Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 311-323

  Chini, Maria Giovanna ^a   De Simone, Rosa ^a   Bruno, Ines ^a   Riccio, Raffaele ^a   Dehm, Friederike ^b   Weinigel, Christina ^c   Barz, Dagmar ^c   Werz, Oliver ^b   Bifulco, Giuseppe ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

5 Lipoxygenase; In silico screening; mPGES 1; Triazole based inhibitors

Indexed keywords

3 NITRO 4[4(4 THIOPHEN 2 YL PHENYL) [1,2,3] TRIAZOL 1 YLMETHYL] BENZOIC ACID; 4' [1(4 CARBOXY 2 NITRO BENZYL) 1H [1,2,3] TRIAZOL 4 YL] BIPHENYL 2 CARBOXYLIC ACID; 4' [1(4 CARBOXY 2 NITRO BENZYL) 1H [1,2,3] TRIAZOL 4 YL] BIPHENYL 3 CARBOXYLIC ACID; 4' [1(4 CARBOXY 2 NITRO BENZYL) 1H[1,2,3] TRIAZOL 4 YL] BIPHENYL 4 CARBOXYLIC ACID; 4[4(3' HYDROXY BIPHENYL 4 YL) [1,2,3] TRIAZOL 1 YLMETHYL] 3 NITRO BENZOIC ACID; 4[4(3',4',5' TRIMETHOXY BIPHENYL 4 YL) [1,2,3] TRIAZOL 1 YLMETHYL] 3 NITRO BENZOIC ACID; 4[4(4 BROMO PHENYL) [1,2,3] TRIAZOL 1 YLMETHYL] 3 NITROBENZOIC ACID; 4[4(4 BROMO PHENYL) [1,2,3] TRIAZOL 1 YLMETHYL] BENZOIC ACID; 4[4(4 BROMO PHENYL) [1,2,3] TRIAZOLE 1 SULFONYL] BENZOIC ACID; 4[4(4' AMINO BIPHENYL 4 YL) [1,2,3] TRIAZOL 1 YLMETHYL] 3 NITRO BENZOIC ACID; 4[4(4' HYDROXY BIPHENYL 4 YL) [1,2,3] TRIAZOL 1 YLMETHYL] 3 NITRO BENZOIC ACID; 4[4(4' METHOXY 3' MORPHOLIN 4 YLMETHYL BIPHENYL 4 YL) [1,2,3] TRIAZOL 1 YLMETHYL] 3 NITRO BENZOIC ACID; 4[4[2' (2 CHLORO 5 TRIFLUOROMETHYL PHENOXYMETHYL) BIPHENYL 4 YL] [1,2,3] TRIAZOL 1 YLMETHYL] 3 NITRO BENZOIC ACID; 4[4[2' (2 CHLORO 5 TRIFLUOROMETHYL PHENOXYMETHYL) BIPHENYL 4 YL] [1,2,3] TRIAZOL 1 YLMETHYL] BENZOIC ACID; 4[4[2' (2 CHLORO 5 TRIFLUOROMETHYL PHENOXYMETHYL) BIPHENYL 4 YL] [1,2,3] TRIAZOLE 1 SULFONYL] BENZOIC ACID; 4[4[3' (MORPHOLINE 4 CARBONYL) BIPHENYL 4 YL] [1,2,3] TRIAZOL 1 YLMETHYL] 3 NITRO BENZOIC ACID; 4[4[4' (6 DIMETHYLAMINO NAPHTHALENE 2 SULFONYLAMINO) BIPHENYL 4 YL] [1,2,3] TRIAZOL 1 YLMETHYL] 3 NITRO BENZOIC ACID; LIPOXYGENASE INHIBITOR; MICROSOMAL PROSTAGLANDIN E2 SYNTHASE; PROSTAGLANDIN E SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL FREE SYSTEM; CONTROLLED STUDY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; NONHUMAN; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

ADULT; ARACHIDONATE 5-LIPOXYGENASE; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; INTRAMOLECULAR OXIDOREDUCTASES; LIGANDS; LIPOXYGENASE INHIBITORS; MOLECULAR DOCKING SIMULATION; PROTEIN CONFORMATION; TRIAZOLES;

EID: 84864408638     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.05.014     Document Type: Article

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