Gastrointestinal toxic side effects of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2-specific inhibitors

American Journal of Medicine

Volumn 110, Issue 3 SUPPL. 1, 2001, Pages 13-19

  Buttgereit, Frank ^a,c   Burmester, Gerd R ^a   Simon, Lee S ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; IBUPROFEN; MISOPROSTOL; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; OMEPRAZOLE; RANITIDINE; ROFECOXIB;

ADULT; AGED; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG RESPONSE; GASTRODUODENAL ULCER; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL TOXICITY; HUMAN; PRIORITY JOURNAL; REVIEW; STOMACH PROTECTION; ULCER PERFORATION;

EID: 0035911015     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0002-9343(00)00728-2     Document Type: Review

References (19)

1. Non-steroidal anti-inflammatory drug gastropathy: Causes and treatment
2. A unifying hypothesis for the mechanism of NSAID related gastrointestinal toxicity
3. In vitro interaction of nonsteroidal anti-inflammatory drugs on oxidative phosphorylation of rat kidney mitochondria: Respiration and ATP synthesis
4. Nonsteroidal antiinflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation
5. Uncoupling effects of diclofenac and aspirin in the perfused liver and isolated hepatic mitochondria of rat
6. Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory
7. Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs
8. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal antiinflammatory drugs
9. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs
10. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs: A randomized, double-blind, placebo-controlled trial
11. Risk factors for serious nonsteroidal-induced gastrointestinal complications: Regression analysis of the MUCOSA trial
12. Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: A randomized controlled trial
13. A randomized trial comparing the effect of rofecoxib, a cyclooxygenase 2-specific inhibitor, with that of ibuprofen on the gastroduodenal mucosa of patients with osteoarthritis
14. Bioenergetics of immune functions: Fundamental and therapeutic aspects
15. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis
16. Analysis of the effect of COX-2 specific inhibitors and recommendations for their use in clinical practice
17. Nonsteroidal anti-inflammatory drugs: How do they damage gastroduodenal mucosa?
18. Cost-effectiveness considerations for COX-2 specific inhibitors
19. Effects of a novel cyclooxygenase (COX)-2 inhibitor on gastric mucosal prostaglandin (PG) synthesis in healthy humans