.J. et al. (2001) Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair system. Cancer Res., 61, 4550-4555.
    • (2001) Cancer Res , vol.61 , pp. 4550-4555
    • Betti, C.J.1
  • 50
    • 0037444282 scopus 로고    scopus 로고
    • Apoptotic stimuli initiate MLL-AF9 translocations that are transcribed in cells capable of division
    • Betti,C.J. et al. (2003) Apoptotic stimuli initiate MLL-AF9 translocations that are transcribed in cells capable of division. Cancer Res., 63, 1377-1381.
    • (2003) Cancer Res , vol.63 , pp. 1377-1381
    • Betti, C.J.1
  • 51
    • 0031908477 scopus 로고    scopus 로고
    • Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: Results from an in vitro and a dietary supplement study
    • Janssen,K et al. (1998) Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: Results from an in vitro and a dietary supplement study. Am. J. Clin. Nutr., 67 255-262.
    • (1998) Am. J. Clin. Nutr , vol.67 , pp. 255-262
    • Janssen, K.1
  • 52
    • 23744472139 scopus 로고    scopus 로고
    • Fetal exposure to phytoestrogens-the difference in phytoestrogen status between mother and fetus
    • Todaka,E. et al. (2005) Fetal exposure to phytoestrogens-the difference in phytoestrogen status between mother and fetus. Environ. Res., 99, 195-203.
    • (2005) Environ. Res , vol.99 , pp. 195-203
    • Todaka, E.1
  • 53
    • 0029897112 scopus 로고    scopus 로고
    • Analysis of foetal expression sites of human type II DNA topoisomerase alpha and beta mRNAs by in situ hybridisation
    • Zandvliet,D.W. et al. (1996) Analysis of foetal expression sites of human type II DNA topoisomerase alpha and beta mRNAs by in situ hybridisation. Biochim. Biophys. Acta, 1307, 239-247.
    • (1996) Biochim. Biophys. Acta , vol.1307 , pp. 239-247
    • Zandvliet, D.W.1
  • 54
    • 13244275108 scopus 로고    scopus 로고
    • Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans
    • Hubbard,G.P. et al. (2004) Ingestion of quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans. J. Thromb. Haemost., 2 2138-2145.
    • (2004) J. Thromb. Haemost , vol.2 , pp. 2138-2145
    • Hubbard, G.P.1
  • 55
    • 0033855919 scopus 로고    scopus 로고
    • The therapeutic potential of flavonoids
    • Wang,H.K. (2000) The therapeutic potential of flavonoids. Expert Opin. Investig. Drugs, 9, 2103-2119.
    • (2000) Expert Opin. Investig. Drugs , vol.9 , pp. 2103-2119
    • Wang, H.K.1
  • 56
    • 33644683613 scopus 로고    scopus 로고
    • Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone
    • Verschoyle,R.D. et al. (2006) Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone. Cancer Chemother. Pharmacol., 57, 1-6.
    • (2006) Cancer Chemother. Pharmacol , vol.57 , pp. 1-6
    • Verschoyle, R.D.1


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