Topoisomerase II and tubulin inhibitors both induce the formation of apoptotic topoisomerase I cleavage complexes

Molecular Cancer Therapeutics

Volumn 5, Issue 12, 2006, Pages 3139-3144

  Sordet, Olivier ^a   Goldman, Abby ^a   Pommier, Yves ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; AMSACRINE; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; ETOPOSIDE; GYRASE INHIBITOR; PACLITAXEL; REACTIVE OXYGEN METABOLITE; TUBULIN INHIBITOR; UNCLASSIFIED DRUG; VINBLASTINE;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL STRAIN HL 60; COLON CARCINOMA; COMPLEX FORMATION; CONTROLLED STUDY; DNA STRAND BREAKAGE; DRUG PROTEIN BINDING; DRUG RESPONSE; ENZYME DEGRADATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL;

AMINO ACID CHLOROMETHYL KETONES; AMSACRINE; APOPTOSIS; CASPASES; CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DOXORUBICIN; ENZYME INHIBITORS; ETOPOSIDE; HL-60 CELLS; HUMANS; PACLITAXEL; REACTIVE OXYGEN SPECIES; TUBULIN MODULATORS; VINBLASTINE;

EID: 33846255783     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-06-0463     Document Type: Article

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