Development of a second generation of inhibitors of microsomal prostaglandin E synthase 1 expression bearing the γ-hydroxybutenolide scaffold

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 19, 2008, Pages 9056-9064

  Aquino, Maurizio ^a   Guerrero, Maria D ^b   Bruno, Ines ^a   Terencio, María C ^b   Paya, Miguel ^b   Riccio, Raffaele ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Hydroxybutenolide derivatives; COX 2; mPGES 1; sPLA2

Indexed keywords

BUTENOLIDE; CYCLOOXYGENASE 2; GAMMA HYDROXYBUTENOLIDE DERIVATIVE; PETROSASPONGIOLIDE M; PHOSPHOLIPASE A2 INHIBITOR; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN SYNTHASE INHIBITOR; SESTERTERPENE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MACROPHAGE ACTIVATION; MICROSOME; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

4-BUTYROLACTONE; ANIMALS; ANTI-INFLAMMATORY AGENTS; BINDING SITES; CELL LINE; CYCLOOXYGENASE 2; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; INTRAMOLECULAR OXIDOREDUCTASES; MACROPHAGES; MICE; MICROSOMES; PHOSPHOLIPASES A2; PROSTAGLANDIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 52949144554     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.08.001     Document Type: Article

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