Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid

Journal of Medicinal Chemistry

Volumn 54, Issue 13, 2011, Pages 4490-4507

  Hieke, Martina ^a,b   Greiner, Christine ^b,c   Dittrich, Michaela ^a   Reisen, Felix ^b   Schneider, Gisbert ^b   Schubert Zsilavecz, Manfred ^a   Werz, Oliver ^d  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c ETH ZURICH   (Switzerland)

^d FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,3 DIPHENETHOXYBENZYLIDENE)HEXANOIC ACID; 2 [(3,5 DIPHENETHOXYPHENYL)THIO]HEXANOIC ACID; 2 [(4,6 DIPHENETHOXYPYRIMIDIN 2 YL)THIO]HEXANOIC ACID; 2 BENZYLHEXANOIC ACID; 2 BENZYLIDENEHEXANOIC ACID; ARACHIDONATE 15 LIPOXYGENASE; BENZENE DERIVATIVE; BENZYL DERIVATIVE; BENZYLIDENE DERIVATIVE; LIPOXYGENASE INHIBITOR; PROSTAGLANDIN E2 DERIVATIVE; PROSTAGLANDIN E2 SYNTHASE 1; PROSTAGLANDIN INHIBITOR; PROSTAGLANDIN SYNTHASE; PYRIMIDINE; SULFIDE; THIOBARBITURIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONCENTRATION (PARAMETERS); DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; LIGAND BINDING; LIPOPHILICITY; MICROSOME; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARACHIDONATE 5-LIPOXYGENASE; BENZENE DERIVATIVES; BINDING SITES; CELLS, CULTURED; CYCLOOXYGENASE INHIBITORS; HEXANOIC ACIDS; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; LIGANDS; LIPOXYGENASE INHIBITORS; MICROSOMES; MODELS, MOLECULAR; PYRIMIDINES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960188500     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200092b     Document Type: Article

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